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The map label for this gene is phr [H]

Identifier: 119357754

GI number: 119357754

Start: 2274228

End: 2275634

Strand: Direct

Name: phr [H]

Synonym: Cpha266_1961

Alternate gene names: 119357754

Gene position: 2274228-2275634 (Clockwise)

Preceding gene: 119357753

Following gene: 119357757

Centisome position: 72.57

GC content: 53.23

Gene sequence:

>1407_bases
ATGTCTGAACATCGGCTGACACAAAAACAGAACGCCCTTATGATTGATCCCCGCCGAACAAGAGTGTTGAACTCCTGCAG
TGACAAACCGGGAGCGGTTATTTACTGGATGTCGCGCGATCAGCGCCTGAACCATAATTGGGCGCTGCTCTTTGCAAGAG
AGAAAGCCGCTCGGAAAGGCCAGCCTCTTGTTGTTGTCTTCGCTCTGGCCCCATCATTCCTCGACGCTCCGTTCAGACAT
TACGACTTCATGCTTAAAGGTCTTGAAGAAACCTCCAAAGCTCTCGAACGGATCAATATCCCCTTTATGCTGCTCGAAGG
AGAGCCGGATACAGAGATCTCACGATATGCCTGCCAGTCCGAAGCAGGAGCTGTCGTTACGGATTTTTCTCCCCTGAACA
TTTCCCGAAACTGGAAAAAAAAGGCAGCCGACATCCTCGACATTCCTCTCTATGAGGTCGATGCCCATAACATTGTCCCC
TGCTGGTATGCATCCGACAAACAGGAGTATGCGGCCAGAACCCTGCGCCCGAAACTGCAGGCCCGCCTTGATGAGTTTCT
TGTTCCGTTTCCAACGATTCTGCCGCTTCCGGCACCTCACGTTCACCACCGCTCTCCCGACTGGAAACAGGTCCGGGAAC
GGCTCCAAAAAGATCGCTCCGTACCGCCGGTGAACCGGATCGCTCCTGGAGAAACGGCCGCAGCAGAATCGCTTGAAAAC
TTCATCAAGAGCAGGCTTTCGGGATATGCCACGGCTAGAAACGACCCGAACAGCAATGCCCTGTCACAACTCTCTCCCTA
CCTTCATTTCGGTCAGATCAGTGCCCAGCATGTTGCGTTGCGGGTTGCCGAAAGCCGTGCGCCACAGAAAGACAAGACGG
CCTTTCTCGAGGAGCTGATTATCCGCAGGGAGCTTTCGGATAATTTCTGCAACTACAACCCGAGCTATGACCGGTTTGAA
GGGATCCCTGCATGGGCGAAGCAAACGCTGCTTCTTCATGGGCAGGACAAACGGGAGTACCTGTACACCATCGACGTTTT
CGAAAAAGCTGCAACGCACGACAAGCTCTGGAACGCTGCCCAATCAGAGCTGGTTCAAAGCGGAAAAATCCACGGTTATA
TGCGGATGTACTGGGCGAAAAAAATTCTCGAATGGAGTTCGTCTCCTCCCGAGGCATTTGAGATGGCGATCTATCTCAAC
GACCGATATGCGCTTGATGGAAGGGATCCTAACGGTTATGCTGGGGTGGCATGGTCGATTGGAGGCTTGCATGACCGCCC
ATGGTTCGAACGTCCGGTCTATGGCAACATCAGATACATGAACGCCAGCGGGTGCAGAAGAAAGTTCGACGTTGAGCGCT
ACATAAGCCGGTTTCGGGAACCGGCGACACTGTTCCCGAATGCGTAA

Upstream 100 bases:

>100_bases
CTCCTCAAACAGTTCGATCTGATCGGAAAGGAGTATACCCGAACGGGTCTCGTGATACTGTACAATTTTCTCGCTCTTGC
CGGTCTCACATGAAGTCGAA

Downstream 100 bases:

>100_bases
ACATCATACCCGCCAGGCTGCCGCGAGTAGAGAAAACTGACCTATGCGATCACCAGATCGATGGTTCTTCGCTGCACATC
CACCGACAGCACCTTGATCT

Product: deoxyribodipyrimidine photo-lyase type II

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSEHRLTQKQNALMIDPRRTRVLNSCSDKPGAVIYWMSRDQRLNHNWALLFAREKAARKGQPLVVVFALAPSFLDAPFRH
YDFMLKGLEETSKALERINIPFMLLEGEPDTEISRYACQSEAGAVVTDFSPLNISRNWKKKAADILDIPLYEVDAHNIVP
CWYASDKQEYAARTLRPKLQARLDEFLVPFPTILPLPAPHVHHRSPDWKQVRERLQKDRSVPPVNRIAPGETAAAESLEN
FIKSRLSGYATARNDPNSNALSQLSPYLHFGQISAQHVALRVAESRAPQKDKTAFLEELIIRRELSDNFCNYNPSYDRFE
GIPAWAKQTLLLHGQDKREYLYTIDVFEKAATHDKLWNAAQSELVQSGKIHGYMRMYWAKKILEWSSSPPEAFEMAIYLN
DRYALDGRDPNGYAGVAWSIGGLHDRPWFERPVYGNIRYMNASGCRRKFDVERYISRFREPATLFPNA

Sequences:

>Translated_468_residues
MSEHRLTQKQNALMIDPRRTRVLNSCSDKPGAVIYWMSRDQRLNHNWALLFAREKAARKGQPLVVVFALAPSFLDAPFRH
YDFMLKGLEETSKALERINIPFMLLEGEPDTEISRYACQSEAGAVVTDFSPLNISRNWKKKAADILDIPLYEVDAHNIVP
CWYASDKQEYAARTLRPKLQARLDEFLVPFPTILPLPAPHVHHRSPDWKQVRERLQKDRSVPPVNRIAPGETAAAESLEN
FIKSRLSGYATARNDPNSNALSQLSPYLHFGQISAQHVALRVAESRAPQKDKTAFLEELIIRRELSDNFCNYNPSYDRFE
GIPAWAKQTLLLHGQDKREYLYTIDVFEKAATHDKLWNAAQSELVQSGKIHGYMRMYWAKKILEWSSSPPEAFEMAIYLN
DRYALDGRDPNGYAGVAWSIGGLHDRPWFERPVYGNIRYMNASGCRRKFDVERYISRFREPATLFPNA
>Mature_467_residues
SEHRLTQKQNALMIDPRRTRVLNSCSDKPGAVIYWMSRDQRLNHNWALLFAREKAARKGQPLVVVFALAPSFLDAPFRHY
DFMLKGLEETSKALERINIPFMLLEGEPDTEISRYACQSEAGAVVTDFSPLNISRNWKKKAADILDIPLYEVDAHNIVPC
WYASDKQEYAARTLRPKLQARLDEFLVPFPTILPLPAPHVHHRSPDWKQVRERLQKDRSVPPVNRIAPGETAAAESLENF
IKSRLSGYATARNDPNSNALSQLSPYLHFGQISAQHVALRVAESRAPQKDKTAFLEELIIRRELSDNFCNYNPSYDRFEG
IPAWAKQTLLLHGQDKREYLYTIDVFEKAATHDKLWNAAQSELVQSGKIHGYMRMYWAKKILEWSSSPPEAFEMAIYLND
RYALDGRDPNGYAGVAWSIGGLHDRPWFERPVYGNIRYMNASGCRRKFDVERYISRFREPATLFPNA

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586398, Length=450, Percent_Identity=49.1111111111111, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24586396, Length=450, Percent_Identity=49.1111111111111, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24586404, Length=153, Percent_Identity=57.516339869281, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53857; Mature: 53726

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS01083 DNA_PHOTOLYASES_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHRLTQKQNALMIDPRRTRVLNSCSDKPGAVIYWMSRDQRLNHNWALLFAREKAARKG
CCCCCCCCCCCCEEECCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEHHHHHCC
QPLVVVFALAPSFLDAPFRHYDFMLKGLEETSKALERINIPFMLLEGEPDTEISRYACQS
CCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHC
EAGAVVTDFSPLNISRNWKKKAADILDIPLYEVDAHNIVPCWYASDKQEYAARTLRPKLQ
CCCEEEECCCCCCCCCCHHHHHCCCEECCCEEECCCCEEEEEECCCHHHHHHHHHHHHHH
ARLDEFLVPFPTILPLPAPHVHHRSPDWKQVRERLQKDRSVPPVNRIAPGETAAAESLEN
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
FIKSRLSGYATARNDPNSNALSQLSPYLHFGQISAQHVALRVAESRAPQKDKTAFLEELI
HHHHHHHCCEECCCCCCCHHHHHHCCHHHHCCCCHHHHHEEEHHHCCCCHHHHHHHHHHH
IRRELSDNFCNYNPSYDRFEGIPAWAKQTLLLHGQDKREYLYTIDVFEKAATHDKLWNAA
HHHHHHCCCCCCCCCHHHHCCCCHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHH
QSELVQSGKIHGYMRMYWAKKILEWSSSPPEAFEMAIYLNDRYALDGRDPNGYAGVAWSI
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEECCCCCCCCEEEEEEC
GGLHDRPWFERPVYGNIRYMNASGCRRKFDVERYISRFREPATLFPNA
CCCCCCCCCCCCCCCCEEEECCCCCCHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SEHRLTQKQNALMIDPRRTRVLNSCSDKPGAVIYWMSRDQRLNHNWALLFAREKAARKG
CCCCCCCCCCCEEECCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEHHHHHCC
QPLVVVFALAPSFLDAPFRHYDFMLKGLEETSKALERINIPFMLLEGEPDTEISRYACQS
CCEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHC
EAGAVVTDFSPLNISRNWKKKAADILDIPLYEVDAHNIVPCWYASDKQEYAARTLRPKLQ
CCCEEEECCCCCCCCCCHHHHHCCCEECCCEEECCCCEEEEEECCCHHHHHHHHHHHHHH
ARLDEFLVPFPTILPLPAPHVHHRSPDWKQVRERLQKDRSVPPVNRIAPGETAAAESLEN
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
FIKSRLSGYATARNDPNSNALSQLSPYLHFGQISAQHVALRVAESRAPQKDKTAFLEELI
HHHHHHHCCEECCCCCCCHHHHHHCCHHHHCCCCHHHHHEEEHHHCCCCHHHHHHHHHHH
IRRELSDNFCNYNPSYDRFEGIPAWAKQTLLLHGQDKREYLYTIDVFEKAATHDKLWNAA
HHHHHHCCCCCCCCCHHHHCCCCHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHH
QSELVQSGKIHGYMRMYWAKKILEWSSSPPEAFEMAIYLNDRYALDGRDPNGYAGVAWSI
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEECCCCCCCCEEEEEEC
GGLHDRPWFERPVYGNIRYMNASGCRRKFDVERYISRFREPATLFPNA
CCCCCCCCCCCCCCCCEEEECCCCCCHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]