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The map label for this gene is ilvD

Identifier: 118580971

GI number: 118580971

Start: 2771890

End: 2773551

Strand: Reverse

Name: ilvD

Synonym: Ppro_2559

Alternate gene names: 118580971

Gene position: 2773551-2771890 (Counterclockwise)

Preceding gene: 118580974

Following gene: 118580970

Centisome position: 69.2

GC content: 66.25

Gene sequence:

>1662_bases
ATGAGAAGCGATACGATTACACAAGGGTTTGAACGCACTCCGCACCGCGCCCTGCTGAAGGGTAGCGGTGTCCCACAGAG
TCAGATGGACAAGCCGTTCATCGGCGTGGCCACCAGCTTTACCGACCTGATTCCCGGGCACGTGGGCATGCGCGACCTGG
AGCGCTTCATCGAGAAGGGGGTCCACACCGGCGGCGGCCACGCCTTCTTCTTCGGCCTGCCCGGCGTGTGCGACGGCATC
GCCATGGGGCACAAGGGGATGCACTACTCCCTGCCGACCCGCGAGCTTATCGCCGACATGGTGGAGTCGGTGGCCGAAGC
CCACCGCCTGGACGGGCTGGTGCTGCTGACCAACTGCGACAAGATCACCCCCGGCATGCTCATGGCCGCCGCCCGGCTGG
ATATCCCCTGCATCGTGGTCACCGCCGGTCCCATGATGAGCGGCCGCGGCCAGGAAGGGCGCAAATTCTCCTTTGTCACC
GATACCTTCGAGGCCATGGCCCGCTACAAGGCCGGCGTGATCAGTGAGAGGGAACTGATGGTCTGCGAGGAGAACGCCTG
CCCTGGCATCGGCTCCTGCCAGGGGCTGTTCACCGCCAACACCATGGCCATCCTGACCGAGACCATGGGCATGAGCCTGC
CGCGCTGCGGCACGGCCCTGGCGGTGTCGGCGCTGAAACGGCGCATCGCCTTTGCCTCGGGGGAGAAGATCGTGGAGCTG
GTGCAGAACAACATCACCCCGCGCAGCATCCTGACCCGCGAGGCCTTCGAGAACGCCATCCGGGTGGACCTGGCCCTGGG
CGGCTCCTCCAACACCGTGCTGCACCTGCTGGCCATCGCCAACGAAGCAGGGGTTGAGCTGCCGCTGGAGACCTTCGACA
TCCTGGCCAAGGAGACCCCCCAACTGGCATCCATGAACCCGGCCGGCGAGCACTTCATGGAGGACCTGGACGTGGCCGGC
GGCGTCAGCGGCGTCATGAAGCAGCTGGGCGACAAGATCAAGGATACGCAGACCCTGTTCGGCCTGACCACCAGGCAGCT
GGCAGCCAGCGTGGAGAACGTGGACGAGACGGTGATCCGTCCGCTTACTAACCCGGTGAAGAAGGAGGGGGGCATCGCGG
TCCTGTTCGGCAACATCGCGCCCAAGGGGGCGGTGGTCAAGCAGTCCGGCGTGTCGGACAAGATGATGAAATTCGAGGGG
ACGGCGCGCTGCTTCGACTCCGAGGAGCTGGCCATGGCCGCCCTGATGGAAGGGGAAATCGTTGCCGGTAATGTGGTGGT
GATCCGCTACGAGGGGCCCAAGGGTGGCCCCGGCATGCGCGAGATGCTGGCTCCCACCGCCGCCCTGATGGGGCTTGGTT
TGGGGGACTCGGTTGCCCTGATCACCGACGGCCGTTTCTCCGGCGGCACCCGTGGTCCCTGCATCGGCCACATCTCCCCC
GAGGCGGCCCAGGGCGGCCCCATCGGCCTGATCCAGGACGGCGACCGCATCTCCCTGGATATCCCGGCTCGCAGGCTGGA
GCTGCTGGTTGATGAGGCTGTGCTGCAGGCACGCGCAGCTACCTGGGTGGCTCCTCCCCCCAAGATTGCCAAGGGGTGGC
TGGCCCGCTACGCCAAGGTGGTTACCTCGGCCCACACCGGCGCGGTGACTACGGCGGAGTAG

Upstream 100 bases:

>100_bases
TTGACTCATATAGTATCTTCTGACACTTGCTCGCCGTGTATCCAACGGCTTTGCGGCAATCCGCGCACAATATTATTCAT
AACCAAGAAGGGGCTGAACC

Downstream 100 bases:

>100_bases
TGTCAGGTAAAAAACAGAATCGATTTGGAATCTGGTGATTTTGTCATTTCCTGATCCCTGAAATGATGTTGCTCTGGTGT
CAGACACGTTTTTCCCAGAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRSDTITQGFERTPHRALLKGSGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKGVHTGGGHAFFFGLPGVCDGI
AMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLDIPCIVVTAGPMMSGRGQEGRKFSFVT
DTFEAMARYKAGVISERELMVCEENACPGIGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVEL
VQNNITPRSILTREAFENAIRVDLALGGSSNTVLHLLAIANEAGVELPLETFDILAKETPQLASMNPAGEHFMEDLDVAG
GVSGVMKQLGDKIKDTQTLFGLTTRQLAASVENVDETVIRPLTNPVKKEGGIAVLFGNIAPKGAVVKQSGVSDKMMKFEG
TARCFDSEELAMAALMEGEIVAGNVVVIRYEGPKGGPGMREMLAPTAALMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EAAQGGPIGLIQDGDRISLDIPARRLELLVDEAVLQARAATWVAPPPKIAKGWLARYAKVVTSAHTGAVTTAE

Sequences:

>Translated_553_residues
MRSDTITQGFERTPHRALLKGSGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKGVHTGGGHAFFFGLPGVCDGI
AMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLDIPCIVVTAGPMMSGRGQEGRKFSFVT
DTFEAMARYKAGVISERELMVCEENACPGIGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVEL
VQNNITPRSILTREAFENAIRVDLALGGSSNTVLHLLAIANEAGVELPLETFDILAKETPQLASMNPAGEHFMEDLDVAG
GVSGVMKQLGDKIKDTQTLFGLTTRQLAASVENVDETVIRPLTNPVKKEGGIAVLFGNIAPKGAVVKQSGVSDKMMKFEG
TARCFDSEELAMAALMEGEIVAGNVVVIRYEGPKGGPGMREMLAPTAALMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EAAQGGPIGLIQDGDRISLDIPARRLELLVDEAVLQARAATWVAPPPKIAKGWLARYAKVVTSAHTGAVTTAE
>Mature_553_residues
MRSDTITQGFERTPHRALLKGSGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKGVHTGGGHAFFFGLPGVCDGI
AMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLDIPCIVVTAGPMMSGRGQEGRKFSFVT
DTFEAMARYKAGVISERELMVCEENACPGIGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVEL
VQNNITPRSILTREAFENAIRVDLALGGSSNTVLHLLAIANEAGVELPLETFDILAKETPQLASMNPAGEHFMEDLDVAG
GVSGVMKQLGDKIKDTQTLFGLTTRQLAASVENVDETVIRPLTNPVKKEGGIAVLFGNIAPKGAVVKQSGVSDKMMKFEG
TARCFDSEELAMAALMEGEIVAGNVVVIRYEGPKGGPGMREMLAPTAALMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EAAQGGPIGLIQDGDRISLDIPARRLELLVDEAVLQARAATWVAPPPKIAKGWLARYAKVVTSAHTGAVTTAE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=608, Percent_Identity=43.0921052631579, Blast_Score=457, Evalue=1e-129,
Organism=Escherichia coli, GI1788157, Length=511, Percent_Identity=31.3111545988258, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI2367371, Length=479, Percent_Identity=33.4029227557411, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1786464, Length=484, Percent_Identity=34.0909090909091, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=561, Percent_Identity=40.9982174688057, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_PELPD (A1AS43)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902221.1
- ProteinModelPortal:   A1AS43
- SMR:   A1AS43
- STRING:   A1AS43
- GeneID:   4572387
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2559
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   AKETPQL
- PhylomeDB:   A1AS43
- ProtClustDB:   PRK00911
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58510; Mature: 58510

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDTITQGFERTPHRALLKGSGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKG
CCCCCCHHHHHCCCCHHHHCCCCCCHHHCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHC
VHTGGGHAFFFGLPGVCDGIAMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCD
CCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
KITPGMLMAAARLDIPCIVVTAGPMMSGRGQEGRKFSFVTDTFEAMARYKAGVISERELM
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEE
VCEENACPGIGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVEL
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
VQNNITPRSILTREAFENAIRVDLALGGSSNTVLHLLAIANEAGVELPLETFDILAKETP
HHCCCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCC
QLASMNPAGEHFMEDLDVAGGVSGVMKQLGDKIKDTQTLFGLTTRQLAASVENVDETVIR
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLTNPVKKEGGIAVLFGNIAPKGAVVKQSGVSDKMMKFEGTARCFDSEELAMAALMEGEI
HHCCHHHHCCCEEEEECCCCCCCCEEECCCCCHHHHHCCCCHHCCCCHHHHHHHHHCCCE
VAGNVVVIRYEGPKGGPGMREMLAPTAALMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EECCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCC
EAAQGGPIGLIQDGDRISLDIPARRLELLVDEAVLQARAATWVAPPPKIAKGWLARYAKV
CCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VTSAHTGAVTTAE
HHHCCCCCEEECC
>Mature Secondary Structure
MRSDTITQGFERTPHRALLKGSGVPQSQMDKPFIGVATSFTDLIPGHVGMRDLERFIEKG
CCCCCCHHHHHCCCCHHHHCCCCCCHHHCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHC
VHTGGGHAFFFGLPGVCDGIAMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCD
CCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
KITPGMLMAAARLDIPCIVVTAGPMMSGRGQEGRKFSFVTDTFEAMARYKAGVISERELM
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEE
VCEENACPGIGSCQGLFTANTMAILTETMGMSLPRCGTALAVSALKRRIAFASGEKIVEL
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
VQNNITPRSILTREAFENAIRVDLALGGSSNTVLHLLAIANEAGVELPLETFDILAKETP
HHCCCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCC
QLASMNPAGEHFMEDLDVAGGVSGVMKQLGDKIKDTQTLFGLTTRQLAASVENVDETVIR
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLTNPVKKEGGIAVLFGNIAPKGAVVKQSGVSDKMMKFEGTARCFDSEELAMAALMEGEI
HHCCHHHHCCCEEEEECCCCCCCCEEECCCCCHHHHHCCCCHHCCCCHHHHHHHHHCCCE
VAGNVVVIRYEGPKGGPGMREMLAPTAALMGLGLGDSVALITDGRFSGGTRGPCIGHISP
EECCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCC
EAAQGGPIGLIQDGDRISLDIPARRLELLVDEAVLQARAATWVAPPPKIAKGWLARYAKV
CCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VTSAHTGAVTTAE
HHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA