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The map label for this gene is guaA

Identifier: 119356142

GI number: 119356142

Start: 331874

End: 333415

Strand: Reverse

Name: guaA

Synonym: Cpha266_0300

Alternate gene names: 119356142

Gene position: 333415-331874 (Counterclockwise)

Preceding gene: 119356143

Following gene: 119356140

Centisome position: 10.64

GC content: 51.56

Gene sequence:

>1542_bases
ATGCAATCGGTAACCGTTCTTGACTTTGGATCTCAATATACCCAGCTTATCGCCCGACGTATCCGCGAACTGGGTATCTA
TTCGGAAATACTGCCGTACAATGCCTCTCCTGAAACCATTCGGGAACATGACCCGAAAGCAATTATCCTCTCGGGAGGCC
CGACAAGCGTCTATGGCGATTCTGCCCTTTTACCTGACGGTGGAGTATTCATGCTGGGAGTACCGGTTCTCGGGATCTGC
TATGGTCTGCAGGCCATAGCAAAACATTTCGGAGGGGAGGTTGCCGGCTCTTCTAAACAGGAGTTTGGCAGGGCTAAAAT
GCTGGTCAGTCATAACGAAGAGTCTGAAAGCCCGCTTTTTCGAAACATTCCTGATTCGGATGTCTGGATGAGCCACGGAG
ACAAGGTGGTCAGACTCCCTGAAGGGTTCAGGGTCACCGCAAGCAGCGAAAACTCGGAAATGTGCGCTCTTGAAAGTTAT
GGGTCAAAAGCCGCTCTCAAGGTTTATGGTCTCCAGTTCCATCCTGAAGTACAGCATACCCTTTATGGCAAACAACTGCT
CTCCAACTTTCTCATCGATATTGCTGGCATTAAACCCGATTGGTCGCCGAAAAGCTTTATCGGTCACCAGATTGAGGAAA
TCAGGGCTCGCGCCGGAAAAGACAAGGTGATTTGCGGCATCAGCGGCGGCGTTGACTCAACAGTCGCAGCAGTGCTTGTA
AGCCAGGCTATAGGAAAACAGCTGCACTGCGTTTTTGTTGATAACGGGCTGCTTCGTAAAAATGAAGCGGTCAAAGTGAT
GAATTTTCTCAAACCACTCGGCCTCTCCGTCACCCTTGCCGATGCCTCGGATCTGTTTCTCAAAAGACTTGATAAGGTGG
CCTCTCCGGAAAAAAAGAGAAAGATTATCGGCAGAACCTTCATTCATGTATTCGAACAGCATCTGAACGAGGAGAAATAT
CTTGTTCAGGGCACGCTCTATCCCGATGTCATTGAGAGCGTCAGCGTCAAGGGTCCTTCAGAAACCATCAAGTCGCACCA
TAACGTTGGCGGCCTGCCGAAGCGCATGAAACTGAAACTCATAGAACCGCTCCGGGAGCTTTTCAAGGACGAGGTACGGG
CTGTGGGTCGTGAACTTGGTATTGCTGAAGATATTCTCATGCGCCACCCGTTCCCCGGTCCGGGTCTTGCCGTCAGGGTG
CTGGGCTCGGTAAGTCGCCCAAGGCTTGACATCCTTCGCGAGGCTGATGAAATTTTCATTGAGGAGCTTAAAACCAGCGG
CCTTTACCAGCATGTCTGGCAGGCGTTTTCAGTGCTTCTACCGGTACAGTCTGTCGGCGTCATGGGAGACAAGCGGACGT
ATGAAAATGTTCTGGCACTTCGGGCTGTTGAATCAACGGATGGCATGACCGCCGACTGGGCGCAACTGCCTCACGATTTC
CTCGCACGTGTCTCGAACCGCATCATCAACGAAGTTCGCGGCATCAACCGGGTTGCCTACGATATTTCCTCCAAACCGCC
AGCGACCATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
CCGACTGAAGGCGATCTCGAACCGGCCCCACAACCGGCAGAGACTCCCGCACAGGAAGGGGCGTTTTGATACTTTCTCAA
TTAACAAACTGTTTTTTACC

Downstream 100 bases:

>100_bases
TGGTTCCGCCCGGTATTTTTCCAGGGCTGACCTTTCATAACAGGCCGGTTTTCGATTCTGCATGAAGAGGAGCGGGCATA
CCGTGAGGCATGCCCGGCCT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQSVTVLDFGSQYTQLIARRIRELGIYSEILPYNASPETIREHDPKAIILSGGPTSVYGDSALLPDGGVFMLGVPVLGIC
YGLQAIAKHFGGEVAGSSKQEFGRAKMLVSHNEESESPLFRNIPDSDVWMSHGDKVVRLPEGFRVTASSENSEMCALESY
GSKAALKVYGLQFHPEVQHTLYGKQLLSNFLIDIAGIKPDWSPKSFIGHQIEEIRARAGKDKVICGISGGVDSTVAAVLV
SQAIGKQLHCVFVDNGLLRKNEAVKVMNFLKPLGLSVTLADASDLFLKRLDKVASPEKKRKIIGRTFIHVFEQHLNEEKY
LVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRV
LGSVSRPRLDILREADEIFIEELKTSGLYQHVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAQLPHDF
LARVSNRIINEVRGINRVAYDISSKPPATIEWE

Sequences:

>Translated_513_residues
MQSVTVLDFGSQYTQLIARRIRELGIYSEILPYNASPETIREHDPKAIILSGGPTSVYGDSALLPDGGVFMLGVPVLGIC
YGLQAIAKHFGGEVAGSSKQEFGRAKMLVSHNEESESPLFRNIPDSDVWMSHGDKVVRLPEGFRVTASSENSEMCALESY
GSKAALKVYGLQFHPEVQHTLYGKQLLSNFLIDIAGIKPDWSPKSFIGHQIEEIRARAGKDKVICGISGGVDSTVAAVLV
SQAIGKQLHCVFVDNGLLRKNEAVKVMNFLKPLGLSVTLADASDLFLKRLDKVASPEKKRKIIGRTFIHVFEQHLNEEKY
LVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRV
LGSVSRPRLDILREADEIFIEELKTSGLYQHVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAQLPHDF
LARVSNRIINEVRGINRVAYDISSKPPATIEWE
>Mature_513_residues
MQSVTVLDFGSQYTQLIARRIRELGIYSEILPYNASPETIREHDPKAIILSGGPTSVYGDSALLPDGGVFMLGVPVLGIC
YGLQAIAKHFGGEVAGSSKQEFGRAKMLVSHNEESESPLFRNIPDSDVWMSHGDKVVRLPEGFRVTASSENSEMCALESY
GSKAALKVYGLQFHPEVQHTLYGKQLLSNFLIDIAGIKPDWSPKSFIGHQIEEIRARAGKDKVICGISGGVDSTVAAVLV
SQAIGKQLHCVFVDNGLLRKNEAVKVMNFLKPLGLSVTLADASDLFLKRLDKVASPEKKRKIIGRTFIHVFEQHLNEEKY
LVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRV
LGSVSRPRLDILREADEIFIEELKTSGLYQHVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAQLPHDF
LARVSNRIINEVRGINRVAYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=560, Percent_Identity=38.5714285714286, Blast_Score=318, Evalue=7e-87,
Organism=Escherichia coli, GI1788854, Length=524, Percent_Identity=53.6259541984733, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1789760, Length=202, Percent_Identity=29.7029702970297, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=577, Percent_Identity=34.315424610052, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71992717, Length=577, Percent_Identity=34.315424610052, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=577, Percent_Identity=34.315424610052, Blast_Score=278, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=525, Percent_Identity=53.5238095238095, Blast_Score=555, Evalue=1e-159,
Organism=Drosophila melanogaster, GI281365319, Length=552, Percent_Identity=36.231884057971, Blast_Score=304, Evalue=9e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CHLPD (A1BD85)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_910786.1
- ProteinModelPortal:   A1BD85
- SMR:   A1BD85
- STRING:   A1BD85
- GeneID:   4570790
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0300
- NMPDR:   fig|290317.7.peg.306
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 56683; Mature: 56683

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 80-80 ACT_SITE 174-174 ACT_SITE 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSVTVLDFGSQYTQLIARRIRELGIYSEILPYNASPETIREHDPKAIILSGGPTSVYGD
CCCEEEEECCHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHCCCCEEEECCCCCCCCCC
SALLPDGGVFMLGVPVLGICYGLQAIAKHFGGEVAGSSKQEFGRAKMLVSHNEESESPLF
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCCCCC
RNIPDSDVWMSHGDKVVRLPEGFRVTASSENSEMCALESYGSKAALKVYGLQFHPEVQHT
CCCCCCCHHHCCCCEEEECCCCCEEEECCCCCCEEEHHHCCCCEEEEEEEEEECCCHHHH
LYGKQLLSNFLIDIAGIKPDWSPKSFIGHQIEEIRARAGKDKVICGISGGVDSTVAAVLV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
SQAIGKQLHCVFVDNGLLRKNEAVKVMNFLKPLGLSVTLADASDLFLKRLDKVASPEKKR
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCHHHH
KIIGRTFIHVFEQHLNEEKYLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKL
HHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHH
IEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRVLGSVSRPRLDILREADEIFI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
EELKTSGLYQHVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAQLPHDF
HHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCHHHHCCHHH
LARVSNRIINEVRGINRVAYDISSKPPATIEWE
HHHHHHHHHHHHHHHHHHEEECCCCCCCEECCC
>Mature Secondary Structure
MQSVTVLDFGSQYTQLIARRIRELGIYSEILPYNASPETIREHDPKAIILSGGPTSVYGD
CCCEEEEECCHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHCCCCEEEECCCCCCCCCC
SALLPDGGVFMLGVPVLGICYGLQAIAKHFGGEVAGSSKQEFGRAKMLVSHNEESESPLF
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCCCCC
RNIPDSDVWMSHGDKVVRLPEGFRVTASSENSEMCALESYGSKAALKVYGLQFHPEVQHT
CCCCCCCHHHCCCCEEEECCCCCEEEECCCCCCEEEHHHCCCCEEEEEEEEEECCCHHHH
LYGKQLLSNFLIDIAGIKPDWSPKSFIGHQIEEIRARAGKDKVICGISGGVDSTVAAVLV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
SQAIGKQLHCVFVDNGLLRKNEAVKVMNFLKPLGLSVTLADASDLFLKRLDKVASPEKKR
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCHHHH
KIIGRTFIHVFEQHLNEEKYLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKL
HHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHH
IEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRVLGSVSRPRLDILREADEIFI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
EELKTSGLYQHVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAQLPHDF
HHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCHHHHCCHHH
LARVSNRIINEVRGINRVAYDISSKPPATIEWE
HHHHHHHHHHHHHHHHHHEEECCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA