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The map label for this gene is ubiB [C]

Identifier: 118580482

GI number: 118580482

Start: 2216023

End: 2217588

Strand: Reverse

Name: ubiB [C]

Synonym: Ppro_2066

Alternate gene names: 118580482

Gene position: 2217588-2216023 (Counterclockwise)

Preceding gene: 118580483

Following gene: 118580481

Centisome position: 55.33

GC content: 62.2

Gene sequence:

>1566_bases
GTGTCCAGACTGCTCCTGCTTATCCGGCTCTACCACCCGGCCAGAATCTACACCGTCTTCCGGGTGCTGCTGACCATATT
TCTCCTGATCCGCAGACGGCCCGACTGGCTGGGGATGGGGCCCCTGGCGCCGGGAGTGCTGGTGGCGGCCATCGAAGGGC
TGGGAGCCAGCTTCATCAAGCTGGCCCAGGTGCTGGCCACCAGGGCGGATTTCTTCGACGCAAGCTACCTGCGGGCCCTG
CAGCAGCTGCATGACCAGCTCTCGCCCATGCCGCGCCAGGATTTTCAGGAGGTCTTTGGCCGGGCTTTCGGCAAGGGGGA
CTGTTTCGGCAGCTTCGACCAGGAACCCTTGGCATGCGCCTCCATCGGCCAGGTTCACCGCGCCCGACTGCACAATGGCG
AACTGGTGGCGGTCAAGCTGTTGCGCAACCGGATCGAACTGGTGGTGCGCGAGGACATTCGCCTGCTGGGGTGGGTTCTG
GCCCTGCTGCAGCCATTGTTTTCTGAATACACCCGCAACTCCATCGAAGCGGTGCTGGCGGCGTTCCGTCGTACCATCCT
GCAGGAGGTGGACATGCGGGTCGAACTTTCCAACCTGGAGCGGTTCCGTCAGATCTATGCCGCTTCGTCTGTTCGACTGC
CCGTTCCCTGGCCCGACTACTGCTCGCGCGATGCGTTGGTGATGAGTTTCGAGGAGGGGGTGCGCTTCGACGACCGGGAA
GGGTTGAGCCGCCTGAATATCCCCTTCGAGGGGCTGATGGAAAAGCTGGTGCTGTTCTACACCGAGCAGATGCTGGTCAA
GGGGCTCTTCCATGCCGACCCGCATCCGGGCAATCTGCTGGTTACCCCGGGGGGGGAACTGGTGCTGCTTGATTTCGGCA
TGGTCAGCAGGATCTCCAACGCCACCCGTCTGGCCATGATCAATGTGGTCAAGGCCGCCGGCGAGCGGGATTTTGAAATG
CTGGTACATGCGGCCCGCAAGCTGGGAATCATTACCGACAACGCCCCCCGTGAGGAGTTGACCGGATTGACGGAAGATCT
CTTCAGCATCTTCGACAACGAGCACCTGAAGGCCACCTCCATGCAGGAGCTGGCCTTCGGCGTGATGGAAACCCTGAAAG
AGTACCCCTTTAAACTGCCCCAGGAGATCATCTATGTCATGCGGGCAAGCTCTATCATCGAGGGGCTGGGCACCCGTTAT
ATCGAGAACTTCAATGGCATCAAGGATGTACTGCCTATCCTCAAGGCCAACCTGACCCGCGCCCTGGGCGAGCGCGACAG
CCTGTGGGGGGTGGTGGTGCACGAACTGGCCCAGTTGCCGCTGACCATGGTCAGGGCCCGTCATCTGGTGGACACCCTGC
AGCAGGGTGAATTGATCGTACGCCTGACCGACGAGGACCGCCGCGCCCTGGTGCGCCCCGTGCAGGTCTGGCTGCGACAG
CTGGCCTGGGTCGCCCTGCTGGTGGCCCTGGCCTTCTACCTGCGGGGGATGGCCCATCCCGTTGCTGGCTGGTTGTCGCT
GGCCTGTTTCTGCGCCGCCGCAATCAGACTGGTATGGAAGTCGTAA

Upstream 100 bases:

>100_bases
CTCAAAGAGACCATCGATGAACTGGGGCTGGCAACCCGCGCCGAAGTCGAGGCCCTGCGGGAAGAGCTGGAAAAACTCCG
TCAGGGGCAGTCCTGATCCG

Downstream 100 bases:

>100_bases
AACCAGGAGGGGGTGTCAAGCGCCCTGAAATTCCAACTGGTATCGGCTGCTCCGCCACCGGGCGCCGATTTCCTCTTTAT
CTCCACATTGCCTGCATATT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSRLLLLIRLYHPARIYTVFRVLLTIFLLIRRRPDWLGMGPLAPGVLVAAIEGLGASFIKLAQVLATRADFFDASYLRAL
QQLHDQLSPMPRQDFQEVFGRAFGKGDCFGSFDQEPLACASIGQVHRARLHNGELVAVKLLRNRIELVVREDIRLLGWVL
ALLQPLFSEYTRNSIEAVLAAFRRTILQEVDMRVELSNLERFRQIYAASSVRLPVPWPDYCSRDALVMSFEEGVRFDDRE
GLSRLNIPFEGLMEKLVLFYTEQMLVKGLFHADPHPGNLLVTPGGELVLLDFGMVSRISNATRLAMINVVKAAGERDFEM
LVHAARKLGIITDNAPREELTGLTEDLFSIFDNEHLKATSMQELAFGVMETLKEYPFKLPQEIIYVMRASSIIEGLGTRY
IENFNGIKDVLPILKANLTRALGERDSLWGVVVHELAQLPLTMVRARHLVDTLQQGELIVRLTDEDRRALVRPVQVWLRQ
LAWVALLVALAFYLRGMAHPVAGWLSLACFCAAAIRLVWKS

Sequences:

>Translated_521_residues
MSRLLLLIRLYHPARIYTVFRVLLTIFLLIRRRPDWLGMGPLAPGVLVAAIEGLGASFIKLAQVLATRADFFDASYLRAL
QQLHDQLSPMPRQDFQEVFGRAFGKGDCFGSFDQEPLACASIGQVHRARLHNGELVAVKLLRNRIELVVREDIRLLGWVL
ALLQPLFSEYTRNSIEAVLAAFRRTILQEVDMRVELSNLERFRQIYAASSVRLPVPWPDYCSRDALVMSFEEGVRFDDRE
GLSRLNIPFEGLMEKLVLFYTEQMLVKGLFHADPHPGNLLVTPGGELVLLDFGMVSRISNATRLAMINVVKAAGERDFEM
LVHAARKLGIITDNAPREELTGLTEDLFSIFDNEHLKATSMQELAFGVMETLKEYPFKLPQEIIYVMRASSIIEGLGTRY
IENFNGIKDVLPILKANLTRALGERDSLWGVVVHELAQLPLTMVRARHLVDTLQQGELIVRLTDEDRRALVRPVQVWLRQ
LAWVALLVALAFYLRGMAHPVAGWLSLACFCAAAIRLVWKS
>Mature_520_residues
SRLLLLIRLYHPARIYTVFRVLLTIFLLIRRRPDWLGMGPLAPGVLVAAIEGLGASFIKLAQVLATRADFFDASYLRALQ
QLHDQLSPMPRQDFQEVFGRAFGKGDCFGSFDQEPLACASIGQVHRARLHNGELVAVKLLRNRIELVVREDIRLLGWVLA
LLQPLFSEYTRNSIEAVLAAFRRTILQEVDMRVELSNLERFRQIYAASSVRLPVPWPDYCSRDALVMSFEEGVRFDDREG
LSRLNIPFEGLMEKLVLFYTEQMLVKGLFHADPHPGNLLVTPGGELVLLDFGMVSRISNATRLAMINVVKAAGERDFEML
VHAARKLGIITDNAPREELTGLTEDLFSIFDNEHLKATSMQELAFGVMETLKEYPFKLPQEIIYVMRASSIIEGLGTRYI
ENFNGIKDVLPILKANLTRALGERDSLWGVVVHELAQLPLTMVRARHLVDTLQQGELIVRLTDEDRRALVRPVQVWLRQL
AWVALLVALAFYLRGMAHPVAGWLSLACFCAAAIRLVWKS

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=300, Percent_Identity=32.3333333333333, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI40254938, Length=282, Percent_Identity=29.0780141843972, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI217035081, Length=303, Percent_Identity=26.4026402640264, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI27363457, Length=286, Percent_Identity=27.972027972028, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI217416386, Length=231, Percent_Identity=30.3030303030303, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI34147522, Length=283, Percent_Identity=26.5017667844523, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI2367309, Length=440, Percent_Identity=24.0909090909091, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17559152, Length=287, Percent_Identity=27.5261324041812, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=299, Percent_Identity=24.4147157190635, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323282, Length=277, Percent_Identity=25.2707581227437, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=269, Percent_Identity=24.1635687732342, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662575, Length=362, Percent_Identity=24.8618784530387, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI22024280, Length=283, Percent_Identity=28.2685512367491, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58984; Mature: 58853

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLLLLIRLYHPARIYTVFRVLLTIFLLIRRRPDWLGMGPLAPGVLVAAIEGLGASFIK
CCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
LAQVLATRADFFDASYLRALQQLHDQLSPMPRQDFQEVFGRAFGKGDCFGSFDQEPLACA
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
SIGQVHRARLHNGELVAVKLLRNRIELVVREDIRLLGWVLALLQPLFSEYTRNSIEAVLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFRRTILQEVDMRVELSNLERFRQIYAASSVRLPVPWPDYCSRDALVMSFEEGVRFDDRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCC
GLSRLNIPFEGLMEKLVLFYTEQMLVKGLFHADPHPGNLLVTPGGELVLLDFGMVSRISN
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECHHHHHHCC
ATRLAMINVVKAAGERDFEMLVHAARKLGIITDNAPREELTGLTEDLFSIFDNEHLKATS
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
MQELAFGVMETLKEYPFKLPQEIIYVMRASSIIEGLGTRYIENFNGIKDVLPILKANLTR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALGERDSLWGVVVHELAQLPLTMVRARHLVDTLQQGELIVRLTDEDRRALVRPVQVWLRQ
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
LAWVALLVALAFYLRGMAHPVAGWLSLACFCAAAIRLVWKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRLLLLIRLYHPARIYTVFRVLLTIFLLIRRRPDWLGMGPLAPGVLVAAIEGLGASFIK
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
LAQVLATRADFFDASYLRALQQLHDQLSPMPRQDFQEVFGRAFGKGDCFGSFDQEPLACA
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
SIGQVHRARLHNGELVAVKLLRNRIELVVREDIRLLGWVLALLQPLFSEYTRNSIEAVLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFRRTILQEVDMRVELSNLERFRQIYAASSVRLPVPWPDYCSRDALVMSFEEGVRFDDRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCC
GLSRLNIPFEGLMEKLVLFYTEQMLVKGLFHADPHPGNLLVTPGGELVLLDFGMVSRISN
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEECHHHHHHCC
ATRLAMINVVKAAGERDFEMLVHAARKLGIITDNAPREELTGLTEDLFSIFDNEHLKATS
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
MQELAFGVMETLKEYPFKLPQEIIYVMRASSIIEGLGTRYIENFNGIKDVLPILKANLTR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ALGERDSLWGVVVHELAQLPLTMVRARHLVDTLQQGELIVRLTDEDRRALVRPVQVWLRQ
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
LAWVALLVALAFYLRGMAHPVAGWLSLACFCAAAIRLVWKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]