Click here to switch to the map view.

The map label for this gene is argH

Identifier: 118581569

GI number: 118581569

Start: 3480879

End: 3482255

Strand: Reverse

Name: argH

Synonym: Ppro_3168

Alternate gene names: 118581569

Gene position: 3482255-3480879 (Counterclockwise)

Preceding gene: 118581570

Following gene: 118581568

Centisome position: 86.88

GC content: 63.62

Gene sequence:

>1377_bases
ATGTCCAAGGATAAACTCTGGGGCGGCCGCTTCACCCAGCCCACCGATGCTTTTGTCGAGGAGTTCACCGCCTCGATCCA
GTTTGACAAGCGCCTGTACCACCAGGACATCCGGGGATCCATCGCCCATGCCCGCATGCTGGGCAAGCAGGGGATCATCC
CCCAGGCGGATGTGGAGGCCATCGTGGAGGGGCTGCAGCAGATCCTGCTGCAGATCGAGGAGGGGAGTTTCGACTTCTCC
ATCTCCCTGGAAGATATCCACATGAACATCGAGTCCCGCCTGTCGGCCAGGATCGGCGAGGCGGGCAAGCGTCTGCACAC
CGGCCGCTCGCGCAACGATCAGGTGGCCCTGGACATCCGCCTCTACCTGCGGGACGAGATCGTGGAGATCACCTCCTACA
TCGACCTCTTGATCGACGCGCTGCTGACCCAGGCCGAGGAGAACGTGGACGTGGTCATGCCCGGCTTCACCCATCTGCAG
ACCGCCCAGCCGATCCTCTTCGCCCACCACATGCTGGCCTACGTGGAGATGTTTAAAAGGGACAGCGGCCGCATGGAGGA
TTGCCTGAAACGGGTCAACGTGCTCCCCCTGGGCGCCGGCGCCCTGGCCGGCACCACCTTTCCCATCGATCGTGACTACG
TGGCCGAGCAACTCGGCTTCCCGGCCATCACCCGCAACTCCCTGGATTCCGTCTCAGACCGCGACTTTGCCCTGGAGTTC
ATCTCCGCCTCGTCGATCCTGATGATGCACCTGTCCCGCCTCTCCGAGGAGCTGATCCTCTGGTCCACCAGCCAGTTCAA
GTTCATCGAGCTGTCCGACGGCTTCTGCACCGGCTCCTCCATCATGCCCCAGAAGAAGAACCCCGATGTGCCGGAGCTGG
TGCGGGGCAAGACCGGCCGGGTCTACGGCAACCTGATGGCGCTCCTGACAGTGATGAAGTCCCTGCCCCTGGCCTACAAC
AAGGACATGCAGGAGGACAAGGAGCCGCTCTTCGACACCATCGACACGGTCAAGGGGAGCCTGAAGGTGTTCAGCGACAT
GATCAGGGAGATGAGCATCTATCCCGAGGCCATGGGCCGGGCCGCAGGCCAGGGTTTCTCCACTGCCACGGATGTGGCCG
ACTACCTGGTGCGCAAGGGGGTGGCCTTCCGCGACGCCCACGAGGCGGTGGGCAAGGCTGTTGCCTACTGCGTCGAGAAC
GAGATGGAGCTCACCGACCTGACCCTGACCGAGTGGGAGCTCTTCTCCCCCCGTTTCGAGCAGGACATCTTCGAGGCGAT
CACCGTGGATGCCTGCATCGACGCGCGCAACGTGCCGGGCGGCACGGCCCGGGAGCAGGTCAAGGGCGAGATCGCCCGCT
GCCGGAAGGGGAAGTAG

Upstream 100 bases:

>100_bases
CTGGCGCGGGCGCCGGGGCAGTAATGCACTATCCTCTCCCTTGAAGGGAGGGGGAATTCAGGGATTGTGAGATTGATTCT
GAAAGCCAACAGGAGAAGAT

Downstream 100 bases:

>100_bases
CGCTCTCCGGCCGCATGAAAGAGTAATTTATGGCATTGCCGGGCGGTTAAGGCTGCGTCCCATGCCAACTCCATGTTTCC
CGAAAGGTTCTTGTATGCGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSKDKLWGGRFTQPTDAFVEEFTASIQFDKRLYHQDIRGSIAHARMLGKQGIIPQADVEAIVEGLQQILLQIEEGSFDFS
ISLEDIHMNIESRLSARIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEITSYIDLLIDALLTQAEENVDVVMPGFTHLQ
TAQPILFAHHMLAYVEMFKRDSGRMEDCLKRVNVLPLGAGALAGTTFPIDRDYVAEQLGFPAITRNSLDSVSDRDFALEF
ISASSILMMHLSRLSEELILWSTSQFKFIELSDGFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKSLPLAYN
KDMQEDKEPLFDTIDTVKGSLKVFSDMIREMSIYPEAMGRAAGQGFSTATDVADYLVRKGVAFRDAHEAVGKAVAYCVEN
EMELTDLTLTEWELFSPRFEQDIFEAITVDACIDARNVPGGTAREQVKGEIARCRKGK

Sequences:

>Translated_458_residues
MSKDKLWGGRFTQPTDAFVEEFTASIQFDKRLYHQDIRGSIAHARMLGKQGIIPQADVEAIVEGLQQILLQIEEGSFDFS
ISLEDIHMNIESRLSARIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEITSYIDLLIDALLTQAEENVDVVMPGFTHLQ
TAQPILFAHHMLAYVEMFKRDSGRMEDCLKRVNVLPLGAGALAGTTFPIDRDYVAEQLGFPAITRNSLDSVSDRDFALEF
ISASSILMMHLSRLSEELILWSTSQFKFIELSDGFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKSLPLAYN
KDMQEDKEPLFDTIDTVKGSLKVFSDMIREMSIYPEAMGRAAGQGFSTATDVADYLVRKGVAFRDAHEAVGKAVAYCVEN
EMELTDLTLTEWELFSPRFEQDIFEAITVDACIDARNVPGGTAREQVKGEIARCRKGK
>Mature_457_residues
SKDKLWGGRFTQPTDAFVEEFTASIQFDKRLYHQDIRGSIAHARMLGKQGIIPQADVEAIVEGLQQILLQIEEGSFDFSI
SLEDIHMNIESRLSARIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEITSYIDLLIDALLTQAEENVDVVMPGFTHLQT
AQPILFAHHMLAYVEMFKRDSGRMEDCLKRVNVLPLGAGALAGTTFPIDRDYVAEQLGFPAITRNSLDSVSDRDFALEFI
SASSILMMHLSRLSEELILWSTSQFKFIELSDGFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKSLPLAYNK
DMQEDKEPLFDTIDTVKGSLKVFSDMIREMSIYPEAMGRAAGQGFSTATDVADYLVRKGVAFRDAHEAVGKAVAYCVENE
MELTDLTLTEWELFSPRFEQDIFEAITVDACIDARNVPGGTAREQVKGEIARCRKGK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=44.3458980044346, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=44.3458980044346, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=42.1286031042129, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=41.6851441241685, Blast_Score=361, Evalue=1e-100,
Organism=Escherichia coli, GI1790398, Length=448, Percent_Identity=47.7678571428571, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321806, Length=448, Percent_Identity=44.8660714285714, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=40.4867256637168, Blast_Score=351, Evalue=5e-97,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=40.4867256637168, Blast_Score=351, Evalue=5e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PELPD (A1ATU1)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902819.1
- ProteinModelPortal:   A1ATU1
- SMR:   A1ATU1
- STRING:   A1ATU1
- GeneID:   4573270
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3168
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   A1ATU1
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51257; Mature: 51126

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDKLWGGRFTQPTDAFVEEFTASIQFDKRLYHQDIRGSIAHARMLGKQGIIPQADVEA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IVEGLQQILLQIEEGSFDFSISLEDIHMNIESRLSARIGEAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHHCCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LYLRDEIVEITSYIDLLIDALLTQAEENVDVVMPGFTHLQTAQPILFAHHMLAYVEMFKR
EHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHC
DSGRMEDCLKRVNVLPLGAGALAGTTFPIDRDYVAEQLGFPAITRNSLDSVSDRDFALEF
CCCCHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
ISASSILMMHLSRLSEELILWSTSQFKFIELSDGFCTGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCEECCCCCCCCCCCCCCHHHHCCCCCH
VYGNLMALLTVMKSLPLAYNKDMQEDKEPLFDTIDTVKGSLKVFSDMIREMSIYPEAMGR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AAGQGFSTATDVADYLVRKGVAFRDAHEAVGKAVAYCVENEMELTDLTLTEWELFSPRFE
HHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHEEEEHHHHHCCCHHH
QDIFEAITVDACIDARNVPGGTAREQVKGEIARCRKGK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKDKLWGGRFTQPTDAFVEEFTASIQFDKRLYHQDIRGSIAHARMLGKQGIIPQADVEA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IVEGLQQILLQIEEGSFDFSISLEDIHMNIESRLSARIGEAGKRLHTGRSRNDQVALDIR
HHHHHHHHHHHHHCCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
LYLRDEIVEITSYIDLLIDALLTQAEENVDVVMPGFTHLQTAQPILFAHHMLAYVEMFKR
EHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHC
DSGRMEDCLKRVNVLPLGAGALAGTTFPIDRDYVAEQLGFPAITRNSLDSVSDRDFALEF
CCCCHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
ISASSILMMHLSRLSEELILWSTSQFKFIELSDGFCTGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCEECCCCCCCCCCCCCCHHHHCCCCCH
VYGNLMALLTVMKSLPLAYNKDMQEDKEPLFDTIDTVKGSLKVFSDMIREMSIYPEAMGR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
AAGQGFSTATDVADYLVRKGVAFRDAHEAVGKAVAYCVENEMELTDLTLTEWELFSPRFE
HHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHEEEEHHHHHCCCHHH
QDIFEAITVDACIDARNVPGGTAREQVKGEIARCRKGK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA