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The map label for this gene is cysG [H]

Identifier: 119355992

GI number: 119355992

Start: 161397

End: 162785

Strand: Direct

Name: cysG [H]

Synonym: Cpha266_0142

Alternate gene names: 119355992

Gene position: 161397-162785 (Clockwise)

Preceding gene: 119355991

Following gene: 119355993

Centisome position: 5.15

GC content: 50.25

Gene sequence:

>1389_bases
ATGACAAAGAGCGACCATAGCCAAAGAGTTGACGTTTCTGAAAAAGGGTATGTTTATATCATCGGCGCAGGGCCTGGCGA
TCCTGAACTGCTGACCATAAAGGCTGAACGCGCCCTCCAGGAGGCCGACGTGCTTCTCTATGACGACCTGGTGTCGGGCG
AACTTGTTGATCAGTTTCAAGGCATTAAAATCTATACGGGAAAACGCAAAGACAGCCATCATTTCGAGCAGGATGAGATC
AACAGCGAAATCGTCCGCCACGCACTGATGGGCAAAAAAGTGGCGAGGCTGAAAGGGGGCGATCCATTTGTTTTCGGGCG
CGGGGGTGAAGAGATCGAGGTGCTCAGAAAAAACGGTATCAGGTATGAAATCATTCCCGGTATCACGGCAGCTTACGGCG
CGAGCGCCTATACCGAAATACCGCTGACCATGAGAAAAATATCCTCGTCGGTGGCGTTCTGTACGGGACATCCGGTCAAC
AAGATTCAGGTTCCTGACGCAGACACGCTGGTATACTATATGGTGGCCTCAACCGTTCACGATGTTCTTGATGCCGTTGT
CAGCAAGGGACGAAGCGAGAATACGAAAGTTGCCATTGTCCAGAACGCGACCAGGTACAATCAGAAAATTTTTACCGGAA
CGCTGGGTGAGTTACGGCGTCGTGAAAAAGCGGTCTACTCGCCCGCACTCCTGATTATCGGCGACAATATCAACCAGTTT
ATCGAGAAGAACTGGTTCTCCGGTAAAAGGAAGGTGCTGCTGACCGGAGGGGATGCAAAGCGATACAATGCAATGGAGCA
TATCATGGTGCATTTTCCCTGCCGGCAGGTCGATGGCGCCGACAGAGAAAGGGTAAAAGAGTATTTTGACGATTTCAGTC
CCTACAGCACCCTGCTTTTTACCAGCAAGTTTTCGGTGAAATATTTCTTTGCCTCATTATTCGAGTATGGCAAGGATGTT
CGCCATCTTGCAGCGGCGACCATCTGCGCAACGGGAAAAGCCGCGGCTCTTGAATTGCAGAAACATGGCGTGATCCCCGA
TTTGTTTTTCGAACCCGACGGTTGCGCCGATATCGTTACCATGTTCAGGGAACGCGGCATGACCGATGAGCATATTCTGC
TTCCCGGTTCAAATCTCGTTGATGAGTATCTTGTTCGTGAACTGACAACGCTTCGTAACAGGGTAACCCCGCTCTGTGTC
TATATGCACGAAGCACAGGAGCATGCTGAGAGCATCGATCTTGCGTTCATTGACGAGATCTATTTCGCCTCTCCGTCGTG
CGTGAACAATTTCAGAACGCTCTACAGCAGCATTCCTGAAAATATAACGGTTACAGCGGCCGATACAAGAACCGAAAAGG
AGTACAGAAGCCTGTTTGGCGAATCGTAA

Upstream 100 bases:

>100_bases
AGAACGCAAAAAAATCGGTTGAGTGGCGCAACAGAATAAAAGCCATGCTGCAAGAGAGTTGACAAGGCGGAATTAGTATT
AACGAACGAGGATTTCATTC

Downstream 100 bases:

>100_bases
CGGATGGATTTGGTGAACCAGATGCCGAATGAAGCGATCGAAGGCGGTTTTTAAATTCTCAAACAGTGATCCCATGAAAA
TAGCTGTCAGTGGAAAAGGG

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTKSDHSQRVDVSEKGYVYIIGAGPGDPELLTIKAERALQEADVLLYDDLVSGELVDQFQGIKIYTGKRKDSHHFEQDEI
NSEIVRHALMGKKVARLKGGDPFVFGRGGEEIEVLRKNGIRYEIIPGITAAYGASAYTEIPLTMRKISSSVAFCTGHPVN
KIQVPDADTLVYYMVASTVHDVLDAVVSKGRSENTKVAIVQNATRYNQKIFTGTLGELRRREKAVYSPALLIIGDNINQF
IEKNWFSGKRKVLLTGGDAKRYNAMEHIMVHFPCRQVDGADRERVKEYFDDFSPYSTLLFTSKFSVKYFFASLFEYGKDV
RHLAAATICATGKAAALELQKHGVIPDLFFEPDGCADIVTMFRERGMTDEHILLPGSNLVDEYLVRELTTLRNRVTPLCV
YMHEAQEHAESIDLAFIDEIYFASPSCVNNFRTLYSSIPENITVTAADTRTEKEYRSLFGES

Sequences:

>Translated_462_residues
MTKSDHSQRVDVSEKGYVYIIGAGPGDPELLTIKAERALQEADVLLYDDLVSGELVDQFQGIKIYTGKRKDSHHFEQDEI
NSEIVRHALMGKKVARLKGGDPFVFGRGGEEIEVLRKNGIRYEIIPGITAAYGASAYTEIPLTMRKISSSVAFCTGHPVN
KIQVPDADTLVYYMVASTVHDVLDAVVSKGRSENTKVAIVQNATRYNQKIFTGTLGELRRREKAVYSPALLIIGDNINQF
IEKNWFSGKRKVLLTGGDAKRYNAMEHIMVHFPCRQVDGADRERVKEYFDDFSPYSTLLFTSKFSVKYFFASLFEYGKDV
RHLAAATICATGKAAALELQKHGVIPDLFFEPDGCADIVTMFRERGMTDEHILLPGSNLVDEYLVRELTTLRNRVTPLCV
YMHEAQEHAESIDLAFIDEIYFASPSCVNNFRTLYSSIPENITVTAADTRTEKEYRSLFGES
>Mature_461_residues
TKSDHSQRVDVSEKGYVYIIGAGPGDPELLTIKAERALQEADVLLYDDLVSGELVDQFQGIKIYTGKRKDSHHFEQDEIN
SEIVRHALMGKKVARLKGGDPFVFGRGGEEIEVLRKNGIRYEIIPGITAAYGASAYTEIPLTMRKISSSVAFCTGHPVNK
IQVPDADTLVYYMVASTVHDVLDAVVSKGRSENTKVAIVQNATRYNQKIFTGTLGELRRREKAVYSPALLIIGDNINQFI
EKNWFSGKRKVLLTGGDAKRYNAMEHIMVHFPCRQVDGADRERVKEYFDDFSPYSTLLFTSKFSVKYFFASLFEYGKDVR
HLAAATICATGKAAALELQKHGVIPDLFFEPDGCADIVTMFRERGMTDEHILLPGSNLVDEYLVRELTTLRNRVTPLCVY
MHEAQEHAESIDLAFIDEIYFASPSCVNNFRTLYSSIPENITVTAADTRTEKEYRSLFGES

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=244, Percent_Identity=40.9836065573771, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6322922, Length=254, Percent_Identity=27.5590551181102, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 51897; Mature: 51765

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSDHSQRVDVSEKGYVYIIGAGPGDPELLTIKAERALQEADVLLYDDLVSGELVDQFQ
CCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHCCEEEEHHHHCCHHHHHCC
GIKIYTGKRKDSHHFEQDEINSEIVRHALMGKKVARLKGGDPFVFGRGGEEIEVLRKNGI
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCCHHHHHHHCCC
RYEIIPGITAAYGASAYTEIPLTMRKISSSVAFCTGHPVNKIQVPDADTLVYYMVASTVH
EEEEECCCHHHHCCCCCEECCHHHHHHHCCEEEECCCCCCEEECCCCCHHHHHHHHHHHH
DVLDAVVSKGRSENTKVAIVQNATRYNQKIFTGTLGELRRREKAVYSPALLIIGDNINQF
HHHHHHHHCCCCCCCEEEEEECCHHHCCCHHHCCHHHHHHHHHHHCCCEEEEECCCHHHH
IEKNWFSGKRKVLLTGGDAKRYNAMEHIMVHFPCRQVDGADRERVKEYFDDFSPYSTLLF
HHHHCCCCCCEEEEECCCHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHCCCCHHHEEE
TSKFSVKYFFASLFEYGKDVRHLAAATICATGKAAALELQKHGVIPDLFFEPDGCADIVT
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHCCCCCCEEECCCCHHHHHH
MFRERGMTDEHILLPGSNLVDEYLVRELTTLRNRVTPLCVYMHEAQEHAESIDLAFIDEI
HHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHHH
YFASPSCVNNFRTLYSSIPENITVTAADTRTEKEYRSLFGES
HHCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TKSDHSQRVDVSEKGYVYIIGAGPGDPELLTIKAERALQEADVLLYDDLVSGELVDQFQ
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHCCEEEEHHHHCCHHHHHCC
GIKIYTGKRKDSHHFEQDEINSEIVRHALMGKKVARLKGGDPFVFGRGGEEIEVLRKNGI
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCCHHHHHHHCCC
RYEIIPGITAAYGASAYTEIPLTMRKISSSVAFCTGHPVNKIQVPDADTLVYYMVASTVH
EEEEECCCHHHHCCCCCEECCHHHHHHHCCEEEECCCCCCEEECCCCCHHHHHHHHHHHH
DVLDAVVSKGRSENTKVAIVQNATRYNQKIFTGTLGELRRREKAVYSPALLIIGDNINQF
HHHHHHHHCCCCCCCEEEEEECCHHHCCCHHHCCHHHHHHHHHHHCCCEEEEECCCHHHH
IEKNWFSGKRKVLLTGGDAKRYNAMEHIMVHFPCRQVDGADRERVKEYFDDFSPYSTLLF
HHHHCCCCCCEEEEECCCHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHCCCCHHHEEE
TSKFSVKYFFASLFEYGKDVRHLAAATICATGKAAALELQKHGVIPDLFFEPDGCADIVT
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEHHHCCCCCCEEECCCCHHHHHH
MFRERGMTDEHILLPGSNLVDEYLVRELTTLRNRVTPLCVYMHEAQEHAESIDLAFIDEI
HHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHHH
YFASPSCVNNFRTLYSSIPENITVTAADTRTEKEYRSLFGES
HHCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA