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The map label for this gene is tyrS [H]

Identifier: 119356645

GI number: 119356645

Start: 927261

End: 928478

Strand: Reverse

Name: tyrS [H]

Synonym: Cpha266_0814

Alternate gene names: 119356645

Gene position: 928478-927261 (Counterclockwise)

Preceding gene: 119356646

Following gene: 119356644

Centisome position: 29.63

GC content: 47.37

Gene sequence:

>1218_bases
ATGCGTTTTCCAATCCTCAAGGAACAGCTTGATATCATTACCGCCAATACCGTAGAAATCATCAGCATCAATGAACTTGA
ACAGAAGCTGGCCGAAAGCATTAAAACTGACAAACCGCTGAAAATCAAGCTTGGCGCCGATCCATCACGACCTGATTTGC
ACCTTGGACATTCTGTAGTACTTGGAAAGTTACGGCAATTTCAGGATCTCGGCCACGAGGCCATTCTGATTATCGGTGAT
TTTACGGCAATGATCGGCGACCCTTCCGGTAAAAGCAAAACAAGACCGCAGCTTTCGGCAGAAGAAGCCCGGCAGAACGG
AGTCAGTTATTTTGAACAGGCTTCAAAAATTCTCGACCCTGAAAAAACCACGATCTGCTATAATGCCGACTGGCTCGGAG
CAATGAAATTCGCCGACGTAATCCGTCTATCGAGCCACTACACTGTTGCGCGAATGCTTGAACGCGATGATTTCGAACGC
AGATACCGTTCGAACGAACCTATTTCCATTCACGAATTTCTCTACCCTCTGGCTCAGGGCATGGATTCGGTTCACCTTGA
AAATGACGTAGAGCTTGGAGGAACAGACCAGAAGTTCAATCTGCTTGTCGGGCGCGACCTGCAGCGCGAATACGGCATCA
AACCTCAGGTCTGCATCACCATGCCGCTTCTTGTGGGTACCGCAGGAGAAGAAAAAATGTCGAAATCGCTCGGTAACGCC
GTCTGTTTCAATGACCTGCCCTCCGACATGTACGGCAAACTGCTCTCAATTCCCGATGCACTTATTGCCCCTTACTGCAA
ACTGCTGCTTCCGGGAGGAAACGCAAACGGCAACGTTATTCTTGATCGGATAGTCGACAGCCCGAGAGATGCCAAAAGAA
CTCTTGCCAGAGAGATCGTAGCGCAGTACTATTCCGCAGAGCAAGCCGACGATGCCGAAACACATTTCGACCAGGTTTTT
GTACATAAAAAAACACCGGACAATATTGAGCTCTTCGAATTCGAAAGCCAGTCCCTGCCTCTGGTTGATCTGCTGGTAAT
CCTTGGAGCCTACACCTCAAAAAGCGAAGCAAGAAGGATGATCCAGCAAAAAGCAGTGCTCGTTAATGATGTAAAAGTCG
AAGACACGAATACGCTTGTCGCTCTTGAAGACAAGCCAACAATTATCAAAGCGGGAAAAAGGAAATTTTTTAAAGTAGCT
GCAAAAAAATCATTTTGA

Upstream 100 bases:

>100_bases
AGGCAAAAAACTCTACGATAAACGCGAAACCATCAAATCAAGAGATGCTGAACGGCAACTGCAGCAACTGAAAAAAACCT
ATTAAACACTATAAAAACCC

Downstream 100 bases:

>100_bases
TTCCCGCTGCTTTTTCCTATAATTGTTCAACTTTGCTAATGTTGAAACCCTGAACCAATAAATTTATCTGGAGGAAAAGC
CTTGTCATTTGTTCCTAAAA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MRFPILKEQLDIITANTVEIISINELEQKLAESIKTDKPLKIKLGADPSRPDLHLGHSVVLGKLRQFQDLGHEAILIIGD
FTAMIGDPSGKSKTRPQLSAEEARQNGVSYFEQASKILDPEKTTICYNADWLGAMKFADVIRLSSHYTVARMLERDDFER
RYRSNEPISIHEFLYPLAQGMDSVHLENDVELGGTDQKFNLLVGRDLQREYGIKPQVCITMPLLVGTAGEEKMSKSLGNA
VCFNDLPSDMYGKLLSIPDALIAPYCKLLLPGGNANGNVILDRIVDSPRDAKRTLAREIVAQYYSAEQADDAETHFDQVF
VHKKTPDNIELFEFESQSLPLVDLLVILGAYTSKSEARRMIQQKAVLVNDVKVEDTNTLVALEDKPTIIKAGKRKFFKVA
AKKSF

Sequences:

>Translated_405_residues
MRFPILKEQLDIITANTVEIISINELEQKLAESIKTDKPLKIKLGADPSRPDLHLGHSVVLGKLRQFQDLGHEAILIIGD
FTAMIGDPSGKSKTRPQLSAEEARQNGVSYFEQASKILDPEKTTICYNADWLGAMKFADVIRLSSHYTVARMLERDDFER
RYRSNEPISIHEFLYPLAQGMDSVHLENDVELGGTDQKFNLLVGRDLQREYGIKPQVCITMPLLVGTAGEEKMSKSLGNA
VCFNDLPSDMYGKLLSIPDALIAPYCKLLLPGGNANGNVILDRIVDSPRDAKRTLAREIVAQYYSAEQADDAETHFDQVF
VHKKTPDNIELFEFESQSLPLVDLLVILGAYTSKSEARRMIQQKAVLVNDVKVEDTNTLVALEDKPTIIKAGKRKFFKVA
AKKSF
>Mature_405_residues
MRFPILKEQLDIITANTVEIISINELEQKLAESIKTDKPLKIKLGADPSRPDLHLGHSVVLGKLRQFQDLGHEAILIIGD
FTAMIGDPSGKSKTRPQLSAEEARQNGVSYFEQASKILDPEKTTICYNADWLGAMKFADVIRLSSHYTVARMLERDDFER
RYRSNEPISIHEFLYPLAQGMDSVHLENDVELGGTDQKFNLLVGRDLQREYGIKPQVCITMPLLVGTAGEEKMSKSLGNA
VCFNDLPSDMYGKLLSIPDALIAPYCKLLLPGGNANGNVILDRIVDSPRDAKRTLAREIVAQYYSAEQADDAETHFDQVF
VHKKTPDNIELFEFESQSLPLVDLLVILGAYTSKSEARRMIQQKAVLVNDVKVEDTNTLVALEDKPTIIKAGKRKFFKVA
AKKSF

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=402, Percent_Identity=26.6169154228856, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1787925, Length=412, Percent_Identity=27.4271844660194, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25145802, Length=233, Percent_Identity=30.4721030042918, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6325160, Length=427, Percent_Identity=27.4004683840749, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20130383, Length=403, Percent_Identity=25.3101736972705, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45310; Mature: 45310

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFPILKEQLDIITANTVEIISINELEQKLAESIKTDKPLKIKLGADPSRPDLHLGHSVV
CCCCCCHHHHHEEECCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHH
LGKLRQFQDLGHEAILIIGDFTAMIGDPSGKSKTRPQLSAEEARQNGVSYFEQASKILDP
HHHHHHHHHCCCEEEEEEECHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
EKTTICYNADWLGAMKFADVIRLSSHYTVARMLERDDFERRYRSNEPISIHEFLYPLAQG
CCCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCC
MDSVHLENDVELGGTDQKFNLLVGRDLQREYGIKPQVCITMPLLVGTAGEEKMSKSLGNA
CCCEECCCCCCCCCCCCEEEEEECCCHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHCCE
VCFNDLPSDMYGKLLSIPDALIAPYCKLLLPGGNANGNVILDRIVDSPRDAKRTLAREIV
EECCCCCHHHHHHHHCCCHHHHHHHHHEEECCCCCCCCEEEEEHHCCCHHHHHHHHHHHH
AQYYSAEQADDAETHFDQVFVHKKTPDNIELFEFESQSLPLVDLLVILGAYTSKSEARRM
HHHHCCCCCCCHHHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHH
IQQKAVLVNDVKVEDTNTLVALEDKPTIIKAGKRKFFKVAAKKSF
HHHHHHHHCCEEEECCCEEEEECCCCCEEHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MRFPILKEQLDIITANTVEIISINELEQKLAESIKTDKPLKIKLGADPSRPDLHLGHSVV
CCCCCCHHHHHEEECCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHH
LGKLRQFQDLGHEAILIIGDFTAMIGDPSGKSKTRPQLSAEEARQNGVSYFEQASKILDP
HHHHHHHHHCCCEEEEEEECHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
EKTTICYNADWLGAMKFADVIRLSSHYTVARMLERDDFERRYRSNEPISIHEFLYPLAQG
CCCEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCC
MDSVHLENDVELGGTDQKFNLLVGRDLQREYGIKPQVCITMPLLVGTAGEEKMSKSLGNA
CCCEECCCCCCCCCCCCEEEEEECCCHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHCCE
VCFNDLPSDMYGKLLSIPDALIAPYCKLLLPGGNANGNVILDRIVDSPRDAKRTLAREIV
EECCCCCHHHHHHHHCCCHHHHHHHHHEEECCCCCCCCEEEEEHHCCCHHHHHHHHHHHH
AQYYSAEQADDAETHFDQVFVHKKTPDNIELFEFESQSLPLVDLLVILGAYTSKSEARRM
HHHHCCCCCCCHHHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHH
IQQKAVLVNDVKVEDTNTLVALEDKPTIIKAGKRKFFKVAAKKSF
HHHHHHHHCCEEEECCCEEEEECCCCCEEHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA