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The map label for this gene is lpxK

Identifier: 119356363

GI number: 119356363

Start: 579252

End: 580319

Strand: Reverse

Name: lpxK

Synonym: Cpha266_0526

Alternate gene names: 119356363

Gene position: 580319-579252 (Counterclockwise)

Preceding gene: 119356364

Following gene: 119356361

Centisome position: 18.52

GC content: 47.85

Gene sequence:

>1068_bases
ATGTCGTTTGATCTCCCCGACATTATCCTGCGGCCTGCATCGCTGCTCTACAAAAACATCATCCGGATCAGAAACAGACT
GTATGATCAGCAAATATTCCACACCTGGCACTCTCCGCTCCCTATTGTTTCGATCGGCAATATTTCAGCAGGTGGTACCG
GAAAAACGCCGCTCGTGGACTGGATTGTGAAATACTATCTCTCTCTGGGCTGTAAACCGGCCATTGTATCGAGAGGTTAC
GGACGAAATACAAAAGGCGTTCAACTGGTATCGGACGGAAAAACAGTGTTGATGAAAAGCAATGCCTGCGGCGATGAAAC
GGCAATGCTTGCCTGGAACAACCGCGACGCCATTGTTATCGTTGCCGAAAAACGAAAAGATGCGGTCACCTTTATCATCA
GACGATTTGCAGAGGCAATGCCTGATGTCATTATTCTCGACGATGCTTTTCAGCACCGGCAGATTGCGCGAAACCTCGAT
ATCGTCGTGATCAACGAAAAAGAACCCTATTTCAGGGCGGACATGATTCCCAAAGGGCGTCTCCGGGAACCATTGATTAA
CCTTGCAAGAGCAGACCTGCTTGTACTCAGCAAGATTACAGGGGGCTCAACAACAGCGGCGATTTCGATGGATCTTGAAC
AGACCGGCAAACCCGTCATCAAAGCCGGAATAGCCGCAGGTAATCTTGTCTGTTTGTCCGGTATGTTTAATACGGCAAAA
GAAAGCCCCGTTCATGCAGGAATAAAAGCTCTTGCCTTTGCAGGAATCGGTTCACCACAAAGCTTTATCGACACCCTTGA
GGGGCAGGGCATTCAAATTGTTTCACACCGATTTTTCCGCGACCATGAATCGTATACTGCAAAAAAAATCGCAGCGCTGC
GACTTGAAGCAGATGAAAAAAAGCTTACCCTTGTCACTACCGAAAAAGACTACTTTAGAATGCTTGGCCAACCCGAACTT
CAGGAAATTCTGCACACCCTCTCATGCTGCTATCTCAAAATCCGGCCGGAATTCACTGAAGGCGAAAAGCTGCTCAAAAC
CATGCTGAACGCCGTTATCAACCGATAA

Upstream 100 bases:

>100_bases
AGCCGCGTCGCAGTTACACTTAAAACGGTAACGGTACCGGAATTCAATAACGAAACCATGCTGCGCAATTTTGCAAGTCA
GCTTTCAAGGAGCTTCACGC

Downstream 100 bases:

>100_bases
CAAATCGTCTCTTATTCCTTGATGATTTTCGAAATCTCCTTGAATTGCTCGCCCTCAGCAATGCGAAGCAGCTCAAATAC
CGCCATTTCAGTGCTTGTAG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSFDLPDIILRPASLLYKNIIRIRNRLYDQQIFHTWHSPLPIVSIGNISAGGTGKTPLVDWIVKYYLSLGCKPAIVSRGY
GRNTKGVQLVSDGKTVLMKSNACGDETAMLAWNNRDAIVIVAEKRKDAVTFIIRRFAEAMPDVIILDDAFQHRQIARNLD
IVVINEKEPYFRADMIPKGRLREPLINLARADLLVLSKITGGSTTAAISMDLEQTGKPVIKAGIAAGNLVCLSGMFNTAK
ESPVHAGIKALAFAGIGSPQSFIDTLEGQGIQIVSHRFFRDHESYTAKKIAALRLEADEKKLTLVTTEKDYFRMLGQPEL
QEILHTLSCCYLKIRPEFTEGEKLLKTMLNAVINR

Sequences:

>Translated_355_residues
MSFDLPDIILRPASLLYKNIIRIRNRLYDQQIFHTWHSPLPIVSIGNISAGGTGKTPLVDWIVKYYLSLGCKPAIVSRGY
GRNTKGVQLVSDGKTVLMKSNACGDETAMLAWNNRDAIVIVAEKRKDAVTFIIRRFAEAMPDVIILDDAFQHRQIARNLD
IVVINEKEPYFRADMIPKGRLREPLINLARADLLVLSKITGGSTTAAISMDLEQTGKPVIKAGIAAGNLVCLSGMFNTAK
ESPVHAGIKALAFAGIGSPQSFIDTLEGQGIQIVSHRFFRDHESYTAKKIAALRLEADEKKLTLVTTEKDYFRMLGQPEL
QEILHTLSCCYLKIRPEFTEGEKLLKTMLNAVINR
>Mature_354_residues
SFDLPDIILRPASLLYKNIIRIRNRLYDQQIFHTWHSPLPIVSIGNISAGGTGKTPLVDWIVKYYLSLGCKPAIVSRGYG
RNTKGVQLVSDGKTVLMKSNACGDETAMLAWNNRDAIVIVAEKRKDAVTFIIRRFAEAMPDVIILDDAFQHRQIARNLDI
VVINEKEPYFRADMIPKGRLREPLINLARADLLVLSKITGGSTTAAISMDLEQTGKPVIKAGIAAGNLVCLSGMFNTAKE
SPVHAGIKALAFAGIGSPQSFIDTLEGQGIQIVSHRFFRDHESYTAKKIAALRLEADEKKLTLVTTEKDYFRMLGQPELQ
EILHTLSCCYLKIRPEFTEGEKLLKTMLNAVINR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=305, Percent_Identity=30.4918032786885, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_CHLPD (A1BDV6)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911007.1
- STRING:   A1BDV6
- GeneID:   4569121
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0526
- NMPDR:   fig|290317.7.peg.549
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   CLSK637887
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 39482; Mature: 39350

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLPDIILRPASLLYKNIIRIRNRLYDQQIFHTWHSPLPIVSIGNISAGGTGKTPLVD
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHH
WIVKYYLSLGCKPAIVSRGYGRNTKGVQLVSDGKTVLMKSNACGDETAMLAWNNRDAIVI
HHHHHHHHCCCCHHHHCCCCCCCCCCEEEEECCCEEEEECCCCCCCEEEEEECCCCEEEE
VAEKRKDAVTFIIRRFAEAMPDVIILDDAFQHRQIARNLDIVVINEKEPYFRADMIPKGR
EECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCEEEECCCCCCEEECCCCCCC
LREPLINLARADLLVLSKITGGSTTAAISMDLEQTGKPVIKAGIAAGNLVCLSGMFNTAK
HHHHHHHHHHHHHHEEEECCCCCCEEEEEECHHHCCCHHHHHCCCCCCEEEEECCHHCCC
ESPVHAGIKALAFAGIGSPQSFIDTLEGQGIQIVSHRFFRDHESYTAKKIAALRLEADEK
CCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHEEEEECCCC
KLTLVTTEKDYFRMLGQPELQEILHTLSCCYLKIRPEFTEGEKLLKTMLNAVINR
EEEEEECCHHHHHHCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFDLPDIILRPASLLYKNIIRIRNRLYDQQIFHTWHSPLPIVSIGNISAGGTGKTPLVD
CCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHH
WIVKYYLSLGCKPAIVSRGYGRNTKGVQLVSDGKTVLMKSNACGDETAMLAWNNRDAIVI
HHHHHHHHCCCCHHHHCCCCCCCCCCEEEEECCCEEEEECCCCCCCEEEEEECCCCEEEE
VAEKRKDAVTFIIRRFAEAMPDVIILDDAFQHRQIARNLDIVVINEKEPYFRADMIPKGR
EECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCEEEECCCCCCEEECCCCCCC
LREPLINLARADLLVLSKITGGSTTAAISMDLEQTGKPVIKAGIAAGNLVCLSGMFNTAK
HHHHHHHHHHHHHHEEEECCCCCCEEEEEECHHHCCCHHHHHCCCCCCEEEEECCHHCCC
ESPVHAGIKALAFAGIGSPQSFIDTLEGQGIQIVSHRFFRDHESYTAKKIAALRLEADEK
CCCHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHEEEEECCCC
KLTLVTTEKDYFRMLGQPELQEILHTLSCCYLKIRPEFTEGEKLLKTMLNAVINR
EEEEEECCHHHHHHCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA