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The map label for this gene is estA [H]

Identifier: 119357893

GI number: 119357893

Start: 2434441

End: 2435112

Strand: Direct

Name: estA [H]

Synonym: Cpha266_2101

Alternate gene names: 119357893

Gene position: 2434441-2435112 (Clockwise)

Preceding gene: 119357892

Following gene: 119357894

Centisome position: 77.68

GC content: 50.3

Gene sequence:

>672_bases
ATGCTGCAACGAAAACATCTCTCTCTGACCTATCTTGAACTCTCAGCCAAAGAACAGGAACAAGCTCCTCTCGTGGTCAT
GCTCCATGGATATGGCAGCAATGAAAAAGATCTCATCCATCTGGCTCCATCGCTCCATCCGGGGTTAACCTGGATCAGCC
CGAGAGCTCCCCGTATGCTTGATTTAGGTATGTTCGGATGGTTTCCTCTTGAATTTACGGCAACAGGCATCACTGTCGAT
TATGAAGCTGCAGGGTTGGCAAGAGACCGGTGCATCGGCTTTCTTTCTGATCTCATAAAGGAGTATCGACCTGCCGGAAA
CAAGGTCTTTCTCACCGGTTTCAGCCAGGGTGCTGTCATGAGCTATCTCATAGCCTTTGCTGCGCCCGAGCTGCTTCACG
GCGTGGTTGCATTCTCAGGCCAGCTTCCGCACCGGCAACTGGTAGATGAAGAAAAACTGGCCATCTTCAACAAGATTCCC
ATGCTTGTTATCCATGGGATTTTTGACGAAATTCTCCCGATTGCAAAAGGGAAGGAGAGTAACCTCTACCTGCAGAACCT
GCTTGCCGATCTGACCTATCAGGAGTACCCGATGGGCCATGAAATCAGTGCGGAAGCAATCTCCCTTGCTTCGAAGTGGC
TGACGAAAAAAGTGAACCTGATCGGCGGGTAA

Upstream 100 bases:

>100_bases
CCCGGACAGGCCGCCGTGTTTTACCATGACGAAGAGGTGCTTGGCGGCGGGTTTATCAGCGCGGTCAACAGAGACCGGTA
ACAACAAGACAACATCACTC

Downstream 100 bases:

>100_bases
AAAACGGGTCGACCGGTGGTATGGAAGAGTCATGTTTTGACCACCATGTTCTGCCCTCATAATCGTATATTCTCTTTTTT
TTTAACGCTGCCATGCCCTG

Product: phospholipase/carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MLQRKHLSLTYLELSAKEQEQAPLVVMLHGYGSNEKDLIHLAPSLHPGLTWISPRAPRMLDLGMFGWFPLEFTATGITVD
YEAAGLARDRCIGFLSDLIKEYRPAGNKVFLTGFSQGAVMSYLIAFAAPELLHGVVAFSGQLPHRQLVDEEKLAIFNKIP
MLVIHGIFDEILPIAKGKESNLYLQNLLADLTYQEYPMGHEISAEAISLASKWLTKKVNLIGG

Sequences:

>Translated_223_residues
MLQRKHLSLTYLELSAKEQEQAPLVVMLHGYGSNEKDLIHLAPSLHPGLTWISPRAPRMLDLGMFGWFPLEFTATGITVD
YEAAGLARDRCIGFLSDLIKEYRPAGNKVFLTGFSQGAVMSYLIAFAAPELLHGVVAFSGQLPHRQLVDEEKLAIFNKIP
MLVIHGIFDEILPIAKGKESNLYLQNLLADLTYQEYPMGHEISAEAISLASKWLTKKVNLIGG
>Mature_223_residues
MLQRKHLSLTYLELSAKEQEQAPLVVMLHGYGSNEKDLIHLAPSLHPGLTWISPRAPRMLDLGMFGWFPLEFTATGITVD
YEAAGLARDRCIGFLSDLIKEYRPAGNKVFLTGFSQGAVMSYLIAFAAPELLHGVVAFSGQLPHRQLVDEEKLAIFNKIP
MLVIHGIFDEILPIAKGKESNLYLQNLLADLTYQEYPMGHEISAEAISLASKWLTKKVNLIGG

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Drosophila melanogaster, GI45553055, Length=208, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45553057, Length=208, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357257, Length=208, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 24762; Mature: 24762

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQRKHLSLTYLELSAKEQEQAPLVVMLHGYGSNEKDLIHLAPSLHPGLTWISPRAPRML
CCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCEEECCCCCCEE
DLGMFGWFPLEFTATGITVDYEAAGLARDRCIGFLSDLIKEYRPAGNKVFLTGFSQGAVM
EECCCCCEEEEEEEECEEEECCHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
SYLIAFAAPELLHGVVAFSGQLPHRQLVDEEKLAIFNKIPMLVIHGIFDEILPIAKGKES
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NLYLQNLLADLTYQEYPMGHEISAEAISLASKWLTKKVNLIGG
CHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLQRKHLSLTYLELSAKEQEQAPLVVMLHGYGSNEKDLIHLAPSLHPGLTWISPRAPRML
CCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCEEECCCCCCEE
DLGMFGWFPLEFTATGITVDYEAAGLARDRCIGFLSDLIKEYRPAGNKVFLTGFSQGAVM
EECCCCCEEEEEEEECEEEECCHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
SYLIAFAAPELLHGVVAFSGQLPHRQLVDEEKLAIFNKIPMLVIHGIFDEILPIAKGKES
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NLYLQNLLADLTYQEYPMGHEISAEAISLASKWLTKKVNLIGG
CHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA