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The map label for this gene is cysM [H]

Identifier: 118581759

GI number: 118581759

Start: 3707164

End: 3708081

Strand: Reverse

Name: cysM [H]

Synonym: Ppro_3359

Alternate gene names: 118581759

Gene position: 3708081-3707164 (Counterclockwise)

Preceding gene: 118581762

Following gene: 118581757

Centisome position: 92.52

GC content: 61.33

Gene sequence:

>918_bases
ATGAAGGGTCAGAGTCTCATCAACGCCATCGGTTCGACGCCGATGGTTGAAATCATCAGCATCAACCCCAACCCGAAGGT
TACCATTCTGGCCAAGCTTGAGGGCAACAACCCCGGAGGTTCGGTAAAGGACCGTCCGGCGCGCCAGATGATCCTGGCAG
CCGAGGCGAGTGGTGAGCTGACACGCGAAAAAATCATCCTGGAGCCCACCTCGGGCAACACCGGCATTGCCCTGGCCATG
ATCGCCGCCGCCCGGGGCTACCGTATCAAGCTGGTTATGCCCGCCTGCGTCAGCGTTGAACGCCGGGGTGTTCTGGAGGC
CTATGGCGCGGAGATCGTCCTCTCACCCGGATGCGAGGCTACCGACGGCGCCATACGCCTGGCCCACAAGATTCACGACG
ATGCGCCTGAGACCTATTTCATGCCCAACCAGTACGCCAACCCCCACAACGCCCTGGCGCACTACGAGACAACCGCACCG
GAAATCATGAGCCAGACCGAAGGGGGCGTCACCCACGTGGTTGCCGGCATGGGCACCGGCGGCACGTTGATGGGGATTGC
ACGCTATTTCCGTGAGGTAAGCCCGAACGTGAAGGTTATCGGTATCGAACCGATGCCGGGGCACAGGATCCAGGGACTGA
AAAACATGCAGGAGGCCATCGTTCCTCCCATTTATAACGAGAATGCCCTTGACCGCAAGATCGTCATTGAAGACGATCCC
GCCTTTGAGACTGCCCGCCTGCTGGCCAGCCACGAGGGGGTCTTCTGCGGCATGTCCGGTGGAGCCGCCATGTCCGGTGC
CCTCCGTCTGGCCGGGGAGCTGGAATCCGGTGTGATCGTGGTCATCCTTCCCGACCGGGGAGACCGCTACCTGAGCACCA
ACCTCTTCACCTCCATGTGCGCCCACTGTCCACCATAG

Upstream 100 bases:

>100_bases
AAAATGTTTTCGCAACTGACGCGGAAACGGGTATATTCACCCCCAATGCCACAGGCCGTGGCCGTCGTTGCCCCCATTCC
CACCACACAGAGGAACAGAT

Downstream 100 bases:

>100_bases
CGAACCGGCGGTCAAACCGGGGCTTTTCAGTCGTTTGTGGCCGAGGGCCCCGGTGTGCCTGTGCGTTCTCTCCAGGGGCG
TGAAGCACGCATTCTTCATG

Product: cysteine synthases

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKGQSLINAIGSTPMVEIISINPNPKVTILAKLEGNNPGGSVKDRPARQMILAAEASGELTREKIILEPTSGNTGIALAM
IAAARGYRIKLVMPACVSVERRGVLEAYGAEIVLSPGCEATDGAIRLAHKIHDDAPETYFMPNQYANPHNALAHYETTAP
EIMSQTEGGVTHVVAGMGTGGTLMGIARYFREVSPNVKVIGIEPMPGHRIQGLKNMQEAIVPPIYNENALDRKIVIEDDP
AFETARLLASHEGVFCGMSGGAAMSGALRLAGELESGVIVVILPDRGDRYLSTNLFTSMCAHCPP

Sequences:

>Translated_305_residues
MKGQSLINAIGSTPMVEIISINPNPKVTILAKLEGNNPGGSVKDRPARQMILAAEASGELTREKIILEPTSGNTGIALAM
IAAARGYRIKLVMPACVSVERRGVLEAYGAEIVLSPGCEATDGAIRLAHKIHDDAPETYFMPNQYANPHNALAHYETTAP
EIMSQTEGGVTHVVAGMGTGGTLMGIARYFREVSPNVKVIGIEPMPGHRIQGLKNMQEAIVPPIYNENALDRKIVIEDDP
AFETARLLASHEGVFCGMSGGAAMSGALRLAGELESGVIVVILPDRGDRYLSTNLFTSMCAHCPP
>Mature_305_residues
MKGQSLINAIGSTPMVEIISINPNPKVTILAKLEGNNPGGSVKDRPARQMILAAEASGELTREKIILEPTSGNTGIALAM
IAAARGYRIKLVMPACVSVERRGVLEAYGAEIVLSPGCEATDGAIRLAHKIHDDAPETYFMPNQYANPHNALAHYETTAP
EIMSQTEGGVTHVVAGMGTGGTLMGIARYFREVSPNVKVIGIEPMPGHRIQGLKNMQEAIVPPIYNENALDRKIVIEDDP
AFETARLLASHEGVFCGMSGGAAMSGALRLAGELESGVIVVILPDRGDRYLSTNLFTSMCAHCPP

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=39.4822006472492, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=39.4822006472492, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=39.4822006472492, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=45.5479452054795, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=40.8945686900958, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=40, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17562970, Length=305, Percent_Identity=39.344262295082, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=40.0673400673401, Blast_Score=193, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI115535073, Length=310, Percent_Identity=40.3225806451613, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=35.5987055016181, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=322, Percent_Identity=35.4037267080745, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=219, Percent_Identity=36.986301369863, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=321, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=35.6037151702786, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321449, Length=321, Percent_Identity=31.4641744548287, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24643623, Length=306, Percent_Identity=35.6209150326797, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20129101, Length=306, Percent_Identity=35.6209150326797, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32425; Mature: 32425

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGQSLINAIGSTPMVEIISINPNPKVTILAKLEGNNPGGSVKDRPARQMILAAEASGEL
CCCHHHHHHHCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCC
TREKIILEPTSGNTGIALAMIAAARGYRIKLVMPACVSVERRGVLEAYGAEIVLSPGCEA
CEEEEEEEECCCCCCHHEEEEHHCCCCEEEEEECCHHHHHHCCHHHHCCCEEEECCCCCC
TDGAIRLAHKIHDDAPETYFMPNQYANPHNALAHYETTAPEIMSQTEGGVTHVVAGMGTG
CCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHEECCCCCHHHHHHCCCCEEEEEEECCCC
GTLMGIARYFREVSPNVKVIGIEPMPGHRIQGLKNMQEAIVPPIYNENALDRKIVIEDDP
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
AFETARLLASHEGVFCGMSGGAAMSGALRLAGELESGVIVVILPDRGDRYLSTNLFTSMC
CHHHHHHHHCCCCEEEECCCCCHHHHHHHEEECCCCCEEEEEECCCCCCEEHHHHHHHHH
AHCPP
HCCCC
>Mature Secondary Structure
MKGQSLINAIGSTPMVEIISINPNPKVTILAKLEGNNPGGSVKDRPARQMILAAEASGEL
CCCHHHHHHHCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCC
TREKIILEPTSGNTGIALAMIAAARGYRIKLVMPACVSVERRGVLEAYGAEIVLSPGCEA
CEEEEEEEECCCCCCHHEEEEHHCCCCEEEEEECCHHHHHHCCHHHHCCCEEEECCCCCC
TDGAIRLAHKIHDDAPETYFMPNQYANPHNALAHYETTAPEIMSQTEGGVTHVVAGMGTG
CCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHEECCCCCHHHHHHCCCCEEEEEEECCCC
GTLMGIARYFREVSPNVKVIGIEPMPGHRIQGLKNMQEAIVPPIYNENALDRKIVIEDDP
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
AFETARLLASHEGVFCGMSGGAAMSGALRLAGELESGVIVVILPDRGDRYLSTNLFTSMC
CHHHHHHHHCCCCEEEECCCCCHHHHHHHEEECCCCCEEEEEECCCCCCEEHHHHHHHHH
AHCPP
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]