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The map label for this gene is nhaA2

Identifier: 118581392

GI number: 118581392

Start: 3256555

End: 3257703

Strand: Reverse

Name: nhaA2

Synonym: Ppro_2987

Alternate gene names: 118581392

Gene position: 3257703-3256555 (Counterclockwise)

Preceding gene: 118581399

Following gene: 118581391

Centisome position: 81.28

GC content: 65.01

Gene sequence:

>1149_bases
ATGAAAAAACATCTCAACCTGTTGCGGGAATTCTCCGTGCCGCTTGTGGCCGGCGTTGTCGTCGCGCTCTTCTGGGCCAA
TCTGGATCCTGCCGGGTACCGCGCCTTCGACTCCACACCGTTCTGGGGGTCCCTGTCGTTCCATTTTATCTCCAATGAGC
TGTTCATGACCCTGTTTTTCGGCATTGCCGCCGTGGAGATCACCCAGAGCTGCATGCCCGGCGGTGACCTGAATCCGATC
TCCCGGGCGGTCAACCCTCTGTTCGGCACCCTGGGGGGGGTGCTGGGGCCGGTGCTGGTCTACCTGGGGCTGAACGCCCT
GGTGGGGCTGCCTGAACTGCGCAACGGCTGGGGGATTCCCACCGCCACGGACATCGCTCTGGCCTGGCTGGCGGCGCGTA
TGGTCTTCGGCCCCGGCCATCCGGCCGTCTCCTATCTGCTGCTGTTGGCGGTGGCCGACGACGCCATCGGCCTGGCCATC
ATCGCGCTGTTCTACCCCGATCCGAATCACCCGGTGGTCGCGGCCTGGCTGCTGCTGACCCTCTTGGGCATGCTGGTTGC
CTGGGGGTTGGGCAGACGGCGCGTGCGCAGCTACTGGCCCTACATCCTGCTGGGAGGGAGCCTGAGCTGGATCGGGCTGC
ACCAGGCCCACCTGCACCCGGCCCTGGCCCTGGTCTTCATCATTCCTTTTCTGCCTCACCGCCTGCGGGAGAGCAGGCAC
CTCTTCGACGACGACCCGGGCGATCGTTCGCCCCTGGCGCAGTTCGAGCATGAGTGGAAGGTGGTGGTGGACTTTGGTCT
GTTTCTGTTCGGCCTGGCCAACGCCGGAGTGGAATTCTCCAGCATCGGCACGGTCACCTGGCTGGTGCTGGTCTCCCTGC
TCGTCGGCAAGACCGTCGGCATCTTCGGCTTCGGCCTGCTGGCGGAGCGGCTCGGCTTCAGAAGGCCGCGGGGCATGAAG
AGGCGTGACCTGCTGGTGGCGGGGGTTGTTGCCGGAACCGGCTTCACCGTGGCGCTGTTTGTCTCCGGATCCGCCTTTTC
CGATCCGGTGATCCAGGCTGCCGCCAAGATGGGAGCCATGTTCAGTCTGGCGGCGGCACTGATCGGCATGCTGCTGGGCC
AGCTGCTGCGCATACGAAAGGTGCATTGA

Upstream 100 bases:

>100_bases
GCTTGCGCCCGGAGGTCAACAGCATTCTTTTCAGGCGCTCTTTCCTGGCCGTCCAAACAGTGCTACACTCCGCCTCCACT
GGTGCAGAAAGGAAGACTGA

Downstream 100 bases:

>100_bases
AGATGATCCATATCATTCAGAGCGACGGGGATGTGCCGGCGGGGCTGGTGGAGGGCGAACTGCGGCGGTTGGGGGTGGAG
CAGCGCACCATCGGCCTGCA

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKKHLNLLREFSVPLVAGVVVALFWANLDPAGYRAFDSTPFWGSLSFHFISNELFMTLFFGIAAVEITQSCMPGGDLNPI
SRAVNPLFGTLGGVLGPVLVYLGLNALVGLPELRNGWGIPTATDIALAWLAARMVFGPGHPAVSYLLLLAVADDAIGLAI
IALFYPDPNHPVVAAWLLLTLLGMLVAWGLGRRRVRSYWPYILLGGSLSWIGLHQAHLHPALALVFIIPFLPHRLRESRH
LFDDDPGDRSPLAQFEHEWKVVVDFGLFLFGLANAGVEFSSIGTVTWLVLVSLLVGKTVGIFGFGLLAERLGFRRPRGMK
RRDLLVAGVVAGTGFTVALFVSGSAFSDPVIQAAAKMGAMFSLAAALIGMLLGQLLRIRKVH

Sequences:

>Translated_382_residues
MKKHLNLLREFSVPLVAGVVVALFWANLDPAGYRAFDSTPFWGSLSFHFISNELFMTLFFGIAAVEITQSCMPGGDLNPI
SRAVNPLFGTLGGVLGPVLVYLGLNALVGLPELRNGWGIPTATDIALAWLAARMVFGPGHPAVSYLLLLAVADDAIGLAI
IALFYPDPNHPVVAAWLLLTLLGMLVAWGLGRRRVRSYWPYILLGGSLSWIGLHQAHLHPALALVFIIPFLPHRLRESRH
LFDDDPGDRSPLAQFEHEWKVVVDFGLFLFGLANAGVEFSSIGTVTWLVLVSLLVGKTVGIFGFGLLAERLGFRRPRGMK
RRDLLVAGVVAGTGFTVALFVSGSAFSDPVIQAAAKMGAMFSLAAALIGMLLGQLLRIRKVH
>Mature_382_residues
MKKHLNLLREFSVPLVAGVVVALFWANLDPAGYRAFDSTPFWGSLSFHFISNELFMTLFFGIAAVEITQSCMPGGDLNPI
SRAVNPLFGTLGGVLGPVLVYLGLNALVGLPELRNGWGIPTATDIALAWLAARMVFGPGHPAVSYLLLLAVADDAIGLAI
IALFYPDPNHPVVAAWLLLTLLGMLVAWGLGRRRVRSYWPYILLGGSLSWIGLHQAHLHPALALVFIIPFLPHRLRESRH
LFDDDPGDRSPLAQFEHEWKVVVDFGLFLFGLANAGVEFSSIGTVTWLVLVSLLVGKTVGIFGFGLLAERLGFRRPRGMK
RRDLLVAGVVAGTGFTVALFVSGSAFSDPVIQAAAKMGAMFSLAAALIGMLLGQLLRIRKVH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=340, Percent_Identity=31.7647058823529, Blast_Score=111, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA2_PELPD (A1ATB4)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902642.1
- ProteinModelPortal:   A1ATB4
- SMR:   A1ATB4
- STRING:   A1ATB4
- GeneID:   4574379
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2987
- eggNOG:   NOG125150
- HOGENOM:   HBG665619
- OMA:   AKMGAML
- PhylomeDB:   A1ATB4
- ProtClustDB:   CLSK828801
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41337; Mature: 41337

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x413ce1c0)-; HASH(0x2220ffa4)-; HASH(0x413676d4)-; HASH(0x23c2a42c)-; HASH(0x253635e4)-; HASH(0x23c2a108)-; HASH(0x26f1588c)-; HASH(0x274e65cc)-; HASH(0x2751ca58)-; HASH(0x26215e30)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHLNLLREFSVPLVAGVVVALFWANLDPAGYRAFDSTPFWGSLSFHFISNELFMTLFF
CCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
GIAAVEITQSCMPGGDLNPISRAVNPLFGTLGGVLGPVLVYLGLNALVGLPELRNGWGIP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
TATDIALAWLAARMVFGPGHPAVSYLLLLAVADDAIGLAIIALFYPDPNHPVVAAWLLLT
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHEEECCCCCCHHHHHHHHHH
LLGMLVAWGLGRRRVRSYWPYILLGGSLSWIGLHQAHLHPALALVFIIPFLPHRLRESRH
HHHHHHHHCCCHHHHHHHCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LFDDDPGDRSPLAQFEHEWKVVVDFGLFLFGLANAGVEFSSIGTVTWLVLVSLLVGKTVG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IFGFGLLAERLGFRRPRGMKRRDLLVAGVVAGTGFTVALFVSGSAFSDPVIQAAAKMGAM
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
FSLAAALIGMLLGQLLRIRKVH
HHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MKKHLNLLREFSVPLVAGVVVALFWANLDPAGYRAFDSTPFWGSLSFHFISNELFMTLFF
CCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
GIAAVEITQSCMPGGDLNPISRAVNPLFGTLGGVLGPVLVYLGLNALVGLPELRNGWGIP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
TATDIALAWLAARMVFGPGHPAVSYLLLLAVADDAIGLAIIALFYPDPNHPVVAAWLLLT
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHEEECCCCCCHHHHHHHHHH
LLGMLVAWGLGRRRVRSYWPYILLGGSLSWIGLHQAHLHPALALVFIIPFLPHRLRESRH
HHHHHHHHCCCHHHHHHHCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LFDDDPGDRSPLAQFEHEWKVVVDFGLFLFGLANAGVEFSSIGTVTWLVLVSLLVGKTVG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IFGFGLLAERLGFRRPRGMKRRDLLVAGVVAGTGFTVALFVSGSAFSDPVIQAAAKMGAM
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHH
FSLAAALIGMLLGQLLRIRKVH
HHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA