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The map label for this gene is nat [H]

Identifier: 119357766

GI number: 119357766

Start: 2287866

End: 2288636

Strand: Reverse

Name: nat [H]

Synonym: Cpha266_1973

Alternate gene names: 119357766

Gene position: 2288636-2287866 (Counterclockwise)

Preceding gene: 119357767

Following gene: 119357756

Centisome position: 73.03

GC content: 50.71

Gene sequence:

>771_bases
ATGAAATCCGACAATTTCAATCTTGAGGCATATTTCGCCAGAATCGGCTTTGAAGCTGACGCTTCGGCGGATTTTACCAC
ACTCAAAGGCATGATGCGTTGCCAGCTTTTTTCGGTGCCGTTCGAAAATCTTGACGTTCAGCAAGGGAAAATCGTCTCGC
TCGTACCGGAAGAGATTTATCGTAAAATCGTTGATCGGAAGAGGGGCGGTTACTGCTATGAGGTGAATGGTCTGTTTGCC
ATGGCCCTCGATGAGTTGGGTATTCCTTACCGCTTTGTGGCCGCACGCCCGATGACCTATCCTGTCCGCCGGCCCAGAAC
ACATATGGCGATCGTGGCAACGATAGATGGTGAACAGTGGCTTTGTGATCTGGGTTTCGGCAGCTACAGCATACGGGAGC
CGGTCAACCTGAACTGGCTTGACCGGGAAATCAGTCAGGATTTCGAAATCTTCAAACTGTCGAAGAGCCCGGAAGGAGAC
TATCTGTTGCAGTCGTTCGTTGATGGCGCATGGAAAAATCTCTATGAGTTCAATCTCTCTCAGCAGGAGTGGGTGGATTT
TGAACCGGCCAACTACCTGAACTCGACGCATCCTGATTCGATTTTTGTCCAGTGGCTGATGGTTGTTCTGCAGAACTCCT
CAGGAAAGGATGTGCTTGTCGGCGAGCGCTTCAAATCAGTATCTCATGGCCGTACGACGGGGTGGACGGTCAAACGGGAA
GAGATACCGGCGTTATTGCAGCAGCAGTTTTCTCTCCGGTACGATCAATGA

Upstream 100 bases:

>100_bases
GCGGGCCGCAGGATACTCTATCAAATAAAACCGGGTCACTCGGTCTCCTCTTGCCGCATGTGCCTTGACGTATTGGTTTT
ATTAAGGTTTTTTTACCATC

Downstream 100 bases:

>100_bases
TTCCAGGTATTTTTGCCGATGCCAGTTCGAGGCTGACGTTGTTGAGGAGCGTCGTGTTTTGAACTGTTTTCGGTAATCTT
TTCCGATAACAGTTCTCTCT

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKSDNFNLEAYFARIGFEADASADFTTLKGMMRCQLFSVPFENLDVQQGKIVSLVPEEIYRKIVDRKRGGYCYEVNGLFA
MALDELGIPYRFVAARPMTYPVRRPRTHMAIVATIDGEQWLCDLGFGSYSIREPVNLNWLDREISQDFEIFKLSKSPEGD
YLLQSFVDGAWKNLYEFNLSQQEWVDFEPANYLNSTHPDSIFVQWLMVVLQNSSGKDVLVGERFKSVSHGRTTGWTVKRE
EIPALLQQQFSLRYDQ

Sequences:

>Translated_256_residues
MKSDNFNLEAYFARIGFEADASADFTTLKGMMRCQLFSVPFENLDVQQGKIVSLVPEEIYRKIVDRKRGGYCYEVNGLFA
MALDELGIPYRFVAARPMTYPVRRPRTHMAIVATIDGEQWLCDLGFGSYSIREPVNLNWLDREISQDFEIFKLSKSPEGD
YLLQSFVDGAWKNLYEFNLSQQEWVDFEPANYLNSTHPDSIFVQWLMVVLQNSSGKDVLVGERFKSVSHGRTTGWTVKRE
EIPALLQQQFSLRYDQ
>Mature_256_residues
MKSDNFNLEAYFARIGFEADASADFTTLKGMMRCQLFSVPFENLDVQQGKIVSLVPEEIYRKIVDRKRGGYCYEVNGLFA
MALDELGIPYRFVAARPMTYPVRRPRTHMAIVATIDGEQWLCDLGFGSYSIREPVNLNWLDREISQDFEIFKLSKSPEGD
YLLQSFVDGAWKNLYEFNLSQQEWVDFEPANYLNSTHPDSIFVQWLMVVLQNSSGKDVLVGERFKSVSHGRTTGWTVKRE
EIPALLQQQFSLRYDQ

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI237649126, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI237649124, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI237649122, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI237649119, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI42741671, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI237649009, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI237649132, Length=274, Percent_Identity=28.4671532846715, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI237649130, Length=274, Percent_Identity=28.4671532846715, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI116295260, Length=236, Percent_Identity=31.3559322033898, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1787736, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 29606; Mature: 29606

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDNFNLEAYFARIGFEADASADFTTLKGMMRCQLFSVPFENLDVQQGKIVSLVPEEIY
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCEEEECHHHHH
RKIVDRKRGGYCYEVNGLFAMALDELGIPYRFVAARPMTYPVRRPRTHMAIVATIDGEQW
HHHHHCCCCCEEEEECCCCEEHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCEE
LCDLGFGSYSIREPVNLNWLDREISQDFEIFKLSKSPEGDYLLQSFVDGAWKNLYEFNLS
EEECCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
QQEWVDFEPANYLNSTHPDSIFVQWLMVVLQNSSGKDVLVGERFKSVSHGRTTGWTVKRE
HHHCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCEEEHH
EIPALLQQQFSLRYDQ
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKSDNFNLEAYFARIGFEADASADFTTLKGMMRCQLFSVPFENLDVQQGKIVSLVPEEIY
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCEEEECHHHHH
RKIVDRKRGGYCYEVNGLFAMALDELGIPYRFVAARPMTYPVRRPRTHMAIVATIDGEQW
HHHHHCCCCCEEEEECCCCEEHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCEE
LCDLGFGSYSIREPVNLNWLDREISQDFEIFKLSKSPEGDYLLQSFVDGAWKNLYEFNLS
EEECCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
QQEWVDFEPANYLNSTHPDSIFVQWLMVVLQNSSGKDVLVGERFKSVSHGRTTGWTVKRE
HHHCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCEEEHH
EIPALLQQQFSLRYDQ
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]