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The map label for this gene is folP [H]

Identifier: 118580668

GI number: 118580668

Start: 2433535

End: 2434737

Strand: Direct

Name: folP [H]

Synonym: Ppro_2253

Alternate gene names: 118580668

Gene position: 2433535-2434737 (Clockwise)

Preceding gene: 118580667

Following gene: 118580669

Centisome position: 60.72

GC content: 67.08

Gene sequence:

>1203_bases
ATGGACCATTTCCAGGCGCGAACGCTCTCCCTGGGCAGTCCGGTCGCCGCCGAGCGCGAACTGCGCCGCATGGGGGTTGA
CCCGGGCGGCATCCAGAGGCTTCTGCCCAAGATGTCCAGCCACTGCATCCAGATCCCTCGCCTGCAGTGCCGCCAGGCCA
ACATCCTCAAACAGGAAATGCTGGCCCTGGGGGGGGATGCGGCGGTTGCCCGCGGCAGCGTGGCCTGCAGCATCGAGGCC
AGCGACGCGATCCTGATGGGAACGGAGAAACAGCTCAGGCAGCTCTGCACAAGACTGGCCCGGCAGCCCTTCGGCCTCCC
CTCCCTGGGGGAAGAGCTGTCCACGCTCCTGGACCGGATCGCCACCCCAGCCTTCTTCTGGCGCACATCCCGGCGGGAGC
TCCCGCTGACACGTCCGCTGATCATGGGCATCCTCAACATAACCCCGGACTCCTTCTCCGACGGCGGCCGCTACCTGGAC
CCGGCACGGGCAGTGGAACGGGCGGAGCAGATGATTGCCGAGGGAGCCGACATCATCGACATCGGCGGCGAGAGCACCCG
CCCCGGCGCCCCGGCCATATCAGCGCAGGAGGAGATCGACCGGGTCGTGCCGGTCATTTCGGCGATCGCCAAGAGTTCAT
CCATCCCTCTCTCCGTGGACAGCTGGAAGGGGGAAGTGGCCCGCCAGGCCATGGACGCCGGAGCGGAGATCATCAACGAC
ATCAGCGGACTCGGCTTCGACCCCTCCCTGGCCCAGGTAGCGGCCACCAGCAAGGCGGGACTGGTGCTGATGCACACGCG
GGGAACACCGGACGGCATGCAGCGCGACACCGAGTACGGCGACCTTTTGGCCGAGGTCATGCAGGGGCTACGCCATTCGA
CAGAGACCGCCCTCTCCGCCGGCGTGGAACGGGAACTGATCTGCCTGGACCCGGGCATAGGCTTCGCCAAGAGCGCCCAG
GGCAACCTGGAGCTCTTGCGGCGTCTGCGGGAATTCCAGAGCCTGGGCCTGCCGCTTCTGGTGGGCACGTCACGAAAATC
GTTCATCGGCGCTGCCATCGGCCGGGAGGTGCATGACCGGCTGTTCGGTACGGCCGCCACTGTGGCCCTGGCGGTGAGCC
ATGGCGCATCCATCCTGCGGGTCCATGACGTGGCAGCCATGCGGGATGTGGCCGACATGGCTCGGGCAATCGTGGAGGGA
TAG

Upstream 100 bases:

>100_bases
GAGGTGGACCGGATCATCGCCGCCGGCGTGCCCACCTGCGGCCAGGGTGCAACGGATTCAGCACAGCAGCAGGAACAGCA
CACCGACATCCAGGTCTGAT

Downstream 100 bases:

>100_bases
GCACTCCCGGCGCTCCTCGCCACGCAACCGAGCCGGATGCGCGCCGCCCCCCCCGGCGGATTCGGGAACAGAACACCCGG
TCTGTTATCAAACAGACACC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDHFQARTLSLGSPVAAERELRRMGVDPGGIQRLLPKMSSHCIQIPRLQCRQANILKQEMLALGGDAAVARGSVACSIEA
SDAILMGTEKQLRQLCTRLARQPFGLPSLGEELSTLLDRIATPAFFWRTSRRELPLTRPLIMGILNITPDSFSDGGRYLD
PARAVERAEQMIAEGADIIDIGGESTRPGAPAISAQEEIDRVVPVISAIAKSSSIPLSVDSWKGEVARQAMDAGAEIIND
ISGLGFDPSLAQVAATSKAGLVLMHTRGTPDGMQRDTEYGDLLAEVMQGLRHSTETALSAGVERELICLDPGIGFAKSAQ
GNLELLRRLREFQSLGLPLLVGTSRKSFIGAAIGREVHDRLFGTAATVALAVSHGASILRVHDVAAMRDVADMARAIVEG

Sequences:

>Translated_400_residues
MDHFQARTLSLGSPVAAERELRRMGVDPGGIQRLLPKMSSHCIQIPRLQCRQANILKQEMLALGGDAAVARGSVACSIEA
SDAILMGTEKQLRQLCTRLARQPFGLPSLGEELSTLLDRIATPAFFWRTSRRELPLTRPLIMGILNITPDSFSDGGRYLD
PARAVERAEQMIAEGADIIDIGGESTRPGAPAISAQEEIDRVVPVISAIAKSSSIPLSVDSWKGEVARQAMDAGAEIIND
ISGLGFDPSLAQVAATSKAGLVLMHTRGTPDGMQRDTEYGDLLAEVMQGLRHSTETALSAGVERELICLDPGIGFAKSAQ
GNLELLRRLREFQSLGLPLLVGTSRKSFIGAAIGREVHDRLFGTAATVALAVSHGASILRVHDVAAMRDVADMARAIVEG
>Mature_400_residues
MDHFQARTLSLGSPVAAERELRRMGVDPGGIQRLLPKMSSHCIQIPRLQCRQANILKQEMLALGGDAAVARGSVACSIEA
SDAILMGTEKQLRQLCTRLARQPFGLPSLGEELSTLLDRIATPAFFWRTSRRELPLTRPLIMGILNITPDSFSDGGRYLD
PARAVERAEQMIAEGADIIDIGGESTRPGAPAISAQEEIDRVVPVISAIAKSSSIPLSVDSWKGEVARQAMDAGAEIIND
ISGLGFDPSLAQVAATSKAGLVLMHTRGTPDGMQRDTEYGDLLAEVMQGLRHSTETALSAGVERELICLDPGIGFAKSAQ
GNLELLRRLREFQSLGLPLLVGTSRKSFIGAAIGREVHDRLFGTAATVALAVSHGASILRVHDVAAMRDVADMARAIVEG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=46.7432950191571, Blast_Score=219, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=33.4375, Blast_Score=155, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 42772; Mature: 42772

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFQARTLSLGSPVAAERELRRMGVDPGGIQRLLPKMSSHCIQIPRLQCRQANILKQEM
CCCCCCHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LALGGDAAVARGSVACSIEASDAILMGTEKQLRQLCTRLARQPFGLPSLGEELSTLLDRI
HHHCCCHHHHCCCEEEEEECCCEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ATPAFFWRTSRRELPLTRPLIMGILNITPDSFSDGGRYLDPARAVERAEQMIAEGADIID
CCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
IGGESTRPGAPAISAQEEIDRVVPVISAIAKSSSIPLSVDSWKGEVARQAMDAGAEIIND
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
ISGLGFDPSLAQVAATSKAGLVLMHTRGTPDGMQRDTEYGDLLAEVMQGLRHSTETALSA
HHCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GVERELICLDPGIGFAKSAQGNLELLRRLREFQSLGLPLLVGTSRKSFIGAAIGREVHDR
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHH
LFGTAATVALAVSHGASILRVHDVAAMRDVADMARAIVEG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDHFQARTLSLGSPVAAERELRRMGVDPGGIQRLLPKMSSHCIQIPRLQCRQANILKQEM
CCCCCCHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LALGGDAAVARGSVACSIEASDAILMGTEKQLRQLCTRLARQPFGLPSLGEELSTLLDRI
HHHCCCHHHHCCCEEEEEECCCEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ATPAFFWRTSRRELPLTRPLIMGILNITPDSFSDGGRYLDPARAVERAEQMIAEGADIID
CCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
IGGESTRPGAPAISAQEEIDRVVPVISAIAKSSSIPLSVDSWKGEVARQAMDAGAEIIND
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
ISGLGFDPSLAQVAATSKAGLVLMHTRGTPDGMQRDTEYGDLLAEVMQGLRHSTETALSA
HHCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GVERELICLDPGIGFAKSAQGNLELLRRLREFQSLGLPLLVGTSRKSFIGAAIGREVHDR
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHH
LFGTAATVALAVSHGASILRVHDVAAMRDVADMARAIVEG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]