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The map label for this gene is aroE

Identifier: 119356543

GI number: 119356543

Start: 807274

End: 808161

Strand: Reverse

Name: aroE

Synonym: Cpha266_0708

Alternate gene names: 119356543

Gene position: 808161-807274 (Counterclockwise)

Preceding gene: 119356544

Following gene: 119356542

Centisome position: 25.79

GC content: 48.31

Gene sequence:

>888_bases
ATGATGCAACCAGAAAAAATTCTCGGCCTTATCGGGCGAAATATAGCCTACTCACGCTCACCCCTGATTCATAATACAGC
TTGCGATCTGCTCGCACTTCCCTATGTTTACACGATTTTCAACATCGCATCTGCTGACCTTATCGAGCCGGCTATTGCAG
GAGCAAGAGCTCTCGGCATAGCCGGACTGAACGTTACCACTCCCTATAAAACAACTGTTGTGCCTTTTCTTGACGAACTC
TCTCCTGAAGCCGCGTCAATCGGAGCAGTCAACACCATCGTCAACAACAACGGTCATCTTGCCGGTTACAATACCGATAT
AGCCGGTTTTGCAGCACCCCTGCGCCCATATGCCCAGCGCATCAAGGGAAATCCGGTCTCTGTTTTCGGTAATGGCGGCG
CGGCACTTGCCGCAATTGAAGCATTCAGAATTTTTTTTCATCCCTGCTGCGTTTACCTGTTTGTCAGGGACAGTGCCAAA
GCAAGCGCAATGCTCGAAAATTATGTTCACAGAGATATCGTAACGCTCTGTTTGATTGAGGAGCTTTTTTCCGGAGAGAG
CGGTGCCATTGCAAAGATCCAGAGATCTCTTGTTATTGTAAACGCAACACCAATAGGCACTGCCGGTCGTCAGAACGAAA
CAGAAACAAGCATTTTACCTCTTGACACGGAGTTACTGCACCCTGATCATATCGTTTACGATATGGTCTACAATCCACTG
TTCACGCCGCTCATCAAGGCGGCAAAAGCCAGCGGCGCTGCAACCATTTCAGGAATCGAGATGCTGCTTGGACAAGCTGC
GCGATCATTTGAACTCTGGACAGGAAAAGAAATGCCACTTGAGCAAGTCAGAGCTGTTCTGATAAATAATCTGCTCTCCT
CTCCATAA

Upstream 100 bases:

>100_bases
AACAACTTTTTCAAAGCACCTTCCCGGAACTTTATCAGCAGGATTCCGTTAGAAAAATGCTTGGCATTTCCTGATCACCC
TCGTCACCGGGACGACCTGC

Downstream 100 bases:

>100_bases
TAATTCTATATACTGCAACAAGAGAATCATACAAACACCATAATTTTTTTTCCATGAATTGGTTTTTTACACTTGCCTCG
ATTGTTATTGTTCTCGACCA

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MMQPEKILGLIGRNIAYSRSPLIHNTACDLLALPYVYTIFNIASADLIEPAIAGARALGIAGLNVTTPYKTTVVPFLDEL
SPEAASIGAVNTIVNNNGHLAGYNTDIAGFAAPLRPYAQRIKGNPVSVFGNGGAALAAIEAFRIFFHPCCVYLFVRDSAK
ASAMLENYVHRDIVTLCLIEELFSGESGAIAKIQRSLVIVNATPIGTAGRQNETETSILPLDTELLHPDHIVYDMVYNPL
FTPLIKAAKASGAATISGIEMLLGQAARSFELWTGKEMPLEQVRAVLINNLLSSP

Sequences:

>Translated_295_residues
MMQPEKILGLIGRNIAYSRSPLIHNTACDLLALPYVYTIFNIASADLIEPAIAGARALGIAGLNVTTPYKTTVVPFLDEL
SPEAASIGAVNTIVNNNGHLAGYNTDIAGFAAPLRPYAQRIKGNPVSVFGNGGAALAAIEAFRIFFHPCCVYLFVRDSAK
ASAMLENYVHRDIVTLCLIEELFSGESGAIAKIQRSLVIVNATPIGTAGRQNETETSILPLDTELLHPDHIVYDMVYNPL
FTPLIKAAKASGAATISGIEMLLGQAARSFELWTGKEMPLEQVRAVLINNLLSSP
>Mature_295_residues
MMQPEKILGLIGRNIAYSRSPLIHNTACDLLALPYVYTIFNIASADLIEPAIAGARALGIAGLNVTTPYKTTVVPFLDEL
SPEAASIGAVNTIVNNNGHLAGYNTDIAGFAAPLRPYAQRIKGNPVSVFGNGGAALAAIEAFRIFFHPCCVYLFVRDSAK
ASAMLENYVHRDIVTLCLIEELFSGESGAIAKIQRSLVIVNATPIGTAGRQNETETSILPLDTELLHPDHIVYDMVYNPL
FTPLIKAAKASGAATISGIEMLLGQAARSFELWTGKEMPLEQVRAVLINNLLSSP

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=293, Percent_Identity=36.518771331058, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789675, Length=268, Percent_Identity=29.4776119402985, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=299, Percent_Identity=27.7591973244147, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_CHLPD (A1BED6)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911187.1
- ProteinModelPortal:   A1BED6
- SMR:   A1BED6
- STRING:   A1BED6
- GeneID:   4569882
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0708
- NMPDR:   fig|290317.7.peg.743
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   LIHNTAC
- ProtClustDB:   CLSK637945
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31608; Mature: 31608

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQPEKILGLIGRNIAYSRSPLIHNTACDLLALPYVYTIFNIASADLIEPAIAGARALGI
CCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
AGLNVTTPYKTTVVPFLDELSPEAASIGAVNTIVNNNGHLAGYNTDIAGFAAPLRPYAQR
ECCCCCCCCHHHHHHHHHHCCCCHHHCCHHHEEECCCCEEEECCCCHHHHHHHHHHHHHH
IKGNPVSVFGNGGAALAAIEAFRIFFHPCCVYLFVRDSAKASAMLENYVHRDIVTLCLIE
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHH
ELFSGESGAIAKIQRSLVIVNATPIGTAGRQNETETSILPLDTELLHPDHIVYDMVYNPL
HHHCCCCCCHHEEEEEEEEEECCCCCCCCCCCCCCCEEECCCHHHCCCCHHHHHHHHHHH
FTPLIKAAKASGAATISGIEMLLGQAARSFELWTGKEMPLEQVRAVLINNLLSSP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMQPEKILGLIGRNIAYSRSPLIHNTACDLLALPYVYTIFNIASADLIEPAIAGARALGI
CCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
AGLNVTTPYKTTVVPFLDELSPEAASIGAVNTIVNNNGHLAGYNTDIAGFAAPLRPYAQR
ECCCCCCCCHHHHHHHHHHCCCCHHHCCHHHEEECCCCEEEECCCCHHHHHHHHHHHHHH
IKGNPVSVFGNGGAALAAIEAFRIFFHPCCVYLFVRDSAKASAMLENYVHRDIVTLCLIE
HCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHH
ELFSGESGAIAKIQRSLVIVNATPIGTAGRQNETETSILPLDTELLHPDHIVYDMVYNPL
HHHCCCCCCHHEEEEEEEEEECCCCCCCCCCCCCCCEEECCCHHHCCCCHHHHHHHHHHH
FTPLIKAAKASGAATISGIEMLLGQAARSFELWTGKEMPLEQVRAVLINNLLSSP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA