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The map label for this gene is ykpB [H]

Identifier: 118581080

GI number: 118581080

Start: 2903148

End: 2904080

Strand: Direct

Name: ykpB [H]

Synonym: Ppro_2669

Alternate gene names: 118581080

Gene position: 2903148-2904080 (Clockwise)

Preceding gene: 118581079

Following gene: 118581085

Centisome position: 72.43

GC content: 60.99

Gene sequence:

>933_bases
ATGAGGATACTGGTTGTTGGCGCAGGAGCAGTGGGGGGATACTTCGGTGGCAGACTGGCCGAGGCGGGATGTGACGTCAC
ATTTCTGGTCAGGGAGCGACGCGCGGCCCAACTGTCCCGAACCGGGCTGGCCATCAGGAGCAGCTTCGGTGACGCGCTTC
TCCGTCCGAATCTCACGAAAGCCGAAGAGATCAAGGAGCAGTATGATCTCGTCCTGTTGAGCTGCAAGGCATATGACCTG
GAGTCGGCCATGGATTCATTCGCCGCCGCAGTGGGACCGCGGACCGTCATCCTGCCGGTATTGAATGGCATGCGCCATCT
GGAGTGTCTGGATGCACGCTTCGGTGCGGATAAGGTCCTCGGCGGGCTCTGCCAGATCGTTGCCACCCTTGATGCAAGCG
GCACCATTCTGCACATGAACGATTCCCACCTGATCGTGTTCGGAGAACGCGACGGGACCAGATCGGAACGGGTGGAAACC
ATCTCCGCCCTGATGGCAGCCGCTGTTTTCGGGTCAAGGGCCAGCGAAACCATACTGCAAGACATGTGGGAGAAATGGGT
ATTCCTGGCCACCCTGGCCGGTATCACCTGCCTGATGCGCGCCTCCCTGGGCGACATTGCCGCTGCTGGCGGTGCCGAAA
TCTCACAGGCCCTCTTCCGGGAGTGCTGCCTGATCGCCGAACACAACGGCCACGGGCCCGGCCCCAAATTCACAAAACGG
ATTGAGGGGATGCTGCAAGCCACGGATTCTTCCATGACGGCATCAATGCTGCGCGACATCGAACGGGGTGGACCGATCGA
AGTCGATCAGGTCATCGTCGACCTGCTGCGGCGCGCACCGGAAGGCATGGGACCGACAGCCCTGTTGCGCATCGTTCAGG
TGCATCTCAGGGCCTACGAAACCAGGAGGTTACGCGGCCAAGCGACTGCCTGA

Upstream 100 bases:

>100_bases
TACACACACTACAGCAAGAGTGCCGGCAACGGGGGTAACGCCCTGTATCGGCACAACCGGAGCCGGTTCGCGACCGCTCC
GTGCATGAAGGAGGCTGGCA

Downstream 100 bases:

>100_bases
GCAGGCTGTGTTCCTCACCCCCAAAAAAACGCTGAGGCCGGCTCCCCAGGGGAGCCGGCCTCAGCGTTTTTTGCATTCAA
GGCAATCACAGATCGTCACT

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRILVVGAGAVGGYFGGRLAEAGCDVTFLVRERRAAQLSRTGLAIRSSFGDALLRPNLTKAEEIKEQYDLVLLSCKAYDL
ESAMDSFAAAVGPRTVILPVLNGMRHLECLDARFGADKVLGGLCQIVATLDASGTILHMNDSHLIVFGERDGTRSERVET
ISALMAAAVFGSRASETILQDMWEKWVFLATLAGITCLMRASLGDIAAAGGAEISQALFRECCLIAEHNGHGPGPKFTKR
IEGMLQATDSSMTASMLRDIERGGPIEVDQVIVDLLRRAPEGMGPTALLRIVQVHLRAYETRRLRGQATA

Sequences:

>Translated_310_residues
MRILVVGAGAVGGYFGGRLAEAGCDVTFLVRERRAAQLSRTGLAIRSSFGDALLRPNLTKAEEIKEQYDLVLLSCKAYDL
ESAMDSFAAAVGPRTVILPVLNGMRHLECLDARFGADKVLGGLCQIVATLDASGTILHMNDSHLIVFGERDGTRSERVET
ISALMAAAVFGSRASETILQDMWEKWVFLATLAGITCLMRASLGDIAAAGGAEISQALFRECCLIAEHNGHGPGPKFTKR
IEGMLQATDSSMTASMLRDIERGGPIEVDQVIVDLLRRAPEGMGPTALLRIVQVHLRAYETRRLRGQATA
>Mature_310_residues
MRILVVGAGAVGGYFGGRLAEAGCDVTFLVRERRAAQLSRTGLAIRSSFGDALLRPNLTKAEEIKEQYDLVLLSCKAYDL
ESAMDSFAAAVGPRTVILPVLNGMRHLECLDARFGADKVLGGLCQIVATLDASGTILHMNDSHLIVFGERDGTRSERVET
ISALMAAAVFGSRASETILQDMWEKWVFLATLAGITCLMRASLGDIAAAGGAEISQALFRECCLIAEHNGHGPGPKFTKR
IEGMLQATDSSMTASMLRDIERGGPIEVDQVIVDLLRRAPEGMGPTALLRIVQVHLRAYETRRLRGQATA

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 33374; Mature: 33374

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGAGAVGGYFGGRLAEAGCDVTFLVRERRAAQLSRTGLAIRSSFGDALLRPNLTK
CEEEEEECCHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCH
AEEIKEQYDLVLLSCKAYDLESAMDSFAAAVGPRTVILPVLNGMRHLECLDARFGADKVL
HHHHHHHHCEEEEECCCHHHHHHHHHHHHHCCCCEEHHHHHCCHHHHHHHHHHCCHHHHH
GGLCQIVATLDASGTILHMNDSHLIVFGERDGTRSERVETISALMAAAVFGSRASETILQ
HHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
DMWEKWVFLATLAGITCLMRASLGDIAAAGGAEISQALFRECCLIAEHNGHGPGPKFTKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
IEGMLQATDSSMTASMLRDIERGGPIEVDQVIVDLLRRAPEGMGPTALLRIVQVHLRAYE
HHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TRRLRGQATA
HHHHCCCCCC
>Mature Secondary Structure
MRILVVGAGAVGGYFGGRLAEAGCDVTFLVRERRAAQLSRTGLAIRSSFGDALLRPNLTK
CEEEEEECCHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCH
AEEIKEQYDLVLLSCKAYDLESAMDSFAAAVGPRTVILPVLNGMRHLECLDARFGADKVL
HHHHHHHHCEEEEECCCHHHHHHHHHHHHHCCCCEEHHHHHCCHHHHHHHHHHCCHHHHH
GGLCQIVATLDASGTILHMNDSHLIVFGERDGTRSERVETISALMAAAVFGSRASETILQ
HHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
DMWEKWVFLATLAGITCLMRASLGDIAAAGGAEISQALFRECCLIAEHNGHGPGPKFTKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
IEGMLQATDSSMTASMLRDIERGGPIEVDQVIVDLLRRAPEGMGPTALLRIVQVHLRAYE
HHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TRRLRGQATA
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]