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The map label for this gene is rmlA1 [H]

Identifier: 118580960

GI number: 118580960

Start: 2761824

End: 2762723

Strand: Reverse

Name: rmlA1 [H]

Synonym: Ppro_2548

Alternate gene names: 118580960

Gene position: 2762723-2761824 (Counterclockwise)

Preceding gene: 118580961

Following gene: 118580959

Centisome position: 68.93

GC content: 60.78

Gene sequence:

>900_bases
ATGTCCCGTGGAATCACCAAGGGAATCGTGCTGGCAGGTGGAGCGGGAAGCCGTCTCTACCCCTTGACGCTGGTGTCCAG
CAAACAACTCCAGCCGGTGTACGACAAGCCGCTGATCTACTACCCTCTGGCGACCCTCATGGCCGCTGGTGTCCGCGATA
TCCTGCTTATATCCACTCCCCACGATATCCCCCGCTTTCATGCGCTCTTGGGTGATGGCTCGCGCTGGGGGGTCTCCCTC
TCCTACATGGTTCAGCCGGAACCGAAGGGGATCGCCCAAGCGTTTTTGCTCGGAGAGGAGTTCATCGCAGATCAGCCGGT
TGCCCTGATCCTGGGGGACAACATCTTCTACGGCAGGATGCATCTGGACCGCATTATGGCCGAGTTTCAGTGGGGGGCGC
GCATCTTCGGCTACCAGGTTCATGATCCCGAACGCTACGGCGTGGTGGAATTCGACTGCGCCGGCACGGTGCTCTCCATC
GAGGAAAAACCGCAGAACCCAAAATCCAGCTACGCCGTGCCGGGGCTGTATCTGTATGACAACCAGGTGGTGTCCATCGC
CAAGGCCATGAAACCTTCCGCCCGGGGAGAACTGGAAATCACCGACGTCAACCTGGAGTACCTACGCCGTGGCCAGTTGA
CCGTGGAGCGCCTGGGGCGGGGCATCGCCTGGCTGGACACCGGTACCCACAAGAGCCTGCTGGAGGCCAGCAATTTCATC
GAAACCATCGAATCGCGCCAGGGGCTGAAGATCGCCTGCCTGGAGGAGATCGCCCTCAGGCTCGGCTTTATCGGCCTGAC
ACAGATGCGGAAGCTGATCAGGGAGACTCCCGTCTCATCCTATGGCGACTACCTCCGGCGGGTCTGCGAAGAGGCGGAGC
GCTGTGCGATCGCTTCCTGA

Upstream 100 bases:

>100_bases
TGGCCGCGGCGATATCCCTTGCCGCCATGTGCGATGGTGTTTGACAGGTTTTTTTCCGCAGTGTAAATTTCACACTCATT
TTTTCCAGGAGGTTTATGTC

Downstream 100 bases:

>100_bases
GAGCGAGGCCCCAACCGGGCTGTGTTTGCCCGTCATTGTGTTCGCCGATCGCTTCCGGCCTCAGAAGCTGCGGCAGGAAG
CGCAGCAGTCATATTTGGCT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSRGITKGIVLAGGAGSRLYPLTLVSSKQLQPVYDKPLIYYPLATLMAAGVRDILLISTPHDIPRFHALLGDGSRWGVSL
SYMVQPEPKGIAQAFLLGEEFIADQPVALILGDNIFYGRMHLDRIMAEFQWGARIFGYQVHDPERYGVVEFDCAGTVLSI
EEKPQNPKSSYAVPGLYLYDNQVVSIAKAMKPSARGELEITDVNLEYLRRGQLTVERLGRGIAWLDTGTHKSLLEASNFI
ETIESRQGLKIACLEEIALRLGFIGLTQMRKLIRETPVSSYGDYLRRVCEEAERCAIAS

Sequences:

>Translated_299_residues
MSRGITKGIVLAGGAGSRLYPLTLVSSKQLQPVYDKPLIYYPLATLMAAGVRDILLISTPHDIPRFHALLGDGSRWGVSL
SYMVQPEPKGIAQAFLLGEEFIADQPVALILGDNIFYGRMHLDRIMAEFQWGARIFGYQVHDPERYGVVEFDCAGTVLSI
EEKPQNPKSSYAVPGLYLYDNQVVSIAKAMKPSARGELEITDVNLEYLRRGQLTVERLGRGIAWLDTGTHKSLLEASNFI
ETIESRQGLKIACLEEIALRLGFIGLTQMRKLIRETPVSSYGDYLRRVCEEAERCAIAS
>Mature_298_residues
SRGITKGIVLAGGAGSRLYPLTLVSSKQLQPVYDKPLIYYPLATLMAAGVRDILLISTPHDIPRFHALLGDGSRWGVSLS
YMVQPEPKGIAQAFLLGEEFIADQPVALILGDNIFYGRMHLDRIMAEFQWGARIFGYQVHDPERYGVVEFDCAGTVLSIE
EKPQNPKSSYAVPGLYLYDNQVVSIAKAMKPSARGELEITDVNLEYLRRGQLTVERLGRGIAWLDTGTHKSLLEASNFIE
TIESRQGLKIACLEEIALRLGFIGLTQMRKLIRETPVSSYGDYLRRVCEEAERCAIAS

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=253, Percent_Identity=26.8774703557312, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI11761619, Length=253, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=62.4137931034483, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790224, Length=281, Percent_Identity=56.9395017793594, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI133931050, Length=185, Percent_Identity=28.1081081081081, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355443, Length=258, Percent_Identity=25.1937984496124, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644084, Length=258, Percent_Identity=25.1937984496124, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33240; Mature: 33109

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGITKGIVLAGGAGSRLYPLTLVSSKQLQPVYDKPLIYYPLATLMAAGVRDILLISTP
CCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECC
HDIPRFHALLGDGSRWGVSLSYMVQPEPKGIAQAFLLGEEFIADQPVALILGDNIFYGRM
CCCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHH
HLDRIMAEFQWGARIFGYQVHDPERYGVVEFDCAGTVLSIEEKPQNPKSSYAVPGLYLYD
HHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEEEC
NQVVSIAKAMKPSARGELEITDVNLEYLRRGQLTVERLGRGIAWLDTGTHKSLLEASNFI
CHHHHHHHHHCCCCCCCEEEEECCHHHHHCCCEEHHHHCCCEEEEECCCHHHHHHHHHHH
ETIESRQGLKIACLEEIALRLGFIGLTQMRKLIRETPVSSYGDYLRRVCEEAERCAIAS
HHHHHCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRGITKGIVLAGGAGSRLYPLTLVSSKQLQPVYDKPLIYYPLATLMAAGVRDILLISTP
CCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECC
HDIPRFHALLGDGSRWGVSLSYMVQPEPKGIAQAFLLGEEFIADQPVALILGDNIFYGRM
CCCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHH
HLDRIMAEFQWGARIFGYQVHDPERYGVVEFDCAGTVLSIEEKPQNPKSSYAVPGLYLYD
HHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEEEC
NQVVSIAKAMKPSARGELEITDVNLEYLRRGQLTVERLGRGIAWLDTGTHKSLLEASNFI
CHHHHHHHHHCCCCCCCEEEEECCHHHHHCCCEEHHHHCCCEEEEECCCHHHHHHHHHHH
ETIESRQGLKIACLEEIALRLGFIGLTQMRKLIRETPVSSYGDYLRRVCEEAERCAIAS
HHHHHCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]