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The map label for this gene is atoC [H]

Identifier: 118580418

GI number: 118580418

Start: 2150069

End: 2151490

Strand: Reverse

Name: atoC [H]

Synonym: Ppro_2002

Alternate gene names: 118580418

Gene position: 2151490-2150069 (Counterclockwise)

Preceding gene: 118580419

Following gene: 118580417

Centisome position: 53.68

GC content: 61.39

Gene sequence:

>1422_bases
ATGACCGACGGCGCCACCTTCACCATCCTGATCGTGGATGACGAGCAGCACATCCTGTTTTCTTCCGAATCCCTGCTCCG
TTTTGCCGGTTTCAGGGAGATACGCACCCTGGATGACAGCCGACGGGTACTGTCGCTGCTGGAAAAGGAGACGATCGACC
TGATCGTCCTGGACCTGTTCATGCCGTATGTGTCCGGCAGGGAGCTGCTGACCCTGCTCAGCCGCGATTATCCCCACATT
CCGGTGATTGTCATGACCGCGGCCGACGAGGTCGATATTGCCGTCGACTGCATGAAGGGGGGTGCCTTCGACTACCTGGT
GAAGCCGGTGGAGAATGCCCGCCTGGTCTCCTGTGTGAAGAGGGCGCTGGAGATCAGCAGTCTGAAGAACCAAGTGTCCC
AACTGCGAGAGCACCTGCTCAGTAACCGCATCGAGAATCCCGGCGCCTTTTCCGCCCTGGTCTCGGTTAGTCCAAAGATG
TCGGCCATCTTCCAGTACTGCGAGGTCATCGCCAGATCGCGGCAGCCGGTGATCATCAACGGCGAGACCGGCACCGGCAA
GGAGCTGATCGCCAAGGCGATCCACACGGCAAGTGGGCTCAAGGGGAAATTCGTGCCGGTCAACGCTGCCGGTCTGGACG
ACAACATGTTTTCCGACACCCTCTTCGGCCACAAGAAGGGGGCCTTTACCGGCGCGGACCAGGCCCGGGCCGGCCTGATA
GCCCAGGCCTCGGGCGGGACCCTGTTTCTGGACGAGATCGGTGACCTGCACGAGGTATCCCAGGTCAAGCTCCTGCGCCT
GCTCCAGGAACAGGAGTACTACCAGGTCGGTTCCGACATGCCGCTGGTCAGCGATGCCCGCGTCATCGTGGCAACCAACA
GGGATCTCCGGGAACTGACCGCGACGGGGAAGTTCCGCAACGACCTCTACTTCAGGCTCTGCACCCATCAGGTTCAACTT
CCCCCCCTGCGGAAGCGTGCGGAGGATATTTCGGTGCTTTTGAACCATTTTCTGGAGGAGTCGGCACAGGAGCTGAAAAA
GAAGAAGCCGTCCTACCCCCCGGAACTGGTCACCCTCCTCTCCCTGTATGATTTTCCCGGCAACGTGCGCGAGATGAAGG
CGCTCATCTTCGACGCCGTGGCCCGCCACGGCAGCGGCGTCCTCTCCCTGGAGCGCTTCAGGGAGCACATTGGAATCCGC
TCTGCACCGCCGGCCTCCGCTTCCCTTCCGGTAAAGGGTGTGGTGGACGGGTTGCGGCAGGCGCTGGACAGGCTTCCCAC
GGTGCGCGAGGTGGAGGAGTACCTGGTGGACGAAGCCATGAAGCTTGCCAACGGCAATCAGGGGATTGCCGCCTCACTGC
TGGGATTCACCCGCCAGACCCTGAACAAGCGCCTGCGCAAGAACAGGGAAAACCTCCCCTGA

Upstream 100 bases:

>100_bases
ACAACGGCATCATCGAGTGCGATTCCAGTCCGGGGAAGGGCACCGTGTTTTATGTCAGAATACCGGCCCTGCGTTTCGAA
CCTGAGGAGAACGGGTTACC

Downstream 100 bases:

>100_bases
ACCCACCGGTCATATCCCCGTTGCATCATCTCGGTTCTCTGCGCCTGCCATGGCCGGGGGGGATGAAACTTTTTTTACAC
CTGTCACCATTGACGACACC

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTDGATFTILIVDDEQHILFSSESLLRFAGFREIRTLDDSRRVLSLLEKETIDLIVLDLFMPYVSGRELLTLLSRDYPHI
PVIVMTAADEVDIAVDCMKGGAFDYLVKPVENARLVSCVKRALEISSLKNQVSQLREHLLSNRIENPGAFSALVSVSPKM
SAIFQYCEVIARSRQPVIINGETGTGKELIAKAIHTASGLKGKFVPVNAAGLDDNMFSDTLFGHKKGAFTGADQARAGLI
AQASGGTLFLDEIGDLHEVSQVKLLRLLQEQEYYQVGSDMPLVSDARVIVATNRDLRELTATGKFRNDLYFRLCTHQVQL
PPLRKRAEDISVLLNHFLEESAQELKKKKPSYPPELVTLLSLYDFPGNVREMKALIFDAVARHGSGVLSLERFREHIGIR
SAPPASASLPVKGVVDGLRQALDRLPTVREVEEYLVDEAMKLANGNQGIAASLLGFTRQTLNKRLRKNRENLP

Sequences:

>Translated_473_residues
MTDGATFTILIVDDEQHILFSSESLLRFAGFREIRTLDDSRRVLSLLEKETIDLIVLDLFMPYVSGRELLTLLSRDYPHI
PVIVMTAADEVDIAVDCMKGGAFDYLVKPVENARLVSCVKRALEISSLKNQVSQLREHLLSNRIENPGAFSALVSVSPKM
SAIFQYCEVIARSRQPVIINGETGTGKELIAKAIHTASGLKGKFVPVNAAGLDDNMFSDTLFGHKKGAFTGADQARAGLI
AQASGGTLFLDEIGDLHEVSQVKLLRLLQEQEYYQVGSDMPLVSDARVIVATNRDLRELTATGKFRNDLYFRLCTHQVQL
PPLRKRAEDISVLLNHFLEESAQELKKKKPSYPPELVTLLSLYDFPGNVREMKALIFDAVARHGSGVLSLERFREHIGIR
SAPPASASLPVKGVVDGLRQALDRLPTVREVEEYLVDEAMKLANGNQGIAASLLGFTRQTLNKRLRKNRENLP
>Mature_472_residues
TDGATFTILIVDDEQHILFSSESLLRFAGFREIRTLDDSRRVLSLLEKETIDLIVLDLFMPYVSGRELLTLLSRDYPHIP
VIVMTAADEVDIAVDCMKGGAFDYLVKPVENARLVSCVKRALEISSLKNQVSQLREHLLSNRIENPGAFSALVSVSPKMS
AIFQYCEVIARSRQPVIINGETGTGKELIAKAIHTASGLKGKFVPVNAAGLDDNMFSDTLFGHKKGAFTGADQARAGLIA
QASGGTLFLDEIGDLHEVSQVKLLRLLQEQEYYQVGSDMPLVSDARVIVATNRDLRELTATGKFRNDLYFRLCTHQVQLP
PLRKRAEDISVLLNHFLEESAQELKKKKPSYPPELVTLLSLYDFPGNVREMKALIFDAVARHGSGVLSLERFREHIGIRS
APPASASLPVKGVVDGLRQALDRLPTVREVEEYLVDEAMKLANGNQGIAASLLGFTRQTLNKRLRKNRENLP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=36.9565217391304, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1790437, Length=463, Percent_Identity=37.5809935205184, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=35.9574468085106, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1788905, Length=382, Percent_Identity=36.9109947643979, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87082117, Length=350, Percent_Identity=38.2857142857143, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1789087, Length=348, Percent_Identity=37.0689655172414, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI87082152, Length=231, Percent_Identity=44.5887445887446, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1789233, Length=209, Percent_Identity=44.0191387559809, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1786524, Length=392, Percent_Identity=32.9081632653061, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI87081872, Length=302, Percent_Identity=36.4238410596026, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1787583, Length=235, Percent_Identity=39.5744680851064, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789828, Length=197, Percent_Identity=43.1472081218274, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87081858, Length=338, Percent_Identity=24.8520710059172, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52465; Mature: 52334

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGATFTILIVDDEQHILFSSESLLRFAGFREIRTLDDSRRVLSLLEKETIDLIVLDLF
CCCCCEEEEEEEECCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MPYVSGRELLTLLSRDYPHIPVIVMTAADEVDIAVDCMKGGAFDYLVKPVENARLVSCVK
HHHHCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEHHCCCCHHHHHCCCCCHHHHHHHH
RALEISSLKNQVSQLREHLLSNRIENPGAFSALVSVSPKMSAIFQYCEVIARSRQPVIIN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
GETGTGKELIAKAIHTASGLKGKFVPVNAAGLDDNMFSDTLFGHKKGAFTGADQARAGLI
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCHHHCCEE
AQASGGTLFLDEIGDLHEVSQVKLLRLLQEQEYYQVGSDMPLVSDARVIVATNRDLRELT
EECCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHH
ATGKFRNDLYFRLCTHQVQLPPLRKRAEDISVLLNHFLEESAQELKKKKPSYPPELVTLL
HCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SLYDFPGNVREMKALIFDAVARHGSGVLSLERFREHIGIRSAPPASASLPVKGVVDGLRQ
HHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
ALDRLPTVREVEEYLVDEAMKLANGNQGIAASLLGFTRQTLNKRLRKNRENLP
HHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDGATFTILIVDDEQHILFSSESLLRFAGFREIRTLDDSRRVLSLLEKETIDLIVLDLF
CCCCEEEEEEEECCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MPYVSGRELLTLLSRDYPHIPVIVMTAADEVDIAVDCMKGGAFDYLVKPVENARLVSCVK
HHHHCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEHHCCCCHHHHHCCCCCHHHHHHHH
RALEISSLKNQVSQLREHLLSNRIENPGAFSALVSVSPKMSAIFQYCEVIARSRQPVIIN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
GETGTGKELIAKAIHTASGLKGKFVPVNAAGLDDNMFSDTLFGHKKGAFTGADQARAGLI
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCHHHCCEE
AQASGGTLFLDEIGDLHEVSQVKLLRLLQEQEYYQVGSDMPLVSDARVIVATNRDLRELT
EECCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHH
ATGKFRNDLYFRLCTHQVQLPPLRKRAEDISVLLNHFLEESAQELKKKKPSYPPELVTLL
HCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SLYDFPGNVREMKALIFDAVARHGSGVLSLERFREHIGIRSAPPASASLPVKGVVDGLRQ
HHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
ALDRLPTVREVEEYLVDEAMKLANGNQGIAASLLGFTRQTLNKRLRKNRENLP
HHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]