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The map label for this gene is pheA [H]

Identifier: 119356374

GI number: 119356374

Start: 592055

End: 592894

Strand: Reverse

Name: pheA [H]

Synonym: Cpha266_0537

Alternate gene names: 119356374

Gene position: 592894-592055 (Counterclockwise)

Preceding gene: 119356378

Following gene: 119356373

Centisome position: 18.92

GC content: 47.02

Gene sequence:

>840_bases
ATGACAAACTGCTTGATCGCCTATCAGGGAGAACCCGGAGCTTACAGTGAAATAGCAGCCCTCCGCATTGGACAGCCAAA
ACCCTGCGAATCATTCGAGGAAGTTTTTGCTGCCGTTGAAAAACACGAAGCCGACTATGCGGTCATCCCCATTGAAAACT
CTCTTGGCGGAAGCATTCACCAGAACTACGACCTTCTTTTACAGCATCCTGTGGTGATCGTTGCCGAAACCTTTGTCAAG
GTTGAACACTGCCTTCTCGGACTTCAGGGATCTTCGGTACAACATGCCGAAAAAGTCCTCTCACACCCCCAGGCGCTGGC
GCAATGCCGAAATTTTTTCAGCTCGCACAAACACCTTAAAGCCGAAGTCGCTTACGATACCGCTGGAAGCGCCAAAATTA
TTGCGGCTGAAAAAAAACCCAAACAGCTCGCCATTGCGTCAAAACGCGCGGGAGAACTGTACGGTCTTGAGATATTACAG
GAAAACCTTGCTGACGAAGAGTGGAATATTACCCGGTTTTTCTGCATTGCCCATGCAGACAATCCCGACACATCGTTCCT
GAAAAACCTCTCGGATACCACACAACAGAAAACTTCGATTGTTTTTACACTGCCCAACGTTCAGGGCTCCCTTTTCAAGT
CGCTGGCAACACTCGCATTACGAGACATCGATATGACTAAAATAGAATCGAGACCATTCAGAAAAAAAGCTTTTGAATAT
CTCTTTTATGTCGACTTTACGGGGCAGCAGAATGAAAGGAACATTTACAATGCCCTTAGGCACCTCAGAGAGTTCGCAAC
AATGGTTAAGGTTCTTGGAAGTTACGGAGTGATTGCATGA

Upstream 100 bases:

>100_bases
AGTATTGTCTGAAAAAGTCCTGATTGTGATAATAGATTTATTTTCTTTAAATAAAATCAAATCCAACTGCAATATTGCAA
GTTAATCACAAGAAAAAATA

Downstream 100 bases:

>100_bases
GCATTGACAATCAATTTGATTTTTTCCAGGCAGGTTGCGGCCAACCGTCTGAAGCAACAAAAAAAAACATACCGGAAAAA
AAACCCGCACTGTTTCTGAT

Product: prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTNCLIAYQGEPGAYSEIAALRIGQPKPCESFEEVFAAVEKHEADYAVIPIENSLGGSIHQNYDLLLQHPVVIVAETFVK
VEHCLLGLQGSSVQHAEKVLSHPQALAQCRNFFSSHKHLKAEVAYDTAGSAKIIAAEKKPKQLAIASKRAGELYGLEILQ
ENLADEEWNITRFFCIAHADNPDTSFLKNLSDTTQQKTSIVFTLPNVQGSLFKSLATLALRDIDMTKIESRPFRKKAFEY
LFYVDFTGQQNERNIYNALRHLREFATMVKVLGSYGVIA

Sequences:

>Translated_279_residues
MTNCLIAYQGEPGAYSEIAALRIGQPKPCESFEEVFAAVEKHEADYAVIPIENSLGGSIHQNYDLLLQHPVVIVAETFVK
VEHCLLGLQGSSVQHAEKVLSHPQALAQCRNFFSSHKHLKAEVAYDTAGSAKIIAAEKKPKQLAIASKRAGELYGLEILQ
ENLADEEWNITRFFCIAHADNPDTSFLKNLSDTTQQKTSIVFTLPNVQGSLFKSLATLALRDIDMTKIESRPFRKKAFEY
LFYVDFTGQQNERNIYNALRHLREFATMVKVLGSYGVIA
>Mature_278_residues
TNCLIAYQGEPGAYSEIAALRIGQPKPCESFEEVFAAVEKHEADYAVIPIENSLGGSIHQNYDLLLQHPVVIVAETFVKV
EHCLLGLQGSSVQHAEKVLSHPQALAQCRNFFSSHKHLKAEVAYDTAGSAKIIAAEKKPKQLAIASKRAGELYGLEILQE
NLADEEWNITRFFCIAHADNPDTSFLKNLSDTTQQKTSIVFTLPNVQGSLFKSLATLALRDIDMTKIESRPFRKKAFEYL
FYVDFTGQQNERNIYNALRHLREFATMVKVLGSYGVIA

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=277, Percent_Identity=33.2129963898917, Blast_Score=159, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324013, Length=304, Percent_Identity=26.6447368421053, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010952
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 31151; Mature: 31020

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNCLIAYQGEPGAYSEIAALRIGQPKPCESFEEVFAAVEKHEADYAVIPIENSLGGSIH
CCCEEEEECCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
QNYDLLLQHPVVIVAETFVKVEHCLLGLQGSSVQHAEKVLSHPQALAQCRNFFSSHKHLK
CCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHEE
AEVAYDTAGSAKIIAAEKKPKQLAIASKRAGELYGLEILQENLADEEWNITRFFCIAHAD
EEEEECCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECC
NPDTSFLKNLSDTTQQKTSIVFTLPNVQGSLFKSLATLALRDIDMTKIESRPFRKKAFEY
CCCHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHEEE
LFYVDFTGQQNERNIYNALRHLREFATMVKVLGSYGVIA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TNCLIAYQGEPGAYSEIAALRIGQPKPCESFEEVFAAVEKHEADYAVIPIENSLGGSIH
CCEEEEECCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
QNYDLLLQHPVVIVAETFVKVEHCLLGLQGSSVQHAEKVLSHPQALAQCRNFFSSHKHLK
CCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHEE
AEVAYDTAGSAKIIAAEKKPKQLAIASKRAGELYGLEILQENLADEEWNITRFFCIAHAD
EEEEECCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECC
NPDTSFLKNLSDTTQQKTSIVFTLPNVQGSLFKSLATLALRDIDMTKIESRPFRKKAFEY
CCCHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHEEE
LFYVDFTGQQNERNIYNALRHLREFATMVKVLGSYGVIA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1512561; 1444388 [H]