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The map label for this gene is purH

Identifier: 118581004

GI number: 118581004

Start: 2812244

End: 2813809

Strand: Reverse

Name: purH

Synonym: Ppro_2592

Alternate gene names: 118581004

Gene position: 2813809-2812244 (Counterclockwise)

Preceding gene: 118581005

Following gene: 118581003

Centisome position: 70.2

GC content: 62.77

Gene sequence:

>1566_bases
ATGGCAAAGATCAAACGGGCGCTGATCAGCGTCTCCAACAAGCGGGGCATCATCGAGTTTTCCAAGGTACTGGCCGGCTA
CGGCGTTGAGATACTCTCCACCGGCGGAACCGCCAAGCTGCTGCGCGATTCGGGCGTGGATGTGAAGGATGTGTCCGAAT
TCACCGGCTTCCCCGAGATGCTGGACGGCCGGGTCAAAACCCTGCACCCCAAGGTGCATGGCGGTCTGCTGGGCATGCGC
GGTAACCCGGAGCATGTGGCCAAGATGCGGGAGTTCGGCATCGAGAACATCGACATGGTGGTGGTCAACCTCTATCCCTT
CGAGGCCACCGTTGCCAAGGAAGGCTGCCTGCTGGTGGATGCCATCGAGAACATCGATATCGGCGGCCCCACCATGCTCC
GCTCCGCGGCCAAGAACTACCCCGACGTTACCGTGCTGGTGGACAGCGTGGATTACGCCACGATCGTGGATGAGATGCGG
GAAAACGGGGGGGAAGTGTCCGCAAAGACCAACTTCGGGCTGGCGGTCAAGGCCTTTCAGCACACAGCGGCCTATGACGG
CGCCATCTCCAACTACCTGGGTGCCCGCCTGGGCGAGGGGGTGGACCCCTTTCCCCCTACCTTCACCTTCCAGGTCAGGA
AGAGCCAGGAACTGCGCTACGGCGAGAACCCCCAGCAGTCGGCGGCATTCTACGTGGAGCGTGATCAGCATGAGGCGTCG
GTTGCCACCTGCCACCAGATCCAGGGCAAGGAACTCTCCTACAACAATATCGCCGATACCGATGCCGCCCTGGAGTGCGT
GAAGCAATTCACCGAGGGGCCGACCTGCGTCATCGTCAAGCATGCCAACCCCTGCGGCGTTGCCATCGGCTCCTCGCTCC
TGGAAGCCTACGACCGGGCCTACTCCACCGACCCGGAATCTGCCTTTGGCGGTATCATTGCCTGCAACAGGGAACTGGAC
CTGGAGACCGCCAGGGCGATCTGCGAGCGCCAGTTCGTGGAGGTGATCGTTGCGCCCACCGCCTCGCCGGAGGCGGTGCA
GGTGGTCTCCTCCAAGAAAAATGTTCGCCTGCTGGTGTACGGCGAATGGCCGCAGACGGTCGTGCCGCGCCTGGATTTCA
AACGGGTCACCGGTGGACTCTTGGTGCAGAGCGCCGATCAGGAACTGTTCAAAAACCTTCAGGTGGTCACCAAACGTCAA
CCCACCCCCGAGGAGCTGATCGATCTCCAGTTCTCCTGGCGGGTGGCCAAGTTCGTCAAATCCAACGCCATCGTGTACGG
CAGGGATGGCATGACCATCGGCGTGGGCGCTGGCCAGATGAGCCGGGTTAATTCGGCGCGCATCGCCGCCATCAAGGCCG
AGCATGCCGGACTCGTGGTCGAGGGGGCGGTCATGGCCTCGGACGCCTTCTTTCCGTTCCGCGACGGCATAGACAATGCG
GCGAGTGTCGGCATCCGGGCGGTGATCCAGCCGGGCGGCAGCATGCGCGACGCCGAGGTCATTGCCGCGGCGGACGAGCA
TGGCATGGCCATGGTCTTCACCGGCATGCGCCACTTCAGGCACTGA

Upstream 100 bases:

>100_bases
AAAACAGAAGGATTCAATGGTGATGGGTGACCCGTTGCCGTTATCCGTTCACCAAGTCACCAGTGACGATATTTTTTACC
CGGAAGGAGCTATCTAATTC

Downstream 100 bases:

>100_bases
AACGATAAACCTGGAAACGAATCTGAACTCACACGAAGGCACGAAGAACACAAGGATATCAGTGCTTCGCCAGTCCTGAA
CCATCGACCCGGATGGCGTT

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MAKIKRALISVSNKRGIIEFSKVLAGYGVEILSTGGTAKLLRDSGVDVKDVSEFTGFPEMLDGRVKTLHPKVHGGLLGMR
GNPEHVAKMREFGIENIDMVVVNLYPFEATVAKEGCLLVDAIENIDIGGPTMLRSAAKNYPDVTVLVDSVDYATIVDEMR
ENGGEVSAKTNFGLAVKAFQHTAAYDGAISNYLGARLGEGVDPFPPTFTFQVRKSQELRYGENPQQSAAFYVERDQHEAS
VATCHQIQGKELSYNNIADTDAALECVKQFTEGPTCVIVKHANPCGVAIGSSLLEAYDRAYSTDPESAFGGIIACNRELD
LETARAICERQFVEVIVAPTASPEAVQVVSSKKNVRLLVYGEWPQTVVPRLDFKRVTGGLLVQSADQELFKNLQVVTKRQ
PTPEELIDLQFSWRVAKFVKSNAIVYGRDGMTIGVGAGQMSRVNSARIAAIKAEHAGLVVEGAVMASDAFFPFRDGIDNA
ASVGIRAVIQPGGSMRDAEVIAAADEHGMAMVFTGMRHFRH

Sequences:

>Translated_521_residues
MAKIKRALISVSNKRGIIEFSKVLAGYGVEILSTGGTAKLLRDSGVDVKDVSEFTGFPEMLDGRVKTLHPKVHGGLLGMR
GNPEHVAKMREFGIENIDMVVVNLYPFEATVAKEGCLLVDAIENIDIGGPTMLRSAAKNYPDVTVLVDSVDYATIVDEMR
ENGGEVSAKTNFGLAVKAFQHTAAYDGAISNYLGARLGEGVDPFPPTFTFQVRKSQELRYGENPQQSAAFYVERDQHEAS
VATCHQIQGKELSYNNIADTDAALECVKQFTEGPTCVIVKHANPCGVAIGSSLLEAYDRAYSTDPESAFGGIIACNRELD
LETARAICERQFVEVIVAPTASPEAVQVVSSKKNVRLLVYGEWPQTVVPRLDFKRVTGGLLVQSADQELFKNLQVVTKRQ
PTPEELIDLQFSWRVAKFVKSNAIVYGRDGMTIGVGAGQMSRVNSARIAAIKAEHAGLVVEGAVMASDAFFPFRDGIDNA
ASVGIRAVIQPGGSMRDAEVIAAADEHGMAMVFTGMRHFRH
>Mature_520_residues
AKIKRALISVSNKRGIIEFSKVLAGYGVEILSTGGTAKLLRDSGVDVKDVSEFTGFPEMLDGRVKTLHPKVHGGLLGMRG
NPEHVAKMREFGIENIDMVVVNLYPFEATVAKEGCLLVDAIENIDIGGPTMLRSAAKNYPDVTVLVDSVDYATIVDEMRE
NGGEVSAKTNFGLAVKAFQHTAAYDGAISNYLGARLGEGVDPFPPTFTFQVRKSQELRYGENPQQSAAFYVERDQHEASV
ATCHQIQGKELSYNNIADTDAALECVKQFTEGPTCVIVKHANPCGVAIGSSLLEAYDRAYSTDPESAFGGIIACNRELDL
ETARAICERQFVEVIVAPTASPEAVQVVSSKKNVRLLVYGEWPQTVVPRLDFKRVTGGLLVQSADQELFKNLQVVTKRQP
TPEELIDLQFSWRVAKFVKSNAIVYGRDGMTIGVGAGQMSRVNSARIAAIKAEHAGLVVEGAVMASDAFFPFRDGIDNAA
SVGIRAVIQPGGSMRDAEVIAAADEHGMAMVFTGMRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=512, Percent_Identity=37.5, Blast_Score=281, Evalue=2e-75,
Organism=Escherichia coli, GI1790439, Length=527, Percent_Identity=64.1366223908918, Blast_Score=679, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985564, Length=504, Percent_Identity=33.9285714285714, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71985574, Length=334, Percent_Identity=27.8443113772455, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985556, Length=60, Percent_Identity=51.6666666666667, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323768, Length=482, Percent_Identity=36.5145228215768, Blast_Score=270, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6323056, Length=484, Percent_Identity=35.7438016528926, Blast_Score=266, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24649832, Length=510, Percent_Identity=37.0588235294118, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_PELPD (A1AS76)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902254.1
- ProteinModelPortal:   A1AS76
- SMR:   A1AS76
- STRING:   A1AS76
- GeneID:   4572925
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2592
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   A1AS76
- ProtClustDB:   PRK00881
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56450; Mature: 56319

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKRALISVSNKRGIIEFSKVLAGYGVEILSTGGTAKLLRDSGVDVKDVSEFTGFPEM
CCHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEECCCCEEHHHCCCCCHHHHHHHCCCHHH
LDGRVKTLHPKVHGGLLGMRGNPEHVAKMREFGIENIDMVVVNLYPFEATVAKEGCLLVD
HCCCCEEECCHHCCCEECCCCCHHHHHHHHHCCCCCEEEEEEEEECCEEECCCCCCEEEE
AIENIDIGGPTMLRSAAKNYPDVTVLVDSVDYATIVDEMRENGGEVSAKTNFGLAVKAFQ
EHHCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCEEEEHHH
HTAAYDGAISNYLGARLGEGVDPFPPTFTFQVRKSQELRYGENPQQSAAFYVERDQHEAS
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHH
VATCHQIQGKELSYNNIADTDAALECVKQFTEGPTCVIVKHANPCGVAIGSSLLEAYDRA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
YSTDPESAFGGIIACNRELDLETARAICERQFVEVIVAPTASPEAVQVVSSKKNVRLLVY
CCCCCCHHCCCEEEECCCCCHHHHHHHHHHHHEEEEEECCCCCHHHHHCCCCCCEEEEEE
GEWPQTVVPRLDFKRVTGGLLVQSADQELFKNLQVVTKRQPTPEELIDLQFSWRVAKFVK
CCCCHHHCCCCCHHHHCCCCEEECCHHHHHHHHHHHHCCCCCHHHHHEEHHHHHHHHHHH
SNAIVYGRDGMTIGVGAGQMSRVNSARIAAIKAEHAGLVVEGAVMASDAFFPFRDGIDNA
CCCEEECCCCCEEEECCCCHHHCCCCEEEEEEECCCCEEEECEEEECCCCCCHHCCCCHH
ASVGIRAVIQPGGSMRDAEVIAAADEHGMAMVFTGMRHFRH
HHCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEHHHHHCC
>Mature Secondary Structure 
AKIKRALISVSNKRGIIEFSKVLAGYGVEILSTGGTAKLLRDSGVDVKDVSEFTGFPEM
CHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEECCCCEEHHHCCCCCHHHHHHHCCCHHH
LDGRVKTLHPKVHGGLLGMRGNPEHVAKMREFGIENIDMVVVNLYPFEATVAKEGCLLVD
HCCCCEEECCHHCCCEECCCCCHHHHHHHHHCCCCCEEEEEEEEECCEEECCCCCCEEEE
AIENIDIGGPTMLRSAAKNYPDVTVLVDSVDYATIVDEMRENGGEVSAKTNFGLAVKAFQ
EHHCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCEEEEHHH
HTAAYDGAISNYLGARLGEGVDPFPPTFTFQVRKSQELRYGENPQQSAAFYVERDQHEAS
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHH
VATCHQIQGKELSYNNIADTDAALECVKQFTEGPTCVIVKHANPCGVAIGSSLLEAYDRA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
YSTDPESAFGGIIACNRELDLETARAICERQFVEVIVAPTASPEAVQVVSSKKNVRLLVY
CCCCCCHHCCCEEEECCCCCHHHHHHHHHHHHEEEEEECCCCCHHHHHCCCCCCEEEEEE
GEWPQTVVPRLDFKRVTGGLLVQSADQELFKNLQVVTKRQPTPEELIDLQFSWRVAKFVK
CCCCHHHCCCCCHHHHCCCCEEECCHHHHHHHHHHHHCCCCCHHHHHEEHHHHHHHHHHH
SNAIVYGRDGMTIGVGAGQMSRVNSARIAAIKAEHAGLVVEGAVMASDAFFPFRDGIDNA
CCCEEECCCCCEEEECCCCHHHCCCCEEEEEEECCCCEEEECEEEECCCCCCHHCCCCHH
ASVGIRAVIQPGGSMRDAEVIAAADEHGMAMVFTGMRHFRH
HHCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA