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The map label for this gene is f1pep1 [H]

Identifier: 119356837

GI number: 119356837

Start: 1148313

End: 1150511

Strand: Reverse

Name: f1pep1 [H]

Synonym: Cpha266_1010

Alternate gene names: 119356837

Gene position: 1150511-1148313 (Counterclockwise)

Preceding gene: 119356838

Following gene: 119356834

Centisome position: 36.71

GC content: 49.16

Gene sequence:

>2199_bases
ATGACAATACCACGTACCGCGCTCTTTTTGTTATGCTTTCTTGCCCTCACTTCTGCGGCTTTCGCTGTAGAAAAACCTGA
ACCTGTTGTTATAAGAAAATCCTTTCCGGAAGCTCAAAAACCTGTTGTGGAAACATGGTGCGGCGAAACAATAGCTGATC
CTTTCCGCGCGATGGAGAACATCAGAAACCCGCAAGTCATCAACTGGCTCAAGCAGGAGAGCGACTATGCCCGCAATACC
CTGCAACGAATTCCCGGAAGAGATAGTCTCATCTCCAAAATGCAGGAATTTGACAAAAGAAAGGTCTCGAAAGTCTATAA
TCTCTCGATTACCGAAAACGACGTCTATTTTTATCTCAAACAGACGCCGTCGGACGAAACAGGCCAGCTCTACTACAGAA
AAGGGTTCCATGGCAAAGAAACCCTGCTGTTCAACCCCTCTTCATCACCTGATAAAGAGAGCCACACGGTTATAGGTACC
ATTTCTCCCTCATTTGACGGATCAAAGGTCGCATTTACCATTTCAAAAAACGGCTCAGAGGATGCGGTTCTCCTGATTAT
GGATGTTGCGACAAAAAAGCTGTTTCCGGAAAAAATCACAAGGTGCCGGTTTGCATCGCCATCATGGCTCAAAACTGGCG
ATGCATTTCTTTACAATCGCCTGCGGGCTCTTGAAAAGCCTGGCGAAAATCCACAGCACAACAGCAAAACATTTCTCCAT
ATACCCGGAACGGACCCGTCAAGAGACCTTGAAATTTTTTCAAGCGCAACAAACCCTGAACTTGTTCTTAATCCGGAAGA
TATTCCCGAAGTGAGTTATGAGAAGGAGAGCGGGCAACTGTTTGCATTTCTCTCAAATGTAGACCGCCGCCTGACAGTTT
ACTATGCGCCCCTCGATCAGCCTGGAAAAAAGAAAACAGCCTGGAAAAAGCTCTTTATCCCGAAAGATGATGTCCACGAT
TTTGCTGTCACGGAGAAGGATATCTACTTTTCATCGCCAAAAAAAGCATCTGGTTTCCGGTTATTGAAAACATCCCTTGA
GCATCCCGATCTTGAGCATGCCGAATTGATCGTTCCGGAAACTCCTGGAGCCACGCTAACCGGATTCACGCTCACCAGCA
GGGGCATCTTCTACACACAATCGAAAAACGGCGTCGAAGAAAAACTCTATCATCAGGAGTACGGAAAAACAGAATCAAAA
GAGATCATCCTGCCTTCCGCTGCCGGAACCATTGCGTTAAGCAGCAAAGGATTCCGCTACCCCGACCTCTGGGTGGTCAT
CGCAGGCTGGAGCAAAGACTACCGACGCTACCGATATGATAGCCGAAACGAAGGAACCTTCAGCCTTGAAACACTCTCAT
CCCCCGCCTTGTACCCGGAATATGAGCGACTGAAAGTCGAAGAACTCATGATACCCTCACACGATGGGGTTATGGTCCCG
CTGTCGATTGTGTACCGGAATGATCTTGATAAAAAAGGAACCAATCCCGTTCTGCTCTACGGCTATGGGGCCTATGGCAA
CGCTCTGACACCTTTTTTCAGCCCATCACTACTGCTCTGGACTCATAAAGGCGGCATTCTTGCCATCGTGCACGCAAGAG
GCGGCGGAGAGCTTGGTGATGCATGGCATACATCGGGAATGAAAACCACGAAGCCGAACACATGGAAAGACCTCATAAGT
TCCGCCGAGTACCTGATCAAGGAGAAATACTCTTCATCTCGACATATCGCAATCAATGGCGCCAGTGCCGGCGGCATTCT
TGTAGGAAAAGCCATGACCGAACGTCCGGATCTTTTTGCCGCAGCGATTCCGCAGGTTGGACTGATGAACCCCCTGCGGG
GTGAGGAAACGCCGAATGGTCCGGTCAACGTACCAGAGTTCGGCACGGTCAAGAAGCCCGATGAATGCAAAGCGCTCATT
GCCATGGATCCCTATCTTTCCATTATTGATGGAGTCCGATACCCGGCTGCACTGGTTACAGCAGGAATCAACGATCCAAG
AGTCAGTGCCTGGCAGCCTGCGAAATTCGCCGCCCGTCTTCAGGCTGCGACAGCCTCAAACAAACCGGTTCTTCTGTTCA
CCGATTTCAAGGCCGGACACGGCATGGGAAACACGAAACAGATGGAGTTTGAATCCCTTGCCGATGTATTGAGTTTCGGA
CTGTGGCAAACCGGCCATCCTGAATTTCAAATCAGGTAA

