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The map label for this gene is nrdZ [H]

Identifier: 118580911

GI number: 118580911

Start: 2706874

End: 2709108

Strand: Direct

Name: nrdZ [H]

Synonym: Ppro_2498

Alternate gene names: 118580911

Gene position: 2706874-2709108 (Clockwise)

Preceding gene: 118580904

Following gene: 118580912

Centisome position: 67.54

GC content: 63.94

Gene sequence:

>2235_bases
ATGAAAAGAGAAAAGACACACCCGACACTGCCCGGTTTATCGAAAAACGCACTCACCGTACTGGAGAAACGCTACCTCAG
GCGTGGTCCGAACGGCACAACGCTGGAGACAGCGGCCGACATGTTCCGCCGGGTGGCCGATACCATCGCGGCGGCCGACC
GCTCCTTCGATGAAACGGCCGATACCGCTGGCCTGGGCGACACCTTCTACCGCATGATGACCAGCTTCGAGTTTCTGCCC
AACTCCCCCACCCTGATGAACGCCGGTCGCGAACTGGGGCAACTCTCGGCCTGCTTCGTGCTTCCGGTGGGGGACTCCAT
GGAGGAAATCTTCGACGCCGTCAAGTACACCGCCCTGATCCACAAGTCCGGCGGCGGCACCGGCTTCTCCTTTTCCCGCC
TGCGCCCGGCCAACGACATGGTCAGCTCCACCACCGGCATTTCCAGCGGACCGCTCTCCTTCATGCGGGTCTTCGACGTG
GCCACCGAGACCATCAAGCAGGGGGGGACGCGGCGCGGGGCCAACATGGCCATCCTCAGAGTCGACCATCCCGACATCGT
GGACTTCATCATGTGCAAGGCCGACCAGAAGCAGCTCAACAACTTCAACATCTCCGTCGGCCTGACCGAGAAGTTCATGC
AGGCCGTGGAGCGGGACGAGGAGTACACCCTGGTCAACCCGCGCAACGGCAAGCAGCACGGCACCCTCAACGCCCGCAAG
GTCTTCCAGCGCATCGTCAAGCAAGCCTGGGAGAACGGCGAGCCGGGCATCGTCTTTTTGGACCGCCTGAACCGCGACAA
CCCCACCCCCCAGGTGGGAGAGATCGAATCCACCAACCCCTGCGGCGAGCAGCCGCTGCTCCCCTACGAATCGTGCAACC
TGGGCTCCATCAACCTGGGCAAGTTCGTGGCCGAGGGGGCCATCGACTGGAACAGGCTGAAGGAGACGGTCCGGAACGCG
GTGCACTTCCTGGACAACGTGATCGAAGCCAACAGCTACCCCCTGCAGCAGATCCACGACATGACCCACGGCAACCGCAA
GATCGGCCTGGGGGTCATGGGCTGGGCCGACATGCTGATCCTGCTGGGCATCCCCTACAGCTCCCCCGAGGCGGTCAAGC
TGGGCACGAAGGTCATGAAGTTCATCAACGACGAGGGGCGCCTGGCTTCCCGTGAGCTGGGCAAGGTCCGCGGTTCCTTC
CCCAACTTCACCGGCTCGACCTTCGACATCAAAGACGCCGAGCCGATGCGCAACGCCACGGTAACCACCATCGCCCCCAC
CGGCACCATTTCCATCATCGCCAACGCCTCATCCGGCGTGGAGCCGCTCTTCGCCGTCTCCTACCTGCGCACCGTCATGG
ACAAGAACGTGCTGGTGGAGGTCAATCCCCATTTCGAGAGGATCGCCAAGGAGCGCGGCTTCTACTCCGAGTCGTTGATG
AAGCGCATCGCCGAGCACGGCACGGTGCAGGGCATCCCCGAAGTGCCCCAGGACGTGCAGGAAATGTTCGTCACCGCCCA
CGACATCTCCCCCAACGACCACATACAGATGCAGGCAGCCTTCCAGTTGCACACCGACAATGCCGTCTCCAAGACCGTCA
ACTTCCCCAATTCGGCAACCATCGAGGACGTGGAGAACGTCTACCGCCTGGCTTACCAGACCGGATGCAAGGGGGTCACC
ATCTACCGTGACGGCTCCCGGGACGAGCAGGTGCTCTCCACCGCCAAGAAGGACGAGGCGCCTCGCGAGGCAGCCGCTGC
TCCCGAAGAAAAGAAGGCGATCAAGCGCGACCGTCCCAAGTCCCTCAGGGGGAGCACCCATCAGATGCAGACCGGCTGCG
GCCCGCTGTACGTTACCATCAACGAGGACAGAAACGGCCTGTTCGAGCTCTTCACCACCATGGGCAAGGCAGGCGGCTGC
GCCGCTTCCCAGAGCGAGGCCATCGGCCGCATGGTCTCCCTGGCATGGCGCAGCGGCGTCCAGGCCCGCCAGGTGGTCAA
GCAGCTCATGGGCATCTCCTGCCACTGCCCCTCCGGCTTCGGAGAAAACCGTGTGCTCTCCTGCGCCGACGCCGTTGCCA
AGGCCATCCAGGCCCACCTGATCGACGGCGGTTACGACATCAGTGCCGTCACCGCCCGCCAGGAGCGCGGCGCCTGCCCG
GAATGCGGCGGCGTGGTCGAACACGAGGGGGGCTGCTCAGTCTGCCACGCCTGCGGCTACTCCGAGTGCGCGTAG

Upstream 100 bases:

>100_bases
CGGCTACAAAATCTTGTATAAACACCCGTTAGCGGACATCACCGCTTCACCCCATACAAACAGACGGCGCAGCTCCGTTC
CCGCCGTAGGAGGAAACCGC

Downstream 100 bases:

>100_bases
CCGCTTCTCCCCTCTGACACCTTACTGCCCCTGTCGCCTCCCCTCACCGGGGGGGGGAGACAGGGGCAGGAATTTTGGTA
TCAGAATTTTCTACGGAAAT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MKREKTHPTLPGLSKNALTVLEKRYLRRGPNGTTLETAADMFRRVADTIAAADRSFDETADTAGLGDTFYRMMTSFEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFSRLRPANDMVSSTTGISSGPLSFMRVFDV
ATETIKQGGTRRGANMAILRVDHPDIVDFIMCKADQKQLNNFNISVGLTEKFMQAVERDEEYTLVNPRNGKQHGTLNARK
VFQRIVKQAWENGEPGIVFLDRLNRDNPTPQVGEIESTNPCGEQPLLPYESCNLGSINLGKFVAEGAIDWNRLKETVRNA
VHFLDNVIEANSYPLQQIHDMTHGNRKIGLGVMGWADMLILLGIPYSSPEAVKLGTKVMKFINDEGRLASRELGKVRGSF
PNFTGSTFDIKDAEPMRNATVTTIAPTGTISIIANASSGVEPLFAVSYLRTVMDKNVLVEVNPHFERIAKERGFYSESLM
KRIAEHGTVQGIPEVPQDVQEMFVTAHDISPNDHIQMQAAFQLHTDNAVSKTVNFPNSATIEDVENVYRLAYQTGCKGVT
IYRDGSRDEQVLSTAKKDEAPREAAAAPEEKKAIKRDRPKSLRGSTHQMQTGCGPLYVTINEDRNGLFELFTTMGKAGGC
AASQSEAIGRMVSLAWRSGVQARQVVKQLMGISCHCPSGFGENRVLSCADAVAKAIQAHLIDGGYDISAVTARQERGACP
ECGGVVEHEGGCSVCHACGYSECA

Sequences:

>Translated_744_residues
MKREKTHPTLPGLSKNALTVLEKRYLRRGPNGTTLETAADMFRRVADTIAAADRSFDETADTAGLGDTFYRMMTSFEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFSRLRPANDMVSSTTGISSGPLSFMRVFDV
ATETIKQGGTRRGANMAILRVDHPDIVDFIMCKADQKQLNNFNISVGLTEKFMQAVERDEEYTLVNPRNGKQHGTLNARK
VFQRIVKQAWENGEPGIVFLDRLNRDNPTPQVGEIESTNPCGEQPLLPYESCNLGSINLGKFVAEGAIDWNRLKETVRNA
VHFLDNVIEANSYPLQQIHDMTHGNRKIGLGVMGWADMLILLGIPYSSPEAVKLGTKVMKFINDEGRLASRELGKVRGSF
PNFTGSTFDIKDAEPMRNATVTTIAPTGTISIIANASSGVEPLFAVSYLRTVMDKNVLVEVNPHFERIAKERGFYSESLM
KRIAEHGTVQGIPEVPQDVQEMFVTAHDISPNDHIQMQAAFQLHTDNAVSKTVNFPNSATIEDVENVYRLAYQTGCKGVT
IYRDGSRDEQVLSTAKKDEAPREAAAAPEEKKAIKRDRPKSLRGSTHQMQTGCGPLYVTINEDRNGLFELFTTMGKAGGC
AASQSEAIGRMVSLAWRSGVQARQVVKQLMGISCHCPSGFGENRVLSCADAVAKAIQAHLIDGGYDISAVTARQERGACP
ECGGVVEHEGGCSVCHACGYSECA
>Mature_744_residues
MKREKTHPTLPGLSKNALTVLEKRYLRRGPNGTTLETAADMFRRVADTIAAADRSFDETADTAGLGDTFYRMMTSFEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFSRLRPANDMVSSTTGISSGPLSFMRVFDV
ATETIKQGGTRRGANMAILRVDHPDIVDFIMCKADQKQLNNFNISVGLTEKFMQAVERDEEYTLVNPRNGKQHGTLNARK
VFQRIVKQAWENGEPGIVFLDRLNRDNPTPQVGEIESTNPCGEQPLLPYESCNLGSINLGKFVAEGAIDWNRLKETVRNA
VHFLDNVIEANSYPLQQIHDMTHGNRKIGLGVMGWADMLILLGIPYSSPEAVKLGTKVMKFINDEGRLASRELGKVRGSF
PNFTGSTFDIKDAEPMRNATVTTIAPTGTISIIANASSGVEPLFAVSYLRTVMDKNVLVEVNPHFERIAKERGFYSESLM
KRIAEHGTVQGIPEVPQDVQEMFVTAHDISPNDHIQMQAAFQLHTDNAVSKTVNFPNSATIEDVENVYRLAYQTGCKGVT
IYRDGSRDEQVLSTAKKDEAPREAAAAPEEKKAIKRDRPKSLRGSTHQMQTGCGPLYVTINEDRNGLFELFTTMGKAGGC
AASQSEAIGRMVSLAWRSGVQARQVVKQLMGISCHCPSGFGENRVLSCADAVAKAIQAHLIDGGYDISAVTARQERGACP
ECGGVVEHEGGCSVCHACGYSECA

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=579, Percent_Identity=27.979274611399, Blast_Score=218, Evalue=2e-56,
Organism=Escherichia coli, GI1789030, Length=619, Percent_Identity=25.686591276252, Blast_Score=141, Evalue=2e-34,
Organism=Escherichia coli, GI2367133, Length=589, Percent_Identity=21.5619694397284, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555242, Length=642, Percent_Identity=27.5700934579439, Blast_Score=229, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322123, Length=607, Percent_Identity=28.33607907743, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6320914, Length=606, Percent_Identity=27.7227722772277, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17352481, Length=568, Percent_Identity=27.8169014084507, Blast_Score=202, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 81329; Mature: 81329

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS01186 EGF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREKTHPTLPGLSKNALTVLEKRYLRRGPNGTTLETAADMFRRVADTIAAADRSFDETA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
DTAGLGDTFYRMMTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALI
HCCCCCHHHHHHHHHHHCCCCCCHHHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHE
HKSGGGTGFSFSRLRPANDMVSSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMAILR
EECCCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
VDHPDIVDFIMCKADQKQLNNFNISVGLTEKFMQAVERDEEYTLVNPRNGKQHGTLNARK
ECCCCHHHHHHHCCCHHHCCCEEEEEECHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHH
VFQRIVKQAWENGEPGIVFLDRLNRDNPTPQVGEIESTNPCGEQPLLPYESCNLGSINLG
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
KFVAEGAIDWNRLKETVRNAVHFLDNVIEANSYPLQQIHDMTHGNRKIGLGVMGWADMLI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHH
LLGIPYSSPEAVKLGTKVMKFINDEGRLASRELGKVRGSFPNFTGSTFDIKDAEPMRNAT
HHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCE
VTTIAPTGTISIIANASSGVEPLFAVSYLRTVMDKNVLVEVNPHFERIAKERGFYSESLM
EEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCHHHHHH
KRIAEHGTVQGIPEVPQDVQEMFVTAHDISPNDHIQMQAAFQLHTDNAVSKTVNFPNSAT
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHCCCCCCCC
IEDVENVYRLAYQTGCKGVTIYRDGSRDEQVLSTAKKDEAPREAAAAPEEKKAIKRDRPK
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCC
SLRGSTHQMQTGCGPLYVTINEDRNGLFELFTTMGKAGGCAASQSEAIGRMVSLAWRSGV
HHCCCCHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCH
QARQVVKQLMGISCHCPSGFGENRVLSCADAVAKAIQAHLIDGGYDISAVTARQERGACP
HHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCC
ECGGVVEHEGGCSVCHACGYSECA
CCCCCEECCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKREKTHPTLPGLSKNALTVLEKRYLRRGPNGTTLETAADMFRRVADTIAAADRSFDETA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
DTAGLGDTFYRMMTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALI
HCCCCCHHHHHHHHHHHCCCCCCHHHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHE
HKSGGGTGFSFSRLRPANDMVSSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMAILR
EECCCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
VDHPDIVDFIMCKADQKQLNNFNISVGLTEKFMQAVERDEEYTLVNPRNGKQHGTLNARK
ECCCCHHHHHHHCCCHHHCCCEEEEEECHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHH
VFQRIVKQAWENGEPGIVFLDRLNRDNPTPQVGEIESTNPCGEQPLLPYESCNLGSINLG
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
KFVAEGAIDWNRLKETVRNAVHFLDNVIEANSYPLQQIHDMTHGNRKIGLGVMGWADMLI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHH
LLGIPYSSPEAVKLGTKVMKFINDEGRLASRELGKVRGSFPNFTGSTFDIKDAEPMRNAT
HHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCE
VTTIAPTGTISIIANASSGVEPLFAVSYLRTVMDKNVLVEVNPHFERIAKERGFYSESLM
EEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCHHHHHH
KRIAEHGTVQGIPEVPQDVQEMFVTAHDISPNDHIQMQAAFQLHTDNAVSKTVNFPNSAT
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHCCCCCCCC
IEDVENVYRLAYQTGCKGVTIYRDGSRDEQVLSTAKKDEAPREAAAAPEEKKAIKRDRPK
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCC
SLRGSTHQMQTGCGPLYVTINEDRNGLFELFTTMGKAGGCAASQSEAIGRMVSLAWRSGV
HHCCCCHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCH
QARQVVKQLMGISCHCPSGFGENRVLSCADAVAKAIQAHLIDGGYDISAVTARQERGACP
HHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCC
ECGGVVEHEGGCSVCHACGYSECA
CCCCCEECCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]