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The map label for this gene is lysN [H]

Identifier: 119357765

GI number: 119357765

Start: 2286508

End: 2287701

Strand: Direct

Name: lysN [H]

Synonym: Cpha266_1972

Alternate gene names: 119357765

Gene position: 2286508-2287701 (Clockwise)

Preceding gene: 119357764

Following gene: 119357768

Centisome position: 72.96

GC content: 52.18

Gene sequence:

>1194_bases
ATGCAACGTTTCTCAAAAGCCGTATCGCTGCTCCGGTCATCTGAAATCAGGGATCTCATGACCCTTGCCTCAAGGCCTGA
CATTATCTCCTTTGCCGGAGGCATGCCTGGCAATGATCTCTTTCCCGTGCAGGAAATAGAAGAGCTCTTCAGCAACCTCG
ACGAGAAAACAAAACAGGCAGCATTTCAGTATGGGCCTACACCGGGTCTTCCCTCTCTGCTTGAATCTCTTTCAGGATTT
CTTGAGCGCAAAGGACTGCCGGTCAAAAGCAACCGGCTGCTCATCACCACCGGTTCCCAGCAGGCACTCAGTCTGCTTGC
CAAAACCTTTATAGATCCGGGGGACCGGGTGCTGGTTGAACAGCCCTGTTTTATTGGAGCTCTTTCAGCATTCCGTTCCT
CTGAAGCCGCGCTGCATGGCATCCCTGTTGACAGGGAGGGACTGGTCATCGATCTGCTCAACGAAGAAATCAGAAAAAAA
GAGAGAGCCAGGCTGCTCTATATCACCCCCTATTTCCATAATCCGGCAGGCCTGCTCTACAGCAAGGAACGTAAAGCAGA
ACTTATCAGAACACTGCAAGGTTCAAACATCCCGCTCATCGAGGATGATGCCTACGGCGACCTGTATTTCCATGAAGAGG
ATCGGGAACGGTTACAACCAATCAAATCCATCGATCCGGAAGACATTGATGTCTGTTATACCGGTTCCTTCTCGAAAATT
CTCGGTCCCGGCCTCAGGCTCGGATGGATGCTCGTCCCTGAAGCGATCCATGAAAAATGCGAGCTGATCAAACAGTCGGC
CGACGCCTGTTCTCCAAGTTTCACCCAGGTGCTCGCTGACGCCTTCATCCGTTCCGGCAAGATCGACAGCTATATTGCCG
GTGTACGTCAGGAATATAAAAAAAGAGCTTCGGCCATGGTTGCCGCTCTGAAGGAGCATCTCCCATCATACGTTCACTAC
AACGAACCAAGGGGCGGATTCTACATCTGGCTGACGCTGCCGGAAGGGAGCGACGCAACGGAGATCATGAAAATCGCCGT
CAAAGGCGGGGCGGTCTTCGTTGCAGGAAAAACCTTTGATCCTGAAGGAAAAAAAAACAACACGCTTCGCCTCTCCTACT
GCAACAACACCCCGGAGCAGATCGCCGAAGGAATTCCGATCATCGCGGCTGCAATCAGGCTGCTCTGCGGTTGA

Upstream 100 bases:

>100_bases
GGCTGATTCCCTTCAAAAAATCATTGCGGTACTCCAGGAACACAAAATGGAACTCCTGCAGGAAGGGGATGTTTACCAGG
TTTAATTTCAAAACACCCCT

Downstream 100 bases:

>100_bases
ACATGGCACATTAGCGCAACCAACCCGACCTTCACGGCCCGGTTCCATGCTCGGGGTCACCACCAGAGAGAACTGTTATC
GGAAAAGATTACCGAAAACA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQRFSKAVSLLRSSEIRDLMTLASRPDIISFAGGMPGNDLFPVQEIEELFSNLDEKTKQAAFQYGPTPGLPSLLESLSGF
LERKGLPVKSNRLLITTGSQQALSLLAKTFIDPGDRVLVEQPCFIGALSAFRSSEAALHGIPVDREGLVIDLLNEEIRKK
ERARLLYITPYFHNPAGLLYSKERKAELIRTLQGSNIPLIEDDAYGDLYFHEEDRERLQPIKSIDPEDIDVCYTGSFSKI
LGPGLRLGWMLVPEAIHEKCELIKQSADACSPSFTQVLADAFIRSGKIDSYIAGVRQEYKKRASAMVAALKEHLPSYVHY
NEPRGGFYIWLTLPEGSDATEIMKIAVKGGAVFVAGKTFDPEGKKNNTLRLSYCNNTPEQIAEGIPIIAAAIRLLCG

Sequences:

