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The map label for this gene is sppA [H]

Identifier: 119356392

GI number: 119356392

Start: 620290

End: 622095

Strand: Direct

Name: sppA [H]

Synonym: Cpha266_0556

Alternate gene names: 119356392

Gene position: 620290-622095 (Clockwise)

Preceding gene: 119356391

Following gene: 119356396

Centisome position: 19.79

GC content: 51.0

Gene sequence:

>1806_bases
GTGAAAGATGTCAATAAAAAATCCGGTTGCTGGAGAATCGGCTGTTTTTCGTTTGTTGTTGTGCCGATTCTCATAGCGGT
ATCGGCTTTTTTTTATTTCCGTTCATCCTATGTTCTTCCGGACAAATTTGTTTTGAGCGTTCCCATTCAGGGAAATCTTG
ATGAGGTGCACTCCCTGAGCTCTTCGTTGCCGTTACTTTCGTCAGCCGAACCGCTGTCGTTTCAGGATCTGCTTTTTCTT
TTCGATCATGCTGCCGGCGACAAGAGGATAGGTTCGATTTTGCTTGAAATAGGGGGAGTGCATGCCAATCCGGCCAAGTT
GACGGAACTCAGGTATTCAATCGAAAAGATGAAGGCTTCCGGGAAAAAAGTTGTGGCTTTTCTCCGTTCGGCAGAGGACA
GCGACTATCTGCTTGCGACGGCCTGTGATTCAATTGTTGTTGAGGAGGGGGGCTTTCTGATGCTTGACGGCCTCAAAGCC
GAGACACTGTTTTATACCAAATCGCTCAATAAAATAGGCATCACTTTCCAGGCATCTCAATGGAAAACGTACAAAAGCGG
CATTGAGCCATTTGTCAGAACAGGGGCAAGTTCCGAGTATCTTGAACAGATCGGCGAGCTCCTTGACGACGTGTACGACG
ACTATCTCGGCTATGCTTCGAAACGCAGAGGTATAAGCCGTGATTCATTGCAGGCGGTTATCGACAACATGGCGCTGCTT
TCGGCAAAAAAAGCGGTTCAGCTTGGCCTTGCTGATGGCATTGCTTCGTCCTGGGCTCTTAACCGCTCACTTGCCGGAAA
AATAACCGGAAGGGAACCGGAGCGTGGTGATGATGTGATGGTGAGTGCGGAGCGTTACCGTGATTCGGTTGAACCGAATT
ATAATGCTGACGGGCGTGATGCAATTGCCTTGATTACCCTTTCGGGTCCGATCTACCGTTCAGGTGGCGCTTCCGGTATG
GGTGTTGCCGAAGGGTTTGACGAAAAGCTTTTGCAGCGCTCTCTGGAGGTTGCGCTTGATAATCGTGACGTCAAGGCTTT
GGTGTTGCGTATCGACAGCCCGGGAGGAGATGCGCTTGCTTCGGCTGATATGCTCGAGATGCTTTATTTTGCAGCAAAGA
AAAAGCCGATTGTAGTTTCCATGTCAGGGGTAGCGGCTTCCGGTGGATATATGGCAGCGCTGGCGGGGAATAAAATTTTT
GCAGAGCCGCTTACCATTACCGGGTCGATAGGGGTCTATGCGCTGAAGCCGGAAATCAGCGGCCTTGTGGAAAAAACAGG
TTTGCAGCGCGAGGTTGTCACTCGCGGCAGGTATGCCGATGCAACTTCGCTTTTCAAGCCGCTTGACAAGGATGCTTACG
ATAAATTTGTTGCCGCTTCCGGCGACGTCTATCATGATTTTGTCAGCAAGGTCGCCACGTCAAGAAAGATGCGGTGGGCT
GCTGCCGATTCGGTAGCCGGGGGGAGGGTCTGGAGCGGAAAAAGAGCGTTGCAGGCAGGACTGATTGACAGCCTCGGCGG
GCTGCACGATGCCATCCGGGAGGCTCAGATTCTCGGTAAAATAGACAAGACGAAAAAACCTCGTATTCTCTTTTATCCTG
AACGGAAAAGCTGGATGGAATCTCTTGCGGAGGGTGACTTTTCCGGCTTCTCCCGGAGCGTGACTATTGCGTTGAAGCAG
CGTCTGATCCATGAGCTTGTTCCTGAAGGCCAATCAAGCTCCATCACTGCTTTTTACGACATGCTGATGGTCTCAGGCCA
ACTGCATCTGATTGCAGCTCTGCCCGGCGAGGTCGTTATCCGCTGA

Upstream 100 bases:

>100_bases
CTCAAATCGCCGCAGGGTGAACCGGATCGTCTGGTAAGCTGTCTGCTTTACCCTTAAGGCGTCAGTTGTCGTTTTTTATC
ACCATTAAGAATATTTCCCA

Downstream 100 bases:

>100_bases
TGAGCATGCTGATACTCTCCCCGGGAGCATGGTGTTTGAGGAGTTGTTCCCGGGGAGGAAGTTCAAGATTTAAAACTTGT
AGGTCATGGAACTCTGGGCT

Product: signal peptide peptidase A

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MKDVNKKSGCWRIGCFSFVVVPILIAVSAFFYFRSSYVLPDKFVLSVPIQGNLDEVHSLSSSLPLLSSAEPLSFQDLLFL
FDHAAGDKRIGSILLEIGGVHANPAKLTELRYSIEKMKASGKKVVAFLRSAEDSDYLLATACDSIVVEEGGFLMLDGLKA
ETLFYTKSLNKIGITFQASQWKTYKSGIEPFVRTGASSEYLEQIGELLDDVYDDYLGYASKRRGISRDSLQAVIDNMALL
SAKKAVQLGLADGIASSWALNRSLAGKITGREPERGDDVMVSAERYRDSVEPNYNADGRDAIALITLSGPIYRSGGASGM
GVAEGFDEKLLQRSLEVALDNRDVKALVLRIDSPGGDALASADMLEMLYFAAKKKPIVVSMSGVAASGGYMAALAGNKIF
AEPLTITGSIGVYALKPEISGLVEKTGLQREVVTRGRYADATSLFKPLDKDAYDKFVAASGDVYHDFVSKVATSRKMRWA
AADSVAGGRVWSGKRALQAGLIDSLGGLHDAIREAQILGKIDKTKKPRILFYPERKSWMESLAEGDFSGFSRSVTIALKQ
RLIHELVPEGQSSSITAFYDMLMVSGQLHLIAALPGEVVIR

Sequences:

>Translated_601_residues
MKDVNKKSGCWRIGCFSFVVVPILIAVSAFFYFRSSYVLPDKFVLSVPIQGNLDEVHSLSSSLPLLSSAEPLSFQDLLFL
FDHAAGDKRIGSILLEIGGVHANPAKLTELRYSIEKMKASGKKVVAFLRSAEDSDYLLATACDSIVVEEGGFLMLDGLKA
ETLFYTKSLNKIGITFQASQWKTYKSGIEPFVRTGASSEYLEQIGELLDDVYDDYLGYASKRRGISRDSLQAVIDNMALL
SAKKAVQLGLADGIASSWALNRSLAGKITGREPERGDDVMVSAERYRDSVEPNYNADGRDAIALITLSGPIYRSGGASGM
GVAEGFDEKLLQRSLEVALDNRDVKALVLRIDSPGGDALASADMLEMLYFAAKKKPIVVSMSGVAASGGYMAALAGNKIF
AEPLTITGSIGVYALKPEISGLVEKTGLQREVVTRGRYADATSLFKPLDKDAYDKFVAASGDVYHDFVSKVATSRKMRWA
AADSVAGGRVWSGKRALQAGLIDSLGGLHDAIREAQILGKIDKTKKPRILFYPERKSWMESLAEGDFSGFSRSVTIALKQ
RLIHELVPEGQSSSITAFYDMLMVSGQLHLIAALPGEVVIR
>Mature_601_residues
MKDVNKKSGCWRIGCFSFVVVPILIAVSAFFYFRSSYVLPDKFVLSVPIQGNLDEVHSLSSSLPLLSSAEPLSFQDLLFL
FDHAAGDKRIGSILLEIGGVHANPAKLTELRYSIEKMKASGKKVVAFLRSAEDSDYLLATACDSIVVEEGGFLMLDGLKA
ETLFYTKSLNKIGITFQASQWKTYKSGIEPFVRTGASSEYLEQIGELLDDVYDDYLGYASKRRGISRDSLQAVIDNMALL
SAKKAVQLGLADGIASSWALNRSLAGKITGREPERGDDVMVSAERYRDSVEPNYNADGRDAIALITLSGPIYRSGGASGM
GVAEGFDEKLLQRSLEVALDNRDVKALVLRIDSPGGDALASADMLEMLYFAAKKKPIVVSMSGVAASGGYMAALAGNKIF
AEPLTITGSIGVYALKPEISGLVEKTGLQREVVTRGRYADATSLFKPLDKDAYDKFVAASGDVYHDFVSKVATSRKMRWA
AADSVAGGRVWSGKRALQAGLIDSLGGLHDAIREAQILGKIDKTKKPRILFYPERKSWMESLAEGDFSGFSRSVTIALKQ
RLIHELVPEGQSSSITAFYDMLMVSGQLHLIAALPGEVVIR

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=491, Percent_Identity=26.8839103869654, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1787527, Length=172, Percent_Identity=31.3953488372093, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 65178; Mature: 65178

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVNKKSGCWRIGCFSFVVVPILIAVSAFFYFRSSYVLPDKFVLSVPIQGNLDEVHSLS
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHH
SSLPLLSSAEPLSFQDLLFLFDHAAGDKRIGSILLEIGGVHANPAKLTELRYSIEKMKAS
HCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
GKKVVAFLRSAEDSDYLLATACDSIVVEEGGFLMLDGLKAETLFYTKSLNKIGITFQASQ
CHHHHHHHHCCCCCCEEEEEECCCEEEECCCEEEEECCCCCEEEEEECCCCEEEEEECCC
WKTYKSGIEPFVRTGASSEYLEQIGELLDDVYDDYLGYASKRRGISRDSLQAVIDNMALL
CHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SAKKAVQLGLADGIASSWALNRSLAGKITGREPERGDDVMVSAERYRDSVEPNYNADGRD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCCCCCCCC
AIALITLSGPIYRSGGASGMGVAEGFDEKLLQRSLEVALDNRDVKALVLRIDSPGGDALA
EEEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHH
SADMLEMLYFAAKKKPIVVSMSGVAASGGYMAALAGNKIFAEPLTITGSIGVYALKPEIS
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCEEEECCEEEEECCCEEEECCHHH
GLVEKTGLQREVVTRGRYADATSLFKPLDKDAYDKFVAASGDVYHDFVSKVATSRKMRWA
HHHHHCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEH
AADSVAGGRVWSGKRALQAGLIDSLGGLHDAIREAQILGKIDKTKKPRILFYPERKSWME
HHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
SLAEGDFSGFSRSVTIALKQRLIHELVPEGQSSSITAFYDMLMVSGQLHLIAALPGEVVI
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEE
R
C
>Mature Secondary Structure
MKDVNKKSGCWRIGCFSFVVVPILIAVSAFFYFRSSYVLPDKFVLSVPIQGNLDEVHSLS
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHH
SSLPLLSSAEPLSFQDLLFLFDHAAGDKRIGSILLEIGGVHANPAKLTELRYSIEKMKAS
HCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
GKKVVAFLRSAEDSDYLLATACDSIVVEEGGFLMLDGLKAETLFYTKSLNKIGITFQASQ
CHHHHHHHHCCCCCCEEEEEECCCEEEECCCEEEEECCCCCEEEEEECCCCEEEEEECCC
WKTYKSGIEPFVRTGASSEYLEQIGELLDDVYDDYLGYASKRRGISRDSLQAVIDNMALL
CHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SAKKAVQLGLADGIASSWALNRSLAGKITGREPERGDDVMVSAERYRDSVEPNYNADGRD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCCCCCCCC
AIALITLSGPIYRSGGASGMGVAEGFDEKLLQRSLEVALDNRDVKALVLRIDSPGGDALA
EEEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHH
SADMLEMLYFAAKKKPIVVSMSGVAASGGYMAALAGNKIFAEPLTITGSIGVYALKPEIS
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCEEEECCEEEEECCCEEEECCHHH
GLVEKTGLQREVVTRGRYADATSLFKPLDKDAYDKFVAASGDVYHDFVSKVATSRKMRWA
HHHHHCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEH
AADSVAGGRVWSGKRALQAGLIDSLGGLHDAIREAQILGKIDKTKKPRILFYPERKSWME
HHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
SLAEGDFSGFSRSVTIALKQRLIHELVPEGQSSSITAFYDMLMVSGQLHLIAALPGEVVI
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEE
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]