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The map label for this gene is lutP [H]

Identifier: 118581143

GI number: 118581143

Start: 2993002

End: 2994948

Strand: Direct

Name: lutP [H]

Synonym: Ppro_2735

Alternate gene names: 118581143

Gene position: 2993002-2994948 (Clockwise)

Preceding gene: 118581142

Following gene: 118581145

Centisome position: 74.68

GC content: 61.22

Gene sequence:

>1947_bases
ATGCCGTGGATTCAGACGTATACACCGGTAGGAGGAAGCATTGGTATGTCGGCGCTGGTTGCCGCCATACCGCTAGTGAT
CATTTTTGTTTGTCTGGCTGTTCTCAAGATGAAGGCCCACAAGGCCACGCCGATCGCGGTGGGAGCGGCATTCATAATTG
CCGTCACCATCTGGGGCATGCCTGCCGACCTGGCGGGCTGGGCCTTTGTGCAGGGGGCTGGTTTCGGCCTCTTTCCGGTC
TTCTACATCGTTCTGACAACCCTGTTCCTGTACAACATCACCGTCAAGGGGGGCCAGTTCGAGATCATCCGCGCATCCCT
GGCCGGTGTTACCGCTGACCGTCGCATCCAGGCCCTGTTGATCGCTTTCTGCTTCGGCGCATTCATCGAGGGCGCGGCCG
GCTTCGGCACGCCGGTTGCCATTGCCGGCGCCACCCTGGTGGGCCTGGGATTCCGTCCCATCTATGCCGCCAGCGTCTGC
CTGATCGCCAACACCGCGCCGGTGGCCTTCGGCGCCATCGGTATCCCGGTCGTGGCCCTGGCAGGCGTCATGGGCTATAC
CGATGAGGGTTTTAAGCTGTCCAAGATGATCGCCCACCAGCTCCCCTTCATCTCGGTCTTCATCCCCTTCTACACCATCC
TGATCATGGTCGGACTGAAGAAGACCCTGGAAGTTCTCCCGGCAGTCATTACCTGCGGCGCAACCTTCGCCTTCCTGCAG
TGGATCACCGCCAGCTACCTTGGCCCCTATCTGCCGGACATCACCGCCTCCCTCGGCTCCATGGCCGCCCTGGTCATCCT
GCTGCAGTTCTGGCAGCCCCCCACCACCTATCACTTCGACCATGAGGAAATGGCCACCAAGGAAGAGCACGGTTATACCG
GCGCCCAGATCTTCCGCGGCTGGGCCCCCTACCTGGCCCTGACCATCTTCGTCCTGCTCTGGGGTCTGCCGTCGGTCAAG
AAGTCTCTCGACAACATCTACAAGCAGGTCATCACCGTCACCGGCTACCATGAAAAAGTCATCAAGGGCGTATCCAAGCC
TGAAGACGGCCTGACAAAGGCCGAAGCGGTCAAAACGGAAGTCAACAAGCTGCTGGCTGAGCTGCCCGCTTCCGAGCCGA
AACTGGCCGACGCCATCGCCAAGCTGAACGAGCTGAAGACCCAGGAAGAAGCGATCGTTCCCATCGAGCAGGGACTGGCC
GGCAAGGGAGCTGTCCTGACCGACGAGCGCTTAGCCGCCTTCGATGCCATCAACAAGAACTCCGGCGCCATAACCACGAT
GACCGCCGACCTGGAAAAGGAAAACCTGATCGTCAAGGACCAGTTCAAGCCGCTTGAGAAGGCTCTCAAGGGCCAGCTGC
CCACCAAGATCGCCGCAAAATACACCTTTAACTTCCTGTCCGCGGCCGGCACCGCCATCCTGATCGCCGCCTTCCTCTCC
TCCTTCATCTGCGGCGTCGGCATGGGCGACGTAATCGGCATCTTCGGCAAGACCTGCAACGCCATGAAGTTCCCGGCCAT
CACCATCGCCGGCGTGCTGGGCCTGGCCTACATCATGAACGTCTCCGGCATGACCAACTGCCTGGGCCTGGTCTTCACCA
AGACCGGCCACTGGTTCCCGTTCGTGGCCCCGTTCATCGGCTGGCTGGGGGTCTTCCTGACCGGTTCCGACACCTCCTCC
AACGTGCTCTTCGGCGGCCTGCAGAAGGCAACCGCCGAATCACTGGGCCTGAGCCCCACCCTGATGGGCGCATCCAACAC
CTCCGGCGGCGTCATGGGCAAGATGATCTCCCCCCAATCCCTTGCAGTTGCCTGCGCAGCCTGCAACATGGTCGGCGAGG
AGGGCACCCTGTTCCGCTTCACCCTCAAGCACTCCCTGTTCCTGACGGCAATCGTCGGCGTCATGGTCTACCTGCAGGCC
TACTACCTGCAGTGGATGATCCCCTGA

Upstream 100 bases:

>100_bases
TTTTTTTGTCTTGACAGCGATAGGCCAAAAAGGATAATTGGTAATGCAAGTTTACGAGTTACCCAAAAACAACCACACCC
ATAAAAGGAGGGAGTAAAAC

Downstream 100 bases:

>100_bases
TAATGGGACGGATATAACGACCACCAACGTGGGTTGAACTGAAAAAGCCGGTCGGGATTAAATTCCCGGCCGGCTTTTTC
AGTTCGCTGCACAATAGCTG

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MPWIQTYTPVGGSIGMSALVAAIPLVIIFVCLAVLKMKAHKATPIAVGAAFIIAVTIWGMPADLAGWAFVQGAGFGLFPV
FYIVLTTLFLYNITVKGGQFEIIRASLAGVTADRRIQALLIAFCFGAFIEGAAGFGTPVAIAGATLVGLGFRPIYAASVC
LIANTAPVAFGAIGIPVVALAGVMGYTDEGFKLSKMIAHQLPFISVFIPFYTILIMVGLKKTLEVLPAVITCGATFAFLQ
WITASYLGPYLPDITASLGSMAALVILLQFWQPPTTYHFDHEEMATKEEHGYTGAQIFRGWAPYLALTIFVLLWGLPSVK
KSLDNIYKQVITVTGYHEKVIKGVSKPEDGLTKAEAVKTEVNKLLAELPASEPKLADAIAKLNELKTQEEAIVPIEQGLA
GKGAVLTDERLAAFDAINKNSGAITTMTADLEKENLIVKDQFKPLEKALKGQLPTKIAAKYTFNFLSAAGTAILIAAFLS
SFICGVGMGDVIGIFGKTCNAMKFPAITIAGVLGLAYIMNVSGMTNCLGLVFTKTGHWFPFVAPFIGWLGVFLTGSDTSS
NVLFGGLQKATAESLGLSPTLMGASNTSGGVMGKMISPQSLAVACAACNMVGEEGTLFRFTLKHSLFLTAIVGVMVYLQA
YYLQWMIP

Sequences:

>Translated_648_residues
MPWIQTYTPVGGSIGMSALVAAIPLVIIFVCLAVLKMKAHKATPIAVGAAFIIAVTIWGMPADLAGWAFVQGAGFGLFPV
FYIVLTTLFLYNITVKGGQFEIIRASLAGVTADRRIQALLIAFCFGAFIEGAAGFGTPVAIAGATLVGLGFRPIYAASVC
LIANTAPVAFGAIGIPVVALAGVMGYTDEGFKLSKMIAHQLPFISVFIPFYTILIMVGLKKTLEVLPAVITCGATFAFLQ
WITASYLGPYLPDITASLGSMAALVILLQFWQPPTTYHFDHEEMATKEEHGYTGAQIFRGWAPYLALTIFVLLWGLPSVK
KSLDNIYKQVITVTGYHEKVIKGVSKPEDGLTKAEAVKTEVNKLLAELPASEPKLADAIAKLNELKTQEEAIVPIEQGLA
GKGAVLTDERLAAFDAINKNSGAITTMTADLEKENLIVKDQFKPLEKALKGQLPTKIAAKYTFNFLSAAGTAILIAAFLS
SFICGVGMGDVIGIFGKTCNAMKFPAITIAGVLGLAYIMNVSGMTNCLGLVFTKTGHWFPFVAPFIGWLGVFLTGSDTSS
NVLFGGLQKATAESLGLSPTLMGASNTSGGVMGKMISPQSLAVACAACNMVGEEGTLFRFTLKHSLFLTAIVGVMVYLQA
YYLQWMIP
>Mature_647_residues
PWIQTYTPVGGSIGMSALVAAIPLVIIFVCLAVLKMKAHKATPIAVGAAFIIAVTIWGMPADLAGWAFVQGAGFGLFPVF
YIVLTTLFLYNITVKGGQFEIIRASLAGVTADRRIQALLIAFCFGAFIEGAAGFGTPVAIAGATLVGLGFRPIYAASVCL
IANTAPVAFGAIGIPVVALAGVMGYTDEGFKLSKMIAHQLPFISVFIPFYTILIMVGLKKTLEVLPAVITCGATFAFLQW
ITASYLGPYLPDITASLGSMAALVILLQFWQPPTTYHFDHEEMATKEEHGYTGAQIFRGWAPYLALTIFVLLWGLPSVKK
SLDNIYKQVITVTGYHEKVIKGVSKPEDGLTKAEAVKTEVNKLLAELPASEPKLADAIAKLNELKTQEEAIVPIEQGLAG
KGAVLTDERLAAFDAINKNSGAITTMTADLEKENLIVKDQFKPLEKALKGQLPTKIAAKYTFNFLSAAGTAILIAAFLSS
FICGVGMGDVIGIFGKTCNAMKFPAITIAGVLGLAYIMNVSGMTNCLGLVFTKTGHWFPFVAPFIGWLGVFLTGSDTSSN
VLFGGLQKATAESLGLSPTLMGASNTSGGVMGKMISPQSLAVACAACNMVGEEGTLFRFTLKHSLFLTAIVGVMVYLQAY
YLQWMIP

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=357, Percent_Identity=43.4173669467787, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1790031, Length=347, Percent_Identity=41.4985590778098, Blast_Score=274, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 68850; Mature: 68719

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWIQTYTPVGGSIGMSALVAAIPLVIIFVCLAVLKMKAHKATPIAVGAAFIIAVTIWGM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PADLAGWAFVQGAGFGLFPVFYIVLTTLFLYNITVKGGQFEIIRASLAGVTADRRIQALL
CHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHCCCHHHHHHHHH
IAFCFGAFIEGAAGFGTPVAIAGATLVGLGFRPIYAASVCLIANTAPVAFGAIGIPVVAL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHH
AGVMGYTDEGFKLSKMIAHQLPFISVFIPFYTILIMVGLKKTLEVLPAVITCGATFAFLQ
HHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WITASYLGPYLPDITASLGSMAALVILLQFWQPPTTYHFDHEEMATKEEHGYTGAQIFRG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
WAPYLALTIFVLLWGLPSVKKSLDNIYKQVITVTGYHEKVIKGVSKPEDGLTKAEAVKTE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHH
VNKLLAELPASEPKLADAIAKLNELKTQEEAIVPIEQGLAGKGAVLTDERLAAFDAINKN
HHHHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHCCCCCCCEECHHHHHHHHHCCCC
SGAITTMTADLEKENLIVKDQFKPLEKALKGQLPTKIAAKYTFNFLSAAGTAILIAAFLS
CCEEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFICGVGMGDVIGIFGKTCNAMKFPAITIAGVLGLAYIMNVSGMTNCLGLVFTKTGHWFP
HHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHH
FVAPFIGWLGVFLTGSDTSSNVLFGGLQKATAESLGLSPTLMGASNTSGGVMGKMISPQS
HHHHHHHHHHHEEECCCCCCCCEECCHHHHHHHHCCCCCEEECCCCCCCCCEECCCCCHH
LAVACAACNMVGEEGTLFRFTLKHSLFLTAIVGVMVYLQAYYLQWMIP
HHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PWIQTYTPVGGSIGMSALVAAIPLVIIFVCLAVLKMKAHKATPIAVGAAFIIAVTIWGM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PADLAGWAFVQGAGFGLFPVFYIVLTTLFLYNITVKGGQFEIIRASLAGVTADRRIQALL
CHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHCCCHHHHHHHHH
IAFCFGAFIEGAAGFGTPVAIAGATLVGLGFRPIYAASVCLIANTAPVAFGAIGIPVVAL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHH
AGVMGYTDEGFKLSKMIAHQLPFISVFIPFYTILIMVGLKKTLEVLPAVITCGATFAFLQ
HHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WITASYLGPYLPDITASLGSMAALVILLQFWQPPTTYHFDHEEMATKEEHGYTGAQIFRG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
WAPYLALTIFVLLWGLPSVKKSLDNIYKQVITVTGYHEKVIKGVSKPEDGLTKAEAVKTE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHH
VNKLLAELPASEPKLADAIAKLNELKTQEEAIVPIEQGLAGKGAVLTDERLAAFDAINKN
HHHHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHCCCCCCCEECHHHHHHHHHCCCC
SGAITTMTADLEKENLIVKDQFKPLEKALKGQLPTKIAAKYTFNFLSAAGTAILIAAFLS
CCEEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFICGVGMGDVIGIFGKTCNAMKFPAITIAGVLGLAYIMNVSGMTNCLGLVFTKTGHWFP
HHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHH
FVAPFIGWLGVFLTGSDTSSNVLFGGLQKATAESLGLSPTLMGASNTSGGVMGKMISPQS
HHHHHHHHHHHEEECCCCCCCCEECCHHHHHHHHCCCCCEEECCCCCCCCCEECCCCCHH
LAVACAACNMVGEEGTLFRFTLKHSLFLTAIVGVMVYLQAYYLQWMIP
HHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]