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The map label for this gene is pgl [H]

Identifier: 118580666

GI number: 118580666

Start: 2430793

End: 2431539

Strand: Direct

Name: pgl [H]

Synonym: Ppro_2251

Alternate gene names: 118580666

Gene position: 2430793-2431539 (Clockwise)

Preceding gene: 118580665

Following gene: 118580667

Centisome position: 60.65

GC content: 68.54

Gene sequence:

>747_bases
ATGAGCGCCACTGTCCGGCGTTTCAACGACGAAGAATCGCTCAGCCGGGCGGCGGCCGAGATTTTCGCCCTGACCGCGGA
ACAGGCGATCGCCTCCCAGGGTCGCTTTTCGGTCCTGCTGAGCGGCGGCGAGACCCCCCGCCGCGCCTATGAGCTTCTCA
GCCAGGAGCCGCTGTGCAGTCGCATACCCTGGCAGGGGGTGCACCTGTTCTGGGGGGACGAACGCTGCGTAGCCGCCACT
GACCCGGCCAGCAACGCCCTGATGGTGCGCAGGGCACTGCTGGACAGAGTCCCGATCCCGGAGGAGCAGATCCACCCCAT
CGCCTGCGGCACCGAACCCGAAGTGGCGGCAGCCCGCTACGAGGCGCTTGTGCGTGCCCATTTTCCCCACGGGGGCGCCC
GTTTCGACCTGGCCCTGCTGGGCCTGGGGGAGGACGGCCACACCGCCTCCCTGTTCCCCGATTCCCCCTCGCTGGGCGAG
CAAGAACACTGGGTGGCGGCGACGCGAAAAAAGGGAGAGGAGATCATGCGCATCTCCCTGACCCCCCCTGCCCTGAACCA
GGCCGAACTGGTGGTGTTCCTGGTCAGCGGCGCACACAAGGCCAGCGTGCTGCACCGGGTGCTGGAGGGGCCATCCATCC
CCCGACTGCTTCCGGCCCAGCTGATCGCACCGTCCCGGGGCAGGCTCGTCTGGATGGTGGACCAGGGGGCGGCACGCCTG
CTGAAAACGACCGTTCCCGCCACGTGA

Upstream 100 bases:

>100_bases
CGGATTTCCCCGACTACCCGGCCGGCAGCTGGGGGCCCGAGGCGGCCGACCGCATGATCGCCCGGGGGGGTCACAACTGG
CTGCAGCCAGGCATGAAGCG

Downstream 100 bases:

>100_bases
AGCCGCTCAAAACGCCCTTCCACAGGTTACGGCGTAGCAAAAAGGTAAACATATTGTAAAGCGATACCTGCTATGGTAGA
GTTTCCAATTTCAAACTGCC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSATVRRFNDEESLSRAAAEIFALTAEQAIASQGRFSVLLSGGETPRRAYELLSQEPLCSRIPWQGVHLFWGDERCVAAT
DPASNALMVRRALLDRVPIPEEQIHPIACGTEPEVAAARYEALVRAHFPHGGARFDLALLGLGEDGHTASLFPDSPSLGE
QEHWVAATRKKGEEIMRISLTPPALNQAELVVFLVSGAHKASVLHRVLEGPSIPRLLPAQLIAPSRGRLVWMVDQGAARL
LKTTVPAT

Sequences:

>Translated_248_residues
MSATVRRFNDEESLSRAAAEIFALTAEQAIASQGRFSVLLSGGETPRRAYELLSQEPLCSRIPWQGVHLFWGDERCVAAT
DPASNALMVRRALLDRVPIPEEQIHPIACGTEPEVAAARYEALVRAHFPHGGARFDLALLGLGEDGHTASLFPDSPSLGE
QEHWVAATRKKGEEIMRISLTPPALNQAELVVFLVSGAHKASVLHRVLEGPSIPRLLPAQLIAPSRGRLVWMVDQGAARL
LKTTVPAT
>Mature_247_residues
SATVRRFNDEESLSRAAAEIFALTAEQAIASQGRFSVLLSGGETPRRAYELLSQEPLCSRIPWQGVHLFWGDERCVAATD
PASNALMVRRALLDRVPIPEEQIHPIACGTEPEVAAARYEALVRAHFPHGGARFDLALLGLGEDGHTASLFPDSPSLGEQ
EHWVAATRKKGEEIMRISLTPPALNQAELVVFLVSGAHKASVLHRVLEGPSIPRLLPAQLIAPSRGRLVWMVDQGAARLL
KTTVPAT

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=237, Percent_Identity=36.2869198312236, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI6912586, Length=247, Percent_Identity=38.0566801619433, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI115533058, Length=219, Percent_Identity=28.7671232876712, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533060, Length=219, Percent_Identity=29.2237442922374, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321957, Length=257, Percent_Identity=30.3501945525292, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321687, Length=256, Percent_Identity=27.34375, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324362, Length=252, Percent_Identity=30.1587301587302, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319918, Length=217, Percent_Identity=29.9539170506912, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641119, Length=236, Percent_Identity=34.3220338983051, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26928; Mature: 26797

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATVRRFNDEESLSRAAAEIFALTAEQAIASQGRFSVLLSGGETPRRAYELLSQEPLCS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHH
RIPWQGVHLFWGDERCVAATDPASNALMVRRALLDRVPIPEEQIHPIACGTEPEVAAARY
CCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHCCCEECCCCCHHHHHHH
EALVRAHFPHGGARFDLALLGLGEDGHTASLFPDSPSLGEQEHWVAATRKKGEEIMRISL
HHHHHHCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEE
TPPALNQAELVVFLVSGAHKASVLHRVLEGPSIPRLLPAQLIAPSRGRLVWMVDQGAARL
CCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHH
LKTTVPAT
HHHCCCCC
>Mature Secondary Structure 
SATVRRFNDEESLSRAAAEIFALTAEQAIASQGRFSVLLSGGETPRRAYELLSQEPLCS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHH
RIPWQGVHLFWGDERCVAATDPASNALMVRRALLDRVPIPEEQIHPIACGTEPEVAAARY
CCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHCCCEECCCCCHHHHHHH
EALVRAHFPHGGARFDLALLGLGEDGHTASLFPDSPSLGEQEHWVAATRKKGEEIMRISL
HHHHHHCCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEE
TPPALNQAELVVFLVSGAHKASVLHRVLEGPSIPRLLPAQLIAPSRGRLVWMVDQGAARL
CCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHH
LKTTVPAT
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]