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The map label for this gene is accC [H]

Identifier: 118580438

GI number: 118580438

Start: 2171350

End: 2172690

Strand: Reverse

Name: accC [H]

Synonym: Ppro_2022

Alternate gene names: 118580438

Gene position: 2172690-2171350 (Counterclockwise)

Preceding gene: 118580439

Following gene: 118580437

Centisome position: 54.21

GC content: 58.99

Gene sequence:

>1341_bases
ATGTTTCATAAGATTCTGATCGCCAACCGGGGCGAGATTGCCCTGCGCATCATCCGGGCCTGCAAGGAACTGGGCATCAA
GACGGTGGCGGTTTACTCCCAACCCGATATCAACTCACTGCACGTCAAGCTGGCCGACGAGAGCGTCTGCATCGGCCCCG
CCGCCAGCGCCCAGAGTTACCTGAATATCAATGCCATCATCAGTGCCGCTGAACTGACCGATGCCGAGGCCATCCACCCC
GGCTACGGGTTTTTGTCGGAAAACGCCGATTTCGCTGAAATCTGCGAAAAGTGCGGCATCACCTTCATCGGCCCCAGCCC
GGAGAGCATGCGCATCATGGGCGACAAGATCAGCGCCCGTCAGGCGGTCACTGCCCAGGGAGTGCCGATCCTGCCCGGCA
CCAAGGAGGGGGTCGCTTCGGTGGATGAGGCCATAACCATTGCCAAGGAGATCGGCTTCCCGGTGATTATCAAGGCTACG
GCAGGGGGGGGCGGTCGCGGCATGAAGATCGTTCACTCCCAGGCGGCGCTCCCCAATGCCTTTGCCACCGCCCGTGCCGA
GGCCCAGTCAGGCTTTGGCAACCCTGAAGTGTACATAGAAAAGTATTGCGAGCACCCGCGTCATGTGGAGATCCAGATCC
TGGCCGACAAGCATGGCAACGTGATTCACCTGGGGGAGCGTGACTGCTCCATCCAGCGGCGCCACCAGAAGCTGATCGAG
GAGGCCCCCTCCACCATCAGTACCCCGGAGCTGCGCGCAGCCATGGGGGAGGCAGCGGTCAGGGCGGCCGCATCGGTTGG
ATACAACAGCGTGGGAACCGTTGAGTTCCTGGTGGACAAAGAGAACAACTTCTATTTCATGGAGATGAATACCCGCGTTC
AGGTGGAGCACCCGGTAACCGAGATGATAACCGGCGTCGACATCGTCCGCGAACAGATCCGCTCGGCAGCCGGCTGTCCT
CTGCGCTATAGGCAGGAGGACATCAAGATCAGCGGCCATGCCATCGAGTGCCGCATCAATGCCGAGGATCCCCACAAGTT
CACCCCCTGTCCCGGCAAGATAACCGCCTACCACCCGCCGGGAGGGCTGGGGGTGCGGGTGGATTCCTTCGTCTATGACC
AGTATACCGTCTTGCCCTATTACGACTCCATGGTGGCCAAGCTGATCGTCCATGCCGAAACGCGGCAGGATGCCATCAAA
CGCATGTCCCGGGCGCTGGACGAGTATATTATCGAGGGTATCAAGACCACCATCTTCTTCCAGAAGAGGATCATGACCAA
CAAGGATTTTATCGAAGGAAACATAGATACATCATTTCTTGAGAGAATCGTGCTGGAGTAG

Upstream 100 bases:

>100_bases
GGGGATGGTTGTGTGAACGTTGATTGCGGGGATCTCCCGCCCACGGCCAGTCCCCCGGCTGACTTTTATCCGTCTGGAGA
ATACAAGAGGTTACCTTTTC

Downstream 100 bases:

>100_bases
ACTATGGACTTTCCTGAAGAGCTCAAGTATTCCCGTGAGCATGTCTGGGTTCGGATCGAGAATGGAACGGCGGTCATCGG
CATCACGGATTTTGCCCAGA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFHKILIANRGEIALRIIRACKELGIKTVAVYSQPDINSLHVKLADESVCIGPAASAQSYLNINAIISAAELTDAEAIHP
GYGFLSENADFAEICEKCGITFIGPSPESMRIMGDKISARQAVTAQGVPILPGTKEGVASVDEAITIAKEIGFPVIIKAT
AGGGGRGMKIVHSQAALPNAFATARAEAQSGFGNPEVYIEKYCEHPRHVEIQILADKHGNVIHLGERDCSIQRRHQKLIE
EAPSTISTPELRAAMGEAAVRAAASVGYNSVGTVEFLVDKENNFYFMEMNTRVQVEHPVTEMITGVDIVREQIRSAAGCP
LRYRQEDIKISGHAIECRINAEDPHKFTPCPGKITAYHPPGGLGVRVDSFVYDQYTVLPYYDSMVAKLIVHAETRQDAIK
RMSRALDEYIIEGIKTTIFFQKRIMTNKDFIEGNIDTSFLERIVLE

Sequences:

>Translated_446_residues
MFHKILIANRGEIALRIIRACKELGIKTVAVYSQPDINSLHVKLADESVCIGPAASAQSYLNINAIISAAELTDAEAIHP
GYGFLSENADFAEICEKCGITFIGPSPESMRIMGDKISARQAVTAQGVPILPGTKEGVASVDEAITIAKEIGFPVIIKAT
AGGGGRGMKIVHSQAALPNAFATARAEAQSGFGNPEVYIEKYCEHPRHVEIQILADKHGNVIHLGERDCSIQRRHQKLIE
EAPSTISTPELRAAMGEAAVRAAASVGYNSVGTVEFLVDKENNFYFMEMNTRVQVEHPVTEMITGVDIVREQIRSAAGCP
LRYRQEDIKISGHAIECRINAEDPHKFTPCPGKITAYHPPGGLGVRVDSFVYDQYTVLPYYDSMVAKLIVHAETRQDAIK
RMSRALDEYIIEGIKTTIFFQKRIMTNKDFIEGNIDTSFLERIVLE
>Mature_446_residues
MFHKILIANRGEIALRIIRACKELGIKTVAVYSQPDINSLHVKLADESVCIGPAASAQSYLNINAIISAAELTDAEAIHP
GYGFLSENADFAEICEKCGITFIGPSPESMRIMGDKISARQAVTAQGVPILPGTKEGVASVDEAITIAKEIGFPVIIKAT
AGGGGRGMKIVHSQAALPNAFATARAEAQSGFGNPEVYIEKYCEHPRHVEIQILADKHGNVIHLGERDCSIQRRHQKLIE
EAPSTISTPELRAAMGEAAVRAAASVGYNSVGTVEFLVDKENNFYFMEMNTRVQVEHPVTEMITGVDIVREQIRSAAGCP
LRYRQEDIKISGHAIECRINAEDPHKFTPCPGKITAYHPPGGLGVRVDSFVYDQYTVLPYYDSMVAKLIVHAETRQDAIK
RMSRALDEYIIEGIKTTIFFQKRIMTNKDFIEGNIDTSFLERIVLE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=51.4606741573034, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=51.4606741573034, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=51.4606741573034, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=48.6486486486487, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=48.6486486486487, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=48.6486486486487, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=49.0909090909091, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=33.4637964774951, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=33.4637964774951, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=33.4637964774951, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=33.4637964774951, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=33.4637964774951, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=32.6171875, Blast_Score=267, Evalue=1e-71,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=59.8194130925508, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1786216, Length=243, Percent_Identity=23.8683127572016, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=48.6607142857143, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=47.0454545454545, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=45.7399103139013, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=29.9603174603175, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=29.9603174603175, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=30.2469135802469, Blast_Score=207, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=45.2488687782805, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.0850111856823, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.9798657718121, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323863, Length=475, Percent_Identity=34.9473684210526, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=33.4622823984526, Blast_Score=253, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=48.4162895927602, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652212, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652210, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652214, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19921944, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652216, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363050, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652224, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652222, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652220, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652218, Length=443, Percent_Identity=48.9841986455982, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=47.0443349753695, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=32.4165029469548, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=32.4165029469548, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=32.4165029469548, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=32.4165029469548, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48928; Mature: 48928

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHKILIANRGEIALRIIRACKELGIKTVAVYSQPDINSLHVKLADESVCIGPAASAQSY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCCCCHHE
LNINAIISAAELTDAEAIHPGYGFLSENADFAEICEKCGITFIGPSPESMRIMGDKISAR
EEEHHEEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCEEEECCCCCHH
QAVTAQGVPILPGTKEGVASVDEAITIAKEIGFPVIIKATAGGGGRGMKIVHSQAALPNA
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCH
FATARAEAQSGFGNPEVYIEKYCEHPRHVEIQILADKHGNVIHLGERDCSIQRRHQKLIE
HHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSTISTPELRAAMGEAAVRAAASVGYNSVGTVEFLVDKENNFYFMEMNTRVQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMITGVDIVREQIRSAAGCPLRYRQEDIKISGHAIECRINAEDPHKFTPCPGKITAYHPP
HHHHHHHHHHHHHHHHCCCCEEECCCCEEEECEEEEEEECCCCCCCCCCCCCCEEEECCC
GGLGVRVDSFVYDQYTVLPYYDSMVAKLIVHAETRQDAIKRMSRALDEYIIEGIKTTIFF
CCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
QKRIMTNKDFIEGNIDTSFLERIVLE
HHHHCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MFHKILIANRGEIALRIIRACKELGIKTVAVYSQPDINSLHVKLADESVCIGPAASAQSY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCCCCHHE
LNINAIISAAELTDAEAIHPGYGFLSENADFAEICEKCGITFIGPSPESMRIMGDKISAR
EEEHHEEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCEEEECCCCCHH
QAVTAQGVPILPGTKEGVASVDEAITIAKEIGFPVIIKATAGGGGRGMKIVHSQAALPNA
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCCH
FATARAEAQSGFGNPEVYIEKYCEHPRHVEIQILADKHGNVIHLGERDCSIQRRHQKLIE
HHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSTISTPELRAAMGEAAVRAAASVGYNSVGTVEFLVDKENNFYFMEMNTRVQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMITGVDIVREQIRSAAGCPLRYRQEDIKISGHAIECRINAEDPHKFTPCPGKITAYHPP
HHHHHHHHHHHHHHHHCCCCEEECCCCEEEECEEEEEEECCCCCCCCCCCCCCEEEECCC
GGLGVRVDSFVYDQYTVLPYYDSMVAKLIVHAETRQDAIKRMSRALDEYIIEGIKTTIFF
CCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
QKRIMTNKDFIEGNIDTSFLERIVLE
HHHHCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]