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The map label for this gene is accC [H]

Identifier: 119356082

GI number: 119356082

Start: 265212

End: 266558

Strand: Reverse

Name: accC [H]

Synonym: Cpha266_0235

Alternate gene names: 119356082

Gene position: 266558-265212 (Counterclockwise)

Preceding gene: 119356083

Following gene: 119356069

Centisome position: 8.51

GC content: 49.96

Gene sequence:

>1347_bases
TTGTTCAAGAAAATACTTGTCGCGAACCGCGGTGAAATTGCATTGCGCATCATGCAAACATGCCGCGAAATGGGAATCAG
TACGGTAGCCGTTTACTCTACCGCTGATGCAGAATCCATCCATGTCAAATATGCCGACGAGGCTGTCTGCATCGGGCCAG
CACTCTCAAGGGAGAGCTATCTGAACATCCCTCGCATCATTGCCGCTGCCGAAGTTACCAATGCTGACGCCATTCATCCC
GGATATGGATTTCTTGCCGAAAATGCCGACTTTGCTGAAGTTTGCTCTTCGGTGAACATCAAGTTTATCGGCCCTACGGC
TAAAATGATCAATCAGATGGGCGACAAGAACACGGCCAAAGCAACGATGATTGCTGCGGGAGTTCCTGTTGTTCCCGGAA
GCCAGGGTCTGGTATCCAATCTTGCAGAAGCTGTTAAAACAGCTCAGAATACCGGCTATCCCGTTATAATAAAACCTACT
GCCGGCGGCGGTGGAAAAGGAATGCGTGTCGTTCATGAGGAAAACCAGCTCGAAAAAGCTCTGAACACCGCCCGGAGCGA
GGCTGAACAGGCATTTGGCAACAGCGGCGTCTATATTGAAAAATTCCTTGAGAATCCCCGCCATGTTGAAATTCAGATTC
TTTCTGATCAGCACGGCAATACCATACACCTTGGCGAACGCGATTGTACGGTTCAGAGAAGGCACCAGAAACTGATTGAG
GAGACGCCGTCGCCGGCCGTTGACGACGCGTTAAGAAAAACCATGGGCGATGCCGCTGTTGCCGCAGCAGCCGCAATCAA
TTATGAAGGTGCCGGAACCATTGAGTTTCTGCTTGACAAGCACGGAAAGTTCTTCTTTATGGAGATGAATACAAGAATTC
AGGTAGAACATCCCGTTACGGAAGAGCGCTATGACGTCGATATTGTTCGTGAACAAATTATCATTGCTGACGGCCAGTCC
ATTGCGGGCCGCACCTTCACGCCAAAAGGCCACTCGATCGAGTGCCGCATCAACGCAGAAGACCCGGATCATCTTTTCCG
CCCCTCACCAGGACAACTCCAGGTATTTCATACTCCCGGAGGTCACGGAGTACGAGTCGACTCTCATGCGTACGCGAGTT
ATGTCGTACCCTCCAACTACGATTCGATGATCGCTAAACTTATCGTCACGGCTCATACAAGAGATGAAGCAATCGCAAGA
ATGTCGCGTGCGCTTGATGAGTTTATCGTGCTTGGCGTCAAAACCACCATACCCTTCCACAAGCAGGTTATGCACTCTGC
TGTTTTTCAGAGCGGCGTGTTCGATACGAGCTTCCTCGAATCTTTTCGATACGAAAAAAGTATTTGA

Upstream 100 bases:

>100_bases
TCTGGCACTATCGTGGAAATTCTTGTTGAAAACGGACATCCGGTCGAATACGATCAGCCGCTGTTCCGCATCAAACCATA
ATCACTCATCGTCATACACC

Downstream 100 bases:

>100_bases
TAAAAACTGAAGCGGTCAACCACAACGGGTTACCTTCTGAAGGGTGCCCCTTGTGATCGACCGTCTGAGTCCGGGTATTG
TTTTTTCCATCCGATCGGCT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFKKILVANRGEIALRIMQTCREMGISTVAVYSTADAESIHVKYADEAVCIGPALSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCSSVNIKFIGPTAKMINQMGDKNTAKATMIAAGVPVVPGSQGLVSNLAEAVKTAQNTGYPVIIKPT
AGGGGKGMRVVHEENQLEKALNTARSEAEQAFGNSGVYIEKFLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
ETPSPAVDDALRKTMGDAAVAAAAAINYEGAGTIEFLLDKHGKFFFMEMNTRIQVEHPVTEERYDVDIVREQIIIADGQS
IAGRTFTPKGHSIECRINAEDPDHLFRPSPGQLQVFHTPGGHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIAR
MSRALDEFIVLGVKTTIPFHKQVMHSAVFQSGVFDTSFLESFRYEKSI

Sequences:

>Translated_448_residues
MFKKILVANRGEIALRIMQTCREMGISTVAVYSTADAESIHVKYADEAVCIGPALSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCSSVNIKFIGPTAKMINQMGDKNTAKATMIAAGVPVVPGSQGLVSNLAEAVKTAQNTGYPVIIKPT
AGGGGKGMRVVHEENQLEKALNTARSEAEQAFGNSGVYIEKFLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
ETPSPAVDDALRKTMGDAAVAAAAAINYEGAGTIEFLLDKHGKFFFMEMNTRIQVEHPVTEERYDVDIVREQIIIADGQS
IAGRTFTPKGHSIECRINAEDPDHLFRPSPGQLQVFHTPGGHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIAR
MSRALDEFIVLGVKTTIPFHKQVMHSAVFQSGVFDTSFLESFRYEKSI
>Mature_448_residues
MFKKILVANRGEIALRIMQTCREMGISTVAVYSTADAESIHVKYADEAVCIGPALSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCSSVNIKFIGPTAKMINQMGDKNTAKATMIAAGVPVVPGSQGLVSNLAEAVKTAQNTGYPVIIKPT
AGGGGKGMRVVHEENQLEKALNTARSEAEQAFGNSGVYIEKFLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
ETPSPAVDDALRKTMGDAAVAAAAAINYEGAGTIEFLLDKHGKFFFMEMNTRIQVEHPVTEERYDVDIVREQIIIADGQS
IAGRTFTPKGHSIECRINAEDPDHLFRPSPGQLQVFHTPGGHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIAR
MSRALDEFIVLGVKTTIPFHKQVMHSAVFQSGVFDTSFLESFRYEKSI

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=47.1910112359551, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=47.1910112359551, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=47.1910112359551, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=47.380410022779, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=46.8325791855204, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=46.8325791855204, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=46.8325791855204, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=29.5275590551181, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=29.5275590551181, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=29.5275590551181, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=29.5275590551181, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=29.5275590551181, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=29.0766208251473, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=54.954954954955, Blast_Score=462, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71987519, Length=446, Percent_Identity=46.6367713004484, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17562816, Length=457, Percent_Identity=43.9824945295405, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=44.7963800904977, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=29.9595141700405, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=28.6836935166994, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=28.6836935166994, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=450, Percent_Identity=43.1111111111111, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=43.9461883408072, Blast_Score=352, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=44.3946188340807, Blast_Score=346, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6323863, Length=484, Percent_Identity=30.1652892561983, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324343, Length=515, Percent_Identity=28.9320388349515, Blast_Score=207, Evalue=4e-54,
Organism=Drosophila melanogaster, GI281363050, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=457, Percent_Identity=45.0765864332604, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=44.8979591836735, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=43.9506172839506, Blast_Score=344, Evalue=6e-95,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=28.8270377733598, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=28.8270377733598, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=28.8270377733598, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=28.8270377733598, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48939; Mature: 48939

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILVANRGEIALRIMQTCREMGISTVAVYSTADAESIHVKYADEAVCIGPALSRESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNIPRIIAAAEVTNADAIHPGYGFLAENADFAEVCSSVNIKFIGPTAKMINQMGDKNTAK
CCCCHHEEEHHCCCCCCCCCCCCEEECCCCHHHHHCCCCEEEECCHHHHHHHHCCCCCCC
ATMIAAGVPVVPGSQGLVSNLAEAVKTAQNTGYPVIIKPTAGGGGKGMRVVHEENQLEKA
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEHHHHHHHH
LNTARSEAEQAFGNSGVYIEKFLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
HHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPAVDDALRKTMGDAAVAAAAAINYEGAGTIEFLLDKHGKFFFMEMNTRIQVEHPVT
HCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCEEEEECCCC
EERYDVDIVREQIIIADGQSIAGRTFTPKGHSIECRINAEDPDHLFRPSPGQLQVFHTPG
CCCCCHHEEEEEEEEECCCCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCC
GHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIARMSRALDEFIVLGVKTTIPFH
CCCEEECCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCHH
KQVMHSAVFQSGVFDTSFLESFRYEKSI
HHHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFKKILVANRGEIALRIMQTCREMGISTVAVYSTADAESIHVKYADEAVCIGPALSRESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNIPRIIAAAEVTNADAIHPGYGFLAENADFAEVCSSVNIKFIGPTAKMINQMGDKNTAK
CCCCHHEEEHHCCCCCCCCCCCCEEECCCCHHHHHCCCCEEEECCHHHHHHHHCCCCCCC
ATMIAAGVPVVPGSQGLVSNLAEAVKTAQNTGYPVIIKPTAGGGGKGMRVVHEENQLEKA
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEHHHHHHHH
LNTARSEAEQAFGNSGVYIEKFLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
HHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPAVDDALRKTMGDAAVAAAAAINYEGAGTIEFLLDKHGKFFFMEMNTRIQVEHPVT
HCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCEEEEECCCC
EERYDVDIVREQIIIADGQSIAGRTFTPKGHSIECRINAEDPDHLFRPSPGQLQVFHTPG
CCCCCHHEEEEEEEEECCCCCCCCEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCC
GHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIARMSRALDEFIVLGVKTTIPFH
CCCEEECCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCHH
KQVMHSAVFQSGVFDTSFLESFRYEKSI
HHHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]