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The map label for this gene is gloB [H]

Identifier: 119356026

GI number: 119356026

Start: 204591

End: 205232

Strand: Reverse

Name: gloB [H]

Synonym: Cpha266_0179

Alternate gene names: 119356026

Gene position: 205232-204591 (Counterclockwise)

Preceding gene: 119356027

Following gene: 119356025

Centisome position: 6.55

GC content: 51.4

Gene sequence:

>642_bases
ATGATCATCAAACAATTCCGAACGGGCGGCGACAGAAACTTAGGCTACCTTGCCGCTGACGAAGTTTCCGGTGACGCTCT
GGTCGTTGACGCATCCTATAATCCAGGCATGATATACAATTTTGCCTGTGAACACGGATTGACGATTCGATACCTCTTTT
CAACACATGGCCACAGCGATCATACCAACGGAAACGCCACGACAAGTCAACTAACCGGCCTCAAACCCCTTCTCTATGGC
GACACGTGCCCTGAAACGGGAATCAGTGTTCGCGCCGGAGCACGATTCCCGCTTGGCTCCGGGAGCGTGCTGATCATACA
TACCCCGGGCCACACCGAAGACTCGATCTGCCTGCATGTCGGAGACGCACTCTTTACCGGCGACACGCTTTTCACCGGAA
AAGTAGGAGGAACCATGACCGCGGAACAGGCTCTTGCGGAATACGATTCACTGCGCAACAAGCTCATGCGCCTGCCTGAC
GAAACAAGAGTTTTTCCGGGACACGATTATGGAAGTTCACCGGCATCAACCATTGCAGAAGAAAAAAAGTCCAATCCGTT
CCTTCTGCAGCCCGATTTCAGATCATTTCTTGCACTCAAACAGAACTGGGCTGCATATAAAAAAGAGCATGGCATAGCAT
AA

Upstream 100 bases:

>100_bases
TGAAAAAAACCCGATTGCCGTTGACAAGGATTTTCCTGCCAGAGCATTTCTTATGCATGTAGAAAAAACAGCCTGACCGT
TTTACCGGAGCAAAAAAATC

Downstream 100 bases:

>100_bases
GGGGGATAGCGATGTTGCGAAATTATATTTTTTTTTACTAAATTGATTTTTTGTACCCTTCGGGTGATTGAGAGGGCATT
CCTGCCTTGTCCAGCTTTCA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MIIKQFRTGGDRNLGYLAADEVSGDALVVDASYNPGMIYNFACEHGLTIRYLFSTHGHSDHTNGNATTSQLTGLKPLLYG
DTCPETGISVRAGARFPLGSGSVLIIHTPGHTEDSICLHVGDALFTGDTLFTGKVGGTMTAEQALAEYDSLRNKLMRLPD
ETRVFPGHDYGSSPASTIAEEKKSNPFLLQPDFRSFLALKQNWAAYKKEHGIA

Sequences:

>Translated_213_residues
MIIKQFRTGGDRNLGYLAADEVSGDALVVDASYNPGMIYNFACEHGLTIRYLFSTHGHSDHTNGNATTSQLTGLKPLLYG
DTCPETGISVRAGARFPLGSGSVLIIHTPGHTEDSICLHVGDALFTGDTLFTGKVGGTMTAEQALAEYDSLRNKLMRLPD
ETRVFPGHDYGSSPASTIAEEKKSNPFLLQPDFRSFLALKQNWAAYKKEHGIA
>Mature_213_residues
MIIKQFRTGGDRNLGYLAADEVSGDALVVDASYNPGMIYNFACEHGLTIRYLFSTHGHSDHTNGNATTSQLTGLKPLLYG
DTCPETGISVRAGARFPLGSGSVLIIHTPGHTEDSICLHVGDALFTGDTLFTGKVGGTMTAEQALAEYDSLRNKLMRLPD
ETRVFPGHDYGSSPASTIAEEKKSNPFLLQPDFRSFLALKQNWAAYKKEHGIA

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI94538320, Length=170, Percent_Identity=33.5294117647059, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI94538322, Length=170, Percent_Identity=33.5294117647059, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI41327741, Length=204, Percent_Identity=29.9019607843137, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538952, Length=219, Percent_Identity=26.4840182648402, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320478, Length=187, Percent_Identity=28.8770053475936, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221330176, Length=210, Percent_Identity=27.6190476190476, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356335, Length=219, Percent_Identity=31.9634703196347, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24667703, Length=219, Percent_Identity=31.5068493150685, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24667711, Length=219, Percent_Identity=31.9634703196347, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 23053; Mature: 23053

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKQFRTGGDRNLGYLAADEVSGDALVVDASYNPGMIYNFACEHGLTIRYLFSTHGHSD
CCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCC
HTNGNATTSQLTGLKPLLYGDTCPETGISVRAGARFPLGSGSVLIIHTPGHTEDSICLHV
CCCCCCCHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEEE
GDALFTGDTLFTGKVGGTMTAEQALAEYDSLRNKLMRLPDETRVFPGHDYGSSPASTIAE
CCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCHHHHHHH
EKKSNPFLLQPDFRSFLALKQNWAAYKKEHGIA
HHCCCCEEECCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIIKQFRTGGDRNLGYLAADEVSGDALVVDASYNPGMIYNFACEHGLTIRYLFSTHGHSD
CCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCC
HTNGNATTSQLTGLKPLLYGDTCPETGISVRAGARFPLGSGSVLIIHTPGHTEDSICLHV
CCCCCCCHHHHCCCCCEEECCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEEE
GDALFTGDTLFTGKVGGTMTAEQALAEYDSLRNKLMRLPDETRVFPGHDYGSSPASTIAE
CCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCHHHHHHH
EKKSNPFLLQPDFRSFLALKQNWAAYKKEHGIA
HHCCCCEEECCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA