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The map label for this gene is hisN [H]

Identifier: 119357596

GI number: 119357596

Start: 2051405

End: 2052181

Strand: Reverse

Name: hisN [H]

Synonym: Cpha266_1799

Alternate gene names: 119357596

Gene position: 2052181-2051405 (Counterclockwise)

Preceding gene: 119357597

Following gene: 119357595

Centisome position: 65.48

GC content: 48.52

Gene sequence:

>777_bases
ATGAGTCCTGAGCTTCAGCTTGCCCTTGAACTGGCCGATCGTGCCGGAAGGTTAACGCTCGAATATTTCAACAGGAAATC
CTTGCAGGTTTTTTCCAAACGTGATGCTACTCCGGTTACAGAAGCAGACCGGAATGCTGAAATACTCATCAGAGAAGGGA
TCAGCGCACGGTATCCACGAGATGGTCTGCTTGGGGAAGAGTTTGATGAAAAGCATGCAGATAACGGGCGCCGGTGGATT
ATTGATCCTATTGACGGTACGAAATCTTTTATTCACGGGGTTCCTCTTTATGGAGTATTGATTGCACTTGAAGAGGAAGG
TTTGCCGCGGCTTGGTGCTGTCGGATTTCCTGCTCTTGGGCAGCTTTTTTATGCTGAAACAGGGTGCGGAGCATTTCTTG
ACGGCACACGAATCGAAGTTTCTTCTCTCAGCTCTCTTGATGATGCGACGGTTGTTTTTACGGAAAAAGAGTATTTGCTC
GATCCTTTATCGGAACACCCTGTTGACCGACTTCGGGTTGAAGCGGGGCTTGTAAGGGGATGGGGGGACTGTTATGGCCA
TATGCTGGTTGCTTCCGGTCGGGCAGAGTTTTCTGTTGATAAAGTGATGAGCCCCTGGGATTGTGCTGCGCTTGTTCCAG
TTGTGAACGAAGCGGGTGGGTGTTGTTTTGATCTTAACGGAAGGGCTACGATATATGGGGATGGTATGGTCAGTGCAAAC
CGTATTCTTGGTATGGAACTTGTTAAATCGATTGAAAAACAGAGGCTGGGGTCGTAA

Upstream 100 bases:

>100_bases
TCGCCATGATACAGTCACCGAGGGGGCGAAATGCCATATCAAATGTTCTCAGCCTGAATAATTTGTTTTTTTTGTCACCA
TTTTAAATATAACATTGCCG

Downstream 100 bases:

>100_bases
TGGTTGTTTTTGGTATGCTTCTTACGATAACCGCTCTGCTTCTTGCCATAGTGATCATGCTGTTGACCGGATGGCCGACA
GGCAGGAAGAAGGAACTTGA

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSPELQLALELADRAGRLTLEYFNRKSLQVFSKRDATPVTEADRNAEILIREGISARYPRDGLLGEEFDEKHADNGRRWI
IDPIDGTKSFIHGVPLYGVLIALEEEGLPRLGAVGFPALGQLFYAETGCGAFLDGTRIEVSSLSSLDDATVVFTEKEYLL
DPLSEHPVDRLRVEAGLVRGWGDCYGHMLVASGRAEFSVDKVMSPWDCAALVPVVNEAGGCCFDLNGRATIYGDGMVSAN
RILGMELVKSIEKQRLGS

Sequences:

>Translated_258_residues
MSPELQLALELADRAGRLTLEYFNRKSLQVFSKRDATPVTEADRNAEILIREGISARYPRDGLLGEEFDEKHADNGRRWI
IDPIDGTKSFIHGVPLYGVLIALEEEGLPRLGAVGFPALGQLFYAETGCGAFLDGTRIEVSSLSSLDDATVVFTEKEYLL
DPLSEHPVDRLRVEAGLVRGWGDCYGHMLVASGRAEFSVDKVMSPWDCAALVPVVNEAGGCCFDLNGRATIYGDGMVSAN
RILGMELVKSIEKQRLGS
>Mature_257_residues
SPELQLALELADRAGRLTLEYFNRKSLQVFSKRDATPVTEADRNAEILIREGISARYPRDGLLGEEFDEKHADNGRRWII
DPIDGTKSFIHGVPLYGVLIALEEEGLPRLGAVGFPALGQLFYAETGCGAFLDGTRIEVSSLSSLDDATVVFTEKEYLLD
PLSEHPVDRLRVEAGLVRGWGDCYGHMLVASGRAEFSVDKVMSPWDCAALVPVVNEAGGCCFDLNGRATIYGDGMVSANR
ILGMELVKSIEKQRLGS

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=265, Percent_Identity=27.5471698113208, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI221625487, Length=265, Percent_Identity=27.5471698113208, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI7657236, Length=233, Percent_Identity=30.9012875536481, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI221625507, Length=142, Percent_Identity=28.8732394366197, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788882, Length=234, Percent_Identity=32.0512820512821, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790659, Length=128, Percent_Identity=35.15625, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193202572, Length=235, Percent_Identity=30.2127659574468, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193202570, Length=234, Percent_Identity=31.6239316239316, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320493, Length=201, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357957, Length=222, Percent_Identity=33.7837837837838, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357329, Length=262, Percent_Identity=30.9160305343511, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24664918, Length=223, Percent_Identity=33.6322869955157, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24664922, Length=260, Percent_Identity=27.6923076923077, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664926, Length=260, Percent_Identity=27.3076923076923, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357303, Length=237, Percent_Identity=28.6919831223629, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28238; Mature: 28107

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPELQLALELADRAGRLTLEYFNRKSLQVFSKRDATPVTEADRNAEILIREGISARYPR
CCCCHHHHHHHHHCCCCEEEEHHCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCC
DGLLGEEFDEKHADNGRRWIIDPIDGTKSFIHGVPLYGVLIALEEEGLPRLGAVGFPALG
CCCCCCHHHHHHCCCCCEEEEECCCCCHHHHCCCCHHHEEEEECCCCCCCCCCCCCHHHH
QLFYAETGCGAFLDGTRIEVSSLSSLDDATVVFTEKEYLLDPLSEHPVDRLRVEAGLVRG
HHHHHCCCCCCEECCCEEEEHHCCCCCCEEEEEECHHHHHCCHHHCCHHHHHHHHHHHHC
WGDCYGHMLVASGRAEFSVDKVMSPWDCAALVPVVNEAGGCCFDLNGRATIYGDGMVSAN
CHHHHHEEEEECCCCCEEHHHCCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHH
RILGMELVKSIEKQRLGS
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPELQLALELADRAGRLTLEYFNRKSLQVFSKRDATPVTEADRNAEILIREGISARYPR
CCCHHHHHHHHHCCCCEEEEHHCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCC
DGLLGEEFDEKHADNGRRWIIDPIDGTKSFIHGVPLYGVLIALEEEGLPRLGAVGFPALG
CCCCCCHHHHHHCCCCCEEEEECCCCCHHHHCCCCHHHEEEEECCCCCCCCCCCCCHHHH
QLFYAETGCGAFLDGTRIEVSSLSSLDDATVVFTEKEYLLDPLSEHPVDRLRVEAGLVRG
HHHHHCCCCCCEECCCEEEEHHCCCCCCEEEEEECHHHHHCCHHHCCHHHHHHHHHHHHC
WGDCYGHMLVASGRAEFSVDKVMSPWDCAALVPVVNEAGGCCFDLNGRATIYGDGMVSAN
CHHHHHEEEEECCCCCEEHHHCCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHH
RILGMELVKSIEKQRLGS
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]