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The map label for this gene is ltrA [H]

Identifier: 119357993

GI number: 119357993

Start: 2542907

End: 2544001

Strand: Reverse

Name: ltrA [H]

Synonym: Cpha266_2214

Alternate gene names: 119357993

Gene position: 2544001-2542907 (Counterclockwise)

Preceding gene: 119357994

Following gene: 119357992

Centisome position: 81.18

GC content: 54.16

Gene sequence:

>1095_bases
ATGAAGGAGAGAACCCGAAGAATTGATGCTGAAACGAGCCGGGAGTCGGATGGTGGCATAGTACCGGAGAAGCAGCCGAA
CAAAGCGAACCCTGAAGCTGCGGAGGTTGTGGAGGGAAGGCCACCAGCCAAGAGGAACACCGGAGAGAAAGCCATCGAAT
GGACACAGAGCCAAAACCCGATGTCTTGCGGACTCGAAGGTGTGCGAAGAAAAGCCAAAGAAGACAAGACCTGTTGCTTC
ACGGCCCTGCTGCATCACATCACCCCCGACATGCTGAGTACCAGCTTCTACGAGCTGAACCGAAAAGCAGCGGAAGGGAC
AGATGGAAAAAGCTGGAAAACGTACGAAGCGCAGCTCGAAGAACGCCTGCCGAAGCTGCACGAAGAAATCCACACAGGCA
GCTACCGGGCCCAACCGGTCAAGAGGGTGTATATCCCGAAAACCGATGGCCAGAAACGCCCGCTGGGCATAACGGCCATA
GAAGACAAGCTTGTCCAGCAAGCAGTTGTCACGGTACTGAACCAGATATACGAAACCGAATTCTATGGGTTCTCCTATGG
ATACCGGCCAGGCCGAGCCCCGGAAAACGCGCTGGATGCCCTGGCAACAGCGATACTGAAACGTCCGATCAACTGGATAC
TGGACGCGGACTTGCAGAAATTCTTCGACAGCATCCCGCACGACAAACTGATGGCCCTCATCAGCATACGCGTTGGCGAC
AAACGGATACTGCGCCTTATCGGAAAATGGCTCAAGACGGGATATATCGAAGACGGGAAGCGATACCGGCAAACAGAAGG
CACACCGCAGGGATCGGTGATCTCACCACTGCTTGCCAACATCTATCTTCACTACGTGGTGGACGAATGGGTCGAACAGG
AGAGACGTCGCCGAAACAACGGCGAAGTCATCATCATCAGGTACGCCGACGATCTTGTGCTGGGATTCCAGTACAAGACA
GAAGCGGAAAGATACCTTGAGGCTCTGAGTGAACGAGTACAAACGTACGGACTGAAACTGCACCCCGAGAAAACGAGCCT
GAAAGAATTCGGAAGATATGCCGAAGAAAGGCGGCGGAAACGCGGGGAGGAATAG

Upstream 100 bases:

>100_bases
GGAGTCGTAGAACTGGAGCATGTGTGGAAGCTCTTTGCGCGGGAATCGGGAGACCCGGTAAGAACCCTGCCCGGAGGCAA
ACGGAAGCAGGGCGGCATCA

Downstream 100 bases:

>100_bases
GGGACGCAGTGCAATAGCGTATAAAATTGTATTTTGCAGTGAGGAATAAACGATTTGTGCAGGCAGCTTTTGAAAAGCAA
AAGACAAGAGAGCCATATGC

Product: RNA-directed DNA polymerase (Reverse transcriptase)

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKERTRRIDAETSRESDGGIVPEKQPNKANPEAAEVVEGRPPAKRNTGEKAIEWTQSQNPMSCGLEGVRRKAKEDKTCCF
TALLHHITPDMLSTSFYELNRKAAEGTDGKSWKTYEAQLEERLPKLHEEIHTGSYRAQPVKRVYIPKTDGQKRPLGITAI
EDKLVQQAVVTVLNQIYETEFYGFSYGYRPGRAPENALDALATAILKRPINWILDADLQKFFDSIPHDKLMALISIRVGD
KRILRLIGKWLKTGYIEDGKRYRQTEGTPQGSVISPLLANIYLHYVVDEWVEQERRRRNNGEVIIIRYADDLVLGFQYKT
EAERYLEALSERVQTYGLKLHPEKTSLKEFGRYAEERRRKRGEE

Sequences:

>Translated_364_residues
MKERTRRIDAETSRESDGGIVPEKQPNKANPEAAEVVEGRPPAKRNTGEKAIEWTQSQNPMSCGLEGVRRKAKEDKTCCF
TALLHHITPDMLSTSFYELNRKAAEGTDGKSWKTYEAQLEERLPKLHEEIHTGSYRAQPVKRVYIPKTDGQKRPLGITAI
EDKLVQQAVVTVLNQIYETEFYGFSYGYRPGRAPENALDALATAILKRPINWILDADLQKFFDSIPHDKLMALISIRVGD
KRILRLIGKWLKTGYIEDGKRYRQTEGTPQGSVISPLLANIYLHYVVDEWVEQERRRRNNGEVIIIRYADDLVLGFQYKT
EAERYLEALSERVQTYGLKLHPEKTSLKEFGRYAEERRRKRGEE
>Mature_364_residues
MKERTRRIDAETSRESDGGIVPEKQPNKANPEAAEVVEGRPPAKRNTGEKAIEWTQSQNPMSCGLEGVRRKAKEDKTCCF
TALLHHITPDMLSTSFYELNRKAAEGTDGKSWKTYEAQLEERLPKLHEEIHTGSYRAQPVKRVYIPKTDGQKRPLGITAI
EDKLVQQAVVTVLNQIYETEFYGFSYGYRPGRAPENALDALATAILKRPINWILDADLQKFFDSIPHDKLMALISIRVGD
KRILRLIGKWLKTGYIEDGKRYRQTEGTPQGSVISPLLANIYLHYVVDEWVEQERRRRNNGEVIIIRYADDLVLGFQYKT
EAERYLEALSERVQTYGLKLHPEKTSLKEFGRYAEERRRKRGEE

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=205, Percent_Identity=33.6585365853659, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6226520, Length=215, Percent_Identity=32.5581395348837, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 41926; Mature: 41926

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50878 RT_POL ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERTRRIDAETSRESDGGIVPEKQPNKANPEAAEVVEGRPPAKRNTGEKAIEWTQSQNP
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHCCCCCC
MSCGLEGVRRKAKEDKTCCFTALLHHITPDMLSTSFYELNRKAAEGTDGKSWKTYEAQLE
HHHCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ERLPKLHEEIHTGSYRAQPVKRVYIPKTDGQKRPLGITAIEDKLVQQAVVTVLNQIYETE
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYGFSYGYRPGRAPENALDALATAILKRPINWILDADLQKFFDSIPHDKLMALISIRVGD
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCH
KRILRLIGKWLKTGYIEDGKRYRQTEGTPQGSVISPLLANIYLHYVVDEWVEQERRRRNN
HHHHHHHHHHHHCCCHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEVIIIRYADDLVLGFQYKTEAERYLEALSERVQTYGLKLHPEKTSLKEFGRYAEERRRK
CCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHH
RGEE
CCCC
>Mature Secondary Structure
MKERTRRIDAETSRESDGGIVPEKQPNKANPEAAEVVEGRPPAKRNTGEKAIEWTQSQNP
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHCCCCCC
MSCGLEGVRRKAKEDKTCCFTALLHHITPDMLSTSFYELNRKAAEGTDGKSWKTYEAQLE
HHHCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ERLPKLHEEIHTGSYRAQPVKRVYIPKTDGQKRPLGITAIEDKLVQQAVVTVLNQIYETE
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYGFSYGYRPGRAPENALDALATAILKRPINWILDADLQKFFDSIPHDKLMALISIRVGD
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCH
KRILRLIGKWLKTGYIEDGKRYRQTEGTPQGSVISPLLANIYLHYVVDEWVEQERRRRNN
HHHHHHHHHHHHCCCHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEVIIIRYADDLVLGFQYKTEAERYLEALSERVQTYGLKLHPEKTSLKEFGRYAEERRRK
CCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHH
RGEE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]