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The map label for this gene is lysC [H]

Identifier: 118580677

GI number: 118580677

Start: 2441380

End: 2442594

Strand: Direct

Name: lysC [H]

Synonym: Ppro_2262

Alternate gene names: 118580677

Gene position: 2441380-2442594 (Clockwise)

Preceding gene: 118580676

Following gene: 118580687

Centisome position: 60.91

GC content: 59.26

Gene sequence:

>1215_bases
ATGGCACTTGTCGTTCAGAAATACGGCGGTACGTCGGTCGGCAATCCCGACCGCATCAGGAACGTCGCCAAGCGGGTCGC
CAGGACCTGTGATGCGGGCAACGAGCTGATCGTTGTCCTTTCTGCCATGTCCGGAGAGACCAACAGACTGGTCTCCCTGG
CCAACGAGATGTGTGAACTGCCCCACGGCCGCGAATACGACACCCTGGTGTCCACCGGCGAACAGGTCACCATCGCCCTT
CTTGCCATGCACCTCAAATCCATGGGATACAAGGCCAAATCGTACCTGGGGTGGCAGGTGCCGATCATCACCGACGACAC
GGCAACCAAGGCGCGCATCGAGCGGATCGAGGACGCACGCATCCGCGCCGATCTGAACGAGGGGACTATCGTGATCGTGG
CCGGTTTCCAGGGCATCGACGCCAACGGCAACATCACCACCCTGGGGCGCGGCGGTTCCGACACCTCGGCGGTTGCCCTG
GCAGCGGCCCTCAAGGCGGATGTGTGCGAGATCTACACCGACGTGGACGGTGTCTACACCACCGACCCCAACATCTGCAA
GGAAGCTCGCAAGATGGAGAGCATCTCCTACGATGAGATGCTGGAACTGGCCAGCCTGGGCGCCAAGGTCCTGCAGATCC
GCTCGGTGGAGTTCGCCAAGAAATACAACGTCAACGTACATGTACGTTCCAGTTTGAATGACAATACCGGTACCATGGTT
ACGAGGGAGAACAAGGATATGGAAGGGATTCTCGTTTCAGGCGTTGCCTATGATAAGAATGAAGCCAAGATCGTCGTCAT
GGGGGTAGCCGACAAACCGGGTACCGCCGCCAGGATCCTGTCGGCGCTTTCCGACGCTTCGATCCCGGTGGACATGATCG
TACAGAACGTGAGCCAGGCCGGCCTGGCAGACTTCACCTTCACCGTCAACAAGACCGACCTGAAACAAGCCATGCAGATC
ACCAACCAGGTTGCCGGCGAACTCCAGGCCAGGGAAGTCATCTCCGACGAGAAGATCAGCAAGATTTCCATCGTCGGCCT
GGGCATGCGCAGCCACGCCGGCGTGGCCACCACCATGTTCTCGGCACTGGCCGCCGCCAACATCAACATCCAGACCATCT
CCACCTCGGAGATCAAGATCTCGGTGATCATCGACGACAAGTACACCGAACTGGCCGTGCGCGTGCTGCATGAGGCATTC
AACCTGCAGGGATAA

Upstream 100 bases:

>100_bases
ACCCAGAAATGCTTTGACCTGATCCGGTTTTGTCTGCTATACAGTGGAGTCCGCCAGCAGCTTGACGGACACCATTACCA
GGAAAGGGAGTACCTGAAGT

Downstream 100 bases:

>100_bases
TCAGCAGCCTCAAAGCGCTGAACGACATGAGCCCCGCCGGAATATCCGGAGGGGCTCATGTCGTATGCAGCTGAATCAAA
TGAGATTAGCGGTGTCTACC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MALVVQKYGGTSVGNPDRIRNVAKRVARTCDAGNELIVVLSAMSGETNRLVSLANEMCELPHGREYDTLVSTGEQVTIAL
LAMHLKSMGYKAKSYLGWQVPIITDDTATKARIERIEDARIRADLNEGTIVIVAGFQGIDANGNITTLGRGGSDTSAVAL
AAALKADVCEIYTDVDGVYTTDPNICKEARKMESISYDEMLELASLGAKVLQIRSVEFAKKYNVNVHVRSSLNDNTGTMV
TRENKDMEGILVSGVAYDKNEAKIVVMGVADKPGTAARILSALSDASIPVDMIVQNVSQAGLADFTFTVNKTDLKQAMQI
TNQVAGELQAREVISDEKISKISIVGLGMRSHAGVATTMFSALAAANINIQTISTSEIKISVIIDDKYTELAVRVLHEAF
NLQG

Sequences:

>Translated_404_residues
MALVVQKYGGTSVGNPDRIRNVAKRVARTCDAGNELIVVLSAMSGETNRLVSLANEMCELPHGREYDTLVSTGEQVTIAL
LAMHLKSMGYKAKSYLGWQVPIITDDTATKARIERIEDARIRADLNEGTIVIVAGFQGIDANGNITTLGRGGSDTSAVAL
AAALKADVCEIYTDVDGVYTTDPNICKEARKMESISYDEMLELASLGAKVLQIRSVEFAKKYNVNVHVRSSLNDNTGTMV
TRENKDMEGILVSGVAYDKNEAKIVVMGVADKPGTAARILSALSDASIPVDMIVQNVSQAGLADFTFTVNKTDLKQAMQI
TNQVAGELQAREVISDEKISKISIVGLGMRSHAGVATTMFSALAAANINIQTISTSEIKISVIIDDKYTELAVRVLHEAF
NLQG
>Mature_403_residues
ALVVQKYGGTSVGNPDRIRNVAKRVARTCDAGNELIVVLSAMSGETNRLVSLANEMCELPHGREYDTLVSTGEQVTIALL
AMHLKSMGYKAKSYLGWQVPIITDDTATKARIERIEDARIRADLNEGTIVIVAGFQGIDANGNITTLGRGGSDTSAVALA
AALKADVCEIYTDVDGVYTTDPNICKEARKMESISYDEMLELASLGAKVLQIRSVEFAKKYNVNVHVRSSLNDNTGTMVT
RENKDMEGILVSGVAYDKNEAKIVVMGVADKPGTAARILSALSDASIPVDMIVQNVSQAGLADFTFTVNKTDLKQAMQIT
NQVAGELQAREVISDEKISKISIVGLGMRSHAGVATTMFSALAAANINIQTISTSEIKISVIIDDKYTELAVRVLHEAFN
LQG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=475, Percent_Identity=31.5789473684211, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1790455, Length=451, Percent_Identity=28.6031042128603, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790376, Length=289, Percent_Identity=25.9515570934256, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=373, Percent_Identity=23.8605898123324, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43394; Mature: 43263

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVVQKYGGTSVGNPDRIRNVAKRVARTCDAGNELIVVLSAMSGETNRLVSLANEMCEL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PHGREYDTLVSTGEQVTIALLAMHLKSMGYKAKSYLGWQVPIITDDTATKARIERIEDAR
CCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCHHHHHHHHHHCCC
IRADLNEGTIVIVAGFQGIDANGNITTLGRGGSDTSAVALAAALKADVCEIYTDVDGVYT
EEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICKEARKMESISYDEMLELASLGAKVLQIRSVEFAKKYNVNVHVRSSLNDNTGTMV
CCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEE
TRENKDMEGILVSGVAYDKNEAKIVVMGVADKPGTAARILSALSDASIPVDMIVQNVSQA
EECCCCCCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHC
GLADFTFTVNKTDLKQAMQITNQVAGELQAREVISDEKISKISIVGLGMRSHAGVATTMF
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHH
SALAAANINIQTISTSEIKISVIIDDKYTELAVRVLHEAFNLQG
HHHHHCCCEEEEEECCEEEEEEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALVVQKYGGTSVGNPDRIRNVAKRVARTCDAGNELIVVLSAMSGETNRLVSLANEMCEL
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PHGREYDTLVSTGEQVTIALLAMHLKSMGYKAKSYLGWQVPIITDDTATKARIERIEDAR
CCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCHHHHHHHHHHCCC
IRADLNEGTIVIVAGFQGIDANGNITTLGRGGSDTSAVALAAALKADVCEIYTDVDGVYT
EEEECCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICKEARKMESISYDEMLELASLGAKVLQIRSVEFAKKYNVNVHVRSSLNDNTGTMV
CCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEE
TRENKDMEGILVSGVAYDKNEAKIVVMGVADKPGTAARILSALSDASIPVDMIVQNVSQA
EECCCCCCCEEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHC
GLADFTFTVNKTDLKQAMQITNQVAGELQAREVISDEKISKISIVGLGMRSHAGVATTMF
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHH
SALAAANINIQTISTSEIKISVIIDDKYTELAVRVLHEAFNLQG
HHHHHCCCEEEEEECCEEEEEEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]