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The map label for this gene is hemA

Identifier: 119357592

GI number: 119357592

Start: 2047899

End: 2049176

Strand: Direct

Name: hemA

Synonym: Cpha266_1795

Alternate gene names: 119357592

Gene position: 2047899-2049176 (Clockwise)

Preceding gene: 119357591

Following gene: 119357593

Centisome position: 65.35

GC content: 45.54

Gene sequence:

>1278_bases
ATGAACATCATTTCAGTTGGTGTTAACCACAAAACTGCACCTATTGAAATCCGTGAAAGAATCTCGCTTTCAGAAGTTCA
AAACAAGGAATTCATTACGGACCTCATTTCAAGCGGACTGGCCCATGAAGCCATGGTCATTTCTACATGCAACCGTACCG
AGCTGTATGTAGTTCCTGCCATGCATGAAGTCACAGGAGAGTATCTGAAAGAGTATCTCATTGCCTATAAGGATGCGCGC
AAGGAAGTTCGTCCTGAACATTTTTTCAGTCGTTTCTATTGCGGTACCGCGCGCCATCTTTTTGAGGTATCGAGTGCCAT
TGACTCCCTGATTCTCGGAGAGGGTCAGATTTTAGGTCAGGTCAAGGATGCATACAGAATTTCCGCTGAAGTTCAGGCTG
CGGGAATTCTCCTCACACGTCTCTGCCATACGGCATTCAGCGTCGCAAAAAAGGTAAAAACCAAAACCAAAATCATGGAG
GGGGCGGTTTCCGTCAGCTACGCTGCCGTTGAACTTGCCCAGAAAATTTTCTCAAATCTCTCCATGAAAAAAATCCTGCT
CATCGGCGCTGGAGAAACAGGAGAGCTTGCGGCGAAACATATGTTTCAGAAAAATGCCCGCAATATCGTTATAACCAACA
GAACTCTTTCAAAAGCCGAAGCTCTTGCTGAAGAGCTCGGAACAAAAAAAGTGCTTCCGTTTGAAAGCTACAAGGATTAC
CTTCACGAGTTTGACATTATCATCACCGCTGTCAGCACAAAAGAGTACGTTCTCAGTGAAGCTGAAATGCACCAGACAAT
GATGAAACGGAGGCTCAAGCCTGTCATCATTCTGGATCTCGGACTGCCGAGAAATGTTGACCCGGATATTGCAAAACTGC
AGAACATGTTTTTGAAGGATATTGATGCTCTCAAACACATTATCGACAAAAATCTTGAACGCCGAAGCGCCGAACTCCCC
AAAGTCAACGCCATAATTGAAGAGGAGCTCATTGCTTTTGGTCAGTGGATCAACACGCTCAAAGTCCGTCCGACCATTGT
CGATCTCCAGTCGAAGTTCATTGAAATCAAGGAGAAGGAACTCGAACGGTACCGCTACAAGGTCAGCGAAGATGAACTCG
CCCGCATGGAGCATCTTACAGACCGAATCCTGAAAAAAATCCTGCATCATCCGATTAAAATGCTCAAGGCTCCTATTGAC
ACAGCCAACAACATTCCGAGCAGAGTCAACCTTGTCCGCAACGTTTTTGACCTTGAAGAACCTAATCAACAACACTAA

Upstream 100 bases:

>100_bases
CACCGCTTTTAGGATATATTATGCATTCAATGATTGTTGTTCTGCATATCCAGGTCATACTTGCATATCCGGTAATCGGC
TCACTTTAAACAACCCTGCT

Downstream 100 bases:

>100_bases
ACAAAATCTGTCATCGCTTTGAAAAAACAGCTTATTATCGGCACCAGATCCAGCCCTCTTGCTTTGTGGCAGGCAGAATT
CACCAAAGCGGAGCTATCGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITDLISSGLAHEAMVISTCNRTELYVVPAMHEVTGEYLKEYLIAYKDAR
KEVRPEHFFSRFYCGTARHLFEVSSAIDSLILGEGQILGQVKDAYRISAEVQAAGILLTRLCHTAFSVAKKVKTKTKIME
GAVSVSYAAVELAQKIFSNLSMKKILLIGAGETGELAAKHMFQKNARNIVITNRTLSKAEALAEELGTKKVLPFESYKDY
LHEFDIIITAVSTKEYVLSEAEMHQTMMKRRLKPVIILDLGLPRNVDPDIAKLQNMFLKDIDALKHIIDKNLERRSAELP
KVNAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEDELARMEHLTDRILKKILHHPIKMLKAPID
TANNIPSRVNLVRNVFDLEEPNQQH

Sequences:

>Translated_425_residues
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITDLISSGLAHEAMVISTCNRTELYVVPAMHEVTGEYLKEYLIAYKDAR
KEVRPEHFFSRFYCGTARHLFEVSSAIDSLILGEGQILGQVKDAYRISAEVQAAGILLTRLCHTAFSVAKKVKTKTKIME
GAVSVSYAAVELAQKIFSNLSMKKILLIGAGETGELAAKHMFQKNARNIVITNRTLSKAEALAEELGTKKVLPFESYKDY
LHEFDIIITAVSTKEYVLSEAEMHQTMMKRRLKPVIILDLGLPRNVDPDIAKLQNMFLKDIDALKHIIDKNLERRSAELP
KVNAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEDELARMEHLTDRILKKILHHPIKMLKAPID
TANNIPSRVNLVRNVFDLEEPNQQH
>Mature_425_residues
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITDLISSGLAHEAMVISTCNRTELYVVPAMHEVTGEYLKEYLIAYKDAR
KEVRPEHFFSRFYCGTARHLFEVSSAIDSLILGEGQILGQVKDAYRISAEVQAAGILLTRLCHTAFSVAKKVKTKTKIME
GAVSVSYAAVELAQKIFSNLSMKKILLIGAGETGELAAKHMFQKNARNIVITNRTLSKAEALAEELGTKKVLPFESYKDY
LHEFDIIITAVSTKEYVLSEAEMHQTMMKRRLKPVIILDLGLPRNVDPDIAKLQNMFLKDIDALKHIIDKNLERRSAELP
KVNAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEDELARMEHLTDRILKKILHHPIKMLKAPID
TANNIPSRVNLVRNVFDLEEPNQQH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=421, Percent_Identity=33.0166270783848, Blast_Score=237, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_CHLPD (A1BHD5)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912236.1
- ProteinModelPortal:   A1BHD5
- SMR:   A1BHD5
- STRING:   A1BHD5
- GeneID:   4570346
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1795
- NMPDR:   fig|290317.7.peg.1884
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   EVRPEHF
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48387; Mature: 48387

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITDLISSGLAHEAMVISTCNRTELYVVPA
CCEEEECCCCCCCCHHHHHHCCHHHHCCHHHHHHHHHCCCCHHHHEEEECCCCEEEEECC
MHEVTGEYLKEYLIAYKDARKEVRPEHFFSRFYCGTARHLFEVSSAIDSLILGEGQILGQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VKDAYRISAEVQAAGILLTRLCHTAFSVAKKVKTKTKIMEGAVSVSYAAVELAQKIFSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SMKKILLIGAGETGELAAKHMFQKNARNIVITNRTLSKAEALAEELGTKKVLPFESYKDY
CEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHH
LHEFDIIITAVSTKEYVLSEAEMHQTMMKRRLKPVIILDLGLPRNVDPDIAKLQNMFLKD
HHHHHHHEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
IDALKHIIDKNLERRSAELPKVNAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKE
HHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LERYRYKVSEDELARMEHLTDRILKKILHHPIKMLKAPIDTANNIPSRVNLVRNVFDLEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
PNQQH
CCCCC
>Mature Secondary Structure
MNIISVGVNHKTAPIEIRERISLSEVQNKEFITDLISSGLAHEAMVISTCNRTELYVVPA
CCEEEECCCCCCCCHHHHHHCCHHHHCCHHHHHHHHHCCCCHHHHEEEECCCCEEEEECC
MHEVTGEYLKEYLIAYKDARKEVRPEHFFSRFYCGTARHLFEVSSAIDSLILGEGQILGQ
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VKDAYRISAEVQAAGILLTRLCHTAFSVAKKVKTKTKIMEGAVSVSYAAVELAQKIFSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SMKKILLIGAGETGELAAKHMFQKNARNIVITNRTLSKAEALAEELGTKKVLPFESYKDY
CEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHH
LHEFDIIITAVSTKEYVLSEAEMHQTMMKRRLKPVIILDLGLPRNVDPDIAKLQNMFLKD
HHHHHHHEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
IDALKHIIDKNLERRSAELPKVNAIIEEELIAFGQWINTLKVRPTIVDLQSKFIEIKEKE
HHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LERYRYKVSEDELARMEHLTDRILKKILHHPIKMLKAPIDTANNIPSRVNLVRNVFDLEE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
PNQQH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA