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The map label for this gene is lspA [H]

Identifier: 118581996

GI number: 118581996

Start: 3979391

End: 3979876

Strand: Direct

Name: lspA [H]

Synonym: Ppro_3597

Alternate gene names: 118581996

Gene position: 3979391-3979876 (Clockwise)

Preceding gene: 118581995

Following gene: 118581997

Centisome position: 99.29

GC content: 62.35

Gene sequence:

>486_bases
ATGGGACGCTGGGCACTCTTCTCCGCGATCTCCGTCGTCGGCCTGCTCCTGGACCAGGCCAGCAAGCTGTACATCCACCG
GAGCATGGAACTCTTTCAGAGCATTCCGGTGATCGACGGTTTCTTCAACATCTTCTACATCAGAAACAGGGGCGCCGCCT
TCAGCTTCCTCTCCCAGGCATCCTGGCGGCTCCCCTTCTTCATCGCCGTTTCCCTGATCGCCTCTGCCGTCATCCTAGTG
GCCTTCGGCAGGCTGCGTAACGACCAGAAGCTGGCCCAAGCCTCCCTGGCCATGATCTTCTCCGGCGCTGTGGGCAACCT
GATCGACCGGGTGCGTATGGGAGAGGTGATCGACTTCCTGGACGTCTACTGGGGGAACCACCACTGGCCGGCCTTCAACG
TGGCCGACTCGTTCATCTGCGTAGGGGTGGCGCTCCTGGCCCTTGACATGCTGCGGGAGGAGCGCCGCGCCAAACGGGCC
GTCTGA

Upstream 100 bases:

>100_bases
GTGAGAAGTGCGAGCGTTGCTGGTGCTACAGCGAGGAGCTGGGCACGGACGCCGGTCACCCGACCATCTGCCCCAAATGC
ACCGCCGCGGTCATTTGACC

Downstream 100 bases:

>100_bases
AGACTCGCCGTACATCCCGCCTCACCGGGGACAGGTCAGCCACTGTATGGCGGCCTGTCCCCTTTTCATTTTTTCCACAA
ACCACCGCCCCCTGGATGAA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MGRWALFSAISVVGLLLDQASKLYIHRSMELFQSIPVIDGFFNIFYIRNRGAAFSFLSQASWRLPFFIAVSLIASAVILV
AFGRLRNDQKLAQASLAMIFSGAVGNLIDRVRMGEVIDFLDVYWGNHHWPAFNVADSFICVGVALLALDMLREERRAKRA
V

Sequences:

>Translated_161_residues
MGRWALFSAISVVGLLLDQASKLYIHRSMELFQSIPVIDGFFNIFYIRNRGAAFSFLSQASWRLPFFIAVSLIASAVILV
AFGRLRNDQKLAQASLAMIFSGAVGNLIDRVRMGEVIDFLDVYWGNHHWPAFNVADSFICVGVALLALDMLREERRAKRA
V
>Mature_160_residues
GRWALFSAISVVGLLLDQASKLYIHRSMELFQSIPVIDGFFNIFYIRNRGAAFSFLSQASWRLPFFIAVSLIASAVILVA
FGRLRNDQKLAQASLAMIFSGAVGNLIDRVRMGEVIDFLDVYWGNHHWPAFNVADSFICVGVALLALDMLREERRAKRAV

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=149, Percent_Identity=38.9261744966443, Blast_Score=100, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18085; Mature: 17954

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRWALFSAISVVGLLLDQASKLYIHRSMELFQSIPVIDGFFNIFYIRNRGAAFSFLSQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCHHHHHHHHC
SWRLPFFIAVSLIASAVILVAFGRLRNDQKLAQASLAMIFSGAVGNLIDRVRMGEVIDFL
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVYWGNHHWPAFNVADSFICVGVALLALDMLREERRAKRAV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GRWALFSAISVVGLLLDQASKLYIHRSMELFQSIPVIDGFFNIFYIRNRGAAFSFLSQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCHHHHHHHHC
SWRLPFFIAVSLIASAVILVAFGRLRNDQKLAQASLAMIFSGAVGNLIDRVRMGEVIDFL
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVYWGNHHWPAFNVADSFICVGVALLALDMLREERRAKRAV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA