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The map label for this gene is rmlA1 [H]

Identifier: 119357791

GI number: 119357791

Start: 2312809

End: 2313708

Strand: Reverse

Name: rmlA1 [H]

Synonym: Cpha266_1998

Alternate gene names: 119357791

Gene position: 2313708-2312809 (Counterclockwise)

Preceding gene: 119357792

Following gene: 119357790

Centisome position: 73.83

GC content: 48.33

Gene sequence:

>900_bases
ATGAAAGGAATAATTCTTGCCGGCGGTTCAGGGACACGCCTTTATCCGATAACGAGGGGTATTTCAAAACAGCTTCTGCC
GGTATACGACAAACCCATGATTTATTATCCCCTCAGTACCTTGATGCTGGGGGGAATCAATGATATCCTTATTATTTCAA
CACCCGAAGATCTGCCTTTGTTTCAGCGTCTGCTGGGAGATGGCAGCGGTTGGGGAATATCGCTTTCCTACAAGGCTCAA
CCATCGCCTGACGGGCTGGCGCAGGCTTTTATTCTTGGTGAAGCGTTTATCGGTTCGGATTCGGTTTGTCTGATTCTCGG
CGATAACATTTTTTTTGGATATGGTTTCAGTTCCATGCTTGATGATGCGGTGAGGATCGTTGAGGAAGAGGCCAAGGCAA
CCATTTTTGGCTACTATGTCCGTGATCCTGAGCGGTATGGCGTGGCGGAATTTGATGAATCCGGCCAGGTGATCTCTCTT
GAAGAGAAGCCTCTGGCTCCCAAATCGAATTATGCCGTTGTCGGGCTCTATTTTTATGACAATTCCGTTGTTGAGATTGC
AAAAACCATTAAACCTTCTGATAGAGGCGAGCTCGAGATCACGTCGGTGAATGAAGAGTATCTGAAACGACGGAAGCTTC
GTCTTTCAATTCTCGGGCGAGGTTTTGCCTGGCTTGATACCGGTACGCACGACTCTTATCAGGAAGCCGGTCACTTTATC
GAGACGGTGGAAAAAAGACAGGGACTGAAGATTGCATGCCCTGAAGAAATTGCATGGCGAAAAGGATGGATCGACGATCG
GCAGCTCAGGGAACTTGCCGCTCCGCTTCTGAAAAATCAGTACGGAGCCTATCTTGTTGAACTGCTTGATCGCAAGGACG
AGTATACCCGGCACCATTGA

Upstream 100 bases:

>100_bases
AAAGCGTATATTAAAGCGCTGTATTTTACATCTTTTTCTTCGCTGTCGTCAGTGCTGTTTTGTTAGCCTTGTATTTTTCC
ATCATGATAGTTCTATCGAA

Downstream 100 bases:

>100_bases
TGCGGGGACTAAACCGTGAGCGATCTGCTGTGTCGTGATAGCGAGCGCAATTGGTATGCCGTTTGCACGACAGGTGTTAT
TGTAATTCTATTCTTTTATC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKGIILAGGSGTRLYPITRGISKQLLPVYDKPMIYYPLSTLMLGGINDILIISTPEDLPLFQRLLGDGSGWGISLSYKAQ
PSPDGLAQAFILGEAFIGSDSVCLILGDNIFFGYGFSSMLDDAVRIVEEEAKATIFGYYVRDPERYGVAEFDESGQVISL
EEKPLAPKSNYAVVGLYFYDNSVVEIAKTIKPSDRGELEITSVNEEYLKRRKLRLSILGRGFAWLDTGTHDSYQEAGHFI
ETVEKRQGLKIACPEEIAWRKGWIDDRQLRELAAPLLKNQYGAYLVELLDRKDEYTRHH

Sequences:

>Translated_299_residues
MKGIILAGGSGTRLYPITRGISKQLLPVYDKPMIYYPLSTLMLGGINDILIISTPEDLPLFQRLLGDGSGWGISLSYKAQ
PSPDGLAQAFILGEAFIGSDSVCLILGDNIFFGYGFSSMLDDAVRIVEEEAKATIFGYYVRDPERYGVAEFDESGQVISL
EEKPLAPKSNYAVVGLYFYDNSVVEIAKTIKPSDRGELEITSVNEEYLKRRKLRLSILGRGFAWLDTGTHDSYQEAGHFI
ETVEKRQGLKIACPEEIAWRKGWIDDRQLRELAAPLLKNQYGAYLVELLDRKDEYTRHH
>Mature_299_residues
MKGIILAGGSGTRLYPITRGISKQLLPVYDKPMIYYPLSTLMLGGINDILIISTPEDLPLFQRLLGDGSGWGISLSYKAQ
PSPDGLAQAFILGEAFIGSDSVCLILGDNIFFGYGFSSMLDDAVRIVEEEAKATIFGYYVRDPERYGVAEFDESGQVISL
EEKPLAPKSNYAVVGLYFYDNSVVEIAKTIKPSDRGELEITSVNEEYLKRRKLRLSILGRGFAWLDTGTHDSYQEAGHFI
ETVEKRQGLKIACPEEIAWRKGWIDDRQLRELAAPLLKNQYGAYLVELLDRKDEYTRHH

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=67.2473867595819, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1790224, Length=289, Percent_Identity=67.4740484429066, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931050, Length=232, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=265, Percent_Identity=26.7924528301887, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355443, Length=236, Percent_Identity=24.5762711864407, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644084, Length=236, Percent_Identity=24.5762711864407, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33532; Mature: 33532

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITRGISKQLLPVYDKPMIYYPLSTLMLGGINDILIISTPEDLPL
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHCCCCCEEEEECCCCCHH
FQRLLGDGSGWGISLSYKAQPSPDGLAQAFILGEAFIGSDSVCLILGDNIFFGYGFSSML
HHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEECCCCEEEEEECCEEEECCHHHHH
DDAVRIVEEEAKATIFGYYVRDPERYGVAEFDESGQVISLEEKPLAPKSNYAVVGLYFYD
HHHHHHHHHHCCEEEEEEEEECCCCCCCCEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
NSVVEIAKTIKPSDRGELEITSVNEEYLKRRKLRLSILGRGFAWLDTGTHDSYQEAGHFI
CCHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHH
ETVEKRQGLKIACPEEIAWRKGWIDDRQLRELAAPLLKNQYGAYLVELLDRKDEYTRHH
HHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITRGISKQLLPVYDKPMIYYPLSTLMLGGINDILIISTPEDLPL
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHCCCCCEEEEECCCCCHH
FQRLLGDGSGWGISLSYKAQPSPDGLAQAFILGEAFIGSDSVCLILGDNIFFGYGFSSML
HHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEECCCCEEEEEECCEEEECCHHHHH
DDAVRIVEEEAKATIFGYYVRDPERYGVAEFDESGQVISLEEKPLAPKSNYAVVGLYFYD
HHHHHHHHHHCCEEEEEEEEECCCCCCCCEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
NSVVEIAKTIKPSDRGELEITSVNEEYLKRRKLRLSILGRGFAWLDTGTHDSYQEAGHFI
CCHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHH
ETVEKRQGLKIACPEEIAWRKGWIDDRQLRELAAPLLKNQYGAYLVELLDRKDEYTRHH
HHHHHHCCCEEECCHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]