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The map label for this gene is hmeD [H]

Identifier: 119355987

GI number: 119355987

Start: 156698

End: 158347

Strand: Direct

Name: hmeD [H]

Synonym: Cpha266_0137

Alternate gene names: 119355987

Gene position: 156698-158347 (Clockwise)

Preceding gene: 119355986

Following gene: 119355988

Centisome position: 5.0

GC content: 49.64

Gene sequence:

>1650_bases
ATGTCGAAATACCTTCCGAAATTATCAGATCTCAAAAAAGACTTTGAGGAAAAACCGAGCATTCTGAAAGGGGATTACTC
TAAAAAAGAGTGGTGGGATACGCCTTTTGAATTTCGCGACGGAAACTGGTCTTTTCCGGCAAAGCCGGAAGTAGTCGAAG
AGCTTGGCTTTCCCAATTCCCGGAAGTGGTCAGCGCTTGACCAGGACTGGAAGCTTCCCGCTGACTGGCAGAAAACGATC
AGCGAGGGTCTGAAGGTTCGCCTGAAAAAATTTCGTTCACTGAAGCTTTATCTCGACTCCTGTGTCCGCTGCGGAGCCTG
CGCCGACAAGTGTCATTTTTTTCTCGGTACGGGCGACCCGAGAAACATGCCTGTTCTGAGGGCGGAACTGCTTCGCTCAG
TCTATCGGAACGATTTTCCTCTGGTTGAAAAGATCCTGAAGGGTTTTTCAGGATCAAGAAAGTTAACGGCGGAGGTGATC
AAAGAGTGGCACATGTACTACTATCAATGTACGGAGTGTCGCCGTTGCTCTGTTTTTTGTCCTCTCGGCATCGATACGGC
GGAAATAACGATGGTTGCGCGTGAGCTTCTGAACCTGATAGGGGTGAACAATAACTGGATTCTGGCCCCTGTTGCCAATT
GCAATCGTACGGGGAATCATCTGGGCATTGAGCCGCATACCTTCGTGCAGAATATTGAGTCGCTGGTCGAAGATATTGAG
GATATGACAGGAGTAAGGGTTAACCCGACGTTCAATCGTAAAGGTGCGGAAATTCTTTTCATAACCCCTTCCGGCGACGT
ATTCGGCGATCCCGGCGTCTATACCATGATGGGTTATCTTCTGCTCTTTCATCATATCGGTCTGGATTACACCATCAGCA
CCTATGCTTCAGAGGGCGGAAATTTCGGCATGTTCACCTCAAACGACATGATGAAAAAGCTGAACGCCAAGATGTATCAT
GAGGCCGAACGCCTGAAGGTGAAATGGATACTTGGCGGCGAATGCGGTCACATGTGGCGCGTTGTACATCAGTATATGAA
TACCATGAACGGGCCCGCCGATTTTCTCGAGGTGCCGGTATCTCCTGTTACCGGAACGAAGTTCAGTAATGCGGCGGCAA
CCAAAATGGTTCATATCGCTGAATTTACGGCTGATCTGATTTATCATAAAAAGCTCAAGCTTGATCCGCGGCGCAACGAT
CATCTGAAAACGACCTTTCATGACTCCTGCAATGTGGCAAGAGGGATGGGTATGTTCGAAGAGCCGCGCTTTGTGCTAAA
CAATGTCTGCAACTCTTTTCATGAAATGCCGGAGAATACCATTCGAGAGCAGACCTTCTGCTGCGGCTCGGGAAGCGGAA
TCAATTCCGAGGAGAACATGGAGATGCGCATGAGAGGGGGATTTCCGAGAGCAAACGCGGTCAGGCATGTCAGGAACCAG
CACCAGGTCGACTCTCTTGTAACGATCTGCGCAATCGACAGGGCAAGCCTTCCCGCGTTGATGAAGTACTGGAATCCGGG
AGTTACGGTCTATGGCCTGCATGAACTGGTCGGAAACGCGCTGGTGATGCAGGGCGAAAAAAAGAGAAAAGAGGACTTGA
GAGAGCATCCAATGAAAGGATTCGACGATGAGGAGGGCGATGTCGATTAA

Upstream 100 bases:

>100_bases
CATGGAACGCAGCCATAAAATTCAGGACTTACACCGAATACGAGGACGAGTATCGCGAAAAGATGAAAAAGGCAAAATTA
CCGGTTGAAAAGCAATAGCC

Downstream 100 bases:

>100_bases
GAAAAACCATATCATTTTCAGCCTGCTCGCGCTCTTGCTGCTGGCTGGATCCTACGCATTCATGCATGTCGTTCAGGCTG
CGGATCCGGTTCCGCCGACC

Product: DsrK protein

Products: NA

Alternate protein names: Hme subunit D [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSKYLPKLSDLKKDFEEKPSILKGDYSKKEWWDTPFEFRDGNWSFPAKPEVVEELGFPNSRKWSALDQDWKLPADWQKTI
SEGLKVRLKKFRSLKLYLDSCVRCGACADKCHFFLGTGDPRNMPVLRAELLRSVYRNDFPLVEKILKGFSGSRKLTAEVI
KEWHMYYYQCTECRRCSVFCPLGIDTAEITMVARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLVEDIE
DMTGVRVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGGNFGMFTSNDMMKKLNAKMYH
EAERLKVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPVSPVTGTKFSNAAATKMVHIAEFTADLIYHKKLKLDPRRND
HLKTTFHDSCNVARGMGMFEEPRFVLNNVCNSFHEMPENTIREQTFCCGSGSGINSEENMEMRMRGGFPRANAVRHVRNQ
HQVDSLVTICAIDRASLPALMKYWNPGVTVYGLHELVGNALVMQGEKKRKEDLREHPMKGFDDEEGDVD

Sequences:

>Translated_549_residues
MSKYLPKLSDLKKDFEEKPSILKGDYSKKEWWDTPFEFRDGNWSFPAKPEVVEELGFPNSRKWSALDQDWKLPADWQKTI
SEGLKVRLKKFRSLKLYLDSCVRCGACADKCHFFLGTGDPRNMPVLRAELLRSVYRNDFPLVEKILKGFSGSRKLTAEVI
KEWHMYYYQCTECRRCSVFCPLGIDTAEITMVARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLVEDIE
DMTGVRVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGGNFGMFTSNDMMKKLNAKMYH
EAERLKVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPVSPVTGTKFSNAAATKMVHIAEFTADLIYHKKLKLDPRRND
HLKTTFHDSCNVARGMGMFEEPRFVLNNVCNSFHEMPENTIREQTFCCGSGSGINSEENMEMRMRGGFPRANAVRHVRNQ
HQVDSLVTICAIDRASLPALMKYWNPGVTVYGLHELVGNALVMQGEKKRKEDLREHPMKGFDDEEGDVD
>Mature_548_residues
SKYLPKLSDLKKDFEEKPSILKGDYSKKEWWDTPFEFRDGNWSFPAKPEVVEELGFPNSRKWSALDQDWKLPADWQKTIS
EGLKVRLKKFRSLKLYLDSCVRCGACADKCHFFLGTGDPRNMPVLRAELLRSVYRNDFPLVEKILKGFSGSRKLTAEVIK
EWHMYYYQCTECRRCSVFCPLGIDTAEITMVARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLVEDIED
MTGVRVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGGNFGMFTSNDMMKKLNAKMYHE
AERLKVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPVSPVTGTKFSNAAATKMVHIAEFTADLIYHKKLKLDPRRNDH
LKTTFHDSCNVARGMGMFEEPRFVLNNVCNSFHEMPENTIREQTFCCGSGSGINSEENMEMRMRGGFPRANAVRHVRNQH
QVDSLVTICAIDRASLPALMKYWNPGVTVYGLHELVGNALVMQGEKKRKEDLREHPMKGFDDEEGDVD

Specific function: Has menaquinol-oxidizing activity. The hmeC and hmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 62711; Mature: 62579

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYLPKLSDLKKDFEEKPSILKGDYSKKEWWDTPFEFRDGNWSFPAKPEVVEELGFPNS
CCCCCCHHHHHHHHHHHCCCHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
RKWSALDQDWKLPADWQKTISEGLKVRLKKFRSLKLYLDSCVRCGACADKCHFFLGTGDP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEECCCC
RNMPVLRAELLRSVYRNDFPLVEKILKGFSGSRKLTAEVIKEWHMYYYQCTECRRCSVFC
CCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
PLGIDTAEITMVARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLVEDIE
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DMTGVRVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGG
HHCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCCC
NFGMFTSNDMMKKLNAKMYHEAERLKVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPV
CCCEECCHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCC
SPVTGTKFSNAAATKMVHIAEFTADLIYHKKLKLDPRRNDHLKTTFHDSCNVARGMGMFE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHCCCCCC
EPRFVLNNVCNSFHEMPENTIREQTFCCGSGSGINSEENMEMRMRGGFPRANAVRHVRNQ
CCHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHH
HQVDSLVTICAIDRASLPALMKYWNPGVTVYGLHELVGNALVMQGEKKRKEDLREHPMKG
HHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEHHHHHCCCEEECCCHHHHHHHHHCCCCC
FDDEEGDVD
CCCCCCCCC
>Mature Secondary Structure 
SKYLPKLSDLKKDFEEKPSILKGDYSKKEWWDTPFEFRDGNWSFPAKPEVVEELGFPNS
CCCCCHHHHHHHHHHHCCCHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
RKWSALDQDWKLPADWQKTISEGLKVRLKKFRSLKLYLDSCVRCGACADKCHFFLGTGDP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCEEEEECCCC
RNMPVLRAELLRSVYRNDFPLVEKILKGFSGSRKLTAEVIKEWHMYYYQCTECRRCSVFC
CCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
PLGIDTAEITMVARELLNLIGVNNNWILAPVANCNRTGNHLGIEPHTFVQNIESLVEDIE
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DMTGVRVNPTFNRKGAEILFITPSGDVFGDPGVYTMMGYLLLFHHIGLDYTISTYASEGG
HHCCCEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHCCCC
NFGMFTSNDMMKKLNAKMYHEAERLKVKWILGGECGHMWRVVHQYMNTMNGPADFLEVPV
CCCEECCHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCC
SPVTGTKFSNAAATKMVHIAEFTADLIYHKKLKLDPRRNDHLKTTFHDSCNVARGMGMFE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHCCCCCC
EPRFVLNNVCNSFHEMPENTIREQTFCCGSGSGINSEENMEMRMRGGFPRANAVRHVRNQ
CCHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHH
HQVDSLVTICAIDRASLPALMKYWNPGVTVYGLHELVGNALVMQGEKKRKEDLREHPMKG
HHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEHHHHHCCCEEECCCHHHHHHHHHCCCCC
FDDEEGDVD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA