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The map label for this gene is rnr [H]

Identifier: 119357755

GI number: 119357755

Start: 2275676

End: 2278051

Strand: Reverse

Name: rnr [H]

Synonym: Cpha266_1962

Alternate gene names: 119357755

Gene position: 2278051-2275676 (Counterclockwise)

Preceding gene: 119357756

Following gene: 119357752

Centisome position: 72.69

GC content: 51.05

Gene sequence:

>2376_bases
GTGGCAAGACAACGAGATAGCCGAAAACCGGGATCGTCCGGAAGGAGAAGAGGTAAGCCGGAGGGAAGGCCGACAGGCGA
AAGGGTTCGCCCTAACGATCATATTCTGATTAACGAGTTTCTTTTCAGACGAGGAGAGAGCTCTCTCGGTGCTGAAATCA
TAACCTTTTTATCTGACCGAGAAGGTGAACGGTTTCGTTCGGTTGATCTTGCTAAACTTCTTGGCTACACTGAATCCAGA
CATCTTCCCGGTTTCTGGTATGTGCTGCACAAACTGCAGGAAGAGGGTGCTGTTGACAAGGATTCCAACCGATGCTACGG
TATGGCAGGCCTCGAAGATGCAACCTATGAAGATCATCTTGTTCATCTGAAGCAGTTTCCTCTGCCCGGTAAAGAGCAGT
TTGTTGTTGATAAGATCTACACCGGACGTCTTTCCACTCATCCAAACGGTTACGGATTTCTTGATGTCGAAGGGTTTGAT
GATGACATTTTCATCAAGGCTGCCGACATGAACTCCTCGATGCATGGCGATGAGGTTGAGGTACAGGTCACCAAAGTGCC
GGAAACCTATGCGTCGAAATCAACTCCGCACCAGCGTTGCGAGGGCATTGTCAAGAGCGTGGTGAAACGACGGGTCACAA
CGATTGTCGGCACGCTTACGCGCGAAAACCGCAGATTTCTTCTCAAGCCTGATGAACGGAAAATTCTGCCGGTGATCGTT
GTGGCGCTGAAAAACGCGGCAAAGGCAAAAGACGGACAGAAAGTTCTTGTCGGCGAGCTCGATTTCAGCAAGGAGGGCGT
TATCAACGCGAAGGTGCTTGAAGTGCTTGGTTCTGCCGGAGACTCGCAGGTCGAGGTGAGCGCCATTGCCCGCAATCACG
GTATCGATGAGACTTTTGAGGCTCCGATTGTCGAGTTTGCCCAGTCCATCAGGGACGGAATTACCGACGAGGATCTCGTT
GGACGTCTCGATATTCGCGACAAGCTTGTTTTCACCATCGATCCTGTTGATGCAAAAGACTTTGACGATGCGCTCTCCCT
TGAGACGCTTACAGGAAACCGCTATCGGATAGGTGTGCATATTGCCGACGTGTCGCACTATGTTCCTGAAGATTCGCTGC
TTGACAAGGAGGCGATGAAACGGGCGACCTCGGTCTATCTTGTCGATCGGGTTATCCCCATGCTTCCCTCAAGGCTTTCC
GAACAGATATGCAGTCTTAACCCCGGCGTAGATCGGATGGCATTTTCCGTCTTTATTACCATGACCGATGCCGGAGAGGT
CGAGAAGCAGGAGTTTCAGAAAACGGCGATACATTCGAAGCGCAGGTTTACCTATGAAGATGTTCAGCAGATTCTGGACT
CCGGAGAGGGTGATTTTGTCGCGGAACTCAAACTGCTCGATACGCTCAGCACAACCCTTCGTGAAAAGCGGTTCAAGCAT
GGCGGCCTTGATTTTGAGACCGAGGAGGTCCGTTTCAGGCTTGGCAGCAAAGGCGAACCGCTTGAGGTGATGAAAAAGGA
GCGTCTCGGAAGCCACCGTCTCATCGAAGAGTTCATGCTGCTTGCAAACCGCAAGGTTGCCGAGTATCTGACCAAAACGT
TTGGCGAAGGGAAAAAAACGCCGCAACCATGTATTTACCGGGTTCACGATGCTCCCCAGTTGGAAAAAGTGGTTATTCTT
TCCAACTTTGTCAAGAGGCTTGGCTATGATCTCAAGCTCAACAGAGGCAAGGATGGTCCTATTGTTACGGCAAAAGCCCT
GCGACAGCTTCTGCAGCAGGTACGGGGCACCAACCTTGAGTTTCTCGTCAATGAACTGGTGCTGCGATCCATGTCAAAGG
CGGTCTATACCGGCGACAATGCCGGGCATTACGGGCTTGGCTTTGAACACTATACCCACTTTACCTCACCGATCAGGCGT
TATCCTGATCTGATTATTCACCGCCTGCTCTTCGAGTATGAGAGTTTGCGTAAAAGCCGCAAAAAAATCACCGAAAAAAG
AGTTGCCGCATTGAAGGCAAAACTTCAGTCTGTCTGTCAGATCTCCAACGAGCGTGAAAAAGGAGCTGTCGAGGCCGAGA
GGGAGTCGATCAAACTCAAGCAGGTCGAGTATATGGCAAGCCATATCGGCAAGGAGTATTCCGGCATAATTTCGGGAGCT
ACAGAATACGGTATTTACGTCCGCATGGTGGATTTTGCCATCGAAGGTCTCGTGCACATGCGCAATCTGACCGACGACTA
CTATGAATATGACGAAGCCAGCTACTCGCTGCTGGGCAAGCGGCGGAAACGGCGGCTTCAGATAGGCAACCGGGTGAAGA
TCAAGGTGCTGTCGGTGGATGTGCAGCGAAGAACCATCGATCTGGTGATCGCATAG

Upstream 100 bases:

>100_bases
TTTTTTTCCTTCGGGAGCATTGATCGGTCATGAAAAGAGGTGGCGTCGGTTCTTTAACGGCGCTGATCGCTTGAGTTTTT
AATATAAATGAGTAAGTGCA

Downstream 100 bases:

>100_bases
GTCAGTTTTCTCTACTCGCGGCAGCCTGGCGGGTATGATGTTTACGCATTCGGGAACAGTGTCGCCGGTTCCCGAAACCG
GCTTATGTAGCGCTCAACGT

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 791; Mature: 790

Protein sequence:

>791_residues
MARQRDSRKPGSSGRRRGKPEGRPTGERVRPNDHILINEFLFRRGESSLGAEIITFLSDREGERFRSVDLAKLLGYTESR
HLPGFWYVLHKLQEEGAVDKDSNRCYGMAGLEDATYEDHLVHLKQFPLPGKEQFVVDKIYTGRLSTHPNGYGFLDVEGFD
DDIFIKAADMNSSMHGDEVEVQVTKVPETYASKSTPHQRCEGIVKSVVKRRVTTIVGTLTRENRRFLLKPDERKILPVIV
VALKNAAKAKDGQKVLVGELDFSKEGVINAKVLEVLGSAGDSQVEVSAIARNHGIDETFEAPIVEFAQSIRDGITDEDLV
GRLDIRDKLVFTIDPVDAKDFDDALSLETLTGNRYRIGVHIADVSHYVPEDSLLDKEAMKRATSVYLVDRVIPMLPSRLS
EQICSLNPGVDRMAFSVFITMTDAGEVEKQEFQKTAIHSKRRFTYEDVQQILDSGEGDFVAELKLLDTLSTTLREKRFKH
GGLDFETEEVRFRLGSKGEPLEVMKKERLGSHRLIEEFMLLANRKVAEYLTKTFGEGKKTPQPCIYRVHDAPQLEKVVIL
SNFVKRLGYDLKLNRGKDGPIVTAKALRQLLQQVRGTNLEFLVNELVLRSMSKAVYTGDNAGHYGLGFEHYTHFTSPIRR
YPDLIIHRLLFEYESLRKSRKKITEKRVAALKAKLQSVCQISNEREKGAVEAERESIKLKQVEYMASHIGKEYSGIISGA
TEYGIYVRMVDFAIEGLVHMRNLTDDYYEYDEASYSLLGKRRKRRLQIGNRVKIKVLSVDVQRRTIDLVIA

Sequences:

>Translated_791_residues
MARQRDSRKPGSSGRRRGKPEGRPTGERVRPNDHILINEFLFRRGESSLGAEIITFLSDREGERFRSVDLAKLLGYTESR
HLPGFWYVLHKLQEEGAVDKDSNRCYGMAGLEDATYEDHLVHLKQFPLPGKEQFVVDKIYTGRLSTHPNGYGFLDVEGFD
DDIFIKAADMNSSMHGDEVEVQVTKVPETYASKSTPHQRCEGIVKSVVKRRVTTIVGTLTRENRRFLLKPDERKILPVIV
VALKNAAKAKDGQKVLVGELDFSKEGVINAKVLEVLGSAGDSQVEVSAIARNHGIDETFEAPIVEFAQSIRDGITDEDLV
GRLDIRDKLVFTIDPVDAKDFDDALSLETLTGNRYRIGVHIADVSHYVPEDSLLDKEAMKRATSVYLVDRVIPMLPSRLS
EQICSLNPGVDRMAFSVFITMTDAGEVEKQEFQKTAIHSKRRFTYEDVQQILDSGEGDFVAELKLLDTLSTTLREKRFKH
GGLDFETEEVRFRLGSKGEPLEVMKKERLGSHRLIEEFMLLANRKVAEYLTKTFGEGKKTPQPCIYRVHDAPQLEKVVIL
SNFVKRLGYDLKLNRGKDGPIVTAKALRQLLQQVRGTNLEFLVNELVLRSMSKAVYTGDNAGHYGLGFEHYTHFTSPIRR
YPDLIIHRLLFEYESLRKSRKKITEKRVAALKAKLQSVCQISNEREKGAVEAERESIKLKQVEYMASHIGKEYSGIISGA
TEYGIYVRMVDFAIEGLVHMRNLTDDYYEYDEASYSLLGKRRKRRLQIGNRVKIKVLSVDVQRRTIDLVIA
>Mature_790_residues
ARQRDSRKPGSSGRRRGKPEGRPTGERVRPNDHILINEFLFRRGESSLGAEIITFLSDREGERFRSVDLAKLLGYTESRH
LPGFWYVLHKLQEEGAVDKDSNRCYGMAGLEDATYEDHLVHLKQFPLPGKEQFVVDKIYTGRLSTHPNGYGFLDVEGFDD
DIFIKAADMNSSMHGDEVEVQVTKVPETYASKSTPHQRCEGIVKSVVKRRVTTIVGTLTRENRRFLLKPDERKILPVIVV
ALKNAAKAKDGQKVLVGELDFSKEGVINAKVLEVLGSAGDSQVEVSAIARNHGIDETFEAPIVEFAQSIRDGITDEDLVG
RLDIRDKLVFTIDPVDAKDFDDALSLETLTGNRYRIGVHIADVSHYVPEDSLLDKEAMKRATSVYLVDRVIPMLPSRLSE
QICSLNPGVDRMAFSVFITMTDAGEVEKQEFQKTAIHSKRRFTYEDVQQILDSGEGDFVAELKLLDTLSTTLREKRFKHG
GLDFETEEVRFRLGSKGEPLEVMKKERLGSHRLIEEFMLLANRKVAEYLTKTFGEGKKTPQPCIYRVHDAPQLEKVVILS
NFVKRLGYDLKLNRGKDGPIVTAKALRQLLQQVRGTNLEFLVNELVLRSMSKAVYTGDNAGHYGLGFEHYTHFTSPIRRY
PDLIIHRLLFEYESLRKSRKKITEKRVAALKAKLQSVCQISNEREKGAVEAERESIKLKQVEYMASHIGKEYSGIISGAT
EYGIYVRMVDFAIEGLVHMRNLTDDYYEYDEASYSLLGKRRKRRLQIGNRVKIKVLSVDVQRRTIDLVIA

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=610, Percent_Identity=30.1639344262295, Blast_Score=251, Evalue=3e-66,
Organism=Homo sapiens, GI190014623, Length=610, Percent_Identity=30.1639344262295, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI134288890, Length=464, Percent_Identity=34.9137931034483, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI19115966, Length=651, Percent_Identity=28.7250384024578, Blast_Score=209, Evalue=1e-53,
Organism=Homo sapiens, GI219521928, Length=651, Percent_Identity=28.7250384024578, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI156105695, Length=369, Percent_Identity=28.1842818428184, Blast_Score=120, Evalue=6e-27,
Organism=Homo sapiens, GI156105693, Length=366, Percent_Identity=28.4153005464481, Blast_Score=116, Evalue=1e-25,
Organism=Escherichia coli, GI87082383, Length=660, Percent_Identity=31.8181818181818, Blast_Score=333, Evalue=3e-92,
Organism=Escherichia coli, GI1787542, Length=595, Percent_Identity=26.7226890756303, Blast_Score=149, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI212645896, Length=559, Percent_Identity=30.2325581395349, Blast_Score=236, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17553506, Length=544, Percent_Identity=29.4117647058824, Blast_Score=218, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324552, Length=487, Percent_Identity=34.7022587268994, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323943, Length=396, Percent_Identity=28.5353535353535, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320499, Length=411, Percent_Identity=21.654501216545, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24654592, Length=590, Percent_Identity=31.1864406779661, Blast_Score=242, Evalue=6e-64,
Organism=Drosophila melanogaster, GI19922976, Length=590, Percent_Identity=31.1864406779661, Blast_Score=242, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24654597, Length=590, Percent_Identity=31.1864406779661, Blast_Score=242, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24649634, Length=572, Percent_Identity=30.2447552447552, Blast_Score=240, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 89808; Mature: 89677

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQRDSRKPGSSGRRRGKPEGRPTGERVRPNDHILINEFLFRRGESSLGAEIITFLSDR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCC
EGERFRSVDLAKLLGYTESRHLPGFWYVLHKLQEEGAVDKDSNRCYGMAGLEDATYEDHL
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHH
VHLKQFPLPGKEQFVVDKIYTGRLSTHPNGYGFLDVEGFDDDIFIKAADMNSSMHGDEVE
HHHHHCCCCCCCCEEEEHEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCEEE
VQVTKVPETYASKSTPHQRCEGIVKSVVKRRVTTIVGTLTRENRRFLLKPDERKILPVIV
EEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
VALKNAAKAKDGQKVLVGELDFSKEGVINAKVLEVLGSAGDSQVEVSAIARNHGIDETFE
HHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHCCCCHHHC
APIVEFAQSIRDGITDEDLVGRLDIRDKLVFTIDPVDAKDFDDALSLETLTGNRYRIGVH
CHHHHHHHHHHCCCCCCHHEECCCCCCEEEEEECCCCCCCCCCHHEEEEECCCEEEEEEE
IADVSHYVPEDSLLDKEAMKRATSVYLVDRVIPMLPSRLSEQICSLNPGVDRMAFSVFIT
EECHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEEE
MTDAGEVEKQEFQKTAIHSKRRFTYEDVQQILDSGEGDFVAELKLLDTLSTTLREKRFKH
EECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHC
GGLDFETEEVRFRLGSKGEPLEVMKKERLGSHRLIEEFMLLANRKVAEYLTKTFGEGKKT
CCCCCCHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
PQPCIYRVHDAPQLEKVVILSNFVKRLGYDLKLNRGKDGPIVTAKALRQLLQQVRGTNLE
CCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEEHHHHHHHHHHHHCCCCHH
FLVNELVLRSMSKAVYTGDNAGHYGLGFEHYTHFTSPIRRYPDLIIHRLLFEYESLRKSR
HHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKITEKRVAALKAKLQSVCQISNEREKGAVEAERESIKLKQVEYMASHIGKEYSGIISGA
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCC
TEYGIYVRMVDFAIEGLVHMRNLTDDYYEYDEASYSLLGKRRKRRLQIGNRVKIKVLSVD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEEEE
VQRRTIDLVIA
ECEEEEEEEEC
>Mature Secondary Structure 
ARQRDSRKPGSSGRRRGKPEGRPTGERVRPNDHILINEFLFRRGESSLGAEIITFLSDR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCC
EGERFRSVDLAKLLGYTESRHLPGFWYVLHKLQEEGAVDKDSNRCYGMAGLEDATYEDHL
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHH
VHLKQFPLPGKEQFVVDKIYTGRLSTHPNGYGFLDVEGFDDDIFIKAADMNSSMHGDEVE
HHHHHCCCCCCCCEEEEHEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCEEE
VQVTKVPETYASKSTPHQRCEGIVKSVVKRRVTTIVGTLTRENRRFLLKPDERKILPVIV
EEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
VALKNAAKAKDGQKVLVGELDFSKEGVINAKVLEVLGSAGDSQVEVSAIARNHGIDETFE
HHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHCCCCHHHC
APIVEFAQSIRDGITDEDLVGRLDIRDKLVFTIDPVDAKDFDDALSLETLTGNRYRIGVH
CHHHHHHHHHHCCCCCCHHEECCCCCCEEEEEECCCCCCCCCCHHEEEEECCCEEEEEEE
IADVSHYVPEDSLLDKEAMKRATSVYLVDRVIPMLPSRLSEQICSLNPGVDRMAFSVFIT
EECHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEEE
MTDAGEVEKQEFQKTAIHSKRRFTYEDVQQILDSGEGDFVAELKLLDTLSTTLREKRFKH
EECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHC
GGLDFETEEVRFRLGSKGEPLEVMKKERLGSHRLIEEFMLLANRKVAEYLTKTFGEGKKT
CCCCCCHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
PQPCIYRVHDAPQLEKVVILSNFVKRLGYDLKLNRGKDGPIVTAKALRQLLQQVRGTNLE
CCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEEHHHHHHHHHHHHCCCCHH
FLVNELVLRSMSKAVYTGDNAGHYGLGFEHYTHFTSPIRRYPDLIIHRLLFEYESLRKSR
HHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKITEKRVAALKAKLQSVCQISNEREKGAVEAERESIKLKQVEYMASHIGKEYSGIISGA
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCC
TEYGIYVRMVDFAIEGLVHMRNLTDDYYEYDEASYSLLGKRRKRRLQIGNRVKIKVLSVD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEEEE
VQRRTIDLVIA
ECEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]