Upstream 100 bases:

>100_bases
CCCCACCACTAAAAAAGCCATGCAGAAACAGCATGGCTTTTTTTATGGGCATCGCTCACTGAAAGCTCTTTTCAGATAAT
CCGCAACAGCCTTGATTACC

Downstream 100 bases:

>100_bases
CCCGGCAACAACTCATCCTGTTCAGTATTACTGAACCCCTGAAACCGATCCGGCACAAGCCCTTTAAGATAGAGTTGCCG
TTTCTCCTCCGCAAACCGTT

Product: oligopeptidase B

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MTIPRTALFLLCFLALTSAAFAVEKPEPVVIRKSFPEAQKPVVETWCGETIADPFRAMENIRNPQVINWLKQESDYARNT
LQRIPGRDSLISKMQEFDKRKVSKVYNLSITENDVYFYLKQTPSDETGQLYYRKGFHGKETLLFNPSSSPDKESHTVIGT
ISPSFDGSKVAFTISKNGSEDAVLLIMDVATKKLFPEKITRCRFASPSWLKTGDAFLYNRLRALEKPGENPQHNSKTFLH
IPGTDPSRDLEIFSSATNPELVLNPEDIPEVSYEKESGQLFAFLSNVDRRLTVYYAPLDQPGKKKTAWKKLFIPKDDVHD
FAVTEKDIYFSSPKKASGFRLLKTSLEHPDLEHAELIVPETPGATLTGFTLTSRGIFYTQSKNGVEEKLYHQEYGKTESK
EIILPSAAGTIALSSKGFRYPDLWVVIAGWSKDYRRYRYDSRNEGTFSLETLSSPALYPEYERLKVEELMIPSHDGVMVP
LSIVYRNDLDKKGTNPVLLYGYGAYGNALTPFFSPSLLLWTHKGGILAIVHARGGGELGDAWHTSGMKTTKPNTWKDLIS
SAEYLIKEKYSSSRHIAINGASAGGILVGKAMTERPDLFAAAIPQVGLMNPLRGEETPNGPVNVPEFGTVKKPDECKALI
AMDPYLSIIDGVRYPAALVTAGINDPRVSAWQPAKFAARLQAATASNKPVLLFTDFKAGHGMGNTKQMEFESLADVLSFG
LWQTGHPEFQIR

Sequences:

>Translated_732_residues
MTIPRTALFLLCFLALTSAAFAVEKPEPVVIRKSFPEAQKPVVETWCGETIADPFRAMENIRNPQVINWLKQESDYARNT
LQRIPGRDSLISKMQEFDKRKVSKVYNLSITENDVYFYLKQTPSDETGQLYYRKGFHGKETLLFNPSSSPDKESHTVIGT
ISPSFDGSKVAFTISKNGSEDAVLLIMDVATKKLFPEKITRCRFASPSWLKTGDAFLYNRLRALEKPGENPQHNSKTFLH
IPGTDPSRDLEIFSSATNPELVLNPEDIPEVSYEKESGQLFAFLSNVDRRLTVYYAPLDQPGKKKTAWKKLFIPKDDVHD
FAVTEKDIYFSSPKKASGFRLLKTSLEHPDLEHAELIVPETPGATLTGFTLTSRGIFYTQSKNGVEEKLYHQEYGKTESK
EIILPSAAGTIALSSKGFRYPDLWVVIAGWSKDYRRYRYDSRNEGTFSLETLSSPALYPEYERLKVEELMIPSHDGVMVP
LSIVYRNDLDKKGTNPVLLYGYGAYGNALTPFFSPSLLLWTHKGGILAIVHARGGGELGDAWHTSGMKTTKPNTWKDLIS
SAEYLIKEKYSSSRHIAINGASAGGILVGKAMTERPDLFAAAIPQVGLMNPLRGEETPNGPVNVPEFGTVKKPDECKALI
AMDPYLSIIDGVRYPAALVTAGINDPRVSAWQPAKFAARLQAATASNKPVLLFTDFKAGHGMGNTKQMEFESLADVLSFG
LWQTGHPEFQIR
>Mature_731_residues
TIPRTALFLLCFLALTSAAFAVEKPEPVVIRKSFPEAQKPVVETWCGETIADPFRAMENIRNPQVINWLKQESDYARNTL
QRIPGRDSLISKMQEFDKRKVSKVYNLSITENDVYFYLKQTPSDETGQLYYRKGFHGKETLLFNPSSSPDKESHTVIGTI
SPSFDGSKVAFTISKNGSEDAVLLIMDVATKKLFPEKITRCRFASPSWLKTGDAFLYNRLRALEKPGENPQHNSKTFLHI
PGTDPSRDLEIFSSATNPELVLNPEDIPEVSYEKESGQLFAFLSNVDRRLTVYYAPLDQPGKKKTAWKKLFIPKDDVHDF
AVTEKDIYFSSPKKASGFRLLKTSLEHPDLEHAELIVPETPGATLTGFTLTSRGIFYTQSKNGVEEKLYHQEYGKTESKE
IILPSAAGTIALSSKGFRYPDLWVVIAGWSKDYRRYRYDSRNEGTFSLETLSSPALYPEYERLKVEELMIPSHDGVMVPL
SIVYRNDLDKKGTNPVLLYGYGAYGNALTPFFSPSLLLWTHKGGILAIVHARGGGELGDAWHTSGMKTTKPNTWKDLISS
AEYLIKEKYSSSRHIAINGASAGGILVGKAMTERPDLFAAAIPQVGLMNPLRGEETPNGPVNVPEFGTVKKPDECKALIA
MDPYLSIIDGVRYPAALVTAGINDPRVSAWQPAKFAARLQAATASNKPVLLFTDFKAGHGMGNTKQMEFESLADVLSFGL
WQTGHPEFQIR

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=702, Percent_Identity=25.0712250712251, Blast_Score=230, Evalue=4e-60,
Organism=Homo sapiens, GI108860686, Length=226, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172420, Length=226, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI284172413, Length=226, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI70778815, Length=226, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI284172438, Length=226, Percent_Identity=30.0884955752212, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI284172431, Length=226, Percent_Identity=30.0884955752212, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI108860692, Length=216, Percent_Identity=30.0925925925926, Blast_Score=97, Evalue=8e-20,
Organism=Escherichia coli, GI1788150, Length=710, Percent_Identity=25.4929577464789, Blast_Score=176, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24583414, Length=757, Percent_Identity=25.6274768824306, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI221510989, Length=269, Percent_Identity=35.3159851301115, Blast_Score=158, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 81643; Mature: 81512

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPRTALFLLCFLALTSAAFAVEKPEPVVIRKSFPEAQKPVVETWCGETIADPFRAMEN
CCCCHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCHHCCHHHHHCCHHHHHHHHHHHH
IRNPQVINWLKQESDYARNTLQRIPGRDSLISKMQEFDKRKVSKVYNLSITENDVYFYLK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEE
QTPSDETGQLYYRKGFHGKETLLFNPSSSPDKESHTVIGTISPSFDGSKVAFTISKNGSE
ECCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCC
DAVLLIMDVATKKLFPEKITRCRFASPSWLKTGDAFLYNRLRALEKPGENPQHNSKTFLH
CEEEEEEEHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
IPGTDPSRDLEIFSSATNPELVLNPEDIPEVSYEKESGQLFAFLSNVDRRLTVYYAPLDQ
ECCCCCCCCHHHEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
PGKKKTAWKKLFIPKDDVHDFAVTEKDIYFSSPKKASGFRLLKTSLEHPDLEHAELIVPE
CCCCCCHHHEECCCCCCCCCCEECCCCEEECCCCCCCCHHHHHHHCCCCCCCCCEEEEEC
TPGATLTGFTLTSRGIFYTQSKNGVEEKLYHQEYGKTESKEIILPSAAGTIALSSKGFRY
CCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCC
PDLWVVIAGWSKDYRRYRYDSRNEGTFSLETLSSPALYPEYERLKVEELMIPSHDGVMVP
CCEEEEEECCCHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHEEEEHEECCCCCCEEEE
LSIVYRNDLDKKGTNPVLLYGYGAYGNALTPFFSPSLLLWTHKGGILAIVHARGGGELGD
EEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCC
AWHTSGMKTTKPNTWKDLISSAEYLIKEKYSSSRHIAINGASAGGILVGKAMTERPDLFA
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCHHH
AAIPQVGLMNPLRGEETPNGPVNVPEFGTVKKPDECKALIAMDPYLSIIDGVRYPAALVT
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCEEEEECHHHHHHHCCCCCHHHEE
AGINDPRVSAWQPAKFAARLQAATASNKPVLLFTDFKAGHGMGNTKQMEFESLADVLSFG
ECCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHC
LWQTGHPEFQIR
CCCCCCCCEEEC
>Mature Secondary Structure 
TIPRTALFLLCFLALTSAAFAVEKPEPVVIRKSFPEAQKPVVETWCGETIADPFRAMEN
CCCHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCHHCCHHHHHCCHHHHHHHHHHHH
IRNPQVINWLKQESDYARNTLQRIPGRDSLISKMQEFDKRKVSKVYNLSITENDVYFYLK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEE
QTPSDETGQLYYRKGFHGKETLLFNPSSSPDKESHTVIGTISPSFDGSKVAFTISKNGSE
ECCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCC
DAVLLIMDVATKKLFPEKITRCRFASPSWLKTGDAFLYNRLRALEKPGENPQHNSKTFLH
CEEEEEEEHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
IPGTDPSRDLEIFSSATNPELVLNPEDIPEVSYEKESGQLFAFLSNVDRRLTVYYAPLDQ
ECCCCCCCCHHHEECCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
PGKKKTAWKKLFIPKDDVHDFAVTEKDIYFSSPKKASGFRLLKTSLEHPDLEHAELIVPE
CCCCCCHHHEECCCCCCCCCCEECCCCEEECCCCCCCCHHHHHHHCCCCCCCCCEEEEEC
TPGATLTGFTLTSRGIFYTQSKNGVEEKLYHQEYGKTESKEIILPSAAGTIALSSKGFRY
CCCCEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCC
PDLWVVIAGWSKDYRRYRYDSRNEGTFSLETLSSPALYPEYERLKVEELMIPSHDGVMVP
CCEEEEEECCCHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHEEEEHEECCCCCCEEEE
LSIVYRNDLDKKGTNPVLLYGYGAYGNALTPFFSPSLLLWTHKGGILAIVHARGGGELGD
EEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCC
AWHTSGMKTTKPNTWKDLISSAEYLIKEKYSSSRHIAINGASAGGILVGKAMTERPDLFA
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCHHH
AAIPQVGLMNPLRGEETPNGPVNVPEFGTVKKPDECKALIAMDPYLSIIDGVRYPAALVT
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCEEEEECHHHHHHHCCCCCHHHEE
AGINDPRVSAWQPAKFAARLQAATASNKPVLLFTDFKAGHGMGNTKQMEFESLADVLSFG
ECCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHC
LWQTGHPEFQIR
CCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]