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The map label for this gene is lysS [H]

Identifier: 119357536

GI number: 119357536

Start: 1964587

End: 1966116

Strand: Direct

Name: lysS [H]

Synonym: Cpha266_1739

Alternate gene names: 119357536

Gene position: 1964587-1966116 (Clockwise)

Preceding gene: 119357535

Following gene: 119357537

Centisome position: 62.69

GC content: 48.1

Gene sequence:

>1530_bases
ATGACGCCTAATGAAAACCCGCAAAGTCCTGGGAACCCCCAGCAGCTCTCTCTTAACGACCAGATGAAAAGGCGTTTGGA
TGAACGACTCCACCTTGCAGAATCCGGAGTGAATCCATACCCTTGCCATTTTGACGTAACGCACTTTTCCGATTCGATCC
TCACTGACTTTCAGGATGATGCAAACGAAACCGTTTCTGTTGCCGGAAGAATCATGACGATCAGAAAAATGGGAAAAGCC
TCGTTTTTCCATCTGCAGGATGCCAACGGCAGAATCCAGATTTACCTGAAAAAAGATGATGTTGGCGAATCCTCCTACCA
GACATTCAAACTGCTCGATATCGGTGATATTGTCGGCGTAAAAGGCTACACCTTCAAAACAAAAACCGGTGAAATATCAG
TACACGCACAGGAATTCTCTTTGCTCAGCAAGTCGCTTCGCCCTATCCCGATAGCCAAGGAAAAAGAGATTGACGGACAG
AAAGTAGTCTATGACGCTTTCAGCGACAAGGAGCTCCGTTACCGCCAGCGCTATGTTGACCTTATCGTCAACCCCGATGT
AAGGCAAACCTTTATCAAGCGCTCCGCAATTGTCTCATTTATGCGCGGGTTTTTCACAGGGCAAGGGTGGCTTGAAGTTG
AAACCCCTATCCTTCAGCCGATTTACGGCGGTGCGGCAGCACGTCCATTCACCACGCATCACAATGCACTCGACATGCAG
CTCTATCTGCGCATTGCCAATGAGCTCTACCTGAAGCGACTCATTGTTGGCGGTTTTGACGGAGTCTTTGAGTTTGCAAA
AGATTTCCGTAACGAAGGCATTGACCGTTTTCACAATCCCGAATTCACCCAGGTTGAGCTCTATGTTGCATACAAGGATT
ACGAGTGGATGATGAAGCTGGTTGAAGAGCTTTTTTATCAGACAGCATGCGCAGTTAACAACTCGGATTCCGTTGTTTTT
CTCGGCAACGACATAAGTCTTAAACCTCCGTTCCGCAGACTCACCATAACGGACTCCATTAAAGAGTATTGCGGTATCGA
TATCACCGATAAAGATGAACATGAGCTTCGGTATATGGCCAGGGATCTTGGACTTGAGCTTGACCCGAAAATCAGCAGCG
GTAAAATCATCGACGAAATATTTGGTGAATTTGTTGAGCCAAAACTTATTCAACCAACATTTATTACCGATTATCCGGTG
GAAATGTCGCCTCTTGCCAAGGAGCATCGATCCAAACCAGGCTTTGTCGAGCGCTTTGAACTCATTGCCGGCGGCAAGGA
GCTCTGCAACTCATTTTCCGAACTCAACGACCCGGTCATTCAGCGAGAACGACTGGAAGCACAGGCAAAACTGCGTCAGC
GAGGCGATGAGGAAGCGATGATTGTCGATGAGGATTTTCTGCGAGCCCTCGAATACGGCATGCCGCCATGTGCGGGACTT
GGTGTAGGTGTCGACAGAATGGTCATGCTGCTCACCGGTCAGGACTCGATAAGAGATGTTATCTTCTTTCCGCACCTGAA
ACCGGAATAG

Upstream 100 bases:

>100_bases
AGAAAATCAGTACCATTCCCTATGTCTGGTACAAAACCATGATAACCGGCTGATCGCCCGATTTAACGACCCAATCAATA
AACAGACCATTGCAGCAAGC

Downstream 100 bases:

>100_bases
CAAACAAGCCGGCAGGTTTTTTTAAGACAAACAGAGCCGTCATGACACTGCGATGCTGGCCTAAACCTGATATTCTCACC
CTTTCCGATTTAATCGGAAA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTPNENPQSPGNPQQLSLNDQMKRRLDERLHLAESGVNPYPCHFDVTHFSDSILTDFQDDANETVSVAGRIMTIRKMGKA
SFFHLQDANGRIQIYLKKDDVGESSYQTFKLLDIGDIVGVKGYTFKTKTGEISVHAQEFSLLSKSLRPIPIAKEKEIDGQ
KVVYDAFSDKELRYRQRYVDLIVNPDVRQTFIKRSAIVSFMRGFFTGQGWLEVETPILQPIYGGAAARPFTTHHNALDMQ
LYLRIANELYLKRLIVGGFDGVFEFAKDFRNEGIDRFHNPEFTQVELYVAYKDYEWMMKLVEELFYQTACAVNNSDSVVF
LGNDISLKPPFRRLTITDSIKEYCGIDITDKDEHELRYMARDLGLELDPKISSGKIIDEIFGEFVEPKLIQPTFITDYPV
EMSPLAKEHRSKPGFVERFELIAGGKELCNSFSELNDPVIQRERLEAQAKLRQRGDEEAMIVDEDFLRALEYGMPPCAGL
GVGVDRMVMLLTGQDSIRDVIFFPHLKPE

Sequences:

>Translated_509_residues
MTPNENPQSPGNPQQLSLNDQMKRRLDERLHLAESGVNPYPCHFDVTHFSDSILTDFQDDANETVSVAGRIMTIRKMGKA
SFFHLQDANGRIQIYLKKDDVGESSYQTFKLLDIGDIVGVKGYTFKTKTGEISVHAQEFSLLSKSLRPIPIAKEKEIDGQ
KVVYDAFSDKELRYRQRYVDLIVNPDVRQTFIKRSAIVSFMRGFFTGQGWLEVETPILQPIYGGAAARPFTTHHNALDMQ
LYLRIANELYLKRLIVGGFDGVFEFAKDFRNEGIDRFHNPEFTQVELYVAYKDYEWMMKLVEELFYQTACAVNNSDSVVF
LGNDISLKPPFRRLTITDSIKEYCGIDITDKDEHELRYMARDLGLELDPKISSGKIIDEIFGEFVEPKLIQPTFITDYPV
EMSPLAKEHRSKPGFVERFELIAGGKELCNSFSELNDPVIQRERLEAQAKLRQRGDEEAMIVDEDFLRALEYGMPPCAGL
GVGVDRMVMLLTGQDSIRDVIFFPHLKPE
>Mature_508_residues
TPNENPQSPGNPQQLSLNDQMKRRLDERLHLAESGVNPYPCHFDVTHFSDSILTDFQDDANETVSVAGRIMTIRKMGKAS
FFHLQDANGRIQIYLKKDDVGESSYQTFKLLDIGDIVGVKGYTFKTKTGEISVHAQEFSLLSKSLRPIPIAKEKEIDGQK
VVYDAFSDKELRYRQRYVDLIVNPDVRQTFIKRSAIVSFMRGFFTGQGWLEVETPILQPIYGGAAARPFTTHHNALDMQL
YLRIANELYLKRLIVGGFDGVFEFAKDFRNEGIDRFHNPEFTQVELYVAYKDYEWMMKLVEELFYQTACAVNNSDSVVFL
GNDISLKPPFRRLTITDSIKEYCGIDITDKDEHELRYMARDLGLELDPKISSGKIIDEIFGEFVEPKLIQPTFITDYPVE
MSPLAKEHRSKPGFVERFELIAGGKELCNSFSELNDPVIQRERLEAQAKLRQRGDEEAMIVDEDFLRALEYGMPPCAGLG
VGVDRMVMLLTGQDSIRDVIFFPHLKPE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=506, Percent_Identity=41.699604743083, Blast_Score=381, Evalue=1e-105,
Organism=Homo sapiens, GI194272210, Length=506, Percent_Identity=41.699604743083, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI1790571, Length=512, Percent_Identity=46.484375, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1789256, Length=511, Percent_Identity=47.1624266144814, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI87082379, Length=324, Percent_Identity=32.4074074074074, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788173, Length=262, Percent_Identity=23.6641221374046, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17535927, Length=523, Percent_Identity=39.961759082218, Blast_Score=377, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535925, Length=523, Percent_Identity=39.961759082218, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71994340, Length=498, Percent_Identity=40.1606425702811, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI32566633, Length=311, Percent_Identity=27.6527331189711, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17551876, Length=477, Percent_Identity=21.8029350104822, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320242, Length=501, Percent_Identity=39.1217564870259, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6324256, Length=493, Percent_Identity=28.3975659229209, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24640849, Length=534, Percent_Identity=39.3258426966292, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24640851, Length=534, Percent_Identity=39.3258426966292, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI17136276, Length=462, Percent_Identity=22.0779220779221, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584738, Length=311, Percent_Identity=26.3665594855305, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 58224; Mature: 58093

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPNENPQSPGNPQQLSLNDQMKRRLDERLHLAESGVNPYPCHFDVTHFSDSILTDFQDD
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHHCCCHHHHHCCCC
ANETVSVAGRIMTIRKMGKASFFHLQDANGRIQIYLKKDDVGESSYQTFKLLDIGDIVGV
CCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCC
KGYTFKTKTGEISVHAQEFSLLSKSLRPIPIAKEKEIDGQKVVYDAFSDKELRYRQRYVD
CCEEEEECCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LIVNPDVRQTFIKRSAIVSFMRGFFTGQGWLEVETPILQPIYGGAAARPFTTHHNALDMQ
EEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCHHHH
LYLRIANELYLKRLIVGGFDGVFEFAKDFRNEGIDRFHNPEFTQVELYVAYKDYEWMMKL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEEECCHHHHHHH
VEELFYQTACAVNNSDSVVFLGNDISLKPPFRRLTITDSIKEYCGIDITDKDEHELRYMA
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCHHHHHHHH
RDLGLELDPKISSGKIIDEIFGEFVEPKLIQPTFITDYPVEMSPLAKEHRSKPGFVERFE
HHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCCCCHHHHHH
LIAGGKELCNSFSELNDPVIQRERLEAQAKLRQRGDEEAMIVDEDFLRALEYGMPPCAGL
HHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCCCCC
GVGVDRMVMLLTGQDSIRDVIFFPHLKPE
CCCHHHEEEEEECCCCCCEEEEECCCCCC
>Mature Secondary Structure 
TPNENPQSPGNPQQLSLNDQMKRRLDERLHLAESGVNPYPCHFDVTHFSDSILTDFQDD
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHHCCCHHHHHCCCC
ANETVSVAGRIMTIRKMGKASFFHLQDANGRIQIYLKKDDVGESSYQTFKLLDIGDIVGV
CCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCC
KGYTFKTKTGEISVHAQEFSLLSKSLRPIPIAKEKEIDGQKVVYDAFSDKELRYRQRYVD
CCEEEEECCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LIVNPDVRQTFIKRSAIVSFMRGFFTGQGWLEVETPILQPIYGGAAARPFTTHHNALDMQ
EEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCHHHH
LYLRIANELYLKRLIVGGFDGVFEFAKDFRNEGIDRFHNPEFTQVELYVAYKDYEWMMKL
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEEECCHHHHHHH
VEELFYQTACAVNNSDSVVFLGNDISLKPPFRRLTITDSIKEYCGIDITDKDEHELRYMA
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCHHHHHHHH
RDLGLELDPKISSGKIIDEIFGEFVEPKLIQPTFITDYPVEMSPLAKEHRSKPGFVERFE
HHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCCCCHHHHHH
LIAGGKELCNSFSELNDPVIQRERLEAQAKLRQRGDEEAMIVDEDFLRALEYGMPPCAGL
HHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCCCCC
GVGVDRMVMLLTGQDSIRDVIFFPHLKPE
CCCHHHEEEEEECCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA