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The map label for this gene is murB

Identifier: 118581687

GI number: 118581687

Start: 3622437

End: 3623324

Strand: Reverse

Name: murB

Synonym: Ppro_3287

Alternate gene names: 118581687

Gene position: 3623324-3622437 (Counterclockwise)

Preceding gene: 118581688

Following gene: 118581686

Centisome position: 90.4

GC content: 66.22

Gene sequence:

>888_bases
GTGAATCTCTCCGGGCTGAACATGCGCGGCCTGCTTCTGGCTGACGAACCCATGAGCCGCCATACCTCCCTCAGGGTGGG
CGGTCCCGCGGACCTGTTCGCCATTCCGGAGGATGCGGACGACCTGCAGGGGTTGCTGCGCCAGCTCAAGGAGAGGGGCA
TCCCCTGGCTGGCCATCGGCAGGGGCAACAACCTGCTGGTGCGCGACAGCGGCATCCGGGGGGCGGTCATCTCCCTGGAG
CGCTTCAACCGTGTCGAGGCTCTCGGCCAGGGGCGCATCCGTGCCGGGGCCGGGGCCGAGAACCTGGCGGTGGTGCGCTT
CGCCCAGGAACAGGGGCTGGGGGGGATCGGCTTCATCTCCGGCATCCCTGGCACCGTTGGCGGCGCCATCAGGATGAACG
CCGGCGCCTACGGCACGGGTATCATGGAACGGACCGAATCCCTGACCCTGCTGCATGACGGCAACGTCAGGGAGTTCGGC
CGCGACGAGCTGGAGTATGGCTACCGCCATCTGGATCTGGCAGCGGGGGACATCATTCTGGAAGCCCTGTTCAGGCTGGA
CCAGCGCGAGGCTGAGCAGACCGAGGAGGAGATCCGCAAAGACCTGGAGCTGCGCCGTGCCAAGCACAGCGTCGGTTTTC
CCAGCGCCGGCTCATTCTTCAAGAACCCCGCCGGCCAGACCGCCTGGCGGCTGATCGACGCCACCGGCATGCGCGGCGAG
CGGGTGGGGGGCGCCCAGGTTTCCCAGGTGCACAGCAACTTCCTGGTGAATACGGGAGGCGCCACTGCCGGAGATTTCCT
GGAACTTTCACGGGTTGTGAAAAAAGCGGTTCTGGCCTCTTGCGGGGTGACCCTGGAGGAGGAAGTGCGTATAGTTGGCG
AGGAGTAA

Upstream 100 bases:

>100_bases
TGCTGGGCATCGTCAAGGAGGGGGACATGGTCATCACCCTGGGGGCCGGCAGCATCTGGCAGCAGGGCGAGGCGCTGGTG
ACGCTTTTGGAGAAAACCTC

Downstream 100 bases:

>100_bases
CGTTATGAATGACATCAGATCCAGAAAGATTGCCGTCCTCATGGGCGGGCTCTCGGCCGAGCGGGAAGTCTCCCTAGCCA
GCGGAGCCGCCGTGTGCCAG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNLSGLNMRGLLLADEPMSRHTSLRVGGPADLFAIPEDADDLQGLLRQLKERGIPWLAIGRGNNLLVRDSGIRGAVISLE
RFNRVEALGQGRIRAGAGAENLAVVRFAQEQGLGGIGFISGIPGTVGGAIRMNAGAYGTGIMERTESLTLLHDGNVREFG
RDELEYGYRHLDLAAGDIILEALFRLDQREAEQTEEEIRKDLELRRAKHSVGFPSAGSFFKNPAGQTAWRLIDATGMRGE
RVGGAQVSQVHSNFLVNTGGATAGDFLELSRVVKKAVLASCGVTLEEEVRIVGEE

Sequences:

>Translated_295_residues
MNLSGLNMRGLLLADEPMSRHTSLRVGGPADLFAIPEDADDLQGLLRQLKERGIPWLAIGRGNNLLVRDSGIRGAVISLE
RFNRVEALGQGRIRAGAGAENLAVVRFAQEQGLGGIGFISGIPGTVGGAIRMNAGAYGTGIMERTESLTLLHDGNVREFG
RDELEYGYRHLDLAAGDIILEALFRLDQREAEQTEEEIRKDLELRRAKHSVGFPSAGSFFKNPAGQTAWRLIDATGMRGE
RVGGAQVSQVHSNFLVNTGGATAGDFLELSRVVKKAVLASCGVTLEEEVRIVGEE
>Mature_295_residues
MNLSGLNMRGLLLADEPMSRHTSLRVGGPADLFAIPEDADDLQGLLRQLKERGIPWLAIGRGNNLLVRDSGIRGAVISLE
RFNRVEALGQGRIRAGAGAENLAVVRFAQEQGLGGIGFISGIPGTVGGAIRMNAGAYGTGIMERTESLTLLHDGNVREFG
RDELEYGYRHLDLAAGDIILEALFRLDQREAEQTEEEIRKDLELRRAKHSVGFPSAGSFFKNPAGQTAWRLIDATGMRGE
RVGGAQVSQVHSNFLVNTGGATAGDFLELSRVVKKAVLASCGVTLEEEVRIVGEE

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_PELPD (A1AU59)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902937.1
- ProteinModelPortal:   A1AU59
- SMR:   A1AU59
- STRING:   A1AU59
- GeneID:   4572281
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3287
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 31789; Mature: 31789

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 169-169 ACT_SITE 218-218 ACT_SITE 288-288

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSGLNMRGLLLADEPMSRHTSLRVGGPADLFAIPEDADDLQGLLRQLKERGIPWLAIG
CCCCCCCCCEEEEECCCCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEE
RGNNLLVRDSGIRGAVISLERFNRVEALGQGRIRAGAGAENLAVVRFAQEQGLGGIGFIS
CCCEEEEEECCCCEEEEEHHHHHHHHHHCCCCEECCCCCCCEEEEEEHHHCCCCCEEHHC
GIPGTVGGAIRMNAGAYGTGIMERTESLTLLHDGNVREFGRDELEYGYRHLDLAAGDIIL
CCCCCCCCEEEECCCCCCCHHHHHCCCEEEEECCCCHHHCCHHHHHCHHHHHHHHHHHHH
EALFRLDQREAEQTEEEIRKDLELRRAKHSVGFPSAGSFFKNPAGQTAWRLIDATGMRGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHCCCCCCC
RVGGAQVSQVHSNFLVNTGGATAGDFLELSRVVKKAVLASCGVTLEEEVRIVGEE
CCCCHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCC
>Mature Secondary Structure
MNLSGLNMRGLLLADEPMSRHTSLRVGGPADLFAIPEDADDLQGLLRQLKERGIPWLAIG
CCCCCCCCCEEEEECCCCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEE
RGNNLLVRDSGIRGAVISLERFNRVEALGQGRIRAGAGAENLAVVRFAQEQGLGGIGFIS
CCCEEEEEECCCCEEEEEHHHHHHHHHHCCCCEECCCCCCCEEEEEEHHHCCCCCEEHHC
GIPGTVGGAIRMNAGAYGTGIMERTESLTLLHDGNVREFGRDELEYGYRHLDLAAGDIIL
CCCCCCCCEEEECCCCCCCHHHHHCCCEEEEECCCCHHHCCHHHHHCHHHHHHHHHHHHH
EALFRLDQREAEQTEEEIRKDLELRRAKHSVGFPSAGSFFKNPAGQTAWRLIDATGMRGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHCCCCCCC
RVGGAQVSQVHSNFLVNTGGATAGDFLELSRVVKKAVLASCGVTLEEEVRIVGEE
CCCCHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA