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The map label for this gene is gmk [H]

Identifier: 119356214

GI number: 119356214

Start: 418378

End: 418962

Strand: Direct

Name: gmk [H]

Synonym: Cpha266_0375

Alternate gene names: 119356214

Gene position: 418378-418962 (Clockwise)

Preceding gene: 119356213

Following gene: 119356215

Centisome position: 13.35

GC content: 43.59

Gene sequence:

>585_bases
ATGACGATCAGCAGAGGGCCGACGGGAAAGCTCGTGGTTTTTTCAGCTCCGTCGGGAACAGGAAAGTCAACGATTGCGAA
AATTGTTCTTGAACGAATTCCTTCGCTCGCTTTTTCCGTATCGGCAACAACAAGACCGATGCGTGCTGGTGAGGAGGAAG
GGGTTCATTATTATTTTCTTGATAAAAAGAAGTTTGAAGAGAAGATTCGTGACGGCGGGTTTATAGAGCATGAATATTTT
TTCAATAACTACTATGGCACATTGCTCGATAAAACGGTTGATGCGGTTAATTCGGGCCATCATCTGCTTTTTGATCTCGA
CGTCAAGGGTGCTTTGAATCTGAAAACTCTTTTTCCTCTTAATTCATTATTGATATTTATAAGGCCTCCTGATATGGCAA
CTCTCAGAGAGAGATTGTTAAAGCGGGAAAGCGAAGATGCGGATGCATTGAATGTTCGTCTTGAGCGGGCTGAACTTGAA
CTTGGTTATGTTGATCAGTTCGATGAGGTGATTGTTAATGATTGTCTCGACCGGGCGGCCGATGCCGTTACGGCGAAAGT
AAGTGAGTTTCTTTCAAACACGTAA

Upstream 100 bases:

>100_bases
GCGTCAAAATCCCAGAGCGCCGAAATCTCACAGAAAATTGTTCATGTAAAAGAAGAGCTTGAGAAAATTCGGGAACAGTT
ACAAAATATCGAGTGATTTT

Downstream 100 bases:

>100_bases
ATACTTGTGCCATGTCGGTTAATCCTGTTGATCTCAACAAGCTGAGAAGTGCGCACGCTAATTTGTACGAGACGGTGGTT
GCGATTTCAAAACGAGCGAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MTISRGPTGKLVVFSAPSGTGKSTIAKIVLERIPSLAFSVSATTRPMRAGEEEGVHYYFLDKKKFEEKIRDGGFIEHEYF
FNNYYGTLLDKTVDAVNSGHHLLFDLDVKGALNLKTLFPLNSLLIFIRPPDMATLRERLLKRESEDADALNVRLERAELE
LGYVDQFDEVIVNDCLDRAADAVTAKVSEFLSNT

Sequences:

>Translated_194_residues
MTISRGPTGKLVVFSAPSGTGKSTIAKIVLERIPSLAFSVSATTRPMRAGEEEGVHYYFLDKKKFEEKIRDGGFIEHEYF
FNNYYGTLLDKTVDAVNSGHHLLFDLDVKGALNLKTLFPLNSLLIFIRPPDMATLRERLLKRESEDADALNVRLERAELE
LGYVDQFDEVIVNDCLDRAADAVTAKVSEFLSNT
>Mature_193_residues
TISRGPTGKLVVFSAPSGTGKSTIAKIVLERIPSLAFSVSATTRPMRAGEEEGVHYYFLDKKKFEEKIRDGGFIEHEYFF
NNYYGTLLDKTVDAVNSGHHLLFDLDVKGALNLKTLFPLNSLLIFIRPPDMATLRERLLKRESEDADALNVRLERAELEL
GYVDQFDEVIVNDCLDRAADAVTAKVSEFLSNT

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=190, Percent_Identity=37.8947368421053, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4504221, Length=190, Percent_Identity=37.8947368421053, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI226874831, Length=190, Percent_Identity=37.8947368421053, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI111154074, Length=163, Percent_Identity=29.4478527607362, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21361598, Length=192, Percent_Identity=25, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI14780902, Length=200, Percent_Identity=26.5, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI52630447, Length=178, Percent_Identity=25.8426966292135, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=173, Percent_Identity=35.8381502890173, Blast_Score=110, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=173, Percent_Identity=42.7745664739884, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193203132, Length=173, Percent_Identity=42.7745664739884, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71984092, Length=185, Percent_Identity=31.3513513513514, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320662, Length=171, Percent_Identity=40.9356725146199, Blast_Score=128, Evalue=6e-31,
Organism=Drosophila melanogaster, GI21356141, Length=178, Percent_Identity=38.7640449438202, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45551002, Length=128, Percent_Identity=30.46875, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI85816106, Length=128, Percent_Identity=30.46875, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI85816281, Length=128, Percent_Identity=30.46875, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI161077626, Length=191, Percent_Identity=25.130890052356, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640542, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554481, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85724806, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554489, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007136, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330166, Length=145, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330162, Length=145, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330164, Length=145, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21750; Mature: 21619

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISRGPTGKLVVFSAPSGTGKSTIAKIVLERIPSLAFSVSATTRPMRAGEEEGVHYYFL
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCEEEEEE
DKKKFEEKIRDGGFIEHEYFFNNYYGTLLDKTVDAVNSGHHLLFDLDVKGALNLKTLFPL
CHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCC
NSLLIFIRPPDMATLRERLLKRESEDADALNVRLERAELELGYVDQFDEVIVNDCLDRAA
CCEEEEECCCCHHHHHHHHHHCCCCCCCHHHEEEEEHHEEECCHHHHHHHHHHHHHHHHH
DAVTAKVSEFLSNT
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TISRGPTGKLVVFSAPSGTGKSTIAKIVLERIPSLAFSVSATTRPMRAGEEEGVHYYFL
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCEEEEEE
DKKKFEEKIRDGGFIEHEYFFNNYYGTLLDKTVDAVNSGHHLLFDLDVKGALNLKTLFPL
CHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCC
NSLLIFIRPPDMATLRERLLKRESEDADALNVRLERAELELGYVDQFDEVIVNDCLDRAA
CCEEEEECCCCHHHHHHHHHHCCCCCCCHHHEEEEEHHEEECCHHHHHHHHHHHHHHHHH
DAVTAKVSEFLSNT
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA