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The map label for this gene is sdhA [H]

Identifier: 119355951

GI number: 119355951

Start: 116807

End: 118783

Strand: Reverse

Name: sdhA [H]

Synonym: Cpha266_0101

Alternate gene names: 119355951

Gene position: 118783-116807 (Counterclockwise)

Preceding gene: 119355952

Following gene: 119355950

Centisome position: 3.79

GC content: 52.81

Gene sequence:

>1977_bases
ATGAAAGCATTGTTCAACGATAAACATGATTCTTTAATGATACCTCTCGCTGCCGGAATTCCTGAAGGCCCTATCAGTGA
AAAGTGGACTTCCTATAAATCAGGTGCTCGGCTTGTCAACCCAAACAACAAGAGAAAACTCGATATTATCGTTGTCGGCA
CCGGTCTTGCCGGTGCTTCGGCAGCAGCCACGCTCGGCCAGCTGGGATACCGGGTGAAAGTGTTCTGCTATCAGGATACG
CCCCGAAGAGCCCACAGCATTGCCGCCCAGGGAGGCATCAATGCCGCAAAAAACTATCAGAACGATGGCGACAGTGTCTA
CAGACTGTTCTACGACACCATAAAAGGAGGCGATTACCGCGCGCGCGAAGCAAACGTCTACCGCCTTGCGGAAGTCAGTC
GCGAAATTATTGATCTTTGCGTTGCCCAGGGAGTACCTTTTGCCCGTGAGTATGGCGGCCTTCTTGCCAACCGGTCATTC
GGAGGCGCGCAGGTTTCGCGAACATTCTATGCCCGCGGTCAAACCGGACAGCAGTTGCTGCTTGGCGCCTACGGAGCATT
GAGCCGACAGATTGCGGCAGGAACCGTTACGCTTTACAACCGAAGGGATGTGCTCGACATGGTGATCGAAGAGGGCAAGG
CAAGAGGCATCATTGCCCGAAACCTTGTTACAGGAGAAATAGAGTCCCACTCTGCCCATGCCGTGGTTCTTGCCAGCGGG
GGATACGGCAACGTCTTCTATCTCTCCACCAATGCCATGGGTTCCAACGTTACTCCTGCATGGAGCGCATATAAAAAAGG
CGCCTTTTTTGCCAACCCCGCATTTACCCAGATACATCCGACCTGTATTCCCGTTCACGGCGATTTTCAGTCCAAGCTCA
CTCTGATGAGCGAAAGTCTCCGCAATGACGGCAGAATCTGGGTGCCGACAGATAAAGCAATTGCCGAAAAGCTCAGAAAA
AACGAAATCACGCCGCTTGATGTTGCCGAAAAAGATCGCGACTACTATCTGGAACGACGTTACCCGGCATTCGGCAATCT
CGTGCCTCGCGACGTCGCATCGAGAGCTGCCAAAGAACGCTGCGATGCAGGCAATGGCGTCGGCATTACAGGCATGGCGG
TCTATCTTGATTTTGCCGACGCCATAAAACGCAAGGGGCACGACACGATTGACGCGCTCTATGGAAACCTGTTCCAGATG
TATGAACAGATTTCCGCAGACGATCCCTACAAAACCCCGATGAAAATCTACCCTGCCGTTCACTATACCATGGGCGGCTT
ATGGGTTGACTATAATCTGATGACGACCGTTCCCGGCCTCTTTTCAATCGGCGAATGCAACTTTTCCGATCACGGCGCCA
ATCGTCTCGGAGCGTCCGCGCTCATGCAGGGGCTGGCAGACGGATATTTTATTCTTCCCTATACCATCGGAAACTATCTT
GCCTCCGAAATTCATACCCCGAGAATCGAGACCGGCTGCAGCGCCTTCGAACTTGCGGCACAATCGGTTAACGACCGTCT
CAGCAGGCTCATGCATACAGGGGGGAAACAATCGGTGGATTACTTCCACCGTAAATTAGGCCTGATCATGTGGGAGTATT
GCGGCATGGCAAGAACCCGAGAGGGTCTTATAAAAGCCCTTGACCTTATAAACGAACTGAAAACCGCGTTCGCTCTCGAC
GTTCGCATTCCCGGCGGCATGCAGGAGTATAACCCGGAGCTTGAGAAGGCCTGTCGGGTAGCCGATTTTATTGAACTGGG
CGAGCTGATGGTTCGGGACGCACTGCAACGGAACGAATCATGCGGCGGCCATTTCAGGGAGGAGTTCCAGACCCCTGAAG
GCGAAGCGCTGCGCAACGATGAGGAATTTGCCTTTGTCGGTGCATGGATGTATAACGGGCCTGACACAAAACCATCTCTG
CACCGCGAAAACCTGCAATTCAGCGAGATCAAACTCTCGCAGAGATGCTATAAATAA

Upstream 100 bases:

>100_bases
CGCTGAAGGTTATCGGCACGATCTATGCCGTTGTCATCAGCGGCGGGTTCATGGCGATCCCGATCTTTTTCTTGCTATTC
AGATAGATTAACAATTGCTA

Downstream 100 bases:

>100_bases
TTGACGATGAATTTCACGCTCAAAATCTGGCGACAGAGCAACACCAAAGCAAAAGGCGGTCTGGTTACCTACAACGTTGC
GGATATATCGGCTGAATGCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MKALFNDKHDSLMIPLAAGIPEGPISEKWTSYKSGARLVNPNNKRKLDIIVVGTGLAGASAAATLGQLGYRVKVFCYQDT
PRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSREIIDLCVAQGVPFAREYGGLLANRSF
GGAQVSRTFYARGQTGQQLLLGAYGALSRQIAAGTVTLYNRRDVLDMVIEEGKARGIIARNLVTGEIESHSAHAVVLASG
GYGNVFYLSTNAMGSNVTPAWSAYKKGAFFANPAFTQIHPTCIPVHGDFQSKLTLMSESLRNDGRIWVPTDKAIAEKLRK
NEITPLDVAEKDRDYYLERRYPAFGNLVPRDVASRAAKERCDAGNGVGITGMAVYLDFADAIKRKGHDTIDALYGNLFQM
YEQISADDPYKTPMKIYPAVHYTMGGLWVDYNLMTTVPGLFSIGECNFSDHGANRLGASALMQGLADGYFILPYTIGNYL
ASEIHTPRIETGCSAFELAAQSVNDRLSRLMHTGGKQSVDYFHRKLGLIMWEYCGMARTREGLIKALDLINELKTAFALD
VRIPGGMQEYNPELEKACRVADFIELGELMVRDALQRNESCGGHFREEFQTPEGEALRNDEEFAFVGAWMYNGPDTKPSL
HRENLQFSEIKLSQRCYK

Sequences:

>Translated_658_residues
MKALFNDKHDSLMIPLAAGIPEGPISEKWTSYKSGARLVNPNNKRKLDIIVVGTGLAGASAAATLGQLGYRVKVFCYQDT
PRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSREIIDLCVAQGVPFAREYGGLLANRSF
GGAQVSRTFYARGQTGQQLLLGAYGALSRQIAAGTVTLYNRRDVLDMVIEEGKARGIIARNLVTGEIESHSAHAVVLASG
GYGNVFYLSTNAMGSNVTPAWSAYKKGAFFANPAFTQIHPTCIPVHGDFQSKLTLMSESLRNDGRIWVPTDKAIAEKLRK
NEITPLDVAEKDRDYYLERRYPAFGNLVPRDVASRAAKERCDAGNGVGITGMAVYLDFADAIKRKGHDTIDALYGNLFQM
YEQISADDPYKTPMKIYPAVHYTMGGLWVDYNLMTTVPGLFSIGECNFSDHGANRLGASALMQGLADGYFILPYTIGNYL
ASEIHTPRIETGCSAFELAAQSVNDRLSRLMHTGGKQSVDYFHRKLGLIMWEYCGMARTREGLIKALDLINELKTAFALD
VRIPGGMQEYNPELEKACRVADFIELGELMVRDALQRNESCGGHFREEFQTPEGEALRNDEEFAFVGAWMYNGPDTKPSL
HRENLQFSEIKLSQRCYK
>Mature_658_residues
MKALFNDKHDSLMIPLAAGIPEGPISEKWTSYKSGARLVNPNNKRKLDIIVVGTGLAGASAAATLGQLGYRVKVFCYQDT
PRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSREIIDLCVAQGVPFAREYGGLLANRSF
GGAQVSRTFYARGQTGQQLLLGAYGALSRQIAAGTVTLYNRRDVLDMVIEEGKARGIIARNLVTGEIESHSAHAVVLASG
GYGNVFYLSTNAMGSNVTPAWSAYKKGAFFANPAFTQIHPTCIPVHGDFQSKLTLMSESLRNDGRIWVPTDKAIAEKLRK
NEITPLDVAEKDRDYYLERRYPAFGNLVPRDVASRAAKERCDAGNGVGITGMAVYLDFADAIKRKGHDTIDALYGNLFQM
YEQISADDPYKTPMKIYPAVHYTMGGLWVDYNLMTTVPGLFSIGECNFSDHGANRLGASALMQGLADGYFILPYTIGNYL
ASEIHTPRIETGCSAFELAAQSVNDRLSRLMHTGGKQSVDYFHRKLGLIMWEYCGMARTREGLIKALDLINELKTAFALD
VRIPGGMQEYNPELEKACRVADFIELGELMVRDALQRNESCGGHFREEFQTPEGEALRNDEEFAFVGAWMYNGPDTKPSL
HRENLQFSEIKLSQRCYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=403, Percent_Identity=29.5285359801489, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1790597, Length=584, Percent_Identity=29.6232876712329, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1788928, Length=595, Percent_Identity=25.3781512605042, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786942, Length=603, Percent_Identity=25.8706467661692, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505833, Length=554, Percent_Identity=29.4223826714801, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17550100, Length=608, Percent_Identity=27.6315789473684, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322701, Length=602, Percent_Identity=27.7408637873754, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322416, Length=587, Percent_Identity=26.7461669505963, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17137288, Length=588, Percent_Identity=27.3809523809524, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24655642, Length=588, Percent_Identity=27.3809523809524, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24655647, Length=588, Percent_Identity=27.3809523809524, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24663005, Length=599, Percent_Identity=27.3789649415693, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 72780; Mature: 72780

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALFNDKHDSLMIPLAAGIPEGPISEKWTSYKSGARLVNPNNKRKLDIIVVGTGLAGAS
CCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCEEECCCCCCEEEEEEEECCCCCHH
AAATLGQLGYRVKVFCYQDTPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYR
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCC
AREANVYRLAEVSREIIDLCVAQGVPFAREYGGLLANRSFGGAQVSRTFYARGQTGQQLL
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHHHEEEECCCCCHHHH
LGAYGALSRQIAAGTVTLYNRRDVLDMVIEEGKARGIIARNLVTGEIESHSAHAVVLASG
HHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCCCCCEEEECEEECCCCCCCCCEEEEEEC
GYGNVFYLSTNAMGSNVTPAWSAYKKGAFFANPAFTQIHPTCIPVHGDFQSKLTLMSESL
CCCCEEEEEECCCCCCCCCCHHHHHCCCEECCCCCCEECCEEEEECCCHHHHHHHHHHHH
RNDGRIWVPTDKAIAEKLRKNEITPLDVAEKDRDYYLERRYPAFGNLVPRDVASRAAKER
CCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHH
CDAGNGVGITGMAVYLDFADAIKRKGHDTIDALYGNLFQMYEQISADDPYKTPMKIYPAV
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCC
HYTMGGLWVDYNLMTTVPGLFSIGECNFSDHGANRLGASALMQGLADGYFILPYTIGNYL
EEEECCEEEECCHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHH
ASEIHTPRIETGCSAFELAAQSVNDRLSRLMHTGGKQSVDYFHRKLGLIMWEYCGMARTR
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
EGLIKALDLINELKTAFALDVRIPGGMQEYNPELEKACRVADFIELGELMVRDALQRNES
HHHHHHHHHHHHHHHHEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
CGGHFREEFQTPEGEALRNDEEFAFVGAWMYNGPDTKPSLHRENLQFSEIKLSQRCYK
CCCHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKALFNDKHDSLMIPLAAGIPEGPISEKWTSYKSGARLVNPNNKRKLDIIVVGTGLAGAS
CCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCEEECCCCCCEEEEEEEECCCCCHH
AAATLGQLGYRVKVFCYQDTPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYR
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCC
AREANVYRLAEVSREIIDLCVAQGVPFAREYGGLLANRSFGGAQVSRTFYARGQTGQQLL
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHHHEEEECCCCCHHHH
LGAYGALSRQIAAGTVTLYNRRDVLDMVIEEGKARGIIARNLVTGEIESHSAHAVVLASG
HHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCCCCCEEEECEEECCCCCCCCCEEEEEEC
GYGNVFYLSTNAMGSNVTPAWSAYKKGAFFANPAFTQIHPTCIPVHGDFQSKLTLMSESL
CCCCEEEEEECCCCCCCCCCHHHHHCCCEECCCCCCEECCEEEEECCCHHHHHHHHHHHH
RNDGRIWVPTDKAIAEKLRKNEITPLDVAEKDRDYYLERRYPAFGNLVPRDVASRAAKER
CCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHH
CDAGNGVGITGMAVYLDFADAIKRKGHDTIDALYGNLFQMYEQISADDPYKTPMKIYPAV
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCC
HYTMGGLWVDYNLMTTVPGLFSIGECNFSDHGANRLGASALMQGLADGYFILPYTIGNYL
EEEECCEEEECCHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHH
ASEIHTPRIETGCSAFELAAQSVNDRLSRLMHTGGKQSVDYFHRKLGLIMWEYCGMARTR
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
EGLIKALDLINELKTAFALDVRIPGGMQEYNPELEKACRVADFIELGELMVRDALQRNES
HHHHHHHHHHHHHHHHEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
CGGHFREEFQTPEGEALRNDEEFAFVGAWMYNGPDTKPSLHRENLQFSEIKLSQRCYK
CCCHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]