Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 118580895

GI number: 118580895

Start: 2688145

End: 2690061

Strand: Reverse

Name: sdhA [H]

Synonym: Ppro_2482

Alternate gene names: 118580895

Gene position: 2690061-2688145 (Counterclockwise)

Preceding gene: 118580896

Following gene: 118580894

Centisome position: 67.12

GC content: 59.57

Gene sequence:

>1917_bases
GTGATACTTGATGGAAAATGTCCTACTGGACCTATTCAGCAAACCTGGGACAAGCACCGCTTCGATCTGAAGCTGGTCAA
TCCTGCCAATAAGCGTAAATATAACGTCATCGTGGTCGGTACCGGTCTGGCCGGTGGCGCCGCCGCCGCTTCGCTCGGTG
AACTGGGCTACAATGTTCAGGCCTTCTGTTATCAGGATTCCCCTCGCCGCGCGCACTCCATCGCCGCACAGGGTGGTATC
AACGCTGCCAAGAACTATCCCAATGACGGTGACTCCATCTACCGGCTGTTCTACGACACCATCAAGGGGGGCGACTTCCG
CGCCCGTGAAGCCGACGTCTGGCGTCTGGCCCAGGTGTCCAACAACATCATCGACCAGTGCGTCGCCCAAGGCGTTCCCT
TTGCCCGCGACTATGCCGGCTACCTGGATAACCGCTCCTTCGGTGGCGCCCAGGTTTCCCGTACCTTCTACGCCCGTGGC
CAGACCGGTCAGCAGCTCCTCCTGGGCGCCTACACCGCCCTGTCCCGCCAGATCAACGCCGGTACGGTCAAGATGTACAA
CCGCCGCGAAATGCTCGATCTGGTGGTGGTTGACGGCGTTGCCCGCGGTATTACCGTCCGCAACCTGATCACCGGCGAGA
TCGAAAGCTATGCAGCCGATGCCGTCTGTTTGGCAACCGGTGGCTACGTCAACGTATTCTACCTCTCCACCAACGCCATG
GGCTGCTCGGTTACCGCCATCTGGAAGGCACACAAGAAGGGCGCCTTCTTCGCCAACCCCTGCTACACCCAGATTCACCC
GACCTGTATCCCCCAGGCCGGCGACTACCAGTCCAAGCTGACCCTGATGTCCGAGTCGCTGCGTAACGACGGACGCTGCT
GGGTTCCCAAGAAGAAAGAGGACTGCGGCAAGCATCCCAACGAGATCCCGGAAGATGCCCGTGACTACTACCTGGAGCGC
AAGTACCCCTCATTCGGTAACCTGGCTCCCCGCGACATCGCCTCCCGCGCCGCCAAGGAAGCCTGCGACGACGGTCGTGG
CGTCGGCCCCGGCGGCCGTGGTGTGTACCTGGACTTCGCCGCTTCCATCAAGCGCGTCGGCCAGCCGAAGATCGCCGAGC
GTTACGGCAACCTCTTCGAAATGTACGAGAAGATCACCGACGAGGACGGTTACAAGCGTCCCATGCGTATGTACCCCGCG
CCGCACTACTCCATGGGCGGCCTGTGGGTCGACTACAACCTGATGAGCAATATCCCCGGCCTGTTCGTCCTCGGTGAGGC
AAACTTCTCCGTGCACGGCGCCAACCGTCTGGGTGCTTCCGCTCTCATGCAGGGTCTTGCCGACGGCTACTTCGTCATTC
CTTACACCATCGGCGGCTATCTGGCCGGCATCAAGGATCCGGGCACGATCAAGGCCGACCATCCCGAGTTCAGGAAGGCC
GAGGACGACGTCAAGTCCAGCGTCAATAAATACCTCTCCATCAATGGCAAGAAGACAACTTCGGAGTTTATGCGCGAACT
GGGTTCCCTGATGTGGGAAAACTGCGGTATGGCTCGCACCAAGGAATCCCTGGAGTCCAACCTGCAGAAGATTCCTGCAC
TGCGCGAAGAGTTCTGGAAGAATGTCAAGGTGTCCGGTACCGGTGCTGACTTCAATCAGCAGCTGGAAAACGCCGGCCGC
ACCGCCGACTTCCTCGAGTTCGCCGAGCTCATGTGCCGCGATGCCCTGCACCGCAACGAATCCTGCGGTGGCCACTTCCG
CGAAGAGTATCAGGAACTTGGCGAAGCCCAGCGTGACGACGTCAACTACTGCTATGTCGGCGCGTGGGAGTACAAGGGCG
TTGGCAAAGAGCCCGAGCTGCACAAAGAGCCTTTGAAGTTTGATAATGTACATCTTGCCATAAGGAGCTACAAGTAA

Upstream 100 bases:

>100_bases
GATTGTGAAGGCTGGTACGGTCGTGGCACTCGTGCTGTTCCTGGGGTATGTTTCCGTTCCGCTGTCGATCTTTCTCAATA
TCTTGAAATAGGGGGTTACC

Downstream 100 bases:

>100_bases
TGAGCGATCACAAGACAATGACACTGACACTGATCGTGTGGCGCCAAAAGGATGCCAGCGATCCGGGAAAGTTTGAGACC
TATACCGCTAAGAACATCAC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MILDGKCPTGPIQQTWDKHRFDLKLVNPANKRKYNVIVVGTGLAGGAAAASLGELGYNVQAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYTALSRQINAGTVKMYNRREMLDLVVVDGVARGITVRNLITGEIESYAADAVCLATGGYVNVFYLSTNAM
GCSVTAIWKAHKKGAFFANPCYTQIHPTCIPQAGDYQSKLTLMSESLRNDGRCWVPKKKEDCGKHPNEIPEDARDYYLER
KYPSFGNLAPRDIASRAAKEACDDGRGVGPGGRGVYLDFAASIKRVGQPKIAERYGNLFEMYEKITDEDGYKRPMRMYPA
PHYSMGGLWVDYNLMSNIPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIGGYLAGIKDPGTIKADHPEFRKA
EDDVKSSVNKYLSINGKKTTSEFMRELGSLMWENCGMARTKESLESNLQKIPALREEFWKNVKVSGTGADFNQQLENAGR
TADFLEFAELMCRDALHRNESCGGHFREEYQELGEAQRDDVNYCYVGAWEYKGVGKEPELHKEPLKFDNVHLAIRSYK

Sequences:

>Translated_638_residues
MILDGKCPTGPIQQTWDKHRFDLKLVNPANKRKYNVIVVGTGLAGGAAAASLGELGYNVQAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYTALSRQINAGTVKMYNRREMLDLVVVDGVARGITVRNLITGEIESYAADAVCLATGGYVNVFYLSTNAM
GCSVTAIWKAHKKGAFFANPCYTQIHPTCIPQAGDYQSKLTLMSESLRNDGRCWVPKKKEDCGKHPNEIPEDARDYYLER
KYPSFGNLAPRDIASRAAKEACDDGRGVGPGGRGVYLDFAASIKRVGQPKIAERYGNLFEMYEKITDEDGYKRPMRMYPA
PHYSMGGLWVDYNLMSNIPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIGGYLAGIKDPGTIKADHPEFRKA
EDDVKSSVNKYLSINGKKTTSEFMRELGSLMWENCGMARTKESLESNLQKIPALREEFWKNVKVSGTGADFNQQLENAGR
TADFLEFAELMCRDALHRNESCGGHFREEYQELGEAQRDDVNYCYVGAWEYKGVGKEPELHKEPLKFDNVHLAIRSYK
>Mature_638_residues
MILDGKCPTGPIQQTWDKHRFDLKLVNPANKRKYNVIVVGTGLAGGAAAASLGELGYNVQAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYTALSRQINAGTVKMYNRREMLDLVVVDGVARGITVRNLITGEIESYAADAVCLATGGYVNVFYLSTNAM
GCSVTAIWKAHKKGAFFANPCYTQIHPTCIPQAGDYQSKLTLMSESLRNDGRCWVPKKKEDCGKHPNEIPEDARDYYLER
KYPSFGNLAPRDIASRAAKEACDDGRGVGPGGRGVYLDFAASIKRVGQPKIAERYGNLFEMYEKITDEDGYKRPMRMYPA
PHYSMGGLWVDYNLMSNIPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIGGYLAGIKDPGTIKADHPEFRKA
EDDVKSSVNKYLSINGKKTTSEFMRELGSLMWENCGMARTKESLESNLQKIPALREEFWKNVKVSGTGADFNQQLENAGR
TADFLEFAELMCRDALHRNESCGGHFREEYQELGEAQRDDVNYCYVGAWEYKGVGKEPELHKEPLKFDNVHLAIRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=558, Percent_Identity=27.0609318996416, Blast_Score=152, Evalue=8e-37,
Organism=Escherichia coli, GI1790597, Length=543, Percent_Identity=30.0184162062615, Blast_Score=210, Evalue=3e-55,
Organism=Escherichia coli, GI1786942, Length=596, Percent_Identity=27.5167785234899, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788928, Length=594, Percent_Identity=27.2727272727273, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17505833, Length=544, Percent_Identity=27.2058823529412, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17550100, Length=555, Percent_Identity=27.027027027027, Blast_Score=162, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322701, Length=599, Percent_Identity=28.3806343906511, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=27.6559865092749, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI17137288, Length=585, Percent_Identity=28.2051282051282, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24655642, Length=585, Percent_Identity=28.2051282051282, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24655647, Length=585, Percent_Identity=28.2051282051282, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24663005, Length=590, Percent_Identity=25.5932203389831, Blast_Score=147, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70840; Mature: 70840

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDGKCPTGPIQQTWDKHRFDLKLVNPANKRKYNVIVVGTGLAGGAAAASLGELGYNVQ
CEECCCCCCCCHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEE
AFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYTALSRQINA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHCCCC
GTVKMYNRREMLDLVVVDGVARGITVRNLITGEIESYAADAVCLATGGYVNVFYLSTNAM
CEEEEECHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCEEEEECCCEEEEEEEECCCC
GCSVTAIWKAHKKGAFFANPCYTQIHPTCIPQAGDYQSKLTLMSESLRNDGRCWVPKKKE
CCEEEEEEHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHH
DCGKHPNEIPEDARDYYLERKYPSFGNLAPRDIASRAAKEACDDGRGVGPGGRGVYLDFA
HHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHH
ASIKRVGQPKIAERYGNLFEMYEKITDEDGYKRPMRMYPAPHYSMGGLWVDYNLMSNIPG
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEEEHHHCCCC
LFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIGGYLAGIKDPGTIKADHPEFRKA
EEEEECCCEEEECCHHCCHHHHHHHHCCCEEEEEEECCCEEECCCCCCCCCCCCCHHHHH
EDDVKSSVNKYLSINGKKTTSEFMRELGSLMWENCGMARTKESLESNLQKIPALREEFWK
HHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
NVKVSGTGADFNQQLENAGRTADFLEFAELMCRDALHRNESCGGHFREEYQELGEAQRDD
CCEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
VNYCYVGAWEYKGVGKEPELHKEPLKFDNVHLAIRSYK
CCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MILDGKCPTGPIQQTWDKHRFDLKLVNPANKRKYNVIVVGTGLAGGAAAASLGELGYNVQ
CEECCCCCCCCHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEE
AFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYTALSRQINA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHCCCC
GTVKMYNRREMLDLVVVDGVARGITVRNLITGEIESYAADAVCLATGGYVNVFYLSTNAM
CEEEEECHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCEEEEECCCEEEEEEEECCCC
GCSVTAIWKAHKKGAFFANPCYTQIHPTCIPQAGDYQSKLTLMSESLRNDGRCWVPKKKE
CCEEEEEEHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCHH
DCGKHPNEIPEDARDYYLERKYPSFGNLAPRDIASRAAKEACDDGRGVGPGGRGVYLDFA
HHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHH
ASIKRVGQPKIAERYGNLFEMYEKITDEDGYKRPMRMYPAPHYSMGGLWVDYNLMSNIPG
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEEEHHHCCCC
LFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIGGYLAGIKDPGTIKADHPEFRKA
EEEEECCCEEEECCHHCCHHHHHHHHCCCEEEEEEECCCEEECCCCCCCCCCCCCHHHHH
EDDVKSSVNKYLSINGKKTTSEFMRELGSLMWENCGMARTKESLESNLQKIPALREEFWK
HHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
NVKVSGTGADFNQQLENAGRTADFLEFAELMCRDALHRNESCGGHFREEYQELGEAQRDD
CCEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
VNYCYVGAWEYKGVGKEPELHKEPLKFDNVHLAIRSYK
CCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]