Click here to switch to the map view.

The map label for this gene is cobB1 [H]

Identifier: 118580459

GI number: 118580459

Start: 2193043

End: 2193861

Strand: Direct

Name: cobB1 [H]

Synonym: Ppro_2043

Alternate gene names: 118580459

Gene position: 2193043-2193861 (Clockwise)

Preceding gene: 118580458

Following gene: 118580460

Centisome position: 54.72

GC content: 63.86

Gene sequence:

>819_bases
ATGTTCCAGGCCGCGGCCGACGCCATACGCCAGGCACAGGCCTTCATCATTACCGCCGGCGCGGGCATGGGAGTAGATTC
CGGCCTGCCGGATTTTCGCGGCACCAGCGGATTCTGGCAGGCCTACCCCCCTTACGCCAAACGTGGCCTCTCCTTCGCCG
AGGCAGCCAATCCGCTGCACTTCCAGCGCGACCCCTCCTTCGGGTGGGGCTTTTACGGCCATCGCTGCAATCTCTACCGC
TCCACCATCCCCCACGAGGGATTTCACATCCTGCAACACTGGATCCGACGCACCGGGGCCGGCCACTTCATTGTCACCTC
CAACGTGGACGGCCAGTTCCAGAAGGCCGGCTTCGACGAAGCGAATATCCTGGAGGTACACGGTTCCATCCACCACCTGC
AGTGCCTGGAACCGTGCTGCGATTCCATCTGGCCCAATGACGAGACATTCGACATCGACACGCAGGCCATGCGTTCCCGC
TCCATCCCCCGATGCCCCCGCTGTGGCAGCGTCAGCCGCCCCAACATCCTCATGTTCGGCGACTGGTCCTGGCTTTCCGG
GCGCACGGACTGCCAGCAGGCCCGCTTCCAGGGATTCCTGGACATGATGCAGGGGAAACGCTGGGTGGTGATCGAACTGG
GCGCAGGAACGACCATTCCCACCATCCGGGCCACATCGGAGCGACTGGGGCAACGCCTTGACAGTGTCAGGGTGATCCGC
ATCAACCCGCGCGAAGCAGATATCAGGCATCCCCACCTTTCCCTCCCCTGCAACGCCCTGGAGGGGCTGCGACACATCGA
CCGCGTCGTCGGCGACTGA

Upstream 100 bases:

>100_bases
AACTGGCCGACCAGGACCAGATCATGCCCCCCAAGTCAACCTGGTTTGAACCAAAGCTGCGCAGCGGGCTGTTCGTCCAC
CTGCTGGAGTGAGACAGGAC

Downstream 100 bases:

>100_bases
ACCATTGCAAGGTGCGTGTTTTCTCATTTTTCCTTGCCATCGGTCGAACGGTTATGCTACAAAACTATGCTTAACAAATT
CGCACGCCCCGCAACAGACC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MFQAAADAIRQAQAFIITAGAGMGVDSGLPDFRGTSGFWQAYPPYAKRGLSFAEAANPLHFQRDPSFGWGFYGHRCNLYR
STIPHEGFHILQHWIRRTGAGHFIVTSNVDGQFQKAGFDEANILEVHGSIHHLQCLEPCCDSIWPNDETFDIDTQAMRSR
SIPRCPRCGSVSRPNILMFGDWSWLSGRTDCQQARFQGFLDMMQGKRWVVIELGAGTTIPTIRATSERLGQRLDSVRVIR
INPREADIRHPHLSLPCNALEGLRHIDRVVGD

Sequences:

>Translated_272_residues
MFQAAADAIRQAQAFIITAGAGMGVDSGLPDFRGTSGFWQAYPPYAKRGLSFAEAANPLHFQRDPSFGWGFYGHRCNLYR
STIPHEGFHILQHWIRRTGAGHFIVTSNVDGQFQKAGFDEANILEVHGSIHHLQCLEPCCDSIWPNDETFDIDTQAMRSR
SIPRCPRCGSVSRPNILMFGDWSWLSGRTDCQQARFQGFLDMMQGKRWVVIELGAGTTIPTIRATSERLGQRLDSVRVIR
INPREADIRHPHLSLPCNALEGLRHIDRVVGD
>Mature_272_residues
MFQAAADAIRQAQAFIITAGAGMGVDSGLPDFRGTSGFWQAYPPYAKRGLSFAEAANPLHFQRDPSFGWGFYGHRCNLYR
STIPHEGFHILQHWIRRTGAGHFIVTSNVDGQFQKAGFDEANILEVHGSIHHLQCLEPCCDSIWPNDETFDIDTQAMRSR
SIPRCPRCGSVSRPNILMFGDWSWLSGRTDCQQARFQGFLDMMQGKRWVVIELGAGTTIPTIRATSERLGQRLDSVRVIR
INPREADIRHPHLSLPCNALEGLRHIDRVVGD

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=190, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI6912664, Length=190, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI300795542, Length=184, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325242, Length=249, Percent_Identity=24.0963855421687, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30547; Mature: 30547

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQAAADAIRQAQAFIITAGAGMGVDSGLPDFRGTSGFWQAYPPYAKRGLSFAEAANPLH
CCCHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCCE
FQRDPSFGWGFYGHRCNLYRSTIPHEGFHILQHWIRRTGAGHFIVTSNVDGQFQKAGFDE
ECCCCCCCCCCCCCEEEHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCC
ANILEVHGSIHHLQCLEPCCDSIWPNDETFDIDTQAMRSRSIPRCPRCGSVSRPNILMFG
CEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEE
DWSWLSGRTDCQQARFQGFLDMMQGKRWVVIELGAGTTIPTIRATSERLGQRLDSVRVIR
CCHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECHHHHHHHHHCCEEEEE
INPREADIRHPHLSLPCNALEGLRHIDRVVGD
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQAAADAIRQAQAFIITAGAGMGVDSGLPDFRGTSGFWQAYPPYAKRGLSFAEAANPLH
CCCHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHCCCCE
FQRDPSFGWGFYGHRCNLYRSTIPHEGFHILQHWIRRTGAGHFIVTSNVDGQFQKAGFDE
ECCCCCCCCCCCCCEEEHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCC
ANILEVHGSIHHLQCLEPCCDSIWPNDETFDIDTQAMRSRSIPRCPRCGSVSRPNILMFG
CEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEE
DWSWLSGRTDCQQARFQGFLDMMQGKRWVVIELGAGTTIPTIRATSERLGQRLDSVRVIR
CCHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECHHHHHHHHHCCEEEEE
INPREADIRHPHLSLPCNALEGLRHIDRVVGD
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]