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The map label for this gene is lpxB [H]

Identifier: 118581429

GI number: 118581429

Start: 3304026

End: 3305165

Strand: Direct

Name: lpxB [H]

Synonym: Ppro_3024

Alternate gene names: 118581429

Gene position: 3304026-3305165 (Clockwise)

Preceding gene: 118581428

Following gene: 118581430

Centisome position: 82.44

GC content: 65.35

Gene sequence:

>1140_bases
ATGTCTGAACGACGCGTCATGATTGTCGCGGGGGAGGCATCCGGCGACATCTACGGCGCGCAGCTCGCATCGGAAACCGC
CCGGCTCTCCCCGAACATTCGCTTCTTCGGCATCGGCGGCGAGCGCATGCGCGAGGCCGGAGTCCAGACCCTGGTGGACT
CGGCCGACATGGCCGTGGTCGGGCTGGTTGAGGTGTTGCGCCACTTCGACGTCATCGCGAAAGCCTTCCTGAAGTTGAAG
AGGATCCTGCTCCAGACCCCCCCCCACCTACTGGTCCTGATCGACTACCCCGGTTTCAACCTGCGTCTGGCCAGGGTCGC
CCGCAGGTCCGGTGTCAGGGTGCTCTACTACATCAGCCCCCAGATATGGGCCTGGCGCCAGGGACGGGTGCATGAAATCG
CCCGCCTGGTGGATCACATGGCGGTGATATTCCCCTTCGAACTCCCCTTCTACCGGAACGCGGGCGTAGCGGCATCCTTC
GTCGGCCACCCCCTCTACGATCTGGTGGCGGTGGAAGCGAGCCGCGACCAGGCAGCCGCCAGCTTCGGCCTGGACCCCTC
CCGCAGGATCCTGGGACTATTCCCCGGCAGCCGCCGCAGCGAAGTGCAACGGCTGCTGCCGGTCATCGTCCAGGCAGCCG
CGCTCCTGAAACAATGCTATCCGGACCTGCAGCTTGTCCTGCCGCTGGCATCCACCCTGGGGTCCGAGGACATCGCCCCT
CACCTGCCCTCGGACCTCCCGGTCACCATCACCCGTGACCGCATCCACGACCTGATCCGTGGCTGCGACGCAATCATCTC
CGTCTCCGGCACCGTCACCCTGGAAATCGCCCTGCTGGGCACCCCCATGGTGGTGATCTACAAGCTCTCTCCCCTTACCT
ACCAGCTGGCCAGACGGCTGGTGAAGGTGGACAACATCGCGCTGTGCAACATCGTTGCCGGAGAAACGGTGGTACGGGAG
CTGATCCAGGACGACGCCTCGGCCAACGGCATTGCGGCCGAGATCGGGACGATTCTGGATGACGACGCCTATGCCGGCAC
CATCAGGGCCAAGCTGGCAACGGTGCGCTCCCGCCTGGGGCGCGGCGGCGCGGCCCGCAACGTGGCACGCCTGATCCTGG
AAATGGTGGAACAGTCATGA

Upstream 100 bases:

>100_bases
AACCGCTGCCTGTCGCTGCCGATCTACCCCGAGATGCCGGAGGAATCCATCCGGCTGGTGGCGGACACCATATCCGAAGC
GCTGATCGGGAGCTGAACCC

Downstream 100 bases:

>100_bases
ATCCGACCCTGACCCGCACCCTGGCCTACTTCAAACCCTACTGGAAACTGCTGGCGGTCTCTGCGCTCTGCTCAGCCATC
GTGGGGGGCATGGACGGCGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSERRVMIVAGEASGDIYGAQLASETARLSPNIRFFGIGGERMREAGVQTLVDSADMAVVGLVEVLRHFDVIAKAFLKLK
RILLQTPPHLLVLIDYPGFNLRLARVARRSGVRVLYYISPQIWAWRQGRVHEIARLVDHMAVIFPFELPFYRNAGVAASF
VGHPLYDLVAVEASRDQAAASFGLDPSRRILGLFPGSRRSEVQRLLPVIVQAAALLKQCYPDLQLVLPLASTLGSEDIAP
HLPSDLPVTITRDRIHDLIRGCDAIISVSGTVTLEIALLGTPMVVIYKLSPLTYQLARRLVKVDNIALCNIVAGETVVRE
LIQDDASANGIAAEIGTILDDDAYAGTIRAKLATVRSRLGRGGAARNVARLILEMVEQS

Sequences:

>Translated_379_residues
MSERRVMIVAGEASGDIYGAQLASETARLSPNIRFFGIGGERMREAGVQTLVDSADMAVVGLVEVLRHFDVIAKAFLKLK
RILLQTPPHLLVLIDYPGFNLRLARVARRSGVRVLYYISPQIWAWRQGRVHEIARLVDHMAVIFPFELPFYRNAGVAASF
VGHPLYDLVAVEASRDQAAASFGLDPSRRILGLFPGSRRSEVQRLLPVIVQAAALLKQCYPDLQLVLPLASTLGSEDIAP
HLPSDLPVTITRDRIHDLIRGCDAIISVSGTVTLEIALLGTPMVVIYKLSPLTYQLARRLVKVDNIALCNIVAGETVVRE
LIQDDASANGIAAEIGTILDDDAYAGTIRAKLATVRSRLGRGGAARNVARLILEMVEQS
>Mature_378_residues
SERRVMIVAGEASGDIYGAQLASETARLSPNIRFFGIGGERMREAGVQTLVDSADMAVVGLVEVLRHFDVIAKAFLKLKR
ILLQTPPHLLVLIDYPGFNLRLARVARRSGVRVLYYISPQIWAWRQGRVHEIARLVDHMAVIFPFELPFYRNAGVAASFV
GHPLYDLVAVEASRDQAAASFGLDPSRRILGLFPGSRRSEVQRLLPVIVQAAALLKQCYPDLQLVLPLASTLGSEDIAPH
LPSDLPVTITRDRIHDLIRGCDAIISVSGTVTLEIALLGTPMVVIYKLSPLTYQLARRLVKVDNIALCNIVAGETVVREL
IQDDASANGIAAEIGTILDDDAYAGTIRAKLATVRSRLGRGGAARNVARLILEMVEQS

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=333, Percent_Identity=36.036036036036, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41398; Mature: 41267

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERRVMIVAGEASGDIYGAQLASETARLSPNIRFFGIGGERMREAGVQTLVDSADMAVV
CCCCEEEEEEECCCCCEEHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHH
GLVEVLRHFDVIAKAFLKLKRILLQTPPHLLVLIDYPGFNLRLARVARRSGVRVLYYISP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECC
QIWAWRQGRVHEIARLVDHMAVIFPFELPFYRNAGVAASFVGHPLYDLVAVEASRDQAAA
CEEEECCCCHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHCCCHHHHHEEECCCCHHHH
SFGLDPSRRILGLFPGSRRSEVQRLLPVIVQAAALLKQCYPDLQLVLPLASTLGSEDIAP
HCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
HLPSDLPVTITRDRIHDLIRGCDAIISVSGTVTLEIALLGTPMVVIYKLSPLTYQLARRL
CCCCCCCEEEEHHHHHHHHHCCHHHEEECCEEEEEEEEECCCEEEEEECCCHHHHHHHHH
VKVDNIALCNIVAGETVVRELIQDDASANGIAAEIGTILDDDAYAGTIRAKLATVRSRLG
HHHCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
RGGAARNVARLILEMVEQS
CCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SERRVMIVAGEASGDIYGAQLASETARLSPNIRFFGIGGERMREAGVQTLVDSADMAVV
CCCEEEEEEECCCCCEEHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHH
GLVEVLRHFDVIAKAFLKLKRILLQTPPHLLVLIDYPGFNLRLARVARRSGVRVLYYISP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECC
QIWAWRQGRVHEIARLVDHMAVIFPFELPFYRNAGVAASFVGHPLYDLVAVEASRDQAAA
CEEEECCCCHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHCCCHHHHHEEECCCCHHHH
SFGLDPSRRILGLFPGSRRSEVQRLLPVIVQAAALLKQCYPDLQLVLPLASTLGSEDIAP
HCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
HLPSDLPVTITRDRIHDLIRGCDAIISVSGTVTLEIALLGTPMVVIYKLSPLTYQLARRL
CCCCCCCEEEEHHHHHHHHHCCHHHEEECCEEEEEEEEECCCEEEEEECCCHHHHHHHHH
VKVDNIALCNIVAGETVVRELIQDDASANGIAAEIGTILDDDAYAGTIRAKLATVRSRLG
HHHCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
RGGAARNVARLILEMVEQS
CCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA