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The map label for this gene is yhdN [H]

Identifier: 119357716

GI number: 119357716

Start: 2228136

End: 2229095

Strand: Reverse

Name: yhdN [H]

Synonym: Cpha266_1920

Alternate gene names: 119357716

Gene position: 2229095-2228136 (Counterclockwise)

Preceding gene: 119357717

Following gene: 119357709

Centisome position: 71.13

GC content: 53.65

Gene sequence:

>960_bases
ATGCTGAAACGTCGTCTTGGAAATACGGATATGGAGATTACTCTCCTCGGGTTTGGAAGTTGGGCGATCGGGGGCGGCAA
TTGGGCTTACGGATGGGGAGCTCAGAATGATCAGGATGCTGTGGAGGCTATCGTTCGGGCTGTAGATCTCGGCATGAACT
GGATTGATACAGCGGCGGTTTACGGGCTCGGCCATGCAGAAGAGCTGGTGGGCAGGGCAGTTGCTTCAATGCAGGAAAAA
CCGTTTATTTTTACCAAATGCGCTCTGGTATGGGACGAAACCCGATCGGTCAGCAGTTCGCTCAAGGCGGGATCTGTACG
CCGGGAATGTGAAGCGAGCCTTCAGCGACTGCAGGTGAACGCCATTGATCTCTATCAGATGCACTGGCCGGATCCGGATG
AGGATATCGAGGAGGGCTGGCTGGAGATGGCAAAATTGCAGTCGGAAGGTCTTGTGCGGCATATCGGTGTTTCAAATTTT
ACGGTTGCCCAGATGCAAAGGGCTCTTGCGATTGCGCCCATCGCTTCACTGCAGCCACCCTATTCCATGTTGCGCCGAGC
TATTGAAAAGGAGATTCTTCCTTTCTGTTTCGATAACAACATCGGCGTTATTGTCTATTCCCCTATGTTGTCCGGTATGT
TGAGCGGTGCCATGACAAAAGATCGCGCGGCGTCTTTTGCCAAAGATGACTGGCGACGAAATAACAGGGAGTTTCAGGAG
CCAAGGCTTTCACGTAACCTTGAACTGGTTGAACTTCTCAGGCAGGTCGGAGCTCTTTACGGCAGATCCGCGGGTGAGGT
TGCCATAGCCTGGGCGCTTCGCCATCCTGTGGTGACCGGCGTGATTGTTGGCGGACGCAACGCCCTTCAGGTGGAGGGTG
TGATCGGGGCAGGGGAGTTTCTCCTATCAGATGAGGATGCCTCTCGGATAGAGTCGTTTATTGCCACGATGTACGCATAG

Upstream 100 bases:

>100_bases
ACGAGCTGATTATCGGTCGTTCAAATACCGCTTTATTCTCTGAATCAGAATCCGAAGAGACCGACGAAACGGACCGGAAT
AAACATAAACAGTCATTATA

Downstream 100 bases:

>100_bases
GCAGAGCGCGCCTTTTCAGGGTCGGAATATCCGGTAATCGATATCGAACTTTTTTACCCGTAGTCCCATGATCCGGTCTG
AAAGGCCAAGTTGTGCCGCT

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MLKRRLGNTDMEITLLGFGSWAIGGGNWAYGWGAQNDQDAVEAIVRAVDLGMNWIDTAAVYGLGHAEELVGRAVASMQEK
PFIFTKCALVWDETRSVSSSLKAGSVRRECEASLQRLQVNAIDLYQMHWPDPDEDIEEGWLEMAKLQSEGLVRHIGVSNF
TVAQMQRALAIAPIASLQPPYSMLRRAIEKEILPFCFDNNIGVIVYSPMLSGMLSGAMTKDRAASFAKDDWRRNNREFQE
PRLSRNLELVELLRQVGALYGRSAGEVAIAWALRHPVVTGVIVGGRNALQVEGVIGAGEFLLSDEDASRIESFIATMYA

Sequences:

>Translated_319_residues
MLKRRLGNTDMEITLLGFGSWAIGGGNWAYGWGAQNDQDAVEAIVRAVDLGMNWIDTAAVYGLGHAEELVGRAVASMQEK
PFIFTKCALVWDETRSVSSSLKAGSVRRECEASLQRLQVNAIDLYQMHWPDPDEDIEEGWLEMAKLQSEGLVRHIGVSNF
TVAQMQRALAIAPIASLQPPYSMLRRAIEKEILPFCFDNNIGVIVYSPMLSGMLSGAMTKDRAASFAKDDWRRNNREFQE
PRLSRNLELVELLRQVGALYGRSAGEVAIAWALRHPVVTGVIVGGRNALQVEGVIGAGEFLLSDEDASRIESFIATMYA
>Mature_319_residues
MLKRRLGNTDMEITLLGFGSWAIGGGNWAYGWGAQNDQDAVEAIVRAVDLGMNWIDTAAVYGLGHAEELVGRAVASMQEK
PFIFTKCALVWDETRSVSSSLKAGSVRRECEASLQRLQVNAIDLYQMHWPDPDEDIEEGWLEMAKLQSEGLVRHIGVSNF
TVAQMQRALAIAPIASLQPPYSMLRRAIEKEILPFCFDNNIGVIVYSPMLSGMLSGAMTKDRAASFAKDDWRRNNREFQE
PRLSRNLELVELLRQVGALYGRSAGEVAIAWALRHPVVTGVIVGGRNALQVEGVIGAGEFLLSDEDASRIESFIATMYA

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=328, Percent_Identity=26.8292682926829, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4504825, Length=325, Percent_Identity=26.7692307692308, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI27436966, Length=313, Percent_Identity=24.2811501597444, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI27436962, Length=313, Percent_Identity=24.2811501597444, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI27436964, Length=313, Percent_Identity=24.2811501597444, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI27436971, Length=317, Percent_Identity=23.6593059936909, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI223718702, Length=298, Percent_Identity=28.5234899328859, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI41152114, Length=299, Percent_Identity=27.0903010033445, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI223468663, Length=337, Percent_Identity=23.7388724035608, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI41327764, Length=277, Percent_Identity=28.5198555956679, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI24497577, Length=338, Percent_Identity=25.1479289940828, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI5174391, Length=338, Percent_Identity=25.1479289940828, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788070, Length=322, Percent_Identity=34.1614906832298, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87081735, Length=318, Percent_Identity=27.0440251572327, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788081, Length=263, Percent_Identity=29.277566539924, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789375, Length=337, Percent_Identity=25.8160237388724, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789199, Length=348, Percent_Identity=25.2873563218391, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082198, Length=207, Percent_Identity=29.951690821256, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786400, Length=149, Percent_Identity=31.5436241610738, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787674, Length=223, Percent_Identity=27.3542600896861, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI212645785, Length=174, Percent_Identity=29.8850574712644, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17550248, Length=210, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=338, Percent_Identity=25.4437869822485, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320576, Length=253, Percent_Identity=27.6679841897233, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320079, Length=292, Percent_Identity=25.6849315068493, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24662789, Length=228, Percent_Identity=28.9473684210526, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644950, Length=324, Percent_Identity=25.6172839506173, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24657054, Length=311, Percent_Identity=24.1157556270096, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646155, Length=229, Percent_Identity=29.2576419213974, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356425, Length=230, Percent_Identity=27.8260869565217, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24640980, Length=325, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129731, Length=195, Percent_Identity=29.7435897435897, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24662781, Length=228, Percent_Identity=28.5087719298246, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45549126, Length=327, Percent_Identity=23.8532110091743, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35237; Mature: 35237

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRRLGNTDMEITLLGFGSWAIGGGNWAYGWGAQNDQDAVEAIVRAVDLGMNWIDTAAV
CCCCCCCCCCCEEEEEEECCEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
YGLGHAEELVGRAVASMQEKPFIFTKCALVWDETRSVSSSLKAGSVRRECEASLQRLQVN
HCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
AIDLYQMHWPDPDEDIEEGWLEMAKLQSEGLVRHIGVSNFTVAQMQRALAIAPIASLQPP
CEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
YSMLRRAIEKEILPFCFDNNIGVIVYSPMLSGMLSGAMTKDRAASFAKDDWRRNNREFQE
HHHHHHHHHHHHCCEEECCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHC
PRLSRNLELVELLRQVGALYGRSAGEVAIAWALRHPVVTGVIVGGRNALQVEGVIGAGEF
HHHHCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCEEEEEECCCCEEEEEEEEECCCE
LLSDEDASRIESFIATMYA
EECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKRRLGNTDMEITLLGFGSWAIGGGNWAYGWGAQNDQDAVEAIVRAVDLGMNWIDTAAV
CCCCCCCCCCCEEEEEEECCEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
YGLGHAEELVGRAVASMQEKPFIFTKCALVWDETRSVSSSLKAGSVRRECEASLQRLQVN
HCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
AIDLYQMHWPDPDEDIEEGWLEMAKLQSEGLVRHIGVSNFTVAQMQRALAIAPIASLQPP
CEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
YSMLRRAIEKEILPFCFDNNIGVIVYSPMLSGMLSGAMTKDRAASFAKDDWRRNNREFQE
HHHHHHHHHHHHCCEEECCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHC
PRLSRNLELVELLRQVGALYGRSAGEVAIAWALRHPVVTGVIVGGRNALQVEGVIGAGEF
HHHHCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCEEEEEECCCCEEEEEEEEECCCE
LLSDEDASRIESFIATMYA
EECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]