>Translated_397_residues
MQRFSKAVSLLRSSEIRDLMTLASRPDIISFAGGMPGNDLFPVQEIEELFSNLDEKTKQAAFQYGPTPGLPSLLESLSGF
LERKGLPVKSNRLLITTGSQQALSLLAKTFIDPGDRVLVEQPCFIGALSAFRSSEAALHGIPVDREGLVIDLLNEEIRKK
ERARLLYITPYFHNPAGLLYSKERKAELIRTLQGSNIPLIEDDAYGDLYFHEEDRERLQPIKSIDPEDIDVCYTGSFSKI
LGPGLRLGWMLVPEAIHEKCELIKQSADACSPSFTQVLADAFIRSGKIDSYIAGVRQEYKKRASAMVAALKEHLPSYVHY
NEPRGGFYIWLTLPEGSDATEIMKIAVKGGAVFVAGKTFDPEGKKNNTLRLSYCNNTPEQIAEGIPIIAAAIRLLCG
>Mature_397_residues
MQRFSKAVSLLRSSEIRDLMTLASRPDIISFAGGMPGNDLFPVQEIEELFSNLDEKTKQAAFQYGPTPGLPSLLESLSGF
LERKGLPVKSNRLLITTGSQQALSLLAKTFIDPGDRVLVEQPCFIGALSAFRSSEAALHGIPVDREGLVIDLLNEEIRKK
ERARLLYITPYFHNPAGLLYSKERKAELIRTLQGSNIPLIEDDAYGDLYFHEEDRERLQPIKSIDPEDIDVCYTGSFSKI
LGPGLRLGWMLVPEAIHEKCELIKQSADACSPSFTQVLADAFIRSGKIDSYIAGVRQEYKKRASAMVAALKEHLPSYVHY
NEPRGGFYIWLTLPEGSDATEIMKIAVKGGAVFVAGKTFDPEGKKNNTLRLSYCNNTPEQIAEGIPIIAAAIRLLCG

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=422, Percent_Identity=27.2511848341232, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI33469970, Length=422, Percent_Identity=27.2511848341232, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4507369, Length=192, Percent_Identity=26.5625, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1787710, Length=349, Percent_Identity=28.9398280802292, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790797, Length=390, Percent_Identity=26.4102564102564, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71994472, Length=403, Percent_Identity=23.8213399503722, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=403, Percent_Identity=23.8213399503722, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321236, Length=474, Percent_Identity=23.4177215189873, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321000, Length=259, Percent_Identity=28.957528957529, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321929, Length=473, Percent_Identity=22.4101479915433, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356535, Length=412, Percent_Identity=25.4854368932039, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 43938; Mature: 43938

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFSKAVSLLRSSEIRDLMTLASRPDIISFAGGMPGNDLFPVQEIEELFSNLDEKTKQA
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AFQYGPTPGLPSLLESLSGFLERKGLPVKSNRLLITTGSQQALSLLAKTFIDPGDRVLVE
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEE
QPCFIGALSAFRSSEAALHGIPVDREGLVIDLLNEEIRKKERARLLYITPYFHNPAGLLY
CCHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCEECCCCCEE
SKERKAELIRTLQGSNIPLIEDDAYGDLYFHEEDRERLQPIKSIDPEDIDVCYTGSFSKI
CHHHHHHHHHHHCCCCCCEECCCCCCCEEEECCHHHHHCHHHCCCCCCCEEEECCCHHHH
LGPGLRLGWMLVPEAIHEKCELIKQSADACSPSFTQVLADAFIRSGKIDSYIAGVRQEYK
HCCCCHHHHEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KRASAMVAALKEHLPSYVHYNEPRGGFYIWLTLPEGSDATEIMKIAVKGGAVFVAGKTFD
HHHHHHHHHHHHHCCHHEECCCCCCCEEEEEEECCCCCHHHHHHHEECCCEEEEECCCCC
PEGKKNNTLRLSYCNNTPEQIAEGIPIIAAAIRLLCG
CCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQRFSKAVSLLRSSEIRDLMTLASRPDIISFAGGMPGNDLFPVQEIEELFSNLDEKTKQA
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AFQYGPTPGLPSLLESLSGFLERKGLPVKSNRLLITTGSQQALSLLAKTFIDPGDRVLVE
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEE
QPCFIGALSAFRSSEAALHGIPVDREGLVIDLLNEEIRKKERARLLYITPYFHNPAGLLY
CCHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCEECCCCCEE
SKERKAELIRTLQGSNIPLIEDDAYGDLYFHEEDRERLQPIKSIDPEDIDVCYTGSFSKI
CHHHHHHHHHHHCCCCCCEECCCCCCCEEEECCHHHHHCHHHCCCCCCCEEEECCCHHHH
LGPGLRLGWMLVPEAIHEKCELIKQSADACSPSFTQVLADAFIRSGKIDSYIAGVRQEYK
HCCCCHHHHEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KRASAMVAALKEHLPSYVHYNEPRGGFYIWLTLPEGSDATEIMKIAVKGGAVFVAGKTFD
HHHHHHHHHHHHHCCHHEECCCCCCCEEEEEEECCCCCHHHHHHHEECCCEEEEECCCCC
PEGKKNNTLRLSYCNNTPEQIAEGIPIIAAAIRLLCG
CCCCCCCEEEEEECCCCHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA