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The map label for this gene is ilvC

Identifier: 119356682

GI number: 119356682

Start: 974184

End: 975176

Strand: Reverse

Name: ilvC

Synonym: Cpha266_0851

Alternate gene names: 119356682

Gene position: 975176-974184 (Counterclockwise)

Preceding gene: 119356683

Following gene: 119356681

Centisome position: 31.12

GC content: 51.76

Gene sequence:

>993_bases
ATGAACGTTTACTATGAGCAGGATGCCGATCTCGGTTTTCTTCAGGGGAAAAATATCGCGGTGCTCGGATACGGAAGCCA
GGGTCATGCTCACGCCCTGAACCTTAAAGACAGCGGCATGAACGTCTGCGTCGGACTTCGCTCCGACAGCACCTCATGCC
AGAAGGCAAGAGATGCCGGACTTGAGGTCAAAACTATCGCTGATGCCGTTACATGGGCAGACATCGTGATGGTGCTGCTT
CCCGACCAGAACCAGAAAGCGATTTACGAAGCCGAAATTGCGCCGAACCTCGTACCGGGCAACACGCTTGCCTTTGCTCA
CGGATTCAATATTCACTACAAGCAGATTATTCCTCAGGAAACGATCAACGTTATCATGATCGCTCCGAAAAGCCCCGGTC
ACCTCGTACGACGCACCTTTACGCAGGGCAACGGCGTTCCCTGCCTCATCGCTGTTCACCAGGACTACACCGGCGAAGCC
AAACAGCAGGCTCTTGCATGGGCCAAAGGCCTTGGCGGCACCAAAGCAGGCGTTATTGAAACAACGATCAAGAACGAAAC
TGAAACCGACCTTTTCGGTGAACAGGCCGTTCTATGCGGCGGATCTGCCGAGCTTATCAAAGCAGGTTTCGAAACGCTTG
TCGAGGCGGGATATCCTGAAGAACTCGCCTATTTCGAATGTATGCACGAGCTGAAACTGATTGTGGATCTTTACTACGAA
GGTGGACTCTCCAGAATGAACTATTCCGTCAGCGATACCGCAGAATACGGTGGTATGACCCGCGGACCTCGCCTGATTAC
CCCGGCTGTGAAAGCGGAGATGAAAAAAATTCTCGAAGAGGTTCAGGACGGACGCTTTGCCAGAGAGTTTATCGATGAAT
GCCAGAACGGATATCCGAATCTTAACCGCCTCAGGGAGGAGAACCGTACCCATTCAATCGAAAAAGTCGGCGCAAGACTA
CGCGAGATGATGAGCTGGCTTATCAAAAAATAA

Upstream 100 bases:

>100_bases
CGTACGGTATCAGGGAACTGGCCCGTTCCGGTGCGGTTGCCATACACCGGGGAGAATCATAACCGTTTTATTATATCGTC
AATCAAAATCAACTCTACAG

Downstream 100 bases:

>100_bases
CCGCATCCTATAAAACGTATGTATAAGATTGTTTCAATACCGGGTGACGGTATCGGCCCGGAAGTCGTTGCTGGCGCCGT
TACCGTGCTCAGAAAAATCT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNVYYEQDADLGFLQGKNIAVLGYGSQGHAHALNLKDSGMNVCVGLRSDSTSCQKARDAGLEVKTIADAVTWADIVMVLL
PDQNQKAIYEAEIAPNLVPGNTLAFAHGFNIHYKQIIPQETINVIMIAPKSPGHLVRRTFTQGNGVPCLIAVHQDYTGEA
KQQALAWAKGLGGTKAGVIETTIKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAREFIDECQNGYPNLNRLREENRTHSIEKVGARL
REMMSWLIKK

Sequences:

>Translated_330_residues
MNVYYEQDADLGFLQGKNIAVLGYGSQGHAHALNLKDSGMNVCVGLRSDSTSCQKARDAGLEVKTIADAVTWADIVMVLL
PDQNQKAIYEAEIAPNLVPGNTLAFAHGFNIHYKQIIPQETINVIMIAPKSPGHLVRRTFTQGNGVPCLIAVHQDYTGEA
KQQALAWAKGLGGTKAGVIETTIKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAREFIDECQNGYPNLNRLREENRTHSIEKVGARL
REMMSWLIKK
>Mature_330_residues
MNVYYEQDADLGFLQGKNIAVLGYGSQGHAHALNLKDSGMNVCVGLRSDSTSCQKARDAGLEVKTIADAVTWADIVMVLL
PDQNQKAIYEAEIAPNLVPGNTLAFAHGFNIHYKQIIPQETINVIMIAPKSPGHLVRRTFTQGNGVPCLIAVHQDYTGEA
KQQALAWAKGLGGTKAGVIETTIKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAREFIDECQNGYPNLNRLREENRTHSIEKVGARL
REMMSWLIKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=320, Percent_Identity=32.8125, Blast_Score=144, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=325, Percent_Identity=31.6923076923077, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CHLPD (A1BES5)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911326.1
- ProteinModelPortal:   A1BES5
- SMR:   A1BES5
- STRING:   A1BES5
- GeneID:   4570445
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0851
- NMPDR:   fig|290317.7.peg.906
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36405; Mature: 36405

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYYEQDADLGFLQGKNIAVLGYGSQGHAHALNLKDSGMNVCVGLRSDSTSCQKARDAG
CCCEECCCCCEEEECCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHCC
LEVKTIADAVTWADIVMVLLPDQNQKAIYEAEIAPNLVPGNTLAFAHGFNIHYKQIIPQE
CCHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCEEHHHHCCCC
TINVIMIAPKSPGHLVRRTFTQGNGVPCLIAVHQDYTGEAKQQALAWAKGLGGTKAGVIE
CCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
TTIKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
EECCCCCCHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAREFIDECQNGYPN
CCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
LNRLREENRTHSIEKVGARLREMMSWLIKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVYYEQDADLGFLQGKNIAVLGYGSQGHAHALNLKDSGMNVCVGLRSDSTSCQKARDAG
CCCEECCCCCEEEECCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHCC
LEVKTIADAVTWADIVMVLLPDQNQKAIYEAEIAPNLVPGNTLAFAHGFNIHYKQIIPQE
CCHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCEEHHHHCCCC
TINVIMIAPKSPGHLVRRTFTQGNGVPCLIAVHQDYTGEAKQQALAWAKGLGGTKAGVIE
CCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
TTIKNETETDLFGEQAVLCGGSAELIKAGFETLVEAGYPEELAYFECMHELKLIVDLYYE
EECCCCCCHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRLITPAVKAEMKKILEEVQDGRFAREFIDECQNGYPN
CCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
LNRLREENRTHSIEKVGARLREMMSWLIKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA