Click here to switch to the map view.

The map label for this gene is fadH [C]

Identifier: 119356597

GI number: 119356597

Start: 867902

End: 869842

Strand: Reverse

Name: fadH [C]

Synonym: Cpha266_0765

Alternate gene names: 119356597

Gene position: 869842-867902 (Counterclockwise)

Preceding gene: 119356605

Following gene: 119356596

Centisome position: 27.76

GC content: 49.0

Gene sequence:

>1941_bases
ATGTACACCAGACTATTCAGCCCTATAACGATAGGCTCCGTAGAGATCAAAAACCGCGTAGCAATGACCGCTATGGGAGT
TAACCTTGCTGCTGCGGGCGGTGGCATTAACGATGATATAATCGCTTTTTATGAAGCACGTGCACGAGGTGGCACCGGAC
TGATCATAAGCGGAATATGTCGTGTTATGGATGGTGAAGGAGCTGGAGAAGCTTGTCAGATCGCAGCAAGAAATACGGCA
GACCTCCAGGGATTGGGTCGGCTCGTCGATACTGTCCATAAGTACGATACAAGGCTATTTCTGCAACTCCATCATCCTGG
CCGCAACTATGGACTTGGCAGTGAGCAACCGGTTTCAGCATCACCGGTCACAACACTTTTCCATTGTAAAACACCCCGAG
CCCTTACTGTTCCTGAAATTGAAACCATTCAACAAGCATTCGTCAATGGCGCTCACTTAGCCAGAGTTGCCGGTGCCGAC
GGTGTTGAACTTCATGGCGCACATGGTTACCTGATCAATGGCTTTCTGTCTCCGTATCTCAATAAACGAACCGACCAATA
TGGAAACAGTTTTGAAAACCGTATGCGGTTTTTACTCGAAATCGTGTCAGGCATCAGAAACAGGTGCGGAAAGAATTTTC
CCATTGGAGTCCGCCTTTCGGTTGATGAATTCCTTGGACAGTATGGGAACGACCTTGCAACATCATGCAGGATCGCATCA
GAGCTTGAACTTGCGGGTATAGACTTTCTTGATATCAGTTGTACGATTCCCGACAGTCCCGAAATAAATGCCTGTATAGA
ACCTGGAACGTTCGAGCAGGGATGGAAAAAGTACATGGCCGCCGAAATCAAAAAGTTCGTGAAGATCCCGTTAATCGCTG
TTGCCAACATTAAAGACCCCGACATAGCAGAAGCAATTCTTGAAGAGAATTGCTGTGATCTGGTAGGCGTCGCACGCGGC
CATCTCGCGGACCCGGAGTGGTGCAACAAGGCAAAAACTGCAGGAATGGAACAGACAATCCGAAAGTGTATAGGGTGTCT
TGTCTGTTTCGACGAGATAGAACATGGACGGCATGTCAAATGTTCTGTCAATCCGAAAACCGGACGCGAGCGTGAATTCG
AGAATATGGTACATAATGGCGCTGGCCGTACGGTCGCAGTGATCGGTGGCGGACCATCAGGAATCACAGCGGCTCTGGTT
TTGCAACAACGAGGCTTTCAAACCGTCCTGTTCGATCCATTACCCCGGCTTGGCGGCATGTTGAACGTAGCCGACAAAGG
AATCGGCAAGGATAAGATTACCTGTTGCGTTGAATCAATGATCGTTCAATCGGATCGATCCGGCATCCAGTTAAGACTCG
GTGAAAACGCGACGATTGACAAAATCAAATCGCTCTCCCCATGCGGAGTCTTTATCGCCTGCGGTGCCGAACCGCTTATT
CCGGAAATACCCGGCATCGATGGTCAGAATGTCTTCACTGCAGAAGATGTGCTGCTTAAAAAGGTCAGGGTCATCGGTGA
TTGCATTATCGCAGGATCAGGAATGACTGGTCTTGAAACTGCGGAAGTCGTTGTCAGAGAGGGCCATAAAACAACCCTCA
TCGACATGCTGCCGGAAATAGGCTATGGTGCGGAACCGACTGTCATCCTTGACATCAGGCGACGAATGGAGCAATACAAT
CCAACGTATATGCCTGGGCATAAACTTGTACGGATTATACCCGATGGAGTGGATGTCGAGAACATACAGAACGGCTTGAC
GGTTTTCGTGCCAGCTCGCACGGTAATACTTGCACTTGGGGTACGTCCGCAAAAGACCATTGTCGAGCAGTTCAAAGCGG
CTTTTCCTGAAGCGAAAGTTATTGGCGATGCATCACATGGAGGAAGAATTCTTGATGCCACCCAGGATGCCTATGGTAAG
GCTTTTGTGTTTAACCCGTAA

Upstream 100 bases:

>100_bases
TAAAGTTCTTTTATATAGCGACATTACCCGAATATTCCTTCAGATACCAGTCAGGTTGTTTTGATTATTTAATAATTAAT
AAAATCAACTTGAGGGGAAA

Downstream 100 bases:

>100_bases
TCACACCATAAAACAAGGAGTCAATCATGAATGAAACTGCCGCATACTACAAAGGAAGGGTCGCCATTGTGACCGGAGGC
GCATCGGGCATCGGTCTTGC

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MYTRLFSPITIGSVEIKNRVAMTAMGVNLAAAGGGINDDIIAFYEARARGGTGLIISGICRVMDGEGAGEACQIAARNTA
DLQGLGRLVDTVHKYDTRLFLQLHHPGRNYGLGSEQPVSASPVTTLFHCKTPRALTVPEIETIQQAFVNGAHLARVAGAD
GVELHGAHGYLINGFLSPYLNKRTDQYGNSFENRMRFLLEIVSGIRNRCGKNFPIGVRLSVDEFLGQYGNDLATSCRIAS
ELELAGIDFLDISCTIPDSPEINACIEPGTFEQGWKKYMAAEIKKFVKIPLIAVANIKDPDIAEAILEENCCDLVGVARG
HLADPEWCNKAKTAGMEQTIRKCIGCLVCFDEIEHGRHVKCSVNPKTGREREFENMVHNGAGRTVAVIGGGPSGITAALV
LQQRGFQTVLFDPLPRLGGMLNVADKGIGKDKITCCVESMIVQSDRSGIQLRLGENATIDKIKSLSPCGVFIACGAEPLI
PEIPGIDGQNVFTAEDVLLKKVRVIGDCIIAGSGMTGLETAEVVVREGHKTTLIDMLPEIGYGAEPTVILDIRRRMEQYN
PTYMPGHKLVRIIPDGVDVENIQNGLTVFVPARTVILALGVRPQKTIVEQFKAAFPEAKVIGDASHGGRILDATQDAYGK
AFVFNP

Sequences:

>Translated_646_residues
MYTRLFSPITIGSVEIKNRVAMTAMGVNLAAAGGGINDDIIAFYEARARGGTGLIISGICRVMDGEGAGEACQIAARNTA
DLQGLGRLVDTVHKYDTRLFLQLHHPGRNYGLGSEQPVSASPVTTLFHCKTPRALTVPEIETIQQAFVNGAHLARVAGAD
GVELHGAHGYLINGFLSPYLNKRTDQYGNSFENRMRFLLEIVSGIRNRCGKNFPIGVRLSVDEFLGQYGNDLATSCRIAS
ELELAGIDFLDISCTIPDSPEINACIEPGTFEQGWKKYMAAEIKKFVKIPLIAVANIKDPDIAEAILEENCCDLVGVARG
HLADPEWCNKAKTAGMEQTIRKCIGCLVCFDEIEHGRHVKCSVNPKTGREREFENMVHNGAGRTVAVIGGGPSGITAALV
LQQRGFQTVLFDPLPRLGGMLNVADKGIGKDKITCCVESMIVQSDRSGIQLRLGENATIDKIKSLSPCGVFIACGAEPLI
PEIPGIDGQNVFTAEDVLLKKVRVIGDCIIAGSGMTGLETAEVVVREGHKTTLIDMLPEIGYGAEPTVILDIRRRMEQYN
PTYMPGHKLVRIIPDGVDVENIQNGLTVFVPARTVILALGVRPQKTIVEQFKAAFPEAKVIGDASHGGRILDATQDAYGK
AFVFNP
>Mature_646_residues
MYTRLFSPITIGSVEIKNRVAMTAMGVNLAAAGGGINDDIIAFYEARARGGTGLIISGICRVMDGEGAGEACQIAARNTA
DLQGLGRLVDTVHKYDTRLFLQLHHPGRNYGLGSEQPVSASPVTTLFHCKTPRALTVPEIETIQQAFVNGAHLARVAGAD
GVELHGAHGYLINGFLSPYLNKRTDQYGNSFENRMRFLLEIVSGIRNRCGKNFPIGVRLSVDEFLGQYGNDLATSCRIAS
ELELAGIDFLDISCTIPDSPEINACIEPGTFEQGWKKYMAAEIKKFVKIPLIAVANIKDPDIAEAILEENCCDLVGVARG
HLADPEWCNKAKTAGMEQTIRKCIGCLVCFDEIEHGRHVKCSVNPKTGREREFENMVHNGAGRTVAVIGGGPSGITAALV
LQQRGFQTVLFDPLPRLGGMLNVADKGIGKDKITCCVESMIVQSDRSGIQLRLGENATIDKIKSLSPCGVFIACGAEPLI
PEIPGIDGQNVFTAEDVLLKKVRVIGDCIIAGSGMTGLETAEVVVREGHKTTLIDMLPEIGYGAEPTVILDIRRRMEQYN
PTYMPGHKLVRIIPDGVDVENIQNGLTVFVPARTVILALGVRPQKTIVEQFKAAFPEAKVIGDASHGGRILDATQDAYGK
AFVFNP

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=543, Percent_Identity=32.5966850828729, Blast_Score=249, Evalue=5e-67,
Organism=Escherichia coli, GI1787939, Length=344, Percent_Identity=29.9418604651163, Blast_Score=109, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17564188, Length=233, Percent_Identity=32.618025751073, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17559802, Length=230, Percent_Identity=36.0869565217391, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17540738, Length=262, Percent_Identity=30.1526717557252, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559804, Length=231, Percent_Identity=31.1688311688312, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17565138, Length=234, Percent_Identity=33.7606837606838, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI72001454, Length=230, Percent_Identity=33.0434782608696, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17566914, Length=225, Percent_Identity=30.6666666666667, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321973, Length=240, Percent_Identity=30.8333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325086, Length=240, Percent_Identity=30.4166666666667, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 69725; Mature: 69725

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTRLFSPITIGSVEIKNRVAMTAMGVNLAAAGGGINDDIIAFYEARARGGTGLIISGIC
CCCCCCCCEEECCEECCCEEEEEEECCEEEECCCCCCCCCEEEEEHHCCCCCCCHHHHHH
RVMDGEGAGEACQIAARNTADLQGLGRLVDTVHKYDTRLFLQLHHPGRNYGLGSEQPVSA
HHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCC
SPVTTLFHCKTPRALTVPEIETIQQAFVNGAHLARVAGADGVELHGAHGYLINGFLSPYL
CCCEEEEECCCCCEECCCCHHHHHHHHHCCHHHEEECCCCCEEEECCCCEEHHHHHHHHH
NKRTDQYGNSFENRMRFLLEIVSGIRNRCGKNFPIGVRLSVDEFLGQYGNDLATSCRIAS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
ELELAGIDFLDISCTIPDSPEINACIEPGTFEQGWKKYMAAEIKKFVKIPLIAVANIKDP
HHEECCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCC
DIAEAILEENCCDLVGVARGHLADPEWCNKAKTAGMEQTIRKCIGCLVCFDEIEHGRHVK
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEE
CSVNPKTGREREFENMVHNGAGRTVAVIGGGPSGITAALVLQQRGFQTVLFDPLPRLGGM
EEECCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCHHHHCCE
LNVADKGIGKDKITCCVESMIVQSDRSGIQLRLGENATIDKIKSLSPCGVFIACGAEPLI
EEHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCEEEEECCCCCC
PEIPGIDGQNVFTAEDVLLKKVRVIGDCIIAGSGMTGLETAEVVVREGHKTTLIDMLPEI
CCCCCCCCCCEECHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHC
GYGAEPTVILDIRRRMEQYNPTYMPGHKLVRIIPDGVDVENIQNGLTVFVPARTVILALG
CCCCCCEEEHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHCCCCEEEECHHEEEEEEC
VRPQKTIVEQFKAAFPEAKVIGDASHGGRILDATQDAYGKAFVFNP
CCCHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCEEEECC
>Mature Secondary Structure
MYTRLFSPITIGSVEIKNRVAMTAMGVNLAAAGGGINDDIIAFYEARARGGTGLIISGIC
CCCCCCCCEEECCEECCCEEEEEEECCEEEECCCCCCCCCEEEEEHHCCCCCCCHHHHHH
RVMDGEGAGEACQIAARNTADLQGLGRLVDTVHKYDTRLFLQLHHPGRNYGLGSEQPVSA
HHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCC
SPVTTLFHCKTPRALTVPEIETIQQAFVNGAHLARVAGADGVELHGAHGYLINGFLSPYL
CCCEEEEECCCCCEECCCCHHHHHHHHHCCHHHEEECCCCCEEEECCCCEEHHHHHHHHH
NKRTDQYGNSFENRMRFLLEIVSGIRNRCGKNFPIGVRLSVDEFLGQYGNDLATSCRIAS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
ELELAGIDFLDISCTIPDSPEINACIEPGTFEQGWKKYMAAEIKKFVKIPLIAVANIKDP
HHEECCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCC
DIAEAILEENCCDLVGVARGHLADPEWCNKAKTAGMEQTIRKCIGCLVCFDEIEHGRHVK
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEE
CSVNPKTGREREFENMVHNGAGRTVAVIGGGPSGITAALVLQQRGFQTVLFDPLPRLGGM
EEECCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCHHHHCCE
LNVADKGIGKDKITCCVESMIVQSDRSGIQLRLGENATIDKIKSLSPCGVFIACGAEPLI
EEHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCEEEEECCCCCC
PEIPGIDGQNVFTAEDVLLKKVRVIGDCIIAGSGMTGLETAEVVVREGHKTTLIDMLPEI
CCCCCCCCCCEECHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHC
GYGAEPTVILDIRRRMEQYNPTYMPGHKLVRIIPDGVDVENIQNGLTVFVPARTVILALG
CCCCCCEEEHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHCCCCEEEECHHEEEEEEC
VRPQKTIVEQFKAAFPEAKVIGDASHGGRILDATQDAYGKAFVFNP
CCCHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]