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The map label for this gene is dapA

Identifier: 119356411

GI number: 119356411

Start: 646224

End: 647114

Strand: Reverse

Name: dapA

Synonym: Cpha266_0575

Alternate gene names: 119356411

Gene position: 647114-646224 (Counterclockwise)

Preceding gene: 119356412

Following gene: 119356407

Centisome position: 20.65

GC content: 48.82

Gene sequence:

>891_bases
ATGTCCACACGATACATTGCAGGATCGGCCGTTGCTCTTGTCACGCCTTTCAGGAAGAACAACACTATCGATACCGACGC
ATTAAAAAAACTGGTTCAGTTCCATATCGAAGCGGGAACCGATATCATCATCCCATGCGGAACTACCGGAGAATCGCCAA
CCCTGACTTCCGATGAACAGTTCCGGATTATCCGCATTGTCAGCGAAGAGGCCGATGGAAAAATCATGGTTGCTGCGGGA
GCTGGCACCAACGCAACCGCTCATGCCGTAGAGCTTGCAAAAAACGCGGAAAAAGCCGGAGCCTCAGCCATTCTGTCGGT
GGCCCCTTATTATAACAAACCCTCTCAGGAAGGATTCTATCAGCACTTCCGACATATTGCCGAAGCGGTTTCTGTTCCGA
TTATTGTTTACAATGTTCCGGGAAGAACCGGGAGCAACCTGTCGGCGTCAACAATTCTGAGGCTTGCCAGAGACTTTGCA
AATATTGCTGCCGTCAAGGAAGCTTCAGATAACATGAACCAGATCATGGAACTTCTCGAAGAGAGACCGGAAAACTTTTC
GGTCATGACAGGAGAGGATATGCTGATACTGCCATTCATGGCAATGGGAGGTGACGGGGTAATATCTGTGGCGGCAAACC
AGATTCCATCAACGGTAAAACAACTGGTCATTGCAGCAAAACAAGGAAATCTTGACGAAGCCCGCGCCTTAAACCGCAAG
TACCGCAGACTGTTCAAAATGAACTTCATCGAAAGCAATCCTGTGCCGGTTAAGTACTGCCTCTCCCTGATGGGAATGAT
TGAGGAGAACTACCGACTGCCGCTTGTCCCGTTATCCGATGAAAACAAGGCTGTCCTGAAAAAAGAGATGGAGTTCCTCG
GGCTTATTTAA

Upstream 100 bases:

>100_bases
CCGGAGAGCTTCTTGAAGGCGCAAAATCCGTTTAGAAAATGAGAAACTTTGCATTATAATGCGTACCATGTCAAGTTTCT
GATTAACAAGGGATACCATT

Downstream 100 bases:

>100_bases
GAGCCCCGAGGTATTCCACAAAAGCGTCAAGCTCCGCTTTGGTACGTTTTTCCGTAACGGCAACAAGCAGACCGGCTTCA
TCGTACACGGAAAGATCGCA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSTRYIAGSAVALVTPFRKNNTIDTDALKKLVQFHIEAGTDIIIPCGTTGESPTLTSDEQFRIIRIVSEEADGKIMVAAG
AGTNATAHAVELAKNAEKAGASAILSVAPYYNKPSQEGFYQHFRHIAEAVSVPIIVYNVPGRTGSNLSASTILRLARDFA
NIAAVKEASDNMNQIMELLEERPENFSVMTGEDMLILPFMAMGGDGVISVAANQIPSTVKQLVIAAKQGNLDEARALNRK
YRRLFKMNFIESNPVPVKYCLSLMGMIEENYRLPLVPLSDENKAVLKKEMEFLGLI

Sequences:

>Translated_296_residues
MSTRYIAGSAVALVTPFRKNNTIDTDALKKLVQFHIEAGTDIIIPCGTTGESPTLTSDEQFRIIRIVSEEADGKIMVAAG
AGTNATAHAVELAKNAEKAGASAILSVAPYYNKPSQEGFYQHFRHIAEAVSVPIIVYNVPGRTGSNLSASTILRLARDFA
NIAAVKEASDNMNQIMELLEERPENFSVMTGEDMLILPFMAMGGDGVISVAANQIPSTVKQLVIAAKQGNLDEARALNRK
YRRLFKMNFIESNPVPVKYCLSLMGMIEENYRLPLVPLSDENKAVLKKEMEFLGLI
>Mature_295_residues
STRYIAGSAVALVTPFRKNNTIDTDALKKLVQFHIEAGTDIIIPCGTTGESPTLTSDEQFRIIRIVSEEADGKIMVAAGA
GTNATAHAVELAKNAEKAGASAILSVAPYYNKPSQEGFYQHFRHIAEAVSVPIIVYNVPGRTGSNLSASTILRLARDFAN
IAAVKEASDNMNQIMELLEERPENFSVMTGEDMLILPFMAMGGDGVISVAANQIPSTVKQLVIAAKQGNLDEARALNRKY
RRLFKMNFIESNPVPVKYCLSLMGMIEENYRLPLVPLSDENKAVLKKEMEFLGLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=297, Percent_Identity=25.5892255892256, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13540533, Length=253, Percent_Identity=24.5059288537549, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788823, Length=290, Percent_Identity=40.3448275862069, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI87082415, Length=263, Percent_Identity=31.5589353612167, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1789620, Length=291, Percent_Identity=28.1786941580756, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786463, Length=275, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CHLPD (A1BE04)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911055.1
- ProteinModelPortal:   A1BE04
- SMR:   A1BE04
- STRING:   A1BE04
- GeneID:   4569170
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0575
- NMPDR:   fig|290317.7.peg.603
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32296; Mature: 32164

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRYIAGSAVALVTPFRKNNTIDTDALKKLVQFHIEAGTDIIIPCGTTGESPTLTSDEQ
CCCCEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCC
FRIIRIVSEEADGKIMVAAGAGTNATAHAVELAKNAEKAGASAILSVAPYYNKPSQEGFY
EEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHEEEECCCCCCCCCCHHH
QHFRHIAEAVSVPIIVYNVPGRTGSNLSASTILRLARDFANIAAVKEASDNMNQIMELLE
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ERPENFSVMTGEDMLILPFMAMGGDGVISVAANQIPSTVKQLVIAAKQGNLDEARALNRK
HCCCCCEEECCCCEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YRRLFKMNFIESNPVPVKYCLSLMGMIEENYRLPLVPLSDENKAVLKKEMEFLGLI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
STRYIAGSAVALVTPFRKNNTIDTDALKKLVQFHIEAGTDIIIPCGTTGESPTLTSDEQ
CCCEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCC
FRIIRIVSEEADGKIMVAAGAGTNATAHAVELAKNAEKAGASAILSVAPYYNKPSQEGFY
EEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHEEEECCCCCCCCCCHHH
QHFRHIAEAVSVPIIVYNVPGRTGSNLSASTILRLARDFANIAAVKEASDNMNQIMELLE
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ERPENFSVMTGEDMLILPFMAMGGDGVISVAANQIPSTVKQLVIAAKQGNLDEARALNRK
HCCCCCEEECCCCEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YRRLFKMNFIESNPVPVKYCLSLMGMIEENYRLPLVPLSDENKAVLKKEMEFLGLI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA