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The map label for this gene is dhaT [H]

Identifier: 118580417

GI number: 118580417

Start: 2148462

End: 2149625

Strand: Reverse

Name: dhaT [H]

Synonym: Ppro_2001

Alternate gene names: 118580417

Gene position: 2149625-2148462 (Counterclockwise)

Preceding gene: 118580418

Following gene: 118580416

Centisome position: 53.63

GC content: 58.33

Gene sequence:

>1164_bases
ATGGCATTGGCTGAACAGGTATACAACTTTTATATCCCCGCAATAACGAAGATGGGTATCGGCGCTGTAAAGGAACTGGG
ACCTTGCGCTCAGTTTCTCAAGGGTACCAAAGCGCTGCTCGTTACCGATAAGGGCATGGCGGATCTTGGCGTTGCCGATC
GGATGAAACAACTGCTCGAGGTTGACGGTGTCCAGTGTGTCATTTTCAGTGGTGCGGAACCAAACCCCACCGATCTGAAC
GTGCGGGCCGGGATCAAGGTGTATCGCGAAAACAACTGTGACATGCTCGTGAGCCTTGGTGGGGGCAGTTCCCATGACTG
CGCCAAAGGGATCGGAATTGTTGCCACAAATGACGGTGATATCCGTGATTTCGCCGGAGTTGATACCTTCAAGAATGCGC
TGCCCCCCTTTATTGCCATCAACACCACCGCCGGCACCGCCAGTGAGATGACATCGTTTGCCGTCATTACCAACAGCGAT
ATTCATGTGAAGATGATCTTTGCCAGCCCCAGGATTACCGCCACCATCGCAATCAACGATCCGGCCCTGATGGTCGGCCT
CCCTGCGCCATTGACCGCCTCAACCGGCATGGACGCACTCACCCATGCGGTGGAGGCGTATGTGGCGGCTCTCGCGAACC
CGGTCACCGATGCCTGCGCCATTGCGGCCATCAAGCTTATCGCGGAATATCTTCCCCAGGCCGTTGCCAACGGCAGCAAC
CTTGAGGCCCGGGACAAGATGGCGTACGCCGAATATCTGGCAGGCATGGCATTCAGCAACGCCGGCATCGGCATCGTTCA
TGCCATGGCGCATCAGCCGGGCGCCCTGCTCAACAAGCCCCACGGCGTCTGCAACGCTATCCTGCTCCCCCACGGTTGCA
GTTTCAACCTGATCGCCTGTCCCCAGCGCTACGCCGATATCGCCCAGGCCATGGGGGTGGACACCACCGGACTGATGCCC
ATGGAGGCTGCCGAGAGGGGCGTGGAAGCCATCCGCAAACTCTCCGCCGCGGTGGGTATCCCCGCCGGTCTCTCGGAAAT
CGGTGTCAAGACGAGCGACATTCCCACACTGGCCGAAAACGCCATCAAGGACATCTGCTGTCTCTTCAATCCCCGCACCA
TAAAGCTGGACGACCTGACCAGGCTGTACACCGAGGCGATGTAA

Upstream 100 bases:

>100_bases
GGTTCCTTTGAATGTACGTGCTGTCAGCGGTGGGAAATGAGCCGTGAGCGTGGCGCGACAATCCGGATAACGAACCATAC
CGACGAGGAGGAAACAGACC

Downstream 100 bases:

>100_bases
GGCGCGCGTCAGGTGGCCCTTCCCCCTTTCCCTCCCCTCATCGGGATGGGGGAAAGGGGGAAGGGCAGGGGATATGGCGG
GAGCAGATGACAGTCGCGCA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MALAEQVYNFYIPAITKMGIGAVKELGPCAQFLKGTKALLVTDKGMADLGVADRMKQLLEVDGVQCVIFSGAEPNPTDLN
VRAGIKVYRENNCDMLVSLGGGSSHDCAKGIGIVATNDGDIRDFAGVDTFKNALPPFIAINTTAGTASEMTSFAVITNSD
IHVKMIFASPRITATIAINDPALMVGLPAPLTASTGMDALTHAVEAYVAALANPVTDACAIAAIKLIAEYLPQAVANGSN
LEARDKMAYAEYLAGMAFSNAGIGIVHAMAHQPGALLNKPHGVCNAILLPHGCSFNLIACPQRYADIAQAMGVDTTGLMP
MEAAERGVEAIRKLSAAVGIPAGLSEIGVKTSDIPTLAENAIKDICCLFNPRTIKLDDLTRLYTEAM

Sequences:

>Translated_387_residues
MALAEQVYNFYIPAITKMGIGAVKELGPCAQFLKGTKALLVTDKGMADLGVADRMKQLLEVDGVQCVIFSGAEPNPTDLN
VRAGIKVYRENNCDMLVSLGGGSSHDCAKGIGIVATNDGDIRDFAGVDTFKNALPPFIAINTTAGTASEMTSFAVITNSD
IHVKMIFASPRITATIAINDPALMVGLPAPLTASTGMDALTHAVEAYVAALANPVTDACAIAAIKLIAEYLPQAVANGSN
LEARDKMAYAEYLAGMAFSNAGIGIVHAMAHQPGALLNKPHGVCNAILLPHGCSFNLIACPQRYADIAQAMGVDTTGLMP
MEAAERGVEAIRKLSAAVGIPAGLSEIGVKTSDIPTLAENAIKDICCLFNPRTIKLDDLTRLYTEAM
>Mature_386_residues
ALAEQVYNFYIPAITKMGIGAVKELGPCAQFLKGTKALLVTDKGMADLGVADRMKQLLEVDGVQCVIFSGAEPNPTDLNV
RAGIKVYRENNCDMLVSLGGGSSHDCAKGIGIVATNDGDIRDFAGVDTFKNALPPFIAINTTAGTASEMTSFAVITNSDI
HVKMIFASPRITATIAINDPALMVGLPAPLTASTGMDALTHAVEAYVAALANPVTDACAIAAIKLIAEYLPQAVANGSNL
EARDKMAYAEYLAGMAFSNAGIGIVHAMAHQPGALLNKPHGVCNAILLPHGCSFNLIACPQRYADIAQAMGVDTTGLMPM
EAAERGVEAIRKLSAAVGIPAGLSEIGVKTSDIPTLAENAIKDICCLFNPRTIKLDDLTRLYTEAM

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=410, Percent_Identity=26.5853658536585, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=50.5291005291005, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1789163, Length=372, Percent_Identity=41.1290322580645, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI87082107, Length=385, Percent_Identity=38.7012987012987, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1787493, Length=377, Percent_Identity=33.6870026525199, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789386, Length=398, Percent_Identity=26.1306532663317, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=415, Percent_Identity=26.0240963855422, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=368, Percent_Identity=47.2826086956522, Blast_Score=334, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24657991, Length=420, Percent_Identity=28.0952380952381, Blast_Score=144, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 40483; Mature: 40352

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALAEQVYNFYIPAITKMGIGAVKELGPCAQFLKGTKALLVTDKGMADLGVADRMKQLLE
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCHHHHHHHHHH
VDGVQCVIFSGAEPNPTDLNVRAGIKVYRENNCDMLVSLGGGSSHDCAKGIGIVATNDGD
CCCCEEEEEECCCCCCCCEEEECCEEEEECCCCCEEEEECCCCCCCHHCCCEEEEECCCC
IRDFAGVDTFKNALPPFIAINTTAGTASEMTSFAVITNSDIHVKMIFASPRITATIAIND
CHHHCCCHHHHHCCCCEEEEECCCCCHHHHCEEEEEECCCEEEEEEEECCCEEEEEEECC
PALMVGLPAPLTASTGMDALTHAVEAYVAALANPVTDACAIAAIKLIAEYLPQAVANGSN
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
LEARDKMAYAEYLAGMAFSNAGIGIVHAMAHQPGALLNKPHGVCNAILLPHGCSFNLIAC
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHCCCCCCHHEEEEECCCCCCCEEEC
PQRYADIAQAMGVDTTGLMPMEAAERGVEAIRKLSAAVGIPAGLSEIGVKTSDIPTLAEN
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHH
AIKDICCLFNPRTIKLDDLTRLYTEAM
HHHHHHHHCCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure 
ALAEQVYNFYIPAITKMGIGAVKELGPCAQFLKGTKALLVTDKGMADLGVADRMKQLLE
CHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCHHHHHHHHHH
VDGVQCVIFSGAEPNPTDLNVRAGIKVYRENNCDMLVSLGGGSSHDCAKGIGIVATNDGD
CCCCEEEEEECCCCCCCCEEEECCEEEEECCCCCEEEEECCCCCCCHHCCCEEEEECCCC
IRDFAGVDTFKNALPPFIAINTTAGTASEMTSFAVITNSDIHVKMIFASPRITATIAIND
CHHHCCCHHHHHCCCCEEEEECCCCCHHHHCEEEEEECCCEEEEEEEECCCEEEEEEECC
PALMVGLPAPLTASTGMDALTHAVEAYVAALANPVTDACAIAAIKLIAEYLPQAVANGSN
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
LEARDKMAYAEYLAGMAFSNAGIGIVHAMAHQPGALLNKPHGVCNAILLPHGCSFNLIAC
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHCCCCCCHHEEEEECCCCCCCEEEC
PQRYADIAQAMGVDTTGLMPMEAAERGVEAIRKLSAAVGIPAGLSEIGVKTSDIPTLAEN
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHH
AIKDICCLFNPRTIKLDDLTRLYTEAM
HHHHHHHHCCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]