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The map label for this gene is folE [H]

Identifier: 119356804

GI number: 119356804

Start: 1118466

End: 1119125

Strand: Reverse

Name: folE [H]

Synonym: Cpha266_0976

Alternate gene names: 119356804

Gene position: 1119125-1118466 (Counterclockwise)

Preceding gene: 119356805

Following gene: 119356784

Centisome position: 35.71

GC content: 48.33

Gene sequence:

>660_bases
ATGCCGTCAGATATCTCGGTCAGTAAAACTCCGTCATCCTTAAATTCCGGAGGATTTTGTGAAGATGATGAGTGCCTCAT
GGATGGTGATACGGCCAGTCCGGAAGAGATAAGCAATCTTTCAGGAGCGGTTTCGATGCTCCTTCAGGGGATCGGCGAGA
ATCCTGATCGTGAAGGGTTGCTCAAAACCCCCGAACGTGTCGCTCGATCAATGCGTTTCCTTACACGCGGCTACAGACAG
AATCCCGAAGAACTCCTTAAAAAAGCAGTATTCACAGAATCGTACGATGAAATGGTACTGGTCCGGGATATCGACATCTT
TTCGATGTGCGAACACCATCTTCTTCCGTTTTTCGGTAAAGCGCATGTCGCTTACATCCCTGACGGTAAAATTGTAGGCC
TTTCAAAAATCGGCAGGGTCGTCGAAGTCTTTGCAAGGAGACTTCAGGTACAGGAACGCCTCACCCAGCAGATTCGCGAT
GCCATTCAGGATGTTCTCAACCCTAAAGGCGTTGCTGTTGTCATTGAAGCAAAACACCTCTGCATGGTCATGCGAGGGGT
AGAAAAACTGAATTCGGTTACAACCACCTCTGCGATGTCCGGTGAATTTATCTCTTCACCATCCACTCGAAGCGAGTTTT
TACGTCTTATCGGTGCCTGA

Upstream 100 bases:

>100_bases
CTTGCTGTCGTCATATGGGATATTCTTGACCTTCGATTACAACAATTCAACAACAGAGAGATAACTCTCTATGAAGTAAA
AATCTATGAAACAGGAAAAA

Downstream 100 bases:

>100_bases
AATGGCGCATGTTCTGCTGCGGCATCTTATTCTGGCCGCAGCAGCCAGACATATCCGTAACTACTTTTCAAGCCACCCGG
AAAGTATCTCCTGGCCGGCC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MPSDISVSKTPSSLNSGGFCEDDECLMDGDTASPEEISNLSGAVSMLLQGIGENPDREGLLKTPERVARSMRFLTRGYRQ
NPEELLKKAVFTESYDEMVLVRDIDIFSMCEHHLLPFFGKAHVAYIPDGKIVGLSKIGRVVEVFARRLQVQERLTQQIRD
AIQDVLNPKGVAVVIEAKHLCMVMRGVEKLNSVTTTSAMSGEFISSPSTRSEFLRLIGA

Sequences:

>Translated_219_residues
MPSDISVSKTPSSLNSGGFCEDDECLMDGDTASPEEISNLSGAVSMLLQGIGENPDREGLLKTPERVARSMRFLTRGYRQ
NPEELLKKAVFTESYDEMVLVRDIDIFSMCEHHLLPFFGKAHVAYIPDGKIVGLSKIGRVVEVFARRLQVQERLTQQIRD
AIQDVLNPKGVAVVIEAKHLCMVMRGVEKLNSVTTTSAMSGEFISSPSTRSEFLRLIGA
>Mature_218_residues
PSDISVSKTPSSLNSGGFCEDDECLMDGDTASPEEISNLSGAVSMLLQGIGENPDREGLLKTPERVARSMRFLTRGYRQN
PEELLKKAVFTESYDEMVLVRDIDIFSMCEHHLLPFFGKAHVAYIPDGKIVGLSKIGRVVEVFARRLQVQERLTQQIRDA
IQDVLNPKGVAVVIEAKHLCMVMRGVEKLNSVTTTSAMSGEFISSPSTRSEFLRLIGA

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=181, Percent_Identity=57.4585635359116, Blast_Score=234, Evalue=6e-62,
Organism=Homo sapiens, GI4503949, Length=181, Percent_Identity=57.4585635359116, Blast_Score=234, Evalue=6e-62,
Organism=Homo sapiens, GI66932970, Length=154, Percent_Identity=52.5974025974026, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI66932972, Length=141, Percent_Identity=56.0283687943262, Blast_Score=183, Evalue=9e-47,
Organism=Escherichia coli, GI1788476, Length=194, Percent_Identity=42.2680412371134, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560486, Length=201, Percent_Identity=53.7313432835821, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6321706, Length=183, Percent_Identity=55.7377049180328, Blast_Score=219, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24656782, Length=183, Percent_Identity=56.2841530054645, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24656791, Length=183, Percent_Identity=56.2841530054645, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24656796, Length=183, Percent_Identity=56.2841530054645, Blast_Score=218, Evalue=2e-57,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 24193; Mature: 24062

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDISVSKTPSSLNSGGFCEDDECLMDGDTASPEEISNLSGAVSMLLQGIGENPDREGL
CCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
LKTPERVARSMRFLTRGYRQNPEELLKKAVFTESYDEMVLVRDIDIFSMCEHHLLPFFGK
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCHHCC
AHVAYIPDGKIVGLSKIGRVVEVFARRLQVQERLTQQIRDAIQDVLNPKGVAVVIEAKHL
CEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHH
CMVMRGVEKLNSVTTTSAMSGEFISSPSTRSEFLRLIGA
HHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PSDISVSKTPSSLNSGGFCEDDECLMDGDTASPEEISNLSGAVSMLLQGIGENPDREGL
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
LKTPERVARSMRFLTRGYRQNPEELLKKAVFTESYDEMVLVRDIDIFSMCEHHLLPFFGK
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCHHCC
AHVAYIPDGKIVGLSKIGRVVEVFARRLQVQERLTQQIRDAIQDVLNPKGVAVVIEAKHL
CEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHH
CMVMRGVEKLNSVTTTSAMSGEFISSPSTRSEFLRLIGA
HHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA