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The map label for this gene is dxs [H]

Identifier: 119356506

GI number: 119356506

Start: 764861

End: 766792

Strand: Reverse

Name: dxs [H]

Synonym: Cpha266_0671

Alternate gene names: 119356506

Gene position: 766792-764861 (Counterclockwise)

Preceding gene: 119356507

Following gene: 119356502

Centisome position: 24.47

GC content: 50.78

Gene sequence:

>1932_bases
ATGGAAGACTCTATTCCCGTTCCTGTATCGCAAGAGAGCTCAATACTTGCATCCATTCACAGTCCAGAAGACCTGAAAAA
GCTCTCTCTGGAAGATCTTCAGCACGTTGCCGATGAGTGCCGTCGTGAAGTGATCAACCTTGTTGCACAAAATGGCGGTC
ATTTCGCATCAAGTCTCGGCGTTGTGGAACTAAGCGTAGCCTTACATTACGTCTACAATTCGCCACGAGACAAAATAGTC
TGGGATGTCGGCCATCAGGCCTATATCCATAAAATTCTGACCGGAAGAAGAGAGAGCATGAAAACCAACCGGCAATACGG
GGGACTGGCCGGATTTCCAAGAATTTTTGAAAGTCCCTACGACGCTTTCGGTACCGGACATGCATCCACATCTATCTCAG
CAGCCGCAGGCATGGCTGCCGCACGAGACCTTTCCGGAGGAACCGAAAAAATGATCGCGGTGATAGGTGACGGCAGCATG
ACCGGCGGGATGGCATTTGAGGCCATGAACCATCTGGGCGACACCAAAAGCGATGTTCTGGTCATTCTGAACGACAACCA
GATGGCCATTTCGCCAAGTACAGGCGGACTGAAAACCCATCTTGTCAACATCGCTCTGAACAAGACTTATAACAAAACCC
GAAAGTTTATCTGGAACTCCATCTCTCTTTTAAACAATGATCTCGGCGATACAGCAAAAAGCCTTGTAAGAAAACTGGAA
GACGGCATTAAAGCCGCTTTCACACCCGGAGCATTCTTTGAAGCGCTCGGTCTGCGATATTTCGGACCTATTGACGGGCA
CAATCTTGAACAGCTTGTCAAGGCACTCAAGGAGATGCAGGAGCTTCCCCACCCGAAACTCCTGCATGTCGTCACGACAA
AAGGAAAAGGCTTCAAGCCTGCCGAAGAAAACCAGAGCAAATGGCATGCCCACAACGGCGGTTTCGATACAACGACCGGC
AAGACAATTGTTACCGCCCAAAAAGCCGGGCCGCCAAAATATCAGGAGGTTTTTGGCGAAACCCTTGTTGAGCTTGCCCT
GAAAGATCCGCGCATCACAGCCATCACTGCTGCCATGCCGAGCGGAACATCCCTTGACCTGTTTCAGAACGCTCTGCCGA
ACCGGTTCTTTGATGTCGGCATTGCCGAACAACATGCCGTAACTTTTGCGGCTGGACTTGCCATTCAGGGCTTCAAGCCT
GTCTGCGCCATTTATTCCACCTTTCTGCAACGCGGATACGACCAGATCATCCACGATGTTGCCCAGCAGAACCTTCATGT
CGTCTTTGCCATTGACCGTGCCGGTCTGGTAGGAGAGGACGGCCCGACGCATCACGGAGCTTTTGACCTCTCCTTCCTGC
AGCCCATTCCCAACTTCGTCATTATGGCGCCTTCGGATGAGCAGGAACTTCGCAACATGCTCTATACCGCTCTCTACCAT
GTTACCGGACCTGTCGCCATTCGCTACCCAAGAGGAAACGGCACCGGCATTGCCCTGAACAAAACCCTGATTCCGCTTGA
AATCGGGAAAGGCAGAATTATCCGGCAGGGAAACGGGATCGCACTGCTTGCAGCCGGGCCCCTTGTGTGGAGAGCCCTTG
AAGTGGCCGAAGCGCTGCAAAAGGAGGGAATGAATCCTCTGGTGGCTGACATGCGCTTTATTAAACCTCTCGATACGGAA
CTGATTGAAGAAATTGCCCAACAGGTAACGCATCTGGTCGTCATTGAAGAAAACAGCATGATCGGCGGACTGGGAAGCGG
AGTCATCGATTATATCAATAGCAGAAAGAGTAAAATTCCGGTACTGAAAACAGGACTTCCTGACGCCTTCGTCACCCACG
GATCAATGGAGGAACTTTACAGAGAAACCGGACTTGATGTTGTGGGAATAACAAAAAGCATAAAGGATTTCTATCCCGGA
AACGTTACATGA

Upstream 100 bases:

>100_bases
TGGTCGCAAGAAAAAGCATATGAGCAGTTCATCCCCCCTACGGAAAAGCAATCGAGAGCGTTTCCCGCAACAAAAAGCAA
TCGCACAGCATCATACCCAT

Downstream 100 bases:

>100_bases
AGGAGTGAGAAGAGGGCGAGAAGAGCCCGAACCGAAAGATTTGCATAAATCCCGGCCAACAGATCGTCAACCATGATTCC
CCAGCCACCGGGGAGCTGCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MEDSIPVPVSQESSILASIHSPEDLKKLSLEDLQHVADECRREVINLVAQNGGHFASSLGVVELSVALHYVYNSPRDKIV
WDVGHQAYIHKILTGRRESMKTNRQYGGLAGFPRIFESPYDAFGTGHASTSISAAAGMAAARDLSGGTEKMIAVIGDGSM
TGGMAFEAMNHLGDTKSDVLVILNDNQMAISPSTGGLKTHLVNIALNKTYNKTRKFIWNSISLLNNDLGDTAKSLVRKLE
DGIKAAFTPGAFFEALGLRYFGPIDGHNLEQLVKALKEMQELPHPKLLHVVTTKGKGFKPAEENQSKWHAHNGGFDTTTG
KTIVTAQKAGPPKYQEVFGETLVELALKDPRITAITAAMPSGTSLDLFQNALPNRFFDVGIAEQHAVTFAAGLAIQGFKP
VCAIYSTFLQRGYDQIIHDVAQQNLHVVFAIDRAGLVGEDGPTHHGAFDLSFLQPIPNFVIMAPSDEQELRNMLYTALYH
VTGPVAIRYPRGNGTGIALNKTLIPLEIGKGRIIRQGNGIALLAAGPLVWRALEVAEALQKEGMNPLVADMRFIKPLDTE
LIEEIAQQVTHLVVIEENSMIGGLGSGVIDYINSRKSKIPVLKTGLPDAFVTHGSMEELYRETGLDVVGITKSIKDFYPG
NVT

Sequences:

>Translated_643_residues
MEDSIPVPVSQESSILASIHSPEDLKKLSLEDLQHVADECRREVINLVAQNGGHFASSLGVVELSVALHYVYNSPRDKIV
WDVGHQAYIHKILTGRRESMKTNRQYGGLAGFPRIFESPYDAFGTGHASTSISAAAGMAAARDLSGGTEKMIAVIGDGSM
TGGMAFEAMNHLGDTKSDVLVILNDNQMAISPSTGGLKTHLVNIALNKTYNKTRKFIWNSISLLNNDLGDTAKSLVRKLE
DGIKAAFTPGAFFEALGLRYFGPIDGHNLEQLVKALKEMQELPHPKLLHVVTTKGKGFKPAEENQSKWHAHNGGFDTTTG
KTIVTAQKAGPPKYQEVFGETLVELALKDPRITAITAAMPSGTSLDLFQNALPNRFFDVGIAEQHAVTFAAGLAIQGFKP
VCAIYSTFLQRGYDQIIHDVAQQNLHVVFAIDRAGLVGEDGPTHHGAFDLSFLQPIPNFVIMAPSDEQELRNMLYTALYH
VTGPVAIRYPRGNGTGIALNKTLIPLEIGKGRIIRQGNGIALLAAGPLVWRALEVAEALQKEGMNPLVADMRFIKPLDTE
LIEEIAQQVTHLVVIEENSMIGGLGSGVIDYINSRKSKIPVLKTGLPDAFVTHGSMEELYRETGLDVVGITKSIKDFYPG
NVT
>Mature_643_residues
MEDSIPVPVSQESSILASIHSPEDLKKLSLEDLQHVADECRREVINLVAQNGGHFASSLGVVELSVALHYVYNSPRDKIV
WDVGHQAYIHKILTGRRESMKTNRQYGGLAGFPRIFESPYDAFGTGHASTSISAAAGMAAARDLSGGTEKMIAVIGDGSM
TGGMAFEAMNHLGDTKSDVLVILNDNQMAISPSTGGLKTHLVNIALNKTYNKTRKFIWNSISLLNNDLGDTAKSLVRKLE
DGIKAAFTPGAFFEALGLRYFGPIDGHNLEQLVKALKEMQELPHPKLLHVVTTKGKGFKPAEENQSKWHAHNGGFDTTTG
KTIVTAQKAGPPKYQEVFGETLVELALKDPRITAITAAMPSGTSLDLFQNALPNRFFDVGIAEQHAVTFAAGLAIQGFKP
VCAIYSTFLQRGYDQIIHDVAQQNLHVVFAIDRAGLVGEDGPTHHGAFDLSFLQPIPNFVIMAPSDEQELRNMLYTALYH
VTGPVAIRYPRGNGTGIALNKTLIPLEIGKGRIIRQGNGIALLAAGPLVWRALEVAEALQKEGMNPLVADMRFIKPLDTE
LIEEIAQQVTHLVVIEENSMIGGLGSGVIDYINSRKSKIPVLKTGLPDAFVTHGSMEELYRETGLDVVGITKSIKDFYPG
NVT

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=687, Percent_Identity=23.1441048034935, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI4507521, Length=687, Percent_Identity=23.1441048034935, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI225637459, Length=555, Percent_Identity=22.7027027027027, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI225637463, Length=555, Percent_Identity=22.7027027027027, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI225637461, Length=555, Percent_Identity=22.7027027027027, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI133778974, Length=568, Percent_Identity=23.0633802816901, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI156564403, Length=255, Percent_Identity=24.7058823529412, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI291084858, Length=247, Percent_Identity=24.2914979757085, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1786622, Length=625, Percent_Identity=49.44, Blast_Score=602, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=24.6290801186944, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319698, Length=229, Percent_Identity=25.764192139738, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551847, Length=638, Percent_Identity=24.7648902821317, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45550715, Length=638, Percent_Identity=24.7648902821317, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24645119, Length=511, Percent_Identity=25.0489236790607, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24666278, Length=606, Percent_Identity=24.7524752475248, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358145, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650940, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69775; Mature: 69775

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDSIPVPVSQESSILASIHSPEDLKKLSLEDLQHVADECRREVINLVAQNGGHFASSLG
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
VVELSVALHYVYNSPRDKIVWDVGHQAYIHKILTGRRESMKTNRQYGGLAGFPRIFESPY
CEEHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHCCCH
DAFGTGHASTSISAAAGMAAARDLSGGTEKMIAVIGDGSMTGGMAFEAMNHLGDTKSDVL
HHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCEE
VILNDNQMAISPSTGGLKTHLVNIALNKTYNKTRKFIWNSISLLNNDLGDTAKSLVRKLE
EEECCCEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DGIKAAFTPGAFFEALGLRYFGPIDGHNLEQLVKALKEMQELPHPKLLHVVTTKGKGFKP
HHHHEECCCHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
AEENQSKWHAHNGGFDTTTGKTIVTAQKAGPPKYQEVFGETLVELALKDPRITAITAAMP
CCCCCCCEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
SGTSLDLFQNALPNRFFDVGIAEQHAVTFAAGLAIQGFKPVCAIYSTFLQRGYDQIIHDV
CCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AQQNLHVVFAIDRAGLVGEDGPTHHGAFDLSFLQPIPNFVIMAPSDEQELRNMLYTALYH
HHCCEEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCCCEEEECCCCHHHHHHHHHHHHHH
VTGPVAIRYPRGNGTGIALNKTLIPLEIGKGRIIRQGNGIALLAAGPLVWRALEVAEALQ
HCCCEEEEEECCCCCEEEEECEEEEEEECCCEEEECCCCEEEEECCHHHHHHHHHHHHHH
KEGMNPLVADMRFIKPLDTELIEEIAQQVTHLVVIEENSMIGGLGSGVIDYINSRKSKIP
HCCCCHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VLKTGLPDAFVTHGSMEELYRETGLDVVGITKSIKDFYPGNVT
EEECCCCHHHHCCCCHHHHHHHHCCCEEEHHHHHHHCCCCCCC
>Mature Secondary Structure
MEDSIPVPVSQESSILASIHSPEDLKKLSLEDLQHVADECRREVINLVAQNGGHFASSLG
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
VVELSVALHYVYNSPRDKIVWDVGHQAYIHKILTGRRESMKTNRQYGGLAGFPRIFESPY
CEEHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHCCCH
DAFGTGHASTSISAAAGMAAARDLSGGTEKMIAVIGDGSMTGGMAFEAMNHLGDTKSDVL
HHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCEE
VILNDNQMAISPSTGGLKTHLVNIALNKTYNKTRKFIWNSISLLNNDLGDTAKSLVRKLE
EEECCCEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DGIKAAFTPGAFFEALGLRYFGPIDGHNLEQLVKALKEMQELPHPKLLHVVTTKGKGFKP
HHHHEECCCHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
AEENQSKWHAHNGGFDTTTGKTIVTAQKAGPPKYQEVFGETLVELALKDPRITAITAAMP
CCCCCCCEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
SGTSLDLFQNALPNRFFDVGIAEQHAVTFAAGLAIQGFKPVCAIYSTFLQRGYDQIIHDV
CCCCHHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AQQNLHVVFAIDRAGLVGEDGPTHHGAFDLSFLQPIPNFVIMAPSDEQELRNMLYTALYH
HHCCEEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCCCEEEECCCCHHHHHHHHHHHHHH
VTGPVAIRYPRGNGTGIALNKTLIPLEIGKGRIIRQGNGIALLAAGPLVWRALEVAEALQ
HCCCEEEEEECCCCCEEEEECEEEEEEECCCEEEECCCCEEEEECCHHHHHHHHHHHHHH
KEGMNPLVADMRFIKPLDTELIEEIAQQVTHLVVIEENSMIGGLGSGVIDYINSRKSKIP
HCCCCHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VLKTGLPDAFVTHGSMEELYRETGLDVVGITKSIKDFYPGNVT
EEECCCCHHHHCCCCHHHHHHHHCCCEEEHